Co-administration of attenuated Mycoplasma hyopneumoniae 168 strain with bacterial DNA enhances the local and systemic immune response after intranasal vaccination in pigs.

abstract：:An experimental infection with classical swine fever (CSF) virus in E2 sub-unit marker vaccine vaccinated gilts was conducted in order to evaluate the effect of vaccination on virus transmission and course of the disease. Therefore, clinical signs as well as horizontal and vertical virus transmission were monitored in...

journal_title：Vaccine

authors： Dewulf J,Laevens H,Koenen F,Mintiens K,de Kruif A

更新日期：2001-10-12 00:00:00

abstract：:In order to evaluate in humans the safety and immunogenicity of a Pseudomonas aeruginosa vaccine composed of outer membrane proteins (OMPs), CFC-101, we carried out a phase I/IIa clinical trial in healthy male volunteers. Groups of six volunteers were immunized either subcutaneously (s.c.) or intramuscularly (i.m.) wi...

journal_title：Vaccine

authors： Jang IJ,Kim IS,Park WJ,Yoo KS,Yim DS,Kim HK,Shin SG,Chang WH,Lee NG,Jung SB,Ahn DH,Cho YJ,Ahn BY,Lee Y,Kim YG,Nam SW,Kim HS

更新日期：1999-01-01 00:00:00

abstract：:Bacterial infectious diseases remain the single most important threat to health worldwide. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed to provide efficacious solutions against many others. The advent of whole-genome sequencing changed the ...

journal_title：Vaccine

authors： Serruto D,Serino L,Masignani V,Pizza M

更新日期：2009-05-26 00:00:00

abstract：INTRODUCTION:S. aureus is a pathogen to which individuals are exposed shortly after birth, with immune responses to S. aureus increasing during childhood. There is marked heterogeneity between the anti- S. aureus immune responses of different humans, the basis of which is not fully understood. METHODS:To investigate d...

journal_title：Vaccine

authors： Flaxman A,Yamaguchi Y,van Diemen PM,Rollier C,Allen E,Elshina E,Wyllie DH

更新日期：2019-01-14 00:00:00

abstract：:Anti-angiogenesis represents an indispensible strategy for cancer therapy. As a strictly endothelial-specific adhesion molecule, vascular endothelial cadherin (VE-cadherin, VE-cad) is a promising anti-angiogenesis target. In this study a recombinant adenovirus vector modified with mannan was used to deliver VE-cad (Ad...

journal_title：Vaccine

authors： Zhao Z,Yao Y,Ding Z,Chen X,Xie K,Luo Y,Zhang J,Chen X,Wu X,Xu J,Zhao J,Niu T,Liu J,Li Q,Zhang W,Wen Y,Su J,Hu B,Bu H,Wei Y,Wu Y

更新日期：2011-06-06 00:00:00

abstract：:Lassa virus (LASV) causes a severe hemorrhagic fever endemic throughout western Africa. Because of the ability to cause lethal disease in humans, limited treatment options, and potential as a bioweapon, the need for vaccines to prevent LASV epidemic is urgent. However, LASV vaccine development has been hindered by the...

journal_title：Vaccine

authors： Li Q,Liu Q,Huang W,Wu J,Nie J,Wang M,Zhao C,Zhang L,Wang Y

更新日期：2017-09-12 00:00:00

abstract：OBJECTIVE:Rotavirus is the most common cause of severe diarrhea in children. Two rotavirus vaccines (RotaTeq and Rotarix) have been licensed in Taiwan. We have investigated whether routine infant immunization with either vaccine could be cost-effective in Taiwan. METHODS:We modeled specific disease outcomes including ...

journal_title：Vaccine

authors： Wu CL,Yang YC,Huang LM,Chen KT

更新日期：2009-03-04 00:00:00

abstract：:We previously created a live vaccine against equine influenza based the new reassortant cold-adapted (Ca) strain A/HK/Otar/6:2/2010. The live vaccine contains surface proteins (HA, NA) from the wild-type virus A/equine/Otar/764/2007 (Н3N8; American Lineage Florida Clade 2), and internal proteins (PB2, PB1, PA, NP, M, ...

journal_title：Vaccine

authors： Tabynov K,Kydyrbayev Zh,Ryskeldinova Sh,Assanzhanova N,Sansyzbay A

更新日期：2014-05-23 00:00:00

abstract：:The aim of the present study was to investigate the immune response to native outer membrane vesicles (NOMVs) of Neisseria lactamica with and without Bordetella pertussis (BP) as adjuvant in intranasal (i.n./i.m) immunization. N. lactamica NOMVs delivered intranasally (i.n) to BALB/c mice in a final volume of 5microl ...

journal_title：Vaccine

authors： Ito AY,Néri S,Machado MS,Tunes CF,De Gaspari EN

更新日期：2009-05-26 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) represents a major cattle disease with multiple forms including fetal infections resulting in persistently infected (PI) cattle. The objectives of this study were to investigate the immune response to six vaccines, five modified live viral (MLV) and one killed vaccine containing BVDV...

