当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Past, present and future of HIV vaccine trials in developing countries.

Past, present and future of HIV vaccine trials in developing countries.

Abstract：

:A safe, effective and accessible preventive vaccine is our best long-term hope for the control of the HIV/AIDS pandemic. The first phase I trial of an HIV vaccine was conducted in the US in 1987. Since then, >30 candidate vaccines have been tested in over 60 phase I/II clinical trials, involving >8000 healthy human volunteers. The majority of these trials have been conducted in the US and Europe, however, trials have also been conducted in developing countries (Brazil, China, Cuba, Haiti, Kenya, Thailand, and Uganda), including an ongoing phase III efficacy trial of a rgp120 candidate vaccine in Thailand. The effort to develop and evaluate HIV vaccines must increase, especially in Africa.

journal_name

Vaccine

journal_title

Vaccine

authors

Esparza J,Osmanov S,Pattou-Markovic C,Touré C,Chang ML,Nixon S

doi

10.1016/s0264-410x(02)00062-2

subject

Has Abstract

pub_date

2002-05-06 00:00:00

pages

1897-8

issue

15

eissn

0264-410X

issn

1873-2518

pii

S0264410X02000622

journal_volume

20

pub_type

杂志文章,评审

相关文献

VACCINE文献大全
  • Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections.

    abstract：:A safe and effective pan-filovirus vaccine is highly desirable since the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) cause highly lethal disease typified by unimpeded viral replication and severe hemorrhagic fever. Previously, we showed that expression of the homologous glycoprotein (GP) and matrix protein...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.11.070

    authors： Swenson DL,Warfield KL,Negley DL,Schmaljohn A,Aman MJ,Bavari S

    更新日期：2005-04-27 00:00:00

  • Flagellin-HA vaccines protect ferrets and mice against H5N1 highly pathogenic avian influenza virus (HPAIV) infections.

    abstract：:In order to meet the global demand for rapid production of pandemic influenza vaccines, we have developed a recombinant fusion vaccine platform in which the globular head of hemagglutinin (HA) antigen is genetically fused to bacterial flagellin (a TLR5 ligand). These flagellin-HA fusion vaccine candidates elicit highl...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.09.013

    authors： Liu G,Song L,Reiserova L,Trivedi U,Li H,Liu X,Noah D,Hou F,Weaver B,Tussey L

    更新日期：2012-11-06 00:00:00

  • Antigenic differentiation of classical swine fever vaccinal strain PAV-250 from other strains, including field strains from Mexico.

    abstract：:Twenty-nine classical swine fever virus (CSFv) strains were grown in the PK15 or SK6 cell lines. Antigenic differentiation studies were performed using monoclonal antibodies (McAbs), produced at Lelystad (CDI-DLO), The Netherlands. The monoclonals which were classified numerically as monoclonals 2-13. Epitope map patt...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.07.045

    authors： Mendoza S,Correa-Giron P,Aguilera E,Colmenares G,Torres O,Cruz T,Romero A,Hernandez-Baumgarten E,Ciprián A

    更新日期：2007-10-10 00:00:00

  • Vaccination with recombinant tick antigens for the control of Ixodes scapularis adult infestations.

    abstract：:Antigens protective against Ixodes scapularis infestations were identified by cDNA expression library immunization (ELI) and analysis of expressed sequenced tags (EST). Three cDNAs protective against larval tick infestations, 4F8, with homology to a nucleotidase, and 4D8 and 4E6 of unknown function, were characterized...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.08.004

    authors： Almazán C,Kocan KM,Blouin EF,de la Fuente J

    更新日期：2005-11-16 00:00:00

  • Efficient extracellular production of recombinant Escherichia coli heat-labile enterotoxin B subunit by using the expression/secretion system of Bacillus brevis and its mucosal immunoadjuvanticity.

