A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways.

abstract：:Monoclonal antibody 3C9 was the starting material in the definition of the epitope that led to the synthesis of the first efficient peptide vaccine against a viral disease (canine parvovirus) in the natural host (dog). In this report, we have analysed the specificity of the antibody at the single amino acid level and ...

journal_title：Vaccine

authors： Langeveld JP,Martinez-Torrecuadrada J,Boshuizen RS,Meloen RH,Ignacio Casal J

更新日期：2001-03-21 00:00:00

abstract：:Currently, infections of hand, foot and mouth disease (HFMD) due to Human Enterovirus 71 (EV71) cannot be prevented or treated, as there are no suitable vaccines or antiviral drugs. This study aimed to identify potential vaccine candidates for EV71 using in silico analysis of its viral capsid proteins. A combined in s...

journal_title：Vaccine

authors： Kirk K,Poh CL,Fecondo J,Pourianfar H,Shaw J,Grollo L

更新日期：2012-11-19 00:00:00

abstract：:Pertussis is an acute respiratory infectious disease caused by the bacterium Bordetella pertussis. Although pertussis vaccination was introduced in the 1960s, pertussis is still an endemic disease in China. To better understand the genetic diversity of the Chinese B. pertussis population, we characterized 115 clinical...

journal_title：Vaccine

authors： Xu Y,Zhang L,Tan Y,Wang L,Zhang S,Wang J

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Mycobacterial infections greatly affect human and animal health worldwide, and vaccines are effective, sustainable and economic interventions for the prevention and control of these infectious diseases. Recent results support the use of zebrafish as a model for studying the pathophysiology of mycobacterial i...

journal_title：Vaccine

authors： Risalde MA,López V,Contreras M,Mateos-Hernández L,Gortázar C,de la Fuente J

更新日期：2018-07-16 00:00:00

abstract：:The neuraminidase (NA) protein of influenza A viruses (IAV) has important functional roles in the viral replication cycle. Antibodies specific to NA can reduce viral replication and limit disease severity, but are not routinely measured. We analyzed NA inhibiting (NI) antibody titers in serum and respiratory specimens...

journal_title：Vaccine

authors： Sandbulte MR,Gauger PC,Kitikoon P,Chen H,Perez DR,Roth JA,Vincent AL

更新日期：2016-07-19 00:00:00

abstract：:Our initial results with a bovine papilloma virus (BPV) vector expression system indicated that we could produce significant amounts of Epstein-Barr virus (EBV) gp340/220 in the supernatant of a mouse fibroblast cell line. We have now extended these findings to show that the truncated version of gp340/220, where the m...

journal_title：Vaccine

authors： Madej M,Conway MJ,Morgan AJ,Sweet J,Wallace L,Qualtiere LF,Arrand JR,Mackett M

更新日期：1992-01-01 00:00:00

abstract：:The objective of this paper is to review adaptive immunity of young animals using examples from my own experience and from the literature. Trials carried out by us with a modified live and inactivated canine parvovirus vaccine in newborn puppies provide evidence of the immune capacity of these puppies. With regard to ...

journal_title：Vaccine

authors： Chappuis G

更新日期：1998-08-01 00:00:00

abstract：:Immunization with xenogeneic DNA is a promising cancer treatment to overcome tolerance to self-antigens. Heat shock protein 70 (HSP70) is over-expressed in various kinds of tumors and is believed to be involved in tumor progression. This study tested a xenogeneic chicken HSP70 (chHSP70) DNA vaccine in an experimental ...

journal_title：Vaccine

authors： Yu WY,Chuang TF,Guichard C,El-Garch H,Tierny D,Laio AT,Lin CS,Chiou KH,Tsai CL,Liu CH,Li WC,Fischer L,Chu RM

更新日期：2011-04-18 00:00:00

abstract：:Globally the most commonly utilised immunisation against influenza is the trivalent inactivated influenza vaccine (TIV) derived from an A/H1N1, an A/H3N2 and aB type influenza virus. Vaccine effectiveness of TIV varies year to year, depending on how well antigenically matched the strains in the vaccine are compared to...

journal_title：Vaccine

authors： Ana-Sosa-Batiz F,Johnston APR,Hogarth PM,Wines BD,Barr I,Wheatley AK,Kent SJ

更新日期：2017-11-07 00:00:00

abstract：:Different subsets of dendritic cells (DC) elicit qualitatively different immune responses. In mice, two lymphoid tissue-resident subsets, CD8α(+) and CD8α(-), have been implicated in the induction of T helper 1 (Th1) or Th2 responses, respectively. Moreover, CD8α(+) DC appear to play a major role in priming CD8(+) T l...

journal_title：Vaccine

authors： Suleman M,Galea S,Gavard F,Merillon N,Klonjkowski B,Tartour E,Richardson J