journal_title：Vaccine

authors： Fulton RW,Cook BJ,Payton ME,Burge LJ,Step DL

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Dengue diagnosis confirmation and surveillance are widely based on serological assays to detect anti-dengue IgM or IgG antibodies since such tests are affordable/user-friendly. The World Health Organization identified serological based diagnosis as a potential tool to define probable dengue cases in the cont...

journal_title：Vaccine

authors： Plennevaux E,Sabchareon A,Limkittikul K,Chanthavanich P,Sirivichayakul C,Moureau A,Boaz M,Wartel TA,Saville M,Bouckenooghe A

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:Liposome encapsulated neutralizing epitope protein of Hepatitis E virus (HEV), rNEp, our Hepatitis E vaccine candidate, was shown to be immunogenic and safe in pregnant and non-pregnant mice and yielded sterilizing immunity in rhesus monkeys. METHODS:The current study in Balb/c mice assessed the levels and ...

journal_title：Vaccine

authors： Kulkarni SP,Thanapati S,Arankalle VA,Tripathy AS

更新日期：2016-11-21 00:00:00

abstract：:A prospective, randomised, controlled observer-blind trial measuring the efficacy and immunogenicity of trivalent influenza vaccine (TIV) and the immunogenicity of quadrivalent meningococcal conjugate vaccine (MCV) in pregnant women and their infants up to 6 months of age was conducted in Mali. Here we reported the im...

journal_title：Vaccine

authors： Findlow H,Tapia MD,Sow SO,Haidara FC,Coulibaly F,Keita AM,Diallo F,Doumbia M,Traore A,Schluterman N,Clark DA,Borrow R,Levine MM

更新日期：2019-04-24 00:00:00

abstract：BACKGROUND:While many clinicians encounter parents or adolescents who refuse HPV vaccine, little is known about the prevalence of hesitancy for HPV vaccine nationally or its association with vaccination. METHODS:In April 2019, we surveyed families with adolescents 11-17 years using a national online panel (Knowledge P...

journal_title：Vaccine

authors： Szilagyi PG,Albertin CS,Gurfinkel D,Saville AW,Vangala S,Rice JD,Helmkamp L,Zimet GD,Valderrama R,Breck A,Rand CM,Humiston SG,Kempe A

更新日期：2020-08-27 00:00:00

abstract：OBJECTIVES:Using dynamic transmission models we evaluated the health and cost outcomes of adding acellular pertussis (aP) vaccination of pregnant women to infant vaccination in three Brazilian states that represent different socioeconomic conditions. The primary objective was to determine whether the same model structu...

journal_title：Vaccine

authors： Luz PM,Struchiner CJ,Kim SY,Minamisava R,Andrade ALS,Sanderson C,Russell LB,Toscano CM

更新日期：2021-01-03 00:00:00

abstract：:Despite the licensure of the pneumococcal conjugate vaccine (PCV) in the US and other Western countries for over 14 years, as of September 2014 only 4 South Asian countries were using PCV in their universal immunization program. To generate momentum toward addressing this issue a "South Asia symposium on pneumococcal ...

journal_title：Vaccine

authors： Kumar R,Arora N,Santosham M

更新日期：2016-05-17 00:00:00

abstract：:A number of clinical reports of drug interactions with influenza vaccine have been made. We hypothesized that CYP3A4 activity would decrease following influenza immunization. Fifteen healthy subjects had erythromycin breath tests (ERMBT) and influenza antibody titer hemagglutinin inhibition assay (HIA) before and afte...

journal_title：Vaccine

authors： Hayney MS,Hammes RJ,Fine JP,Bianco JA

更新日期：2001-12-12 00:00:00

abstract：:We demonstrated the feasibility of collecting and disseminating mid-season estimates of influenza vaccine coverage. We surveyed a nationally representative sample of U.S. adults (n = 3972) via the Internet about use of influenza vaccination as of mid-November 2008. Findings were presented on 10 December 2008 to the me...

journal_title：Vaccine

authors： Harris KM,Maurer J,Lurie N

更新日期：2009-06-08 00:00:00

abstract：:Early studies using DNA immunization suggest the potential benefits of this form of immunization including: long-lived immunity, a broad spectrum of immune responses (both cell-mediated immunity and humoral responses) and the simultaneous induction of immunity to a variety of pathogens through the use of multivalent v...

journal_title：Vaccine

authors： van Drunen Littel-van den Hurk S,Loehr BI,Babiuk LA

更新日期：2001-03-21 00:00:00

abstract：:This report provides an overview of methods used to conduct systematic reviews for the US Food and Drug Administration (FDA) Mini-Sentinel project, which is designed to inform the development of safety monitoring tools for FDA-regulated products including vaccines. The objective of these reviews was to summarize the l...

journal_title：Vaccine

authors： McPheeters ML,Sathe NA,Jerome RN,Carnahan RM

更新日期：2013-12-30 00:00:00

abstract：:The emergence of pneumococcal strains resistant to penicillin caused a lot of problems in the therapy of invasive diseases, and added new dimensions to the role of immunisation. In addition to the currently available 23-valent pneumococcal polysaccharide vaccine (PPV) and a new 7-valent conjugate vaccine (PCV) (Prevna...

journal_title：Vaccine

authors： Paragi M,Kolman J,Kraigher A,Cizman M,Gubina M,Ribic H,Slovenian Meningitis Study Group.

