Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components.

abstract：:We reviewed studies of rotavirus in MEDLINE and the Chinese literature to get a preliminary estimate of the burden of rotavirus gastroenteritis in China and the epidemiology of the disease. Studies were selected if they were conducted for a period 1 year or more, had more than 100 patients enrolled, and used an accept...

journal_title：Vaccine

authors： Orenstein EW,Fang ZY,Xu J,Liu C,Shen K,Qian Y,Jiang B,Kilgore PE,Glass RI

更新日期：2007-01-05 00:00:00

abstract：:In 2004, we conducted a study in Piemonte (Italy), in order to describe incidence, treatment, hospitalizations and costs of herpes zoster (HZ), in population over 14 years of age. Twenty-four regional general practitioners, with 26,394 patients >14 years in charge (0.71% of the regional population), reported prospecti...

journal_title：Vaccine

authors： Di Legami V,Gianino MM,Ciofi degli Atti M,Massari M,Migliardi A,Tomba GS,Zotti C,Zoster Study Group.

更新日期：2007-10-23 00:00:00

abstract：OBJECTIVE:The study objectives were to evaluate injection practices in China in the post GAVI project era and provide guidance for policy makers to update national standards for injection practices and further improve vaccination services. METHODS:We conducted a national stratified, cross-sectional survey in October 2...

journal_title：Vaccine

authors： Wu Z,Cui F,Chen Y,Miao N,Gong X,Luo H,Wang F,Zheng H,Kane M,Hadler SC,Hutin YJ,Liang X,Yang W

更新日期：2013-12-27 00:00:00

abstract：:In order to meet the global demand for rapid production of pandemic influenza vaccines, we have developed a recombinant fusion vaccine platform in which the globular head of hemagglutinin (HA) antigen is genetically fused to bacterial flagellin (a TLR5 ligand). These flagellin-HA fusion vaccine candidates elicit highl...

journal_title：Vaccine

authors： Liu G,Song L,Reiserova L,Trivedi U,Li H,Liu X,Noah D,Hou F,Weaver B,Tussey L

更新日期：2012-11-06 00:00:00

abstract：:The canarypox vaccine vector (ALVAC) technology has been used to develop and license several vaccines for companion animals and horses in the European Union and USA. ALVAC is a ubiquitous vector with high biosafety since it is non-replicative in mammalians, is genetically and physically stable, and able to induce both...

journal_title：Vaccine

authors： Poulet H,Minke J,Pardo MC,Juillard V,Nordgren B,Audonnet JC

更新日期：2007-07-26 00:00:00

abstract：BACKGROUND:Protein-polysaccharide conjugate vaccines such as Haemophilus influenzae type b (Hib), meningococcal, and pneumococcal vaccine, induce immunological memory and longer lasting protection than plain polysaccharide vaccines. The most common proteins used as carriers are tetanus toxoid (TT) and cross reacting ma...

journal_title：Vaccine

authors： Voysey M,Sadarangani M,Clutterbuck E,Bolgiano B,Pollard AJ

更新日期：2016-07-25 00:00:00

abstract：:Measles remains a major cause of worldwide infant mortality despite the use of current live attenuated vaccines. New approaches to measles virus (MV) vaccine development are critical to interrupt the spread of MV. In this study, we report the results using a DNA vaccine expressing a fusion of the measles hemagglutinin...

journal_title：Vaccine

authors： Green TD,Newton BR,Rota PA,Xu Y,Robinson HL,Ross TM

更新日期：2001-10-12 00:00:00

abstract：:Interaction of native proteinaceous antigens during the recognition and the effector phases of an immune response leads to antigenic conformational modifications which may elicit additional specific immune response. Protein cross-linking and conformation restraining formaldehyde and glutaraldehyde have been extensivel...

journal_title：Vaccine

authors： Cepica A,Beauregard M,Qian B

更新日期：1998-12-01 00:00:00

abstract：:Outer membrane protein PhoE of Escherichia coli was used for the expression of antigenic determinants of foot-and-mouth disease virus. Five hybrid PhoE proteins were constructed containing different combinations of two antigenic determinants of VP1 protein of the virus. The hybrid proteins were expressed in two E. col...

journal_title：Vaccine

authors： Agterberg M,Adriaanse H,Lankhof H,Meloen R,Tommassen J

更新日期：1990-02-01 00:00:00

abstract：:The identification of MHC class II-restricted peptides has become a priority for the development of peptide-based prophylactic and therapeutic vaccines. The aim of this study was to assess the correlations between peptide-binding assays on purified HLA II molecules and immunization of human HLA II transgenic mice defi...

journal_title：Vaccine

authors： Depil S,Angyalosi G,Moralès O,Delacre M,Delhem N,François V,Georges B,Hammer J,Maillère B,Auriault C,Pancré V

