Abstract：
:The gene encoding for a major surface glycoprotein, gp63, of Leishmania major was cloned into the eukaryotic expression plasmid pCDNAI with CMV or RSV promoters. The highly susceptible Balb/c mice were injected intramuscularly with 100 micrograms/mouse of the purified plasmid. The plasmids were found to be stable in vivo for at least 40 days after injection and expressed significant levels of gp63, demonstrable by immunohistological staining with specific antibody. The immunized mice developed significant resistance against L. major infection compared to controls similarly immunized with the empty plasmid. Spleen cells from the immunized mice produced significant levels of IL-2 and IFN-gamma but no detectable IL-4 when cultured with leishmanial antigens in vitro.
journal_name
Vaccinejournal_title
Vaccineauthors
Xu D,Liew FYdoi
10.1016/0264-410x(94)90079-5subject
Has Abstractpub_date
1994-12-01 00:00:00pages
1534-6issue
16eissn
0264-410Xissn
1873-2518pii
0264-410X(94)90079-5journal_volume
12pub_type
杂志文章相关文献
VACCINE文献大全abstract：:Breast milk (colostrum [col]/milk) components and gut commensals play important roles in neonatal immune maturation, establishment of gut homeostasis and immune responses to enteric pathogens and oral vaccines. We investigated the impact of colonization by probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacteri...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.02.020
更新日期：2013-04-08 00:00:00
abstract：:To facilitate site-directed chemical coupling of antigens to the heat labile enterotoxin B subunit of Escherichia coli (LTB), a series of genetically modified fusion proteins of LTB were constructed. The LTB fusion proteins had modified versions of a short (14 amino acid) spacer epitope called the Pk tag attached at t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)00375-2
更新日期：1999-03-17 00:00:00
abstract：:Safety of and humoral immune response to the anti-influenza vaccine in coronary artery disease (CAD) patients were evaluated. The trivalent vaccine was administered to 137 eligible CAD patients and 67 age- and sex-matched healthy individuals. Antibody (Ab) titers were measured before and 1 month after vaccination. CAD...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.09.108
更新日期：2009-12-10 00:00:00
abstract：:This study investigates the background to low uptake of nasal influenza vaccination in Polish pupils in Edinburgh, Scotland. In autumn 2018, one week after their child's nasal flu vaccination sessions, 365 Polish parents were sent a questionnaire exploring influences on their vaccination choices. The questionnaire inc...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.02.028
更新日期：2020-03-17 00:00:00
abstract：:To study the regulation of the human immune response to hepatitis B surface antigen (HBsAg) we have carefully monitored the in vivo humoral and in vitro cellular immune responses to HBsAg in 50 subjects receiving four doses of hepatitis B vaccine according to a 0, 1, 2, 12 month vaccination scheme. Twenty-three subjec...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(94)90290-9
更新日期：1994-07-01 00:00:00
abstract：:The 2-1-1 rabies postexposure treatment schedule is an abbreviated regimen in which a tissue culture rabies vaccine is administered intramuscularly at two sites on day 0, and at one site on days 7 and 21. Compared to the standard five-dose intramuscular regimen, the 2-1-1 schedule reduces the number of clinic visits f...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(91)90244-z
更新日期：1991-08-01 00:00:00
abstract：:For infants immunized with Haemophilus influenzae type b conjugate vaccines, booster immunization is usually recommended in the second year of life, typically between 12 and 18 months. This study assessed the effect of age at booster immunization on pre-immunization antibody trough levels and on subsequent responses, ...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0264-410x(98)00232-1
更新日期：1999-02-12 00:00:00
abstract：:The conventional approach to vaccine development requires cultivation of the pathogenic microorganism and its dissection using biochemical, immunological, and microbiological methods in order to identify the components important for immunity. This method, while successful in many cases, failed to provide a solution fo...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00554-5
更新日期：2001-03-21 00:00:00
abstract：:Based on studies on the genetic and molecular basis of Shigella flexneri invasive properties, we have constructed and evaluated a double mutant of S. flexneri serotype 5 for utilization as a live attenuated oral vaccine against shigellosis. The first mutation, icsA, blocks intracellular spread of bacteria as well as c...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(89)90160-6
更新日期：1989-10-01 00:00:00
abstract：:An inactivated hepatitis A vaccine was given to 104 seronegative volunteers aged between 19 and 60 years according to two schedules: 0, 1 and 2 months or 0, 1 and 6 months. The vaccine was well tolerated and 97 and 100% of vaccinees developed a serum antibody response following a single and two doses of vaccine respec...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(92)90563-y
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:We related seroprevalence and outbreaks data in order to identify factors that could explain the occurrence of outbreaks despite high vaccination coverage in Medellín Colombia. METHODS:Samples from a population seroprevalence data obtained in 2009 in a random survey were analyzed. IgG levels were determined ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.08.088
更新日期：2015-10-13 00:00:00
abstract：:A major challenge for poultry vaccination is the design of vaccines that protect against multiple pathogens via a single protective dose delivered through mass vaccination methods. In this investigation, we examined herpesvirus of turkeys (HVT) as a vaccine vector for delivery of haemagglutinin (HA) antigen of highly ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.08.115
更新日期：2011-10-26 00:00:00
abstract：:Therapeutic immunization of HIV-1-infected individuals with or without anti-retroviral therapy is a new promising disease prevention. To induce a new cytotoxic T(CD8) lymphocyte (CTL) immunity during chronic HIV-1 infection 15 infrequently targeted but conserved HLA-supertype binding CTL epitopes from Gag, Pol, Nef, E...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.07.025
更新日期：2011-09-16 00:00:00
