A phase I evaluation of inactivated influenza A/H5N1 vaccine administered by the intradermal or the intramuscular route.


:In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven subjects received a third dose. All regimens were safe and well tolerated. Antibody responses after two or three doses were low (






Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA




Has Abstract


2010-04-09 00:00:00
















  • In vitro evaluation of human hybrid cell lines generated by fusion of B-lymphoblastoid cells and ex vivo tumour cells as candidate vaccines for haematological malignancies.

    abstract::Fusions of dendritic cells (DCs) and tumour cells have been shown to induce protective immunity to tumour challenge in animal models, and to represent a promising approach to cancer immunotherapy. The broader clinical application of this approach, however, is potentially constrained by the lack of replicative capacity...


    pub_type: 杂志文章


    authors: Mohamed YS,Dunnion D,Teobald I,Walewska R,Browning MJ

    更新日期:2012-10-12 00:00:00

  • Recombinant CP40 from Corynebacterium pseudotuberculosis confers protection in mice after challenge with a virulent strain.

    abstract:BACKGROUND:Caseous Lymphadenitis (CLA) is a contagious, infectious, chronic disease caused by Corynebacterium pseudotuberculosis, which affects mainly sheep and goats. The clinical prevalence of CLA in Brazil is 30%, resulting in decreased milk production, weight loss, and unusable meat and leather. Prophylaxis is base...


    pub_type: 杂志文章


    authors: Droppa-Almeida D,Vivas WL,Silva KK,Rezende AF,Simionatto S,Meyer R,Lima-Verde IB,Delagostin O,Borsuk S,Padilha FF

    更新日期:2016-02-17 00:00:00

  • Time and motion study to compare electronic and hybrid data collection systems during the pandemic (H1N1) 2009 influenza vaccination campaign.

    abstract::During the pandemic (H1N1) 2009 vaccination campaign, vaccine providers collected immunization data using hybrid (paper-based and electronic methods) and electronic data systems. We measured staff time in seconds spent on data collection tasks to compare system efficiencies. The sample consisted of 38 organizations ac...


    pub_type: 杂志文章


    authors: Quach S,Hamid JS,Pereira JA,Heidebrecht CL,Foisy J,Bettinger JA,Rosella L,Crowcroft NS,Deeks SL,Quan SD,Finkelstein M,Guay M,Buckeridge DL,Sikora CA,Kwong JC,Public Health Agency of Canada\/Canadian Institutes of Health Res

    更新日期:2011-02-24 00:00:00

  • Induction of a cellular immune response to a defined T-cell epitope as an insert in the flagellin of a live vaccine strain of Salmonella.

    abstract::Attenuated strains of Salmonella have been used as vaccines to deliver heterologous antigens mainly to generate a humoral immune response. However, little is known about their ability to induce a cell-mediated immune response to the T-cell epitopes of another infectious agent or how optimally to deliver these epitopes...


    pub_type: 杂志文章


    authors: Verma NK,Ziegler HK,Stocker BA,Schoolnik GK

    更新日期:1995-02-01 00:00:00

  • High immunogenicity of delayed third dose of hepatitis B vaccine in travellers.

    abstract::Travellers often present late for the third dose of hepatitis B vaccination and measuring anti-HBs serology is common practice to ensure that these individuals are protected. We assessed the adequacy of immune response in 86 healthy travellers who had their third dose of hepatitis B (HB) vaccine performed more than 1 ...


    pub_type: 杂志文章


    authors: Jackson Y,Chappuis F,Mezger N,Kanappa K,Loutan L

    更新日期:2007-04-30 00:00:00

  • A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial.

    abstract:BACKGROUND:The severe acute respiratory syndrome (SARS) virus is a member of the Coronaviridae (CoV) family that first appeared in the Guangdong Province of China in 2002 and was recognized as an emerging infectious disease in March 2003. Over 8000 cases and 900 deaths occurred during the epidemic. We report the safety...


    pub_type: 杂志文章


    authors: Martin JE,Louder MK,Holman LA,Gordon IJ,Enama ME,Larkin BD,Andrews CA,Vogel L,Koup RA,Roederer M,Bailer RT,Gomez PL,Nason M,Mascola JR,Nabel GJ,Graham BS,VRC 301 Study Team.

