Abstract:
:Mycobacterium bovis causes tuberculosis in cattle. Because current therapies inadequately prevent disease spread, new therapies for M. bovis infections are urgently needed. We treated M. bovis-infected cattle with combinations of DNA vaccines, resulting in significantly reduced pulmonary bacterial loads compared with the untreated group. Further, the pathological changes of lungs were also slight and the lesions were limited in animals treated with the combined DNA vaccines, whereas untreated animals had extensive lung fibrosis and consolidated lesions. This is the first report of DNA vaccine used to treat M. bovis. Thus, combined DNA vaccines may provide enhanced immunotherapeutic efficacy for treatment of bovine tuberculosis.
journal_name
Vaccinejournal_title
Vaccineauthors
Hu XD,Chen ST,Yu DH,Li SX,Cai Hdoi
10.1016/j.vaccine.2008.12.055subject
Has Abstractpub_date
2009-02-25 00:00:00pages
1317-22issue
9eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)00007-3journal_volume
27pub_type
杂志文章相关文献
VACCINE文献大全abstract::Breast milk (colostrum [col]/milk) components and gut commensals play important roles in neonatal immune maturation, establishment of gut homeostasis and immune responses to enteric pathogens and oral vaccines. We investigated the impact of colonization by probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacteri...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.02.020
更新日期:2013-04-08 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of the monovalent rotavirus vaccine (RV1) to prevent rotavirus diarrhea admissions to emergency departments (ED) in Colombia. METHODS:A multicenter case-control study was carried out in six Colombian cities from 2011 to January, 2013. Cases were laboratory confirmed rotavirus diar...
journal_title:Vaccine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.vaccine.2014.03.064
更新日期:2014-05-23 00:00:00
abstract::Leishmania donovani promastigote soluble antigens (sLAg) were encapsulated in non-phosphatidylcholine (non-PC) liposomes (escheriosomes) prepared from E. coli lipids. The escheriosome-based vaccine was investigated for its potential to elicit a protective immune response against experimental visceral leishmaniasis. Th...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.10.025
更新日期:2006-03-10 00:00:00
abstract::Post-licensure real world evaluation of vaccine implementation is important for establishing evidence of vaccine effectiveness (VE) and programme impact, including indirect effects. Large cohort studies offer an important epidemiological approach for evaluating VE, but have inherent methodological challenges. Since Ma...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2015.07.062
更新日期:2015-09-11 00:00:00
abstract::The outer capsid protein VP4 is an important target for the development of a recombinant rotavirus vaccine because it mediates the attachment and penetration of rotavirus. Due to the poor solubility of full-length VP4, VP8 was explored as candidate rotavirus vaccines in the past years. In previous studies, it has been...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.03.011
更新日期:2018-04-12 00:00:00
abstract::We have investigated immunological responses in BALB/c mice following transcutaneous (TC) delivery of fraction 1 (F1) and V subunits from Yersinia pestis in conjunction with an enterotoxin-derived adjuvant (cholera toxin, CT). It was found that two or more TC applications of F1 and V subunits (admixed with cholera tox...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2004.02.049
更新日期:2004-10-22 00:00:00
abstract:INTRODUCTION:Two types of Japanese encephalitis (JE) vaccines, inactivated JE vaccine (JE-I) and live-attenuated JE vaccine (JE-L), are available and used in China. In particular, one JE-L, produced by a domestic manufacturer in China, was prequalified by WHO in 2013. We assessed the safety of JE vaccines in China duri...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.05.021
更新日期:2017-06-22 00:00:00