更新日期：2006-03-20 00:00:00

abstract：:Since vaccination against human papillomavirus (HPV) became available, awareness of HPV has dramatically increased. Implementation of a vaccine program varies internationally yet no studies have explored the influence this has on the public's knowledge of HPV. The present study aimed to explore differences in awarenes...

journal_title：Vaccine

authors： Marlow LA,Zimet GD,McCaffery KJ,Ostini R,Waller J

更新日期：2013-01-21 00:00:00

abstract：:To evaluate long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma, a prospective study was conducted during 2005-2006 influenza season in six public pediatric clinics in Milan and surroundings, Northern Italy. A single dose (0.5 ml) of a virosomal subunit inactivated inf...

journal_title：Vaccine

authors： Zuccotti G,Amendola A,Viganò A,Pariani E,Zappa A,Pogliani L,Giacomet V,Savarino A,Podestà A,Rottoli A,Tanzi E,Zanetti A,Radaelli G

更新日期：2007-09-17 00:00:00

abstract：:Recently, Bacillus subtilis spores were shown to be endowed with strong adjuvant capacity when co-administered with purified antigenic proteins. In the present study we assessed whether spores possess adjuvant properties when combined with DNA vaccines. We showed that B. subtilis spores promoted the activation of dend...

journal_title：Vaccine

authors： Aps LR,Diniz MO,Porchia BF,Sales NS,Moreno AC,Ferreira LC

更新日期：2015-05-11 00:00:00

abstract：:General vaccination with the 7-valent pneumococcal conjugate vaccine was recommended in Germany in July 2006 for all children <2 years. The proportion of reported invasive pneumococcal disease (IPD) caused by vaccine serotypes before vaccine introduction was considerably lower than in the US. We report data from natio...

journal_title：Vaccine

authors： Rückinger S,van der Linden M,Reinert RR,von Kries R,Burckhardt F,Siedler A

更新日期：2009-06-24 00:00:00

abstract：:In many industrialized countries, hepatitis A incidence rates have declined steadily in the past decades. Since future cohorts of non-vaccinated elderly will lack protection against disease and the burden of hepatitis A is higher with increasing age, this could be an argument in favour of taking preventive measures su...

journal_title：Vaccine

authors： Suijkerbuijk AW,Lugnér AK,van Pelt W,Wallinga J,Verhoef LP,de Melker HE,de Wit GA

更新日期：2012-07-27 00:00:00

abstract：:Development of recombinant protective antigen (rPA)-based anthrax vaccines has been hindered by a lack of stability of the vaccines associated with spontaneous deamidation of asparagine (Asn) residues of the rPA antigen during storage. In this study, we explored the role that two deamidation-prone Asn residues located...

journal_title：Vaccine

authors： Verma A,Burns DL

更新日期：2018-10-15 00:00:00

abstract：OBJECTIVES:To perform a systematic review of all serious adverse events (SAEs) after yellow fever vaccination and to assess them according to Brighton Collaboration criteria. METHODS:Nine electronic databases were searched with the terms "yellow fever vaccine" and "adverse events" to 10 July 2013 (no language/date lim...

journal_title：Vaccine

authors： Thomas RE,Spragins W,Lorenzetti DL

更新日期：2013-12-16 00:00:00

abstract：:Universal infant vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) has nearly eliminated PCV7-serotype invasive pneumococcal disease (IPD) in young U.S. children, but has been accompanied by increases in the incidence of serotype 19A IPD. Because antibiotic-non-susceptible 19A has increased more than...

journal_title：Vaccine

authors： Van Effelterre T,Moore MR,Fierens F,Whitney CG,White L,Pelton SI,Hausdorff WP

更新日期：2010-05-07 00:00:00

abstract：:A reverse genetics infectious bursal disease virus (RG-IBDV) that contained authentic 3' RNA sequence was characterized both in vitro and in vivo. LP1-IBDV, a cell line-adapted IBDV strain variant E (VE) was used as the parent virus for constructing viral cDNA clones. Authentic 3' RNA sequence was generated by using c...

journal_title：Vaccine

authors： Mosley YY,Wu CC,Lin TL

更新日期：2013-01-11 00:00:00

abstract：:To investigate the 1918/19 influenza pandemic daily number of new hospitalizations in the only hospital in Florence (Central Italy) were analyzed. In order to describe the transmission dynamics of the 1918/1919 pandemic influenza a compartmental epidemic model was used. Model simulations show a high level of agreement...

journal_title：Vaccine

authors： Rizzo C,Ajelli M,Merler S,Pugliese A,Barbetta I,Salmaso S,Manfredi P

更新日期：2011-07-22 00:00:00

abstract：:Biological therapy options for the treatment of rheumatic disease target molecules that can affect the cross-talk between innate and adaptive immune responses upon vaccination. Influenza vaccination in children with rheumatic disease has been recommended, but there are only sparse data on the quality of vaccine respon...

