Immunotherapy with combined DNA vaccines is an effective treatment for M. bovis infection in cattle.

Abstract:

:Mycobacterium bovis causes tuberculosis in cattle. Because current therapies inadequately prevent disease spread, new therapies for M. bovis infections are urgently needed. We treated M. bovis-infected cattle with combinations of DNA vaccines, resulting in significantly reduced pulmonary bacterial loads compared with the untreated group. Further, the pathological changes of lungs were also slight and the lesions were limited in animals treated with the combined DNA vaccines, whereas untreated animals had extensive lung fibrosis and consolidated lesions. This is the first report of DNA vaccine used to treat M. bovis. Thus, combined DNA vaccines may provide enhanced immunotherapeutic efficacy for treatment of bovine tuberculosis.

journal_name

Vaccine

journal_title

Vaccine

authors

Hu XD,Chen ST,Yu DH,Li SX,Cai H

doi

10.1016/j.vaccine.2008.12.055

subject

Has Abstract

pub_date

2009-02-25 00:00:00

pages

1317-22

issue

9

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)00007-3

journal_volume

27

pub_type

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