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A humanized monoclonal antibody targeting Staphylococcus aureus.

Abstract：

:This current presentation describes the in vitro and in vivo characterization of Aurexis (tefibazumab), a humanized monoclonal antibody that exhibits a high affinity and specificity and for the Staphylococcus aureus MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules) protein ClfA. Aurexis inhibited ClfA binding to human fibrinogen, and enhanced the opsonophagocytic uptake of ClfA-coated beads. Preclinical in vivo testing revealed that a single administration of Aurexis significantly protected against an IV challenge with a methicillin resistant S. aureus (MRSA) strain in murine septicemia and rabbit infective endocarditis (IE) models. Safety and pharmacokinetic data from a 19-patient phase I study support continued evaluation of Aurexis in phase II studies.

journal_name

Vaccine

journal_title

Vaccine

authors

Patti JM

doi

10.1016/j.vaccine.2004.08.015

subject

Has Abstract

pub_date

2004-12-06 00:00:00

pages

S39-43

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(04)00617-6

journal_volume

22 Suppl 1

pub_type

杂志文章,评审

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