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Immunization of mice with DNA coding for the variable regions of anti-idiotypic antibody generates antigen-specific response.

Abstract：

:Understanding the mechanisms of generation and maintenance of immunological memory is crucial for rational vaccine design. A hypothesis known as relay hypothesis was earlier proposed which explains the maintenance of immunological memory through interaction of idiotypic and anti-idiotypic lymphocytes. In the present study, we have shown that immunization with rinderpest virus hemagglutinin protein specific anti-idiotypic antibody (Ab(2)v(beta)) DNAs coding for heavy and light chains generates antigen-specific antibody and T cell responses as well as Ab1 specific T cell response. We further show that boosting with the recombinant Ab(2)-vbeta proteins generates B and T cell memory response specific for antigen in anti-id DNA primed mice. This study provides experimental evidence for perpetuation of immunological memory through idiotypic network interactions.

journal_name

Vaccine

journal_title

Vaccine

authors

Vani J,Nayak R,Shaila MS

doi

10.1016/j.vaccine.2007.04.005

subject

Has Abstract

pub_date

2007-06-21 00:00:00

pages

4922-30

issue

26

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(07)00409-4

journal_volume

25

pub_type

杂志文章

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