Abstract：
:Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1 sequences to stimulate and detect T-cell responses ex vivo. These "HLA-optimised" peptides captured more HIV-1 Nef-specific responses compared with overlapping peptides of a single consensus sequence, in interferon-gamma enzyme linked immunospot assays. Sites of immune selection can reveal more immunogenic epitopes in HLA-diverse populations and offer insights into the nature of HLA-epitope targeting, which could be applied in vaccine design.
journal_name
Vaccinejournal_title
Vaccineauthors
Almeida CA,Roberts SG,Laird R,McKinnon E,Ahmad I,Keane NM,Chopra A,Kadie C,Heckerman D,Mallal S,John Mdoi
10.1016/j.vaccine.2010.06.091subject
Has Abstractpub_date
2010-08-23 00:00:00pages
6052-7issue
37eissn
0264-410Xissn
1873-2518pii
S0264-410X(10)00932-1journal_volume
28pub_type
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