    abstract：:A gene encoding the mature Escherichia coli heat-labile enterotoxin B subunit (LTB) was introduced in a vector pNU212 and expressed at high levels in Bacillus brevis HPD31. The maximum amount of recombinant LTB (rLTB) secreted into the modified 5PY medium containing erythromycin was about 350 mg l(-1) when cultivated ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00547-2

    authors： Kozuka S,Yasuda Y,Isaka M,Masaki N,Taniguchi T,Matano K,Moriyama A,Ohkuma K,Goto N,Udaka S,Tochikubo K

    更新日期：2000-03-06 00:00:00

  • Influence of elemental impurities in aluminum hydroxide adjuvant on the stability of inactivated Japanese Encephalitis vaccine, IXIARO®.

    abstract：:Aluminum hydroxide is a critical raw material in the production of many vaccines. It is used as an adjuvant in the formulation of the final bulk vaccine, and for this it must meet the specifications of the European Pharmacopeia Monograph. We investigated whether vaccine stability was affected by the presence of trace ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.05.103

    authors： Schlegl R,Weber M,Wruss J,Low D,Queen K,Stilwell S,Lindblad EB,Möhlen M

    更新日期：2015-11-04 00:00:00

  • RNA-based adjuvant CV8102 enhances the immunogenicity of a licensed rabies vaccine in a first-in-human trial.

    abstract：BACKGROUND:We report the first-in-concept human trial of the safety, tolerability and immunogenicity when a novel TLR 7/8/RIG I agonist RNA-based adjuvant, CV8102, was administered alone or mixed with fractional doses of a licensed rabies vaccine (Rabipur®) as model antigen. METHODS:The primary objective was to assess...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.02.024

    authors： Doener F,Hong HS,Meyer I,Tadjalli-Mehr K,Daehling A,Heidenreich R,Koch SD,Fotin-Mleczek M,Gnad-Vogt U

    更新日期：2019-03-22 00:00:00

  • Economic assessment of a high-dose versus a standard-dose influenza vaccine in the US Veteran population: Estimating the impact on hospitalization cost for cardio-respiratory disease.

    abstract：OBJECTIVE:To compare the economic impact of high-dose trivalent (HD) versus standard-dose trivalent (SD) influenza vaccination on direct medical costs for cardio-respiratory hospitalizations in adults aged 65 years or older enrolled in the United States (US) Veteran's Health Administration (VHA). METHODS:Leveraging a ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.06.066

    authors： van Aalst R,Russo EM,Neupane N,Mahmud SM,Mor V,Wilschut J,Chit A,Postma M,Young-Xu Y

    更新日期：2019-07-26 00:00:00

  • Compatibility of a live infectious bovine rhinotraheitis (IBR) marker vaccine and an inactivated bovine viral diarrhoea virus (BVDV) vaccine.

    abstract：:The target animals and vaccination regimes for vaccines against the bovine rhinotracheitis (IBR) and the bovine viral diarrhoea virus (BVDV) are very similar. Therefore, we have compared different schedules for the combined use of a live IBR marker vaccine and an inactivated BVD vaccine. The neutralizing antibody resp...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.06.050

    authors： Alvarez M,Bielsa JM,Santos L,Makoschey B

    更新日期：2007-09-04 00:00:00

  • Vaccination of cats with an attenuated recombinant myxoma virus expressing feline calicivirus capsid protein.

    abstract：:Myxoma virus, a member of the Poxviridae family (genus Leporipoxvirus) is the agent responsible for myxomatosis in the European rabbit. Recombinant myxoma viruses expressing the capsid gene of an F9 strain of feline calicivirus (FCV) were constructed from an apathogenic, laboratory attenuated, isolate of myxoma virus....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00186-x

    authors： McCabe VJ,Tarpey I,Spibey N

    更新日期：2002-06-07 00:00:00

  • Reduction of foot-and-mouth disease (FMD) virus load in nasal excretions, saliva and exhaled air of vaccinated pigs following direct contact challenge.