journal_title：Vaccine

authors： Laestadius Å,Ingelman-Sundberg HM,Myrberg IH,Verme A,Sundberg E,Schweiger B,Saghafian-Hedengren S,Nilsson A

更新日期：2019-06-19 00:00:00

abstract：:In July 1999, the Department of Health launched a campaign to immunise all children aged from 0-17 years with a new vaccine giving protection against meningococcal group C infection. Following the campaign, a survey of Immunisation Co-ordinators in England was conducted to identify strengths and weaknesses of the camp...

journal_title：Vaccine

authors： Lansley M,Bedford H

更新日期：2003-06-20 00:00:00

abstract：BACKGROUND:Expression of recombinant hemagglutinin (rHA) in insect cells represents a technology with proven efficacy in seasonal influenza and with the potential for a rapid response to the emergence of new, pandemic strains. We evaluated the safety and immunogenicity of rHA vaccine (H5/Indonesia/5/05) produced in SF+...

journal_title：Vaccine

authors： Treanor JJ,Essink B,Hull S,Reed S,Izikson R,Patriarca P,Goldenthal KL,Kohberger R,Dunkle LM

更新日期：2013-11-19 00:00:00

abstract：:CRM(197) is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, reduced response to vaccines and/or antigens related to the carrier protein may occur. This study examined responses of infants who, in addition to diphtheria tox...

journal_title：Vaccine

authors： Usonis V,Bakasenas V,Lockhart S,Baker S,Gruber W,Laudat F

更新日期：2008-08-18 00:00:00

abstract：:According to the multiple criteria used, the consensus sequences of HIV-1 gp120 and immunoglobulin heavy chain variable segment, which is more than 40 amino acids long, show structural similarities. We assume that this gp120 sequence might encode idiotopes. If this is the case then the particular idiotope-bearing gp12...

journal_title：Vaccine

authors： Metlas R,Veljković V

更新日期：1995-03-01 00:00:00

abstract：:Several approaches are being taken worldwide to develop vaccines against H5N1 viruses; most of them, however, pose both practical and immunological challenges. One potential strategy for improving the immunogenicity of vaccines involves the use of alphavirus replicons and VP22, a herpes simplex type 1 (HSV-1) protein....

journal_title：Vaccine

authors： Yang SG,Wo JE,Li MW,Mi FF,Yu CB,Lv GL,Cao HC,Lu HF,Wang BH,Zhu H,Li LJ

更新日期：2009-12-09 00:00:00

abstract：:Chagas' disease is a major tropical disease for which a cure for chronic phase does not exist yet. Trypanosoma cruzi trans-sialidase (TS) seems to be involved in relevant processes such as infectivity, host survival and, very importantly, disease pathogenesis. In this study, we show that mice vaccinated with an engine...

journal_title：Vaccine

authors： Fontanella GH,De Vusser K,Laroy W,Daurelio L,Nocito AL,Revelli S,Contreras R

更新日期：2008-05-02 00:00:00

abstract：:Numerous evidence demonstrate Type 1 diabetes (T1D) is due to a loss of immune tolerance to islet antigens, and CD8(+) T cells play an important role in the development of T1D in NOD mice. The novel coinhibitory receptor BTLA may have a regulatory role in maintaining peripheral tolerance, however, its role in autoimmu...

journal_title：Vaccine

authors： Li S,Zhang M,Xiang F,Zhao J,Jiang C,Zhu J

更新日期：2011-10-13 00:00:00

abstract：:Analysis of the anti-haemagglutinin serum antibody proteome from six H1N1pdm09 influenza A vaccinated subjects demonstrated restricted IgG1 heavy chain species encoded by IGHV5-51 and IGHV3-7 gene families in 2 subjects and either IGHV5-51 or IGHV3-7 in 4 individuals. All subjects exhibited a dominant IGKV3-20 light c...

journal_title：Vaccine

authors： Adamson PJ,Al Kindi MA,Wang JJ,Colella AD,Chataway TK,Petrovsky N,Gordon TP,Gordon DL

更新日期：2017-10-09 00:00:00

abstract：:Lassa virus (LASV) causes a severe hemorrhagic fever endemic throughout western Africa. Because of the ability to cause lethal disease in humans, limited treatment options, and potential as a bioweapon, the need for vaccines to prevent LASV epidemic is urgent. However, LASV vaccine development has been hindered by the...

journal_title：Vaccine

authors： Li Q,Liu Q,Huang W,Wu J,Nie J,Wang M,Zhao C,Zhang L,Wang Y

更新日期：2017-09-12 00:00:00