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Immunological profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an infected Plasmodium berghei mouse model.

Abstract：

:We have covalently conjugated an N-terminus Plasmodium vivax apical membrane antigen-1 (AMA-1) peptide to functionalized carbon nanotubes (f-CNT). Immunological characterization of this molecular conjugate revealed that the immunogen-AMA-1 peptide was appropriately presented after being conjugated to CNTs as well as being recognized by BALB/c polyclonal antibodies. Subsequent experiments lead us to assess the AMA-1 peptide alone, as well as the CNT-peptide conjugate regarding rodent malarial infection. Remarkably, the peptide effectively controlled and delayed Plasmodium berghei-challenged animals' parasitaemia. The peptide-CNT conjugate displayed similar immunological properties to the peptide alone by protecting or delaying malarial infection. The peptide presentation by f-CNT to the immune system thus constitutes a promising approach for synthetic malarial vaccine formulation since the immunogen peptide conformation is well preserved.

journal_name

Vaccine

journal_title

Vaccine

authors

Yandar N,Pastorin G,Prato M,Bianco A,Patarroyo ME,Lozano JM

doi

10.1016/j.vaccine.2008.08.014

subject

Has Abstract

pub_date

2008-10-29 00:00:00

pages

5864-73

issue

46

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)01073-6

journal_volume

26

pub_type

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