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Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates.

Abstract：

:The ability of bioinformatics to characterize genomic sequences from pathogenic bacteria for prediction of genes that may encode vaccine candidates, e.g. surface localized proteins, has been evaluated. By applying appropriate tools for genomic mining to the published sequence of Haemophilus influenzae Rd genome, it was possible to identify a putative vaccine candidate, the outer membrane lipoprotein, P6. Proteomics complements genomics by offering abilities to rapidly identify the products of predicted genes, e.g. proteins in outer membrane preparations. The ability to identify the P6 protein uniquely from entries in a sequence database from the expected peptide-mass fingerprint of P6 demonstrates the power of proteomics. The application of proteomics for identification of vaccine candidates for another pathogenic bacterium, Helicobacter pylori using two different approaches is described. The first involves rapid identification of a series of monoclonal antibody reactive proteins from N-terminal sequence tags. The other approach involves identification of proteins in outer membrane preparations by 2-D electrophoresis followed by trypsin digestion and peptide mass map analysis. Our combined studies demonstrate that utilization of genome sequences by application of bioinformatics through genomics and proteomics can expedite the vaccine discovery process by rapidly providing a set of potential candidates for further testing.

journal_name

Vaccine

journal_title

Vaccine

authors

Chakravarti DN,Fiske MJ,Fletcher LD,Zagursky RJ

doi

10.1016/s0264-410x(00)00256-5

subject

Has Abstract

pub_date

2000-11-08 00:00:00

pages

601-12

issue

6

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(00)00256-5

journal_volume

19

pub_type

杂志文章

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