Abstract：
:DNA vaccines are a promising method of immunization against biothreats and emerging infections because they are relatively easy to design, manufacture, store and distribute. However, immunization with DNA vaccines using conventional delivery methods often fails to induce consistent, robust immune responses, especially in species larger than the mouse. Intramuscular (i.m.) delivery of a plasmid encoding anthrax toxin protective antigen (PA) using electroporation (EP), a potent DNA delivery method, rapidly induced anti-PA IgG and toxin neutralizing antibodies within 2 weeks following a single immunization in multiple experimental species. The delivery procedure is particularly dose efficient and thus favorable for achieving target levels of response following vaccine administration in humans. These results suggest that EP may be a valuable platform technology for the delivery of DNA vaccines against anthrax and other biothreat agents.
journal_name
Vaccinejournal_title
Vaccineauthors
Luxembourg A,Hannaman D,Nolan E,Ellefsen B,Nakamura G,Chau L,Tellez O,Little S,Bernard Rdoi
10.1016/j.vaccine.2008.03.064subject
Has Abstractpub_date
2008-09-19 00:00:00pages
5216-22issue
40eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)00354-Xjournal_volume
26pub_type
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