    更新日期:2008-11-25 00:00:00

  • The tuberculosis vaccine H4:IC31 is safe and induces a persistent polyfunctional CD4 T cell response in South African adults: A randomized controlled trial.

    abstract:BACKGROUND:New, more effective vaccines to prevent tuberculosis (TB) disease are needed urgently. H4:IC31 is an investigational vaccine that contains a fusion protein of the immunodominant antigens TB10.4 and Ag85B, formulated in IC31 adjuvant. We assessed the safety and immunogenicity of H4:IC31 in South African adult...


    pub_type: 杂志文章,随机对照试验


    authors: Geldenhuys H,Mearns H,Miles DJ,Tameris M,Hokey D,Shi Z,Bennett S,Andersen P,Kromann I,Hoff ST,Hanekom WA,Mahomed H,Hatherill M,Scriba TJ,H4:IC31 Trial Study Group.,van Rooyen M,Bruce McClain J,Ryall R,de Bruyn G,H4:

    更新日期:2015-07-09 00:00:00

  • Immunogenicity and reactogenicity of the Biken acellular pertussis vaccine in young adults.

    abstract::To assess the reactogenicity and immunogenicity of the Biken acellular pertussis vaccine (Pa) following administration of a single vaccine dose to young adults with or without a history of prior pertussis immunization, 104 healthy, male and female adults without primary pertussis immunization were enrolled in Mainz (f...


    pub_type: 杂志文章


    authors: Schmitt HJ,Mohnike K,Zepp F,Herden P,Hosbach P

    更新日期:2000-10-15 00:00:00

  • Assessment of neutralization of Micrurus venoms with a blend of anti-Micrurus tener and anti-ScNtx antibodies.

    abstract:BACKGROUND:Micrurus venoms contain two main groups of toxic protein components: short-chain α-neurotoxins (SNtx) and phospholipases type A2 (PLA2). In North America, generally, the Micrurus venoms have low abundance of SNtx compared to that of PLA2s; however, both are highly toxic to mammals, and consequently both can ...


    pub_type: 杂志文章


    authors: Archundia IG,de la Rosa G,Olvera F,Calderón A,Benard-Valle M,Alagón A,Corzo G

    更新日期:2021-02-05 00:00:00

  • Safety of 9-valent human papillomavirus vaccine administration among pregnant women: Adverse event reports in the Vaccine Adverse Event Reporting System (VAERS), 2014-2017.

    abstract:INTRODUCTION:9-valent human papillomavirus vaccine (9vHPV) was approved by the Food and Drug Administration (FDA) in December 2014. 9vHPV is not recommended during pregnancy, but some women of childbearing age may be inadvertently exposed. This study aims to evaluate reports submitted to the Vaccine Adverse Event Repor...


    pub_type: 杂志文章


    authors: Landazabal CS,Moro PL,Lewis P,Omer SB

    更新日期:2019-02-21 00:00:00

  • HIV subtypes and recombination strains--strategies for induction of immune responses in man.

    abstract::Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the coreceptor-ligand interactions. We identified a direct interaction between HIV-1 envelope and a cellular rece...


    pub_type: 杂志文章,评审


    authors: Wahren B,Ljungberg K,Rollman E,Levi M,Zuber B,Kjerrström Zuber A,Hinkula J,Leandersson AC,Calarota S,Hejdeman B,Bratt G,Sandström E

    更新日期:2002-05-06 00:00:00

  • DNA immunisation against the CFA/I fimbriae of enterotoxigenic Escherichia coli (ETEC).

