Optimization of influenza A vaccine virus by reverse genetic using chimeric HA and NA genes with an extended PR8 backbone.

abstract：:The incidence of Lyme disease has continued to rise despite attempts to control its spread. Vaccination of zoonotic reservoirs of human pathogens has been successfully used to decrease the incidence of rabies in raccoons and foxes. We have previously reported on the efficacy of a vaccinia virus vectored vaccine to red...

journal_title：Vaccine

authors： Kern A,Zhou CW,Jia F,Xu Q,Hu LT

更新日期：2016-08-31 00:00:00

abstract：:We previously reported the development of an oral vaccine for diabetes based on live attenuated Salmonella-expressing preproinsulin (PPI) as the autoantigen. When combined with host cell-expressed TGFβ, the vaccine prevented the onset of diabetes in non-obese diabetic (NOD) mice. Herein, we investigated factors that c...

journal_title：Vaccine

authors： Husseiny MI,Du W,Mbongue J,Lenz A,Rawson J,Kandeel F,Ferreri K

更新日期：2018-12-18 00:00:00

abstract：INTRODUCTION:Vaccination of pregnant women protects both women and their newborns against some infectious diseases. Thailand implemented tetanus toxoid (TT) vaccination of pregnant women in 1977, which was replaced by tetanus-diphtheria toxoid (dT) vaccination in 2005. The tetanus-diphtheria-acellular pertussis (Tdap) ...

journal_title：Vaccine

authors： Wanlapakorn N,Maertens K,Thongmee T,Srimuan D,Thatsanathorn T,Van Damme P,Leuridan E,Poovorawan Y

更新日期：2020-10-14 00:00:00

abstract：:In order to evaluate a combination of yellow fever and typhoid fever vaccine, we conducted a controlled trial comparing reactogenicity and immunogenicity of Vi polysaccharide (ViPS) vaccine and yellow fever 17D (YF) vaccine after single, simultaneous and combined administration. The combined YF/ViPS vaccine was prepar...

journal_title：Vaccine

authors： Ambrosch F,Fritzell B,Gregor J,Jonas S,Kollaritsch H,Teulieres L,Wiedermann G

更新日期：1994-05-01 00:00:00

abstract：:It is of great interest to develop a pneumonic plague vaccine that would induce combined humoral and cellular immunity in the lung. Here we investigate a novel approach based on targeting of dendritic cells using the DEC-205/CD205 receptor (DEC) via the intranasal route as way to improve mucosal cellular immunity to t...

journal_title：Vaccine

authors： Do Y,Didierlaurent AM,Ryu S,Koh H,Park CG,Park S,Perlin DS,Powell BS,Steinman RM

更新日期：2012-10-05 00:00:00

abstract：:A formalin-inactivated red sea bream iridovirus (RSIV) vaccine was prepared using the culture supernatant of a persistently infected Pagrus major fin cell line (PI-PMF) with IVS-1 strain (RSIV subtype II Meglaocytivirus). Rock bream (Oplegnathus fasciatus) were injected with a high-dose, ultracentrifuged megalocytivir...

journal_title：Vaccine

authors： Kwon WJ,Choi JC,Hong S,Kim YC,Jeong MG,Min JG,Jeong JB,Kim KI,Jeong HD

更新日期：2020-12-03 00:00:00

abstract：:In this work, we explore the effects of O-acetylation on the physical and immunological characteristics of the WHO International Standards of Vi polysaccharide (Vi) from both Citrobacter freundii and Salmonella enterica serovar Typhi. We find that, although structurally identical according to NMR, the two Vi standards...

journal_title：Vaccine

authors： Hitri K,Kuttel MM,De Benedetto G,Lockyer K,Gao F,Hansal P,Rudd TR,Beamish E,Rijpkema S,Ravenscroft N,Bolgiano B

更新日期：2019-06-27 00:00:00

abstract：:We studied with a mouse model and in piglets the requirements to prime for a secondary, mucosal B-cell response against Escherichia coli F4 fimbriae, an important virulence factor of enterotoxigenic E. coli, the agent associated with postweaning diarrhoea in piglets. The major observation obtained with the mouse model...

journal_title：Vaccine

authors： Bianchi AT,Scholten JW,van Zijderveld AM,van Zijderveld FG,Bokhout BA

更新日期：1996-02-01 00:00:00

abstract：:The goal of the present study was to evaluate the influence of the influenza A H1N1/2009 vaccine on dermatomyositis/polymyositis (DM/PM) disease parameters and the potential deleterious effect of therapy on immune response. Thirty-seven DM and 21 PM patients (Bohan and Peter's criteria) were gender- and age-matched to...

journal_title：Vaccine

authors： Shinjo SK,de Moraes JC,Levy-Neto M,Aikawa NE,de Medeiros Ribeiro AC,Schahin Saad CG,Precioso A,Silva CA,Bonfá E

