Abstract：
:A vaccine against the gonadotrophin-releasing hormone (GnRH) is being developed as an immunological method for treatment of prostatic hypertrophy, based on the observation that active immunization against GnRH leads to the production of anti-GnRH antibodies which results in the shrinkage of the prostate gland. We have been investigating the regulation of anti-GnRH antibody responses by carrier molecules. In previous studies we showed that the use of large protein molecules as carriers limits the use of such a vaccine owing to potential problems of carrier-induced anti-haptenic suppression. In this report we show that synthetic T-helper epitopes can be used as carriers for the generation of anti-GnRH antibody responses.
journal_name
Vaccinejournal_title
Vaccineauthors
Sad S,Chauhan VS,Arunan K,Raghupathy Rdoi
10.1016/0264-410x(93)90077-bsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
1145-50issue
11eissn
0264-410Xissn
1873-2518pii
0264-410X(93)90077-Bjournal_volume
11pub_type
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