    abstract::The CFA/I fimbria promotes the attachment of enterotoxigenic Escherichia coli (ETEC) to the surface of human enterocytes. The generation of a protective immune response requires the induction of antibodies able to block the CFA/I-mediated binding of ETEC to receptors located on the small intestine epithelium or on the...


    pub_type: 杂志文章


    authors: Alves AM,Lásaro MO,Almeida DF,Ferreira LC

    更新日期:2000-11-22 00:00:00

  • Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge.

    abstract::The stockpiling of live vaccinia virus vaccines has enhanced biopreparedness against the intentional or accidental release of smallpox. Ongoing research on future generation smallpox vaccines is providing key insights into protective immune responses as well as important information about subunit-vaccine design strate...


    pub_type: 杂志文章


    authors: Xiao Y,Zeng Y,Alexander E,Mehta S,Joshi SB,Buchman GW,Volkin DB,Middaugh CR,Isaacs SN

    更新日期:2013-01-02 00:00:00

  • Quadrivalent meningococcal conjugate vaccines.

    abstract::Neisseria meningitidis is an important cause of bacterial meningitis and septicaemia with most disease caused by meningococci bearing serogroups A, B, C, Y and W-135 polysaccharides. Monovalent serogroup C conjugate vaccines have become established in the immunisation programmes in many countries and the first quadriv...


    pub_type: 杂志文章,评审


    authors: Pace D,Pollard AJ,Messonier NE

    更新日期:2009-06-24 00:00:00

  • Impact of hepatitis B vaccination in a highly endemic area of south Italy and long-term duration of anti-HBs antibody in two cohorts of vaccinated individuals.

    abstract::The aims of this study were to evaluate the impact of hepatitis B vaccination on the changing pattern of HBV infection in a former hyperendemic area (Afragola, South Italy), and to assess the long-term persistence of anti-HBs in two cohorts of individuals vaccinated as infants 18 and 23 years ago. Our data shows a sig...


    pub_type: 杂志文章


    authors: Da Villa G,Romanò L,Sepe A,Iorio R,Paribello N,Zappa A,Zanetti AR

    更新日期:2007-04-20 00:00:00

  • Vaccine-induced host responses against very virulent Marek's disease virus infection in the lungs of chickens.

    abstract::The aim of this study was to investigate the kinetics of virus replication and cellular responses in the lungs following infection with Marek's disease virus (MDV) and/or vaccination with herpesvirus of turkey (HVT) via the respiratory route. Chickens vaccinated with HVT and challenged with MDV had a higher accumulati...


    pub_type: 杂志文章


    authors: Haq K,Abdul-Careem MF,Shanmuganthan S,Thanthrige-Don N,Read LR,Sharif S

    更新日期:2010-08-02 00:00:00

  • Economic analysis for evidence-based policy-making on a national immunization program: a case of rotavirus vaccine in Thailand.

    abstract::Severe diarrhea caused by rotavirus is a health problem worldwide, including Thailand. The World Health Organization has recommended incorporating rotavirus vaccination into national immunization programs. This policy has been implemented in several countries, but not in Thailand where the mortality rate is not high. ...


    pub_type: 杂志文章


    authors: Muangchana C,Riewpaiboon A,Jiamsiri S,Thamapornpilas P,Warinsatian P

    更新日期:2012-04-16 00:00:00

  • Long-term immunogenicity after single and booster dose of a live attenuated hepatitis A vaccine: results from 8-year follow-up.

    abstract::Live, attenuated hepatitis A vaccines are used widely in China but there is uncertainty regarding the persistence of vaccine-induced anti-HAV antibodies after single dose and booster dose administrated at month 12. A large scale clinical trial to evaluate the live, attenuated hepatitis A vaccine was conducted in Hebei...


    pub_type: 杂志文章,随机对照试验


    authors: Wang XY,Xu ZY,Ma JC,von Seidlein L,Zhang Y,Hao ZY,Han OP,Zhang YL,Tian MY,Ouyang PY,Zhang ZY,Han CQ,Xing ZC,Chen JC