    abstract：:In future, a policy of "vaccinate-to-live" may be included in the repertoire of foot-and-mouth disease (FMD) control measures and in support of this approach, we have investigated the hypothesis that vaccine-induced reduction in virus replication and excretion from pigs can be correlated to the severity of clinical si...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.08.058

    authors： Parida S,Fleming L,Oh Y,Mahapatra M,Hamblin P,Gloster J,Doel C,Gubbins S,Paton DJ

    更新日期：2007-11-07 00:00:00

  • Long- and short-time immunological memory in different strains of mice given nasally an adjuvant-combined nasal influenza vaccine.

    abstract：:Immunological memory induced by nasal immunization with adjuvant-combined influenza vaccine was analyzed in different ages and strains of mice. The memory activities were assessed by secondary nasal-wash IgA and serum IgG antibody (Ab) responses and protection against challenge infection with a lethal dose of influenz...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.06.060

    authors： Asanuma H,Fujihashi K,Miyakoshi T,Yoshikawa T,Fujita-Yamaguchi Y,Kojima N,Nakata M,Suzuki Y,Tamura S,Kurata T,Sata T

    更新日期：2007-09-28 00:00:00

  • Meningococcal-group B (MenB) vaccine series completion and adherence to dosing schedule in the United States: A retrospective analysis by vaccine and payer type.

    abstract：BACKGROUND:Two MenB vaccines with different dosing schedules are approved in the US: MenB-4C (2 doses) and MenB-FHbp (2-3 doses). Both vaccines were licensed on the basis of immunogenicity demonstrated after vaccine series completion. We evaluated vaccination completion and adherence to dosing schedules. METHODS:This ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.06.065

    authors： Packnett E,Irwin DE,Novy P,Watson PS,Whelan J,Moore-Schiltz L,Lucci M,Hogea C

    更新日期：2019-09-16 00:00:00

  • Blood stage merozoite surface protein conjugated to nanoparticles induce potent parasite inhibitory antibodies.

    abstract：:In this proof-of-concept study we report the use of <15 nm, water soluble, inorganic nanoparticles as a vaccine delivery system for a blood stage malaria vaccine. The recombinant malarial antigen, Merozoite Surface Protein 1 (rMSP1) of Plasmodium falciparum served as the model vaccine. The rMSP1 was covalently conjuga...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.09.070

    authors： Pusic K,Xu H,Stridiron A,Aguilar Z,Wang A,Hui G

    更新日期：2011-11-08 00:00:00

  • Trivalent inactivated influenza vaccine (IIV3) during pregnancy and six-month infant development.

    abstract：OBJECTIVE:Despite recommendations by professional organizations that all pregnant women receive inactivated influenza vaccine, safety concerns remain a barrier. Our objective was to assess the effect of trivalent influenza vaccines (IIV3) during pregnancy on parent report 6-month infant development. METHODS:We conduct...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.01.059

    authors： Avalos LA,Ferber J,Zerbo O,Naleway AL,Bulkley J,Thompson M,Cragan J,Williams J,Odouli R,Kauffman TL,Ball S,Shifflett P,Li DK

    更新日期：2020-02-28 00:00:00

  • Psychological factors associated with uptake of the childhood influenza vaccine and perception of post-vaccination side-effects: A cross-sectional survey in England.

    abstract：OBJECTIVES:To identify predictors of: uptake of the childhood influenza vaccine in the 2015-2016 influenza season, parental perceptions of side-effects from the influenza vaccine and intention to vaccinate one's child for influenza in the 2016-2017 influenza season. DESIGN:Cross-sectional online survey. SETTING:Data ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.02.031

    authors： Smith LE,Webster RK,Weinman J,Amlôt R,Yiend J,Rubin GJ

    更新日期：2017-04-04 00:00:00

  • Impact of the National Perinatal Hepatitis B Prevention Programme in the Republic of Korea: A retrospective registry-based cohort study.