abstract:INTRODUCTION:Pregnancy is a risk factor for severe influenza. However, data on influenza incidence during pregnancy are scarce. Likewise, no data are available on influenza vaccine coverage in France since national recommendation in 2012. We aimed to assess these points using a novel nationwide web-based surveillance s...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2016.03.034
更新日期:2016-04-29 00:00:00
abstract::The calculation of p(epitope) values, a sequence-based measure of antigenic distance between strains, was developed for human influenza. The potential to apply the p(epitope) value to equine influenza vaccine strain selection was assessed. There was a negative correlation between p(epitope) value and vaccine efficacy ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.06.070
更新日期:2013-12-09 00:00:00
abstract:OBJECTIVE:Evidence-based strategies to address vaccine hesitancy are lacking. Personal values are a measurable psychological construct that could be used to deliver personalized messages to influence vaccine hesitancy and behavior. Our objectives were to develop a valid, reliable self-report survey instrument to measur...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.08.009
更新日期:2019-09-10 00:00:00
abstract::Since the production of influenza vaccines is complicated by the continuous variation of these viruses, it would be desirable to develop vaccines that induce cross-protective immunity against influenza virus strains that circulate in subsequent winter epidemics. We have recently demonstrated that antibodies induced af...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(01)00262-6
更新日期:2001-10-12 00:00:00
abstract:BACKGROUND:Although the mortality from diarrheal diseases has been decreasing dramatically in Iran, it still represents an important proportion of disease burden in children <5 years old. Rotavirus vaccines are among the most effective strategies against diarrheal diseases in specific epidemiological conditions. This s...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.12.035
更新日期:2015-05-07 00:00:00
abstract:OBJECTIVES:The objectives of this study were to estimate the national prevalence of hepatitis B infection in Tunisia using data from a nationwide survey, to compare results with those obtained in 1996 survey and to evaluate the impact of vaccination twenty years after its introduction. METHODS:A National household-bas...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.08.038
更新日期:2018-09-18 00:00:00
abstract::Serotype-specific protective immunity in pediatric patients with invasive pneumococcal disease (IPD) has not been fully investigated. To determine the protective immunity to the infecting serotype, the serotype-specific immunoglobulin G (IgG) levels and opsonization indices (OIs) were examined in 24 Japanese pediatric...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.11.010
更新日期:2013-01-21 00:00:00
abstract:INTRODUCTION:9-valent human papillomavirus vaccine (9vHPV) was approved by the Food and Drug Administration (FDA) in December 2014. 9vHPV is not recommended during pregnancy, but some women of childbearing age may be inadvertently exposed. This study aims to evaluate reports submitted to the Vaccine Adverse Event Repor...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.11.077
更新日期:2019-02-21 00:00:00
abstract::We reported previously on the development of a Bacillus anthracis vaccine strain expressing high levels of recombinant protective antigen (rPA) [Cohen et al., Infec Immun 2000;68(8):4549-58]. To further explore the potential of the B. anthracis platform, we generated several attenuated strains expressing lethal toxin ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2004.11.077
更新日期:2005-12-01 00:00:00
abstract::Two H1N1 progeny viruses derived by mating the attenuated donor virus, the A/Ningxia/72-ts (H3N2), and the A/Beijing/70 (H1N1) wild type virus were characterized for their genotype and their level of attenuation in susceptible adult volunteers. One progeny virus, clone PX62, was not a reassortant since it received eac...