    更新日期:2007-01-05 00:00:00

  • Pertussis immunization in paediatric healthcare workers: knowledge, attitudes, beliefs, and behaviour.

    abstract::Healthcare workers' (HCWs) knowledge, attitudes, and beliefs regarding pertussis immunization were assessed and compared to the rate of vaccine uptake. A questionnaire was distributed to employees at a paediatric and maternity tertiary care centre. Respondents were then offered a dose of the tetanus, diphtheria, and a...


    pub_type: 杂志文章


    authors: Top KA,Halperin BA,Baxendale D,MacKinnon-Cameron D,Halperin SA

    更新日期:2010-03-02 00:00:00

  • Long-term immunogenicity of a single dose of acellular pertussis vaccine in paediatric health-care workers.

    abstract:OBJECTIVE:Monitor the long-term immunogenicity of a single dose of acellular pertussis vaccine in health-care workers. DESIGN:German health-care workers and child-care workers received a single dose of a monovalent acellular pertussis vaccine (PAC-Mérieux) in an open-label study. Blood samples were taken before (n=261...


    pub_type: 临床试验,杂志文章


    authors: Littmann M,Hülsse C,Riffelmann M,Wirsing von König CH

    更新日期:2008-05-02 00:00:00

  • Immunogenicity, safety and tolerability of MF59-adjuvanted seasonal influenza vaccine in children with juvenile idiopathic arthritis.

    abstract::In order to evaluate the immunogenicity, safety, and tolerability of the MF-59 adjuvanted seasonal influenza vaccine in children and adolescents with juvenile idiopathic arthritis (JIA) treated with different anti-rheumatic drugs, 60 pediatric patients with JIA (30 treated with disease-modifying anti-rheumatic drugs [...


    pub_type: 杂志文章


    authors: Dell'Era L,Corona F,Daleno C,Scala A,Principi N,Esposito S

    更新日期:2012-01-20 00:00:00

  • Antigenic properties of the merozoite surface protein 1 gene of Plasmodium vivax.

    abstract::Plasmodium vivax is responsible for an approximate 35 million yearly human cases of malaria. Unfortunately, due to the low mortality rate associated with it and the difficulties of continuously in vitro culturing of this parasite, vaccine development against this human malaria has been largely neglected. In here, the ...


    pub_type: 杂志文章


    authors: de Oliveira CI,Wunderlich G,Levitus G,Soares IS,Rodrigues MM,Tsuji M,del Portillo HA

    更新日期:1999-08-06 00:00:00

  • Molecular adjuvants for malaria DNA vaccines based on the modulation of host-cell apoptosis.

    abstract::Malaria represents a major global health problem but despite extensive efforts, no effective vaccine is available. Various vaccine candidates have been developed that provide protection in animal models, such as a gene gun-delivered DNA vaccine encoding the circumsporozoite protein (CSP) of Plasmodium berghei. A commo...


    pub_type: 杂志文章


    authors: Bergmann-Leitner ES,Leitner WW,Duncan EH,Savranskaya T,Angov E

    更新日期:2009-09-18 00:00:00

  • Evaluation of the safety, reactogenicity and immunogenicity of three recombinant outer surface protein (OspA) lyme vaccines in healthy adults.

    abstract::The safety, reactogenicity and immunogenicity of three candidate Lyme vaccines based on recombinant outer surface protein (OspA) presented in either lipidated or unlipidated forms, were assessed in 300 seronegative volunteers. Subjects received three doses of one of the three formulations at monthly intervals and were...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Van Hoecke C,Comberbach M,De Grave D,Desmons P,Fu D,Hauser P,Lebacq E,Lobet Y,Voet P

    更新日期:1996-12-01 00:00:00

  • Invasive pneumococcal disease: Clinical outcomes and patient characteristics 2-6 years after introduction of 7-valent pneumococcal conjugate vaccine compared to the pre-vaccine period, the Netherlands.