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:The demand on effective and safe anthrax vaccine is increasing as a part of the preparedness for possible bioterrorism in the future. We performed a randomized, single-blind, placebo controlled phase II clinical study to evaluate the immunogenicity and safety of a novel recombinant protective antigen (rPA) a...

journal_title：Vaccine

authors： Kang CK,Kim NH,Kim CJ,Rhie GE,Jo SK,Ahn M,Kang J,Choe PG,Park WB,Kim NJ,Oh MD

更新日期：2019-06-27 00:00:00

abstract：:As part of safety monitoring during a group B meningococcal disease vaccination campaign in New Zealand, we examined the possible excess risk of vaccine-associated simple febrile seizures (SFS). We conducted a cohort analysis using data from active hospital-based surveillance in the South Auckland area and a national ...

journal_title：Vaccine

authors： Stehr-Green P,Radke S,Kieft C,Galloway Y,McNicholas A,Reid S

更新日期：2008-02-06 00:00:00

abstract：:Japanese encephalitis (JE) is the most important cause of acute encephalitis syndrome (AES). Japanese encephalitis virus (JEV), the prototype member of the JE serocomplex, belongs to the genus Flavivirus. The immunogenic proteins envelope (E) and non-structural protein 1 (NS1) of JEV are widely explored for the develo...

journal_title：Vaccine

authors： Nath B,Vandna,Saini HM,Prasad M,Kumar S

更新日期：2020-02-11 00:00:00

abstract：:The presence of resident Langerhans cells (LCs) in the epidermis makes the skin an attractive target for DNA vaccination. However, reliable animal models for cutaneous vaccination studies are limited. We demonstrate an ex vivo human skin model for cutaneous DNA vaccination which can potentially bridge the gap between ...

journal_title：Vaccine

authors： Ng KW,Pearton M,Coulman S,Anstey A,Gateley C,Morrissey A,Allender C,Birchall J

更新日期：2009-10-09 00:00:00

abstract：:The safety and immunogenicity of a single dose of virosome-formulated hepatitis A vaccine was evaluated in healthy seronegative Thai volunteers. Immunization elicited primarily mild transient reactions which did not interfere with normal activities. All subjects possessed > 20 mIU of anti-hepatitis A virus antibody pe...

journal_title：Vaccine

authors： Poovorawan Y,Theamboonlers A,Chumdermpadetsuk S,Glück R,Cryz SJ Jr

更新日期：1995-07-01 00:00:00

abstract：:The immunogenic potential of Vibrio cholerae ghosts (VCG) in comparison with heat-killed whole-cell vibrios (WCV) was evaluated after intraperitoneal immunization of adult mice. Swiss white mice received four doses of VCG or WCV intraperitoneally, consisting of 500 micrograms of lyophilized material in 200 microliters...

journal_title：Vaccine

authors： Eko FO,Hensel A,Bunka S,Lubitz W

更新日期：1994-11-01 00:00:00

abstract：:Cell culture-based manufacturing of influenza vaccines is ideally based on easily scalable platforms using suspension cells that grow in chemically defined media. Consequently, different adherent cell lines selected for high virus yields were adapted to grow in suspension culture. This includes the MDCK suspension cel...

journal_title：Vaccine

authors： Peschel B,Frentzel S,Laske T,Genzel Y,Reichl U

更新日期：2013-11-19 00:00:00

abstract：:One hundred and fourteen children, born to HBsAg-positive mothers received in the first year of life passive active prophylaxis for hepatitis B virus (HBV). They have been followed up to 10 years. A booster dose given in a cohort at the 5th year does not seem to increase protection against HBV. No difference in immuno...

journal_title：Vaccine

authors： Resti M,Azzari C,Mannelli F,Rossi ME,Lionetti P,Vierucci A

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:It is known that antineoplastic treatment may induce secondary immunodeficiency, but studies after childhood sarcoma are rare. Since 1998, the Late Effects Surveillance System (LESS) of the German Society for Paediatric Oncology and Haematology (GPOH) prospectively registers late effects in soft tissue-, ost...

journal_title：Vaccine

authors： Paulides M,Stöhr W,Laws HJ,Graf N,Lakomek M,Berthold F,Schmitt K,Niggli F,Jürgens H,Bielack S,Koscielniak E,Klingebiel T,Langer T

更新日期：2011-02-11 00:00:00

abstract：:Immunization with amyloid-beta (Abeta) peptide reduces amyloid load in animal studies and in humans; however clinical trials resulted in the development of a pro-inflammatory cellular response to Abeta. Apoptosis has been employed to stimulate humoral and Th2-biased cellular immune responses. Thus, we sought to invest...