更新日期：2003-12-01 00:00:00

abstract：:Vaccination is the principal means used to control and treat porcine reproductive and respiratory syndrome virus (PRRSV) infection. An array of PRRS vaccine products is available in various regions of the world. However, despite extensive efforts, little progress has been made to improve efficacy since the first intro...

journal_title：Vaccine

authors： Murtaugh MP,Genzow M

更新日期：2011-10-26 00:00:00

abstract：BACKGROUND:Vaccine coverage estimates lag by years in the US. Commercially available medical claims databases contain timely records of childhood vaccinations given in physician offices. We used such data to track the replacement of the 7-valent pneumococcal conjugate vaccine (PCV7) by PCV13, a new vaccine active again...

journal_title：Vaccine

authors： Schuck-Paim C,Taylor R,Lindley D,Klugman KP,Simonsen L

更新日期：2013-12-05 00:00:00

abstract：:The highly pathogenic avian influenza (HPAI) H5N1 viruses and their spillover into the human population pose substantial economic and public health threats. Although antiviral drugs have some effect in treating influenza infection, vaccination is still the most effective intervention to prevent possible pandemic outbr...

journal_title：Vaccine

authors： Lu Y,Landreth S,Liu G,Brownlie R,Gaba A,Littel-van den Hurk SVD,Gerdts V,Zhou Y

更新日期：2020-02-28 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is the most common cause of bacterial diarrhea worldwide and is an important cause of infant morbidity and mortality in developing nations. ETEC colonization factors (CF) are virulence determinants that appear to be protective antigens in humans and are the major target of vacci...

journal_title：Vaccine

authors： de Lorimier AJ,Byrd W,Hall ER,Vaughan WM,Tang D,Roberts ZJ,McQueen CE,Cassels FJ

更新日期：2003-06-02 00:00:00

abstract：:All patients with congenital clotting disorders attending our centre routinely receive hepatitis B vaccination. We have assessed retrospectively the vaccine responses in 167 such individuals, with a follow-up period of up to 7.5 years. The initial postvaccine anti-HBs response was lower in older patients (p = 0.001), ...

journal_title：Vaccine

authors： Pillay D,Pereira C,Sabin C,Powell L,Zuckerman AJ,Lee CA

更新日期：1994-08-01 00:00:00

abstract：:Heat killed spores of the Gram-positive bacterium Bacillus subtilis have been evaluated as a vaccine delivery system with mucosal adjuvant properties for influenza. Killed spores were able to bind H5N1 virions (NIBRG-14; clade 1) and, when intra-nasally administered to mice, resulting immune responses, both humoral an...

journal_title：Vaccine

authors： Song M,Hong HA,Huang JM,Colenutt C,Khang DD,Nguyen TV,Park SM,Shim BS,Song HH,Cheon IS,Jang JE,Choi JA,Choi YK,Stadler K,Cutting SM

更新日期：2012-05-09 00:00:00

abstract：:Neisseria meningitidis is a leading cause of severe bacterial infections in infants and young children. As a major virulence factor, meningococcal capsular polysaccharide (PS) is poorly immunogenic and generally does not induce immunological memory. Conjugation of PS with a carrier protein can significantly increase t...

journal_title：Vaccine

authors： Xu M,Xing X,Wu Z,Du Y,Hu T

更新日期：2015-10-26 00:00:00

abstract：:Pharmacological manipulation of the balance between pro- and anti-inflammatory mediators emerges as a key aspect of a successful treatment of sepsis. A murine model of septic shock was developed and chosen conjugates (1a, 1b, 8a, 8c) and analogs (T2) of muramyl dipeptide and tuftsin were tested in this model as prospe...

journal_title：Vaccine

authors： Wardowska A,Dzierzbicka K,Szaryńska M,Dabrowska-Szponar M,Wiśniewska K,Myśliwski A,Trzonkowski P

更新日期：2009-01-14 00:00:00

abstract：:Historical evidence demonstrates the validity of the concept "Grand Convergence". The Lancet commission identified the major challenges facing low and lower middle income countries including the unfinished agenda, non-communicable diseases and injuries and an approach to funding and achieving these objectives along wi...

journal_title：Vaccine

authors： Mahmoud A

更新日期：2017-01-20 00:00:00