    abstract:BACKGROUND:Implementation of 7-valent pneumococcal conjugate vaccine (PCV7) in the Dutch national immunization program for infants led to a shift from vaccine to non-vaccine serotypes in invasive pneumococcal disease (IPD) in all age groups. We studied the impact of the serotype shift on clinical syndromes and outcomes...


    pub_type: 杂志文章


    authors: Wagenvoort GH,Sanders EA,Vlaminckx BJ,Elberse KE,de Melker HE,van der Ende A,Knol MJ

    更新日期:2016-02-17 00:00:00

  • A computationally optimized broadly reactive antigen (COBRA) based H5N1 VLP vaccine elicits broadly reactive antibodies in mice and ferrets.

    abstract::Pandemic outbreaks of influenza are caused by the emergence of a pathogenic and transmissible virus to which the human population is immunologically naïve. Recent outbreaks of highly pathogenic avian influenza (HPAI) of the H5N1 subtype are of particular concern because of the high mortality rate (60% case fatality ra...


    pub_type: 杂志文章


    authors: Giles BM,Ross TM

    更新日期:2011-04-05 00:00:00

  • First-in-human safety and immunogenicity investigations of three adjuvanted reduced dose inactivated poliovirus vaccines (IPV-Al SSI) compared to full dose IPV Vaccine SSI when given as a booster vaccination to adolescents with a history of IPV vaccinatio

    abstract:BACKGROUND:There is a demand of affordable IPV in the World. Statens Serum Institut (SSI) has developed three reduced dose IPV formulations adsorbed to aluminium hydroxide; 1/3 IPV-Al, 1/5 IPV-Al and 1/10 IPV-Al SSI, and now report the results of the first investigations in humans. METHODS:240 Danish adolescents, aged...


    pub_type: 杂志文章,随机对照试验


    authors: Lindgren LM,Tingskov PN,Justesen AH,Nedergaard BS,Olsen KJ,Andreasen LV,Kromann I,Sørensen C,Dietrich J,Thierry-Carstensen B

    更新日期:2017-01-23 00:00:00

  • Biodegradable PLGA microspheres as a delivery system for malaria synthetic peptide SPf66.

    abstract::SPf66 is the first chemically synthesised vaccine to elicit a partial protective immune response against malaria. The aluminium hydroxide (alum)-adsorbed SPf66 vaccine is weakly immunogenic and of poor to moderate efficacy in humans. To investigate the possibility of improving SPf66 vaccine immunogenicity, a delivery ...


    pub_type: 杂志文章


    authors: Rosas JE,Hernández RM,Gascón AR,Igartua M,Guzman F,Patarroyo ME,Pedraz JL

    更新日期:2001-08-14 00:00:00

  • Resilience of HPV vaccine uptake in Denmark: Decline and recovery.

    abstract:BACKGROUND:Immunization programs' resilience to shocks is central to their success, but little empirical evidence documents resilience in action. We sought to characterize the decline of HPV vaccination in Denmark after negative media coverage and recovery during a national information campaign. METHODS:We conducted a...


    pub_type: 杂志文章


    authors: Hansen PR,Schmidtblaicher M,Brewer NT

    更新日期:2020-02-11 00:00:00

  • Completeness and timeliness of diphtheria-tetanus-pertussis, measles-mumps-rubella, and polio vaccines in young children with chronic health conditions: A systematic review.

    abstract:OBJECTIVE:To systematically review literature on uptake and timeliness of diphtheria-tetanus-pertussis, measles-mumps-rubella, and/or polio-containing vaccines ininfants who were born preterm, with a low birth weight, and/or with chronic health conditions that were diagnosed within the first 6 months of life. METHODS:...


    pub_type: 杂志文章,meta分析,评审


    authors: Walker EJ,MacDonald NE,Islam N,Le Saux N,Top KA,Fell DB

    更新日期:2019-03-22 00:00:00