journal_title：Vaccine

authors： DaSilva KA,Brown ME,McLaurin J

更新日期：2009-02-25 00:00:00

abstract：:PSMA-VRP is a propagation defective, viral replicon vector system encoding PSMA under phase I evaluation for patients with castration resistant metastatic prostate cancer (CRPC). The product is derived from an attenuated strain of the alphavirus, Venezuelan Equine Encephalitis (VEE) virus, and incorporates multiple re...

journal_title：Vaccine

authors： Slovin SF,Kehoe M,Durso R,Fernandez C,Olson W,Gao JP,Israel R,Scher HI,Morris S

更新日期：2013-01-30 00:00:00

abstract：:The highly pathogenic avian H5N1 influenza virus has the potential to incite a global pandemic. Therefore, there is an urgent need to develop effective vaccines against these viruses. Because it is difficult to predict which strain of influenza will cause a pandemic, it is advantageous to develop vaccines that will co...

journal_title：Vaccine

authors： Ichinohe T,Ainai A,Tashiro M,Sata T,Hasegawa H

更新日期：2009-10-23 00:00:00

abstract：:An enzymatically cleaved glycoprotein fragment (amino acids 28-328: 40 kDa) from influenza virus haemagglutinin (TOPS) was used to assess an intravaginal antigen delivery system, comprising lysophosphatidylcholine (LPC) and degradable starch microspheres (DSM). Three groups of three sheep received intravaginal immuniz...

journal_title：Vaccine

authors： O'Hagan DT,Rafferty D,Wharton S,Illum L

更新日期：1993-01-01 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) is still one of the most serious pathogens in cattle, meriting the development of improved vaccines. Recently, we developed a new adjuvant consisting of poly[di(sodium carboxylatoethylphenoxy)]-phosphazene (PCEP), either CpG ODN or poly(I:C), and an immune defense regulator (IDR) pep...

journal_title：Vaccine

authors： Snider M,Garg R,Brownlie R,van den Hurk JV,van Drunen Littel-van den Hurk S

更新日期：2014-11-28 00:00:00

abstract：:Viral vectors are promising vaccine candidates for eliciting suitable Ag-specific immune response. Since Mycobacterium tuberculosis (Mtb) normally enters hosts via the mucosal surface of the lung, the best defense against Mtb is mucosal vaccines that are capable of inducing both systemic and mucosal immunity. Although...

journal_title：Vaccine

authors： Watanabe K,Matsubara A,Kawano M,Mizuno S,Okamura T,Tsujimura Y,Inada H,Nosaka T,Matsuo K,Yasutomi Y

更新日期：2014-03-26 00:00:00

abstract：:Formalin-killed Streptococcus difficile strains used as vaccines delivered intraperitoneally were able to protect tilapia against a challenge of 100 LD50. The protection obtained was not strain specific. A vaccine based on an S. difficile extract containing 50% protein conjugated to alum also protected tilapia challen...

journal_title：Vaccine

authors： Eldar A,Shapiro O,Bejerano Y,Bercovier H

更新日期：1995-06-01 00:00:00

abstract：:The divergence of regulatory requirements and processes in developing and emerging countries contributes to hamper vaccines' registration, and therefore delay access to high-quality, safe and efficacious vaccines for their respective populations. This report focuses on providing insights on the heterogeneity of regist...

journal_title：Vaccine

authors： Dellepiane N,Pagliusi S,Registration Experts Working Group.

更新日期：2018-06-07 00:00:00

abstract：:Plague is a zoonotic disease caused by Yersinia pestis, an etiological agent of pneumonic and bubonic plague. There is a need for an improved plague vaccine that may overcome the limitation of presently available whole cell vaccine. An alternative approach described here, is the use of protective epitopes from immunod...

journal_title：Vaccine

authors： Tripathi V,Chitralekha KT,Bakshi AR,Tomar D,Deshmukh RA,Baig MA,Rao DN

更新日期：2006-04-12 00:00:00

abstract：:Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus...

journal_title：Vaccine

authors： De Vleeschauwer AR,Zhou X,Lefebvre DJ,Garnier A,Watier F,Pignon C,Lacour SA,Zientara S,Bakkali-Kassimi L,De Clercq K,Klonjkowski B

更新日期：2018-04-12 00:00:00

abstract：:Fish has a soluble form of TLR5 ortholog (TLR5S), which does not exist in mammals. We identified TLR5S from rainbow trout and named rtTLR5S, which was about 38% homologous to the extracellular domains of human (hu) and mouse TLR5. Adjuvancy of rtTLR5S to flagellin response by human TLR5 (huTLR5) was tested in this stu...

journal_title：Vaccine

authors： Tsujita T,Ishii A,Tsukada H,Matsumoto M,Che FS,Seya T

更新日期：2006-03-15 00:00:00