Abstract：
:The calculation of p(epitope) values, a sequence-based measure of antigenic distance between strains, was developed for human influenza. The potential to apply the p(epitope) value to equine influenza vaccine strain selection was assessed. There was a negative correlation between p(epitope) value and vaccine efficacy for pairs of vaccine and challenge strains used in cross-protection studies in ponies that just reached statistical significance (p=0.046) only if one pair of viruses was excluded from the analysis. Thus the p(epitope) value has potential to provide additional data to consider in the decision-making process for updating equine influenza vaccine strains. However, further work is required to define the epitopes of the equine H3N8 haemagglutinin protein recognised by equine antibodies, which could lead to refinement of the p(epitope) value calculation. Furthermore, other factors such as vaccine potency and virulence of circulating strains may also influence vaccine efficacy.
journal_name
Vaccinejournal_title
Vaccineauthors
Daly JM,Elton Ddoi
10.1016/j.vaccine.2013.06.070subject
Has Abstractpub_date
2013-12-09 00:00:00pages
6043-5issue
51eissn
0264-410Xissn
1873-2518pii
S0264-410X(13)00879-7journal_volume
31pub_type
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