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A phase I evaluation of inactivated influenza A/H5N1 vaccine administered by the intradermal or the intramuscular route.

Abstract：

:In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven subjects received a third dose. All regimens were safe and well tolerated. Antibody responses after two or three doses were low (

journal_name

Vaccine

journal_title

Vaccine

authors

Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA

doi

10.1016/j.vaccine.2009.10.152

subject

Has Abstract

pub_date

2010-04-09 00:00:00

pages

3025-9

issue

17

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)01735-6

journal_volume

28

pub_type

杂志文章,随机对照试验

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