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Vaccination with whole-cell vaccine and bacterial protein extract protects tilapia against Streptococcus difficile meningoencephalitis.

Abstract：

:Formalin-killed Streptococcus difficile strains used as vaccines delivered intraperitoneally were able to protect tilapia against a challenge of 100 LD50. The protection obtained was not strain specific. A vaccine based on an S. difficile extract containing 50% protein conjugated to alum also protected tilapia challenged with a virulent S. difficile strain. Protection in tilapia was correlated with the development of specific agglutinins. Western blot analysis supported the hypothesis that only a few proteins act as protective antigens in both the whole-cell vaccine and the streptococcal extract. The high efficacy of these vaccines make them good candidates for the control of streptococcal fish meningoencephalitis.

journal_name

Vaccine

journal_title

Vaccine

authors

Eldar A,Shapiro O,Bejerano Y,Bercovier H

doi

10.1016/0264-410x(94)00067-w

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

867-70

issue

9

eissn

0264-410X

issn

1873-2518

pii

0264410X9400067W

journal_volume

13

pub_type

杂志文章

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