abstract：:The Salmonella rfc gene encodes the O-antigen polymerase. We constructed three strains in which we replaced the native rfc promoter with the arabinose-dependent araC P(BAD) promoter so that rfc expression was dependent on exogenously supplied arabinose provided during in vitro growth. The three mutant strains were des...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.06.074
更新日期：2010-08-23 00:00:00
abstract：:Human intestinal infections with the nematode Strongyloides stercoralis remain a significant problem worldwide and a vaccine would be a useful addition to the tools available to prevent and control this infection. The goal of this study was to test single antigens for their efficacy in a vaccine against S. stercoralis...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.08.030
更新日期：2011-10-19 00:00:00
abstract：:Understanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Several antigens, in addition to the polysaccharide capsule, have been implicated in both the virulence and protective immunity against Streptococcus pneumoniae; one of ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.12.020
更新日期：2012-02-01 00:00:00
abstract：:In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade. In spite...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(99)00236-4
更新日期：1999-10-01 00:00:00
abstract：:Enterohemorrhagic Escherichia coli (EHEC) strains are food borne pathogens with importance in public health. EHEC colonizes the large intestine and causes diarrhea, hemorrhagic colitis and in some cases, life-threatening hemolytic-uremic syndrome (HUS) due to the production of Shiga toxins (Stx). The lack of effective...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2013.05.013
更新日期：2013-07-11 00:00:00
abstract：:The development of effective vaccines against serogroup B meningococci is of great public health importance. We assessed a novel genetically engineered vaccine containing six meningococcal class 1 (PorA) outer membrane proteins representing 80% of prevalent strains in the UK. 103 infants were given the meningococcal v...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00044-4
更新日期：1999-06-04 00:00:00
abstract：OBJECTIVE:To evaluate whether the social media strategy developed for the campaign Stop HPV - stop cervical cancer was successful at engaging target groups in communication regarding HPV vaccination. INTRODUCTION:In 2009, the Human Papillomavirus (HPV) vaccine became part of the Danish childhood vaccination program to...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.05.061
更新日期：2020-06-26 00:00:00
abstract：:Understanding the mechanisms of generation and maintenance of immunological memory is crucial for rational vaccine design. A hypothesis known as relay hypothesis was earlier proposed which explains the maintenance of immunological memory through interaction of idiotypic and anti-idiotypic lymphocytes. In the present s...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.04.005
更新日期：2007-06-21 00:00:00
abstract：:The current human whole-cell vaccine is ineffective against pneumonic plague caused by typical F1 capsule positive (F1+) strains of Yersinia pestis. The authors found this vaccine to also be ineffective against F1-negative (F1-) Y. pestis strains, which have been isolated from a human case and from rodents. For these ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)80110-2
更新日期：1998-07-01 00:00:00
abstract：:Although coxsackievirus A6 (CV-A6) is generally recognized as a causative agent of herpangina in children, CV-A6 infections globally emerged as a new and major cause of epidemic hand-foot-and-mouth-diseases (HFMDs) around 2008. To clarify the longitudinal epidemiology of CV-A6, we carried out sequence and phylogenetic...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.12.065
更新日期：2019-02-14 00:00:00
abstract：:Patients with malignancies are considered to be at increased risk of acquiring influenza. Because of higher complication and case fatality rates, preventive measures such as vaccination are of great interest. The objective of this study was to assess the acceptability, tolerability and immunogenicity of an adjuvant-fr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.09.005
更新日期：2012-11-06 00:00:00
abstract：:The aim of this study was to assess the uptake of varicella vaccine in South Australian children under circumstances where varicella immunisation is recommended, but is not funded by Government. The study examined the main reasons that determined a parent's decision whether or not to have their child immunised with va...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.05.033
更新日期：2005-11-16 00:00:00
abstract：:The World Health Organization, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, and the Bill & Melinda Gates Foundation convened the first Global Vaccine and Immunization Research Forum (GVIRF) in March 2014. This first GVIRF aimed to track recent progress of the Gl...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.11.038
更新日期：2016-03-18 00:00:00
abstract：:Vaccination with plasmid DNA against infectious pathogens including dengue is an active area of investigation. By design, DNA vaccines are able to elicit both antibody responses and cellular immune responses capable of mediating long-term protection. Great technical improvements have been made in dengue DNA vaccine co...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2011.07.019
更新日期：2011-09-23 00:00:00
abstract：:Measles incidence has decreased dramatically in China due to the implement of measles-containing vaccine (MCV). However, a measles epidemic caused resurgence recently, even among vaccinated individuals. To evaluate the effectiveness of current immunization programs and discuss initiatives for the next step in measles ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.03.049
更新日期：2020-05-08 00:00:00
abstract：:In China, no data are available to evaluate the interchangeability between Chinese domestic inactivated hepatitis A vaccines (Healive) and imported inactivated hepatitis A vaccines (Havrix). A double-blind, randomized controlled study was to compare interchangeability and safety of Healive and Havrix among Chinese chi...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2012.04.038
更新日期：2012-06-08 00:00:00
abstract：:Varicella-zoster virus (VZV) is the causative agent of varicella and zoster. The varicella vaccine was developed to control VZV infection in children. The currently available Oka vaccine strain is the only live varicella vaccine approved by the World Health Organization. We previously cloned the complete genome of the...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2014.11.001
更新日期：2016-01-04 00:00:00