    abstract：INTRODUCTION:Hepatitis B is a major preventable cause of morbidity and mortality from chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. We aimed to evaluate the performance and outcomes of the Korean Perinatal Hepatitis B Prevention Programme (PHBPP) and to investigate the impact of the current post-exp...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.05.044

    authors： Yang TU,Jung CW,Kim D,Park HA,Jee Y

    更新日期：2020-07-22 00:00:00

  • Prevalence of type-specific human papillomavirus infection among women in France: Implications for screening, vaccination, and a future generation of multivalent HPV vaccines.

    abstract：:To assess human papillomavirus (HPV) prevalence and genotype distribution by age and cervical cytology/histology status among women undergoing routine gynecological examinations, and to discuss the possible impact on preventive strategies. Liquid-based cytology (LBC) samples were tested for HPV DNA, mRNA, and HPV geno...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.06.013

    authors： Monsonego J,Zerat L,Syrjänen K,Zerat JC,Smith JS,Halfon P

    更新日期：2012-07-27 00:00:00

  • Immunity and protection by adoptive transfer of dendritic cells transfected with hepatitis C NS3/4A mRNA.

    abstract：:In this study, we tested the hypothesis that adoptive transfer of dendritic cells (DCs) transfected ex vivo with mRNA encoding hepatitis C virus (HCV) NS3/4A would initiate potent HCV-specific protective immune responses in vivo. Murine DCs were transfected with NS3/4A mRNA or eGFP mRNA using either electroporation or...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.11.046

    authors： Yu H,Babiuk LA,van Drunen Littel-van den Hurk S

    更新日期：2007-02-26 00:00:00

  • Bivalent rLP2086 (Trumenba®): Development of a well-characterized vaccine through commercialization.

    abstract：:The phrase "Process is the Product" is often applied to biologics, including multicomponent vaccines composed of complex components that evade complete characterization. Vaccine production processes must be defined and locked early in the development cycle to ensure consistent quality of the vaccine throughout scale-u...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.03.100

    authors： Sunasara K,Cundy J,Srinivasan S,Evans B,Sun W,Cook S,Bortell E,Farley J,Griffin D,Bailey Piatchek M,Arch-Douglas K

    更新日期：2018-05-24 00:00:00

  • Expanding immunization coverage in rural India: a review of evidence for the role of community health workers.

    abstract：:Poor routine immunization coverage in India has led to a large burden of vaccine-preventable diseases borne by children under 5 years of age. Despite efforts to strengthen infrastructure and service delivery in the past decade, immunization coverage rates have reached a plateau. To meet the formidable needs of India's...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2009.10.108

    authors： Patel AR,Nowalk MP

    更新日期：2010-01-08 00:00:00

  • Memory T cells and vaccines.

    abstract：:T lymphocytes play a central role in the generation of a protective immune response in many microbial infections. After immunization, dendritic cells take up microbial antigens and traffic to draining lymph nodes where they present processed antigens to naïve T cells. These naïve T cells are stimulated to proliferate ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(02)00407-3

    authors： Esser MT,Marchese RD,Kierstead LS,Tussey LG,Wang F,Chirmule N,Washabaugh MW

    更新日期：2003-01-17 00:00:00

  • Characterization of foot-and-mouth disease virus from outbreaks in Ecuador during 2009-2010 and cross-protection studies with the vaccine strain in use in the region.

    abstract：:During the years 2009 and 2010 relevant epidemic waves of foot-and-mouth disease (FMD) serotype O occurred in Ecuador, representing a great drawback for the last stages of the ongoing eradication program in South America. This study describes the molecular and antigenic characterizations of 29 isolates collected from ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.08.120

    authors： Maradei E,Perez Beascoechea C,Malirat V,Salgado G,Seki C,Pedemonte A,Bonastre P,D'Aloia R,La Torre JL,Mattion N,Rodríguez Toledo J,Bergmann IE

    更新日期：2011-10-26 00:00:00

  • Antibiotic resistance in Vibrio cholerae: Understanding the ecology of resistance genes and mechanisms.

