Abstract：
:The replication of simian immunodeficiency virus (SIV) in acutely infected CD4+ cells can be inhibited in vitro by CD8-suppressor factors (SF) and beta-chemokines induced by immunization of macaques with SIV gp120 and p27 in Alum. A comparison between intradermal, naso-rectal-i.m. and targeted iliac lymph node (TILN) routes showed that immunization by the TILN route elicited the most significant increase in CD8-SF and the beta-chemokines RANTES, MIP-1alpha and MIP-1beta. Increased CD8-SF and beta-chemokines were induced not only in PBMC but also in iliac lymph nodes and spleen of the TILN immunized macaques. Furthermore, CD8-SF and the concentrations of RANTES, MIP-1alpha and MIP-1beta increased with secondary immunizations, suggesting that memory CD8+ cells are involved. Treatment of CD8+ cell culture supernatant with antibodies to RANTES, MIP-1alpha and MIP-1beta neutralized the CD8-SF activity, indicating that blocking the CCR5 by these ligands played an important part in the CD8-SF activity elicited by TILN immunization. Indeed, blocking CCR5 with monoclonal antibodies inhibited SIV replications and MIP-1beta mediated chemotaxis. In contrast, SDF-1 or MAb to CXCR4 failed to suppress SIV replication. However, SDF-1 was able to induce simian PBMC chemotaxis and MAb to CXCR4 inhibited SDF-1 mediated chemotaxis. These results suggest that immunization in macaques induces CD8-SF and beta-chemokines which may prevent SIV infection by blocking the CCR5 coreceptors both in circulating cells and in the rectal and genital draining lymph node cells.
journal_name
Vaccinejournal_title
Vaccineauthors
Wang Y,Tao L,Mitchell E,Bergmeier L,Doyle C,Lehner Tdoi
10.1016/s0264-410x(98)00482-4subject
Has Abstractpub_date
1999-04-09 00:00:00pages
1826-36issue
15-16eissn
0264-410Xissn
1873-2518pii
S0264-410X(98)00482-4journal_volume
17pub_type
杂志文章相关文献
VACCINE文献大全abstract：:CIMAvax-EGF consists of a human recombinant epidermal growth factor (EGF), coupled to P64k, a recombinant carrier protein from N. meningitis, and Montanide ISA 51 as adjuvant. The vaccine immunization induces a specific antibody production, inhibiting the EGF/EGF-R interaction through EGF deprivation. The objective of...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.01.092
更新日期：2012-05-09 00:00:00
abstract：:Francisella tularensis is the intracellular bacterial pathogen causing the respiratory life-threatening disease tularemia. Development of tularemia vaccines has been hampered by an incomplete understanding of the correlates of immunity. Moreover, the importance of lung cellular immunity in vaccine-mediated protection ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.10.053
更新日期：2017-12-15 00:00:00
abstract：:Gamma inulin and Algammulin, two new adjuvants, were examined and compared with alum and Freund's Complete/Incomplete Adjuvant (FCA/FIA), for potentiation of cell-mediated immunity (CMI) and humoral immunity in sheep to a recombinant Taenia ovis antigen. The ability to protect sheep when challenged with live T. ovis e...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(94)00023-g
更新日期：1995-04-01 00:00:00
abstract：:There is currently much interest in generating cytotoxic T lymphocyte (CTL) responses against tumor antigens as a therapy for cancer. In this study mouse fibroblasts (H-2(b)) were genetically modified to express a costimulatory B7.1 and a mature interleukin (IL)-18, and then loaded with an ovalbumin (OVA) epitope (SII...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.12.015
更新日期：2004-06-30 00:00:00
abstract：:OprI is an outer membrane lipoprotein from Pseudomonas aeruginosa, and when fused to a recombinant antigen, will exert adjuvant properties by engaging Toll-like receptor 2, leading to dendritic cell activation. Previous studies have shown that the Neospora caninum (Nc) antigens NcPDI, NcROP2 and NcROP40 are implicated...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.11.060
更新日期：2019-01-14 00:00:00
