Abstract：
:The canarypox vaccine vector (ALVAC) technology has been used to develop and license several vaccines for companion animals and horses in the European Union and USA. ALVAC is a ubiquitous vector with high biosafety since it is non-replicative in mammalians, is genetically and physically stable, and able to induce both humoral and cell-mediated immune responses against the expressed transgene product. Specific rules apply for the development and registration of recombinant vector vaccines. The biology of the vector as well as the recombinant virus must be thoroughly documented to allow the risk assessment of its use in the target species. In particular, its safety for the host and the environment must be extensively demonstrated before field trials can be authorized.
journal_name
Vaccinejournal_title
Vaccineauthors
Poulet H,Minke J,Pardo MC,Juillard V,Nordgren B,Audonnet JCdoi
10.1016/j.vaccine.2006.11.066subject
Has Abstractpub_date
2007-07-26 00:00:00pages
5606-12issue
30eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)01307-7journal_volume
25pub_type
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