journal_title:Vaccine
pub_type: 临床试验,杂志文章
doi:10.1016/0264-410x(84)90083-5
更新日期:1984-09-01 00:00:00
abstract::We tested whether pilus proteins of rabbit diarrhoeagenic Escherichia coli (RDEC-1), incorporated into biodegradable microspheres, could function as safe and effective oral immunogens in the rabbit diarrhoea model. The RDEC-1 adhesin, AF/R1, incorporated into poly(D,L-lactide-co-glycolide) microspheres, was administer...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(93)90018-s
更新日期:1993-01-01 00:00:00
abstract::A total of 105 hybridomas secreting anti-Japanese encephalitis (JE) virus monoclonal antibodies (mAbs) were generated from six fusions against four strains of JE virus: wild-type strains SA14 and G8924 and live attenuated vaccines SA14-5-3 and SA14-14-2 (PDK-9). Most of the mAbs (87%) elicited haemagglutination inhibi...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(92)90372-q
更新日期:1992-01-01 00:00:00
abstract::The case-control methodology is frequently used to evaluate vaccine effectiveness post-licensure. The results of such studies provide important insight into the level of protection afforded by vaccines in a 'real world' context, and are commonly used to guide vaccine policy decisions. However, the potential for bias a...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2017.04.035
更新日期:2017-06-05 00:00:00
abstract::A safe, effective and accessible preventive vaccine is our best long-term hope for the control of the HIV/AIDS pandemic. The first phase I trial of an HIV vaccine was conducted in the US in 1987. Since then, >30 candidate vaccines have been tested in over 60 phase I/II clinical trials, involving >8000 healthy human vo...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/s0264-410x(02)00062-2
更新日期:2002-05-06 00:00:00
abstract::Plasmid DNA vaccines encoding full-length antigen often induce both potent antibody and cytotoxic T lymphocyte (CTL) responses. Here, we examine strategies to exclusively elicit epitope-specific CTL responses using DNA constructs expressing a minimal class I MHC-restricted epitope of the nucleoprotein (NP) of influenz...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(98)00411-3
更新日期:1999-04-09 00:00:00
abstract:BACKGROUND:In 2009, Thailand recommended pregnant women be prioritized for influenza vaccination. Vaccine uptake among Thai pregnant women is lower than other high-risk groups. METHODS:During December 2012-April 2013, we conducted a cross-sectional survey of a convenience sample of Thai pregnant women aged ≥ 15 years ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2016.01.056
更新日期:2016-04-19 00:00:00
abstract::Influenza is a significant cause of morbidity and mortality worldwide, and the World Health Organization highly recommends maternal vaccination during pregnancy. The indirect effect of maternal vaccination on other close contacts other than newborns is unknown. To evaluate this, we conducted a nested substudy between ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.08.014
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:The safety and tolerability of Flublok(®), a purified recombinant hemagglutinin seasonal influenza vaccine, was compared to AFLURIA(®) in a randomized, blinded clinical trial in adults ≥ 50 years of age with attention to hypersensitivity reactions. METHODS:This blinded, randomized trial of healthy adults ≥ ...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.vaccine.2015.10.097
更新日期:2015-11-27 00:00:00
abstract:BACKGROUND:To evaluate the immunological impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPS) at 12 months, for children who have received zero to three infant doses of seven-valent pneumococcal conjugate vaccine (PCV), on responses to a subsequent exposure to a small dose of 23vPPS (mPPS). METHODS:Fiv...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2010.02.087
更新日期:2010-04-26 00:00:00
abstract::Streptococcus pneumoniae (pneumococcus) is responsible for significant morbidity and mortality in worldwide. After introduction of current pneumococcal vaccines, a marked decrease in the incidence of pneumococcal disease was observed. Unfortunately, serotype shifts in carriage and disease, including capsular switch an...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.11.073
更新日期:2012-03-02 00:00:00
abstract::During their sixth annual meeting held in Manila (Philippines), the Asian Rabies Expert Bureau (AREB) reviewed the implementation of programs for rabies prevention, control, and elimination in Asia. AREB members strongly support a "one health" approach for controlling rabies, combining increased public awareness, comm...
journal_title:Vaccine
pub_type:
doi:10.1016/j.vaccine.2010.02.093
更新日期:2010-04-26 00:00:00
abstract::The bacillus Calmette Guérin (BCG) vaccine, the only licensed vaccine against TB, displays partial and variable efficacy, thus making the exploitation of novel vaccination strategies a major priority. Most of the current vaccines in pre-clinical or clinical development are based on the induction of T cells recognizing...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.01.079
更新日期:2017-03-07 00:00:00
abstract::Safety of and humoral immune response to the anti-influenza vaccine in coronary artery disease (CAD) patients were evaluated. The trivalent vaccine was administered to 137 eligible CAD patients and 67 age- and sex-matched healthy individuals. Antibody (Ab) titers were measured before and 1 month after vaccination. CAD...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.09.108
更新日期:2009-12-10 00:00:00