abstract：:GPI-0100 is a semi-synthetic saponin with modifications designed to augment stability and diminish toxicity. Two batches of GPI-0100 (the second with higher purity) were tested with doses ranging between 100 and 5000 microg in groups of five treated prostate cancer patients who had no evidence of disease except for ri...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.01.072
更新日期：2005-05-02 00:00:00
abstract：:Formalin-killed Streptococcus difficile strains used as vaccines delivered intraperitoneally were able to protect tilapia against a challenge of 100 LD50. The protection obtained was not strain specific. A vaccine based on an S. difficile extract containing 50% protein conjugated to alum also protected tilapia challen...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(94)00067-w
更新日期：1995-06-01 00:00:00
abstract：:In this study we have investigated the immunogenicity and antigenicity of synthetic immunocontraceptive vaccine candidates containing T- and B-cell epitopes arranged in different geometries. Two epitopes were selected, a B-cell epitope from fox sperm lactate dehydrogenase C(4) and a B-cell epitope from murine zona pel...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00255-8
更新日期：1999-10-14 00:00:00
abstract：:The effectiveness of HPV vaccine against HSIL+ (pathologically diagnosed CIN2+) in the first cohort in Japan was investigated in 22,743 women aged 20 to 29 years (parts of national cervical cancer screening program of FY [fiscal year] 2015, the Japan Cancer Society). Vaccinated women had a statistically significant 69...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.05.048
更新日期：2018-12-18 00:00:00
abstract：:The objectives of this study were to evaluate the effects of a therapeutic vaccine intervention with a modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine on the dynamics of a heterologous viral infection in a population of pigs, and to determine the clinical and virological response of p...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.03.031
更新日期：2007-05-30 00:00:00
abstract：:Due to ongoing recombination and mutations, HIV permanently escapes from neutralizing antibody (nAb) responses of the host. By the masking of epitopes or shedding of gp120, HIV-1 further impedes an efficient neutralization by Abs. Therefore, nAbs responses of the host are chasing behind a rapidly evolving virus and ma...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2008.11.050
更新日期：2008-12-30 00:00:00
abstract：BACKGROUND:The Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program is the immunization safety monitoring component of FDA's Mini-Sentinel project, a program to actively monitor the safety of medical products using electronic health information. FDA sought to assess the surveillance capabilities of this ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.04.088
更新日期：2013-12-30 00:00:00
abstract：:The ability of a genetically detoxified mutant of heat labile enterotoxin (LTK63) to act as a mucosal adjuvant following intranasal immunization with recombinant gD2 has previously been reported in mice [Ugozzoli M, O'Hagan DT, Ott GS. Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00009-2
更新日期：1999-05-04 00:00:00
abstract：:To demonstrate the potential of pH-sensitive carbonate apatite (CO₃Ap) nanoparticles as DNA vaccine carriers to enhance vaccination efficacy, we examined the humoral and cellular immune responses of C57BL/6 mice immunized with the plasmid expression vector pCI-neo encoding the full-length soluble ovalbumin (OVA) (pCI-...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.09.032
更新日期：2014-10-29 00:00:00
abstract：BACKGROUND:The hepatitis A (HepA) vaccine was recommended by the Advisory Committee on Immunization Practices (ACIP) incrementally from 1996 to 1999. In 2006, HepA vaccine was recommended (1) universally for children aged 12-23 months, (2) for persons who are at increased risk for infection, or (3) for any person wishi...