更新日期：2012-12-17 00:00:00

abstract：:In line with WHO objectives, the Lao Government is committed to eliminate measles by 2012. Yet from 1992 to 2007, the annual incidence of measles remained high while the vaccination coverage showed a wide diversity across provinces. A descriptive study was performed to determine factors affecting compliance with vacci...

journal_title：Vaccine

authors： Phimmasane M,Douangmala S,Koffi P,Reinharz D,Buisson Y

更新日期：2010-09-24 00:00:00

abstract：BACKGROUND:A recent mumps outbreak in Israel despite an ongoing national program of a 2-dose universal childhood vaccination policy since 1988, raised questions regarding population immunity among young adults. OBJECTIVE:To assess the seroprevalence of mumps antibodies among young Israeli adults born after 1987 in ord...

journal_title：Vaccine

authors： Levine H,Ankol OE,Rozhavski V,Davidovitch N,Aboudy Y,Zarka S,Balicer RD

更新日期：2011-03-24 00:00:00

abstract：:Norovirus (NoV) and hepatitis E virus (HEV) are both enterically-transmitted viruses causing gastroenteritis and hepatitis, respectively, in humans. While a vaccine against HEVs recently became available in China, there is no prophylactic or therapeutic approach against NoVs. Both NoV and HEV have surface protrusions ...

journal_title：Vaccine

authors： Wang L,Cao D,Wei C,Meng XJ,Jiang X,Tan M

更新日期：2014-01-16 00:00:00

abstract：BACKGROUND AND PURPOSE:Varicella disease is a risk factor for pediatric Arterial Ischemic Stroke (AIS). Isolated case reports have emerged suggesting that varicella vaccination may also pose a risk for AIS. METHODS:This retrospective population-based cohort study assessed the risk of AIS in children who received a var...

journal_title：Vaccine

authors： MacDonald SE,Dover DC,Hill MD,Kirton A,Simmonds KA,Svenson LW

更新日期：2018-05-11 00:00:00

abstract：:A method was developed for cultivation of the strain Shigella flexneri 2a 77 with two attenuated markers. It ensures the preservation of the initial properties of the strain. The regimen for control of dissolved oxygen level was optimized. It was established that yeast extract is a necessary component of the nutritive...

journal_title：Vaccine

authors： Nenkov P,Bratoeva M,Vitanov T,Marinova S,Denchev V,Linde K

更新日期：1987-09-01 00:00:00

abstract：:Human papillomavirus (HPV)-related morbidity and mortality from cervical cancer primarily occurs in the developing world, where, unfortunately, access to vaccines in general, and expensive newer vaccines in particular, is often more limited than in the industrialized world. In addition, secondary prevention methods su...

journal_title：Vaccine

authors： Kane MA,Sherris J,Coursaget P,Aguado T,Cutts F

更新日期：2006-08-31 00:00:00

abstract：:Vaccination of infants, children and adolescents against the hepatitis B virus (HBV) is mandatory in Italy. It is crucial to assess whether vaccinated subjects have protective antibody level during adulthood when the risk of HBV infection increases due to lifestyle or occupational exposure. Two groups of students atte...

journal_title：Vaccine

authors： Chiara F,Bartolucci GB,Mongillo M,Ferretto L,Nicolli A,Trevisan A

更新日期：2013-03-25 00:00:00

abstract：:A reverse transcriptase polymerase chain reaction (PCR) was used to amplify a 235 bp hypervariable region of the feline calicivirus (FCV) genome which encodes part of the capsid protein. Sequence from this region was used to compare viruses used in three attenuated vaccines to viruses isolated from vaccinated cats wit...

journal_title：Vaccine

authors： Radford AD,Bennett M,McArdle F,Dawson S,Turner PC,Glenn MA,Gaskell RM

更新日期：1997-08-01 00:00:00

abstract：:Cytomegalovirus (CMV) and non-replicating adenoviral vectors can induce expanded, sustained effector-memory CD8+ T-cell responses, termed "memory inflation". During murine CMV (MCMV) infection, CD4+ Tcells maintain inflationary virus-specific CD8+ T-cell responses via IL-2 but not IL-21. Adenovirus vector vaccination ...

journal_title：Vaccine

authors： Gordon CL,Hutchings CL,Highton AJ,Colston JM,Provine NM,Klenerman P

更新日期：2018-11-12 00:00:00

abstract：:The gene encoding for a major surface glycoprotein, gp63, of Leishmania major was cloned into the eukaryotic expression plasmid pCDNAI with CMV or RSV promoters. The highly susceptible Balb/c mice were injected intramuscularly with 100 micrograms/mouse of the purified plasmid. The plasmids were found to be stable in v...

journal_title：Vaccine

authors： Xu D,Liew FY

更新日期：1994-12-01 00:00:00

abstract：:We report the use of recombinant scorpion toxins in the form of fusion proteins as antigens for immunisation in rabbits and mice: the aim was to produce in these animal models protective antisera against the most lethal alpha-type toxins in the venom from the North African scorpion Androctonus australis. The cDNAs enc...