    abstract：:The unique genetic makeup and remarkable competency of Vibrio cholerae are the key factors that help the cholera pathogen adapt rapidly to adverse environmental conditions and resist the detrimental effect of antimicrobial agents. In the last few decades, V. cholerae that causes acute watery diarrhoeal disease cholera...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2019.06.031

    authors： Das B,Verma J,Kumar P,Ghosh A,Ramamurthy T

    更新日期：2020-02-29 00:00:00

  • Modeling cervical cancer prevention in developed countries.

    abstract：:Cytology-based screening has reduced cervical cancer mortality in countries able to implement, sustain and financially support organized programs that achieve broad coverage. These ongoing secondary prevention efforts considerably complicate the question of whether vaccination against human papillomavirus (HPV) types ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.06.009

    authors： Kim JJ,Brisson M,Edmunds WJ,Goldie SJ

    更新日期：2008-08-19 00:00:00

  • Developing a seasonal influenza vaccine recommendation in Kenya: Process and challenges faced by the National Immunization Technical Advisory Group (NITAG).

    abstract：BACKGROUND:In 2014 the Kenya National Immunization Technical Advisory Group (KENITAG) was asked by the Ministry of Health to provide an evidence-based recommendation on whether the seasonal influenza vaccine should be introduced into the national immunization program (NIP). METHODS:We reviewed KENITAG manuals, reports...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.11.062

    authors： Dawa J,Chaves SS,Ba Nguz A,Kalani R,Anyango E,Mutie D,Muthoka P,Tabu C,Maritim M,Amukoye E,Were F,Kenya National Immunization Technical Advisory Group (KENITAG).

    更新日期：2019-01-14 00:00:00

  • Attitudes toward HPV vaccination among parents of adolescent girls in Mysore, India.

    abstract：:This study investigates attitudes toward human papillomavirus (HPV) vaccination among parents of adolescent girls in Mysore, India. Seven focus group discussions were held among parents of adolescent girls stratified by sex, religion and region to explore attitudes about cervical cancer and HPV vaccination. The study ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.06.073

    authors： Madhivanan P,Krupp K,Yashodha MN,Marlow L,Klausner JD,Reingold AL

    更新日期：2009-08-20 00:00:00

  • Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers.

    abstract：:Though widely used, the BCG vaccine has had little apparent effect on rates of adult pulmonary tuberculosis. Moreover, the risk of disseminated BCG disease in immunocompromised individuals means that improved TB vaccines ideally need to be able to efficiently prime mycobacterially-naïve individuals as well as boost in...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2010.02.094

    authors： van Dissel JT,Arend SM,Prins C,Bang P,Tingskov PN,Lingnau K,Nouta J,Klein MR,Rosenkrands I,Ottenhoff TH,Kromann I,Doherty TM,Andersen P

    更新日期：2010-04-30 00:00:00

  • Immunization with recombinant paraflagellar rod protein induces protective immunity against Trypanosoma cruzi infection.

    abstract：:In the present study, we have produced recombinant paraflagellar rod proteins (PFR) and report their use for successful vaccination of mice against Trypanosoma cruzi. This protection is associated with a highly polarized type 1 cytokine production profile. Additionally, we have analyzed the gene sequence encoding PFR-...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00108-7

    authors： Luhrs KA,Fouts DL,Manning JE

    更新日期：2003-06-20 00:00:00

  • Vaccinia virus proteins activate human dendritic cells to induce T cell responses in vitro.

    abstract：:The mechanisms of protection elicited by smallpox vaccine in humans have not been delineated. Dendritic cells (DCs) are the most potent of professional antigen presenting cells which on activation modulate both innate and adaptive immune responses. Immunogenic proteins of vaccinia virus have been identified with prote...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.10.031

    authors： Agrawal S,Gupta S,Agrawal A

    更新日期：2009-01-01 00:00:00