journal_title：Vaccine
pub_type： 历史文章,杂志文章
doi：10.1016/j.vaccine.2018.01.090
更新日期：2018-03-14 00:00:00
abstract：:Mycobacterium bovis causes tuberculosis in cattle. Because current therapies inadequately prevent disease spread, new therapies for M. bovis infections are urgently needed. We treated M. bovis-infected cattle with combinations of DNA vaccines, resulting in significantly reduced pulmonary bacterial loads compared with ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.12.055
更新日期：2009-02-25 00:00:00
abstract：:Infection of rubella virus at the early stages of pregnancy in women who are not immune to rubella often induces congenital anomalies in infants, namely congenital rubella syndrome (CRS). This paper is the first comprehensive report of CRS cases in Japan, compiled from a questionnaire to major hospitals, reports to jo...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.03.055
更新日期：2004-09-28 00:00:00
abstract：BACKGROUND:By the time clinical symptoms of Alzheimer's disease (AD) manifest in patients there is already substantial tau pathology in the brain. Recent evidence also suggests that tau pathology can become self-propagating, further accelerating disease progression. Over the last decade several groups have tested the e...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.03.020
更新日期：2017-04-11 00:00:00
abstract：:Measles virus (MV) vaccine strains use CD46, signaling lymphocyte activation molecule, and nectin-4 in human cells as receptors. Meanwhile, many of them are propagated in primary chicken embryonic fibroblasts (CEFs). Our data revealed that CEFs express a nectin-4 homologous molecule (CEF nectin-4) containing well-cons...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.10.109
更新日期：2016-01-02 00:00:00
abstract：METHODS AND OBJECTIVES:To estimate the infant vaccination coverage in Belgium, a random cluster sample according to the expanded program on immunization (EPI) cluster sampling technique was performed in 1999 in the Flemish (Flanders) and French (Wallonia) speaking community of Belgium. The objective was to document the...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00307-3
更新日期：2001-10-15 00:00:00
abstract：:Visceral leishmaniasis, caused by the intracellular parasite Leishmania donovani is a significant public health problem in many regions of the world. Anti-leishmanial immune defences are primarily dependent on the ability of the host to mount an interleukin-12 (IL-12) driven Th1 type of responses. Thus, IL-12 plays a ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.11.058
更新日期：2006-03-20 00:00:00
abstract：:In this study, we compare four different adjuvants, LT(R192G), CpG ODN, MPL((R))TDM, and alum, for their ability to affect the magnitude, distribution, and duration of antibody responses against F1-V, the lead-candidate antigen for the next generation vaccine against plague, in a murine model. In addition, three diffe...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.09.030
更新日期：2007-11-19 00:00:00
abstract：:We investigated whether a combined DNA vaccine delivered together with the IL-15 gene (DNA-IL-15(+)) enhanced the immune response against Brucella abortus in mice. Mice vaccinated with DNA-IL-15(+) developed a robust humoral response; Brucella-specific antibodies exhibited a dominance of immunoglobulin G2a (IgG2a) ove...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.12.076
更新日期：2010-03-11 00:00:00
abstract：:Assuming that the level of Bacille Calmette Guerin (BCG) coverage gives a measure of access to immunisation services, it is possible to derive what fraction of infants are not immunised against measles due to under-utilisation of existing services (rather than unavailability of services). According to the most recent ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00264-x
更新日期：2001-10-12 00:00:00
abstract：:Orally-administered cholera vaccine (OCV) has been increasingly examined as an additional tool to intervene against endemic and epidemic cholera. In 2013, short- and long-term field experience with OCV under nine distinctive field settings was reported from India, Bangladesh, Vietnam, Guinea, Haiti, and Thailand. Lead...
journal_title：Vaccine
pub_type：
doi：10.1016/j.vaccine.2014.11.031
更新日期：2015-01-15 00:00:00
abstract：:We have shown previously that expression library immunization is viable alternative approach to induce protective immunity against Neisseria meningitidis serogroup B. In this study we report that few rounds of library screening allow identification of protective pools of defined antigens. A previously reported protect...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.04.084
更新日期：2007-07-09 00:00:00
abstract：:A new microparticulate delivery system composed of a stabilizing gelatin/poloxamer microcore surrounded by a PLGA coat was designed to improve the stability of tetanus toxoid (TT) encapsulated in PLGA microspheres. Microcores were prepared by a spray-congealing technique and encapsulated within PLGA using an oil-in-oi...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00313-8
更新日期：1999-11-12 00:00:00
abstract：BACKGROUND:Pseudotuberculosis is an infection caused by the bacterial enteropathogen Yersinia pseudotuberculosis and is considered to be a significant problem in veterinary medicine. We previously found that intranasal administration of a recombinant Lactococcus lactis strain that secretes the low-calcium response V (L...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.09.060
更新日期：2016-11-11 00:00:00
abstract：:Hepatitis B is a parenterally and sexually transmitted disease of global importance. It associates with hepatitis D in a consistent proportion of cases. The disease most frequently runs a subclinical and anicteric course, with a significant number of cases that become chronic. Chronic hepatitis may progress to cirrhos...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/0264-410x(93)90219-n
更新日期：1993-01-01 00:00:00
abstract：:Brucella abortus RB51 is a rough (R) stable vaccine strain used in cattle and is believed to be devoid of O-side chain. We analyzed by use of a panel of monoclonal antibodies (MAbs) directed against seven previously defined O-polysaccharide (O-PS) epitopes the O-chain expression in strain RB51. Two MAbs specific for t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00035-x
更新日期：2002-03-15 00:00:00