journal_title：Vaccine

authors： Legros C,Kaabi H,El Ayeb M,Céard B,Vacher H,Bougis PE,Martin-Eauclaire MF

更新日期：2001-12-12 00:00:00

abstract：:Recently, efforts have been made to fill a so-called "vaccine gap" between Japan and other countries; however, more work remains. Concerns about adverse events following immunization (AEFI) resulted in an historically passive approach to policy making in the National Immunization Program (NIP). For example, reports of...

journal_title：Vaccine

authors： Katsuta T,Moser CA,Feemster KA,Saitoh A,Offit PA

更新日期：2020-10-27 00:00:00

abstract：:We investigated whether a combined DNA vaccine delivered together with the IL-15 gene (DNA-IL-15(+)) enhanced the immune response against Brucella abortus in mice. Mice vaccinated with DNA-IL-15(+) developed a robust humoral response; Brucella-specific antibodies exhibited a dominance of immunoglobulin G2a (IgG2a) ove...

journal_title：Vaccine

authors： Hu XD,Chen ST,Li JY,Yu DH,Yi-Zhang,Cai H

更新日期：2010-03-11 00:00:00

abstract：:Nine pigs were given a single inoculum of 100 microg of the all-D retro peptide corresponding to the immunodominant GH loop encompassing residues 141-159 of capsid protein VP1 of foot-and-mouth disease virus serotype A, sub-type 12. The peptide was conjugated to activated keyhole limpet haemocyanin and oil-adjuvanted ...

journal_title：Vaccine

authors： Nargi F,Kramer E,Mezencio J,Zamparo J,Whetstone C,Van Regenmortel MH,Briand JP,Muller S,Brown F

更新日期：1999-07-16 00:00:00

abstract：:The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix(®)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n=611) were randomised (3:1:1) to receive ...

journal_title：Vaccine

authors： Østergaard L,Silfverdal SA,Berglund J,Flodmark CE,West C,Bianco V,Baine Y,Miller JM

更新日期：2012-01-17 00:00:00

abstract：:Clostridium difficile is the leading cause of hospital-acquired diarrhea, also known as C. difficile associated diarrhea. The two major toxins, toxin A and toxin B are produced by most C. difficile bacteria, but some strains, such as BI/NAP1/027 isolates, produce a third toxin called binary toxin. The precise biologic...

journal_title：Vaccine

authors： Wang S,Rustandi RR,Lancaster C,Hong LG,Thiriot DS,Xie J,Secore S,Kristopeit A,Wang SC,Heinrichs JH

更新日期：2016-03-04 00:00:00

abstract：:We examined the immunogenicity and protective efficacy of a combined DNA vaccine that included six genes encoding immunodominant antigens from Mycobacterium tuberculosis and Brucella abortus. The IL-12 adjuvant system was used for immunization in combination with the combined DNA vaccine (DNA-IL-12(+)). Mice immunized...

journal_title：Vaccine

authors： Yu DH,Li M,Hu XD,Cai H

更新日期：2007-09-17 00:00:00

abstract：BACKGROUND:Household-based caregivers serve an important role in protecting the health of cancer patients, who may be vulnerable to infectious diseases due to their cancer treatments. Caregiver preventive care should be prioritized to maintain continuity of care and to reduce potential for transmission of infectious di...

journal_title：Vaccine

authors： Marellapudi A,King AR,Bednarczyk RA

更新日期：2020-09-11 00:00:00

abstract：:CpG-DNA is currently attracting attention as an effective and safe vaccine adjuvant to prevent from microbial infections. In this report, we examined the effects of oligo B, which is a synthetic CpG-DNA, in mucosal administration of Bacillus Calmette-Guérin (BCG) and diphtheria toxoid (DT). Co-administration with olig...

journal_title：Vaccine

authors： Maeyama J,Komiya T,Takahashi M,Isaka M,Goto N,Yamamoto S

更新日期：2009-02-18 00:00:00

abstract：:Surveillance of adverse events in the field represents an essential part of vaccination strategies. Safety studies conducted before vaccine licensure have often not enough power to detect rare or long-term adverse events. Furthermore, adverse events may be caused by incorrect procedures of storage or administration. C...

journal_title：Vaccine

authors： Tozzi AE

更新日期：2004-05-07 00:00:00

abstract：:This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a lpxL2(-) synX(-) mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one of the three dose groups (25 mcg, 25 mcg with aluminum hydroxide adju...

journal_title：Vaccine

authors： Keiser PB,Gibbs BT,Coster TS,Moran EE,Stoddard MB,Labrie JE 3rd,Schmiel DH,Pinto V,Chen P,Zollinger WD

更新日期：2010-10-08 00:00:00