A respiratory syncytial virus (RSV) vaccine based on parainfluenza virus 5 (PIV5).

abstract：:Mice immunized with plasmid DNA encoding Nef regulatory protein of human immunodeficiency virus type 1 developed high levels of anti-Nef antibodies. After 4 intramuscular injections of 100 microg plasmid DNA, anti-Nef antibodies reached titers up to 2 x 10(4). A significant specific antibody response was maintained fo...

journal_title：Vaccine

authors： Moureau C,Moynier M,Kavsan V,Montagnier L,Bahraoui E

更新日期：1999-09-01 00:00:00

abstract：:On 1 February 2016, in the context of the ongoing Zika virus epidemic, the WHO declared that the recently reported clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern (PHEIC). In response, WHO in collaboration with UNICEF and a working group of indep...

journal_title：Vaccine

authors： Vannice KS,Giersing BK,Kaslow DC,Griffiths E,Meyer H,Barrett A,Durbin AP,Wood D,Hombach J

更新日期：2019-11-28 00:00:00

abstract：:Mucosal but not parenteral vaccination with whole Leishmania amazonensis promastigotes antigens (LaAg) is known to increase host resistance to infection by an as yet unknown immune mechanism. Since early immune responses are critical for infection establishment, in the present study the differential responses elicited...

journal_title：Vaccine

authors： Pereira Silva Bezerra I,Amaral Abib M,Rossi-Bergmann B

更新日期：2018-04-25 00:00:00

abstract：:Every year, meningococcal meningitis causes thousands of deaths within the meningitis belt in sub-Saharan African countries. Large epidemic waves occur with a periodicity of 5-12 years. The waves do correspond to molecular changes in the expression of capsular or subcapsular antigens, which allow the bug to spread in ...

journal_title：Vaccine

authors： Teyssou R,Muros-Le Rouzic E

更新日期：2007-09-03 00:00:00

abstract：:Influenza causes considerable morbidity and mortality and the damage to public health can be considerable. The most effective measures available for the prevention of influenza is vaccination. In most industrialised countries the objective of vaccination is to limit the disease among individuals at risk, especially th...

journal_title：Vaccine

authors： Gasparini R,Lucioni C,Lai P,Maggioni P,Sticchi L,Durando P,Morelli P,Comino I,Calderisi S,Crovari P

更新日期：2002-12-20 00:00:00

abstract：:There is currently much interest in generating cytotoxic T lymphocyte (CTL) responses against tumor antigens as a therapy for cancer. In this study mouse fibroblasts (H-2(b)) were genetically modified to express a costimulatory B7.1 and a mature interleukin (IL)-18, and then loaded with an ovalbumin (OVA) epitope (SII...

journal_title：Vaccine

authors： Chung SW,Cohen EP,Kim TS

更新日期：2004-06-30 00:00:00

abstract：OBJECTIVE:To determine if the addition of a physician peer educator would lead to improved immunization quality when compared to the traditional education provided as part of a vaccines for children (VFC) site visit. METHODS:A randomized controlled trial was conducted. Study participants were private pediatric and fam...

journal_title：Vaccine

authors： Taylor JA,Rietberg K,Greenfield L,Bibus D,Yasuda K,Marcuse EK,Duchin JS

更新日期：2008-08-05 00:00:00

abstract：:In accordance with the end game strategies for polio eradication a synchronized switch plan from tOPV to bOPV was implemented globally in 2016. The National Committee for Polio Eradication (NCCPE) validated the switch activities in India. An expert group of 104 academics conducted field visits in 25 states and 2 Union...

journal_title：Vaccine

authors： Dasgupta R,Sharma S,Sharma N,Banerjee K,Haran EGP,Muliyel JP,Salunke S,Masoodi MA,Haldar P,Bahl S,Bhatnagar P,Joshi S,Arora NK

更新日期：2019-04-17 00:00:00

abstract：:Type I IFN and IL-12 are well documented to serve as so called "signal 3" cytokines, capable of facilitating CD8(+) T cell proliferation, effector function and memory formation. While their ability to serve in this capacity is well established, to date, no non-cytokine signal 3 mediators have been clearly identified. ...

journal_title：Vaccine

authors： Sanchez PJ,Kedl RM

更新日期：2012-02-01 00:00:00

abstract：:In this study, the haemolytic activities of Bupleurum chinense saponins (BCS) and its adjuvant potentials on the immune responses of ICR mice against ovalbumin (OVA) were evaluated. BCS showed a slight haemolytic effect, with its haemolytic percents being 3.32% and 1.19% at the concentrations of 500 and 250 microg/ml,...

journal_title：Vaccine

authors： Sun HX

更新日期：2006-02-27 00:00:00

abstract：PURPOSE:Human Papillomavirus (HPV) vaccine uptake remains low. Although publicly funded programs provide free or low cost vaccines to low-income children, barriers aside from cost may prevent disadvantaged girls from getting vaccinated. Prior studies have shown distance to health care as a potential barrier to utilizin...

journal_title：Vaccine

authors： Tsui J,Singhal R,Rodriguez HP,Gee GC,Glenn BA,Bastani R

更新日期：2013-04-12 00:00:00

abstract：PURPOSE:Meningococcal C conjugate vaccine was included in December 2000 in the Spanish childhood vaccination at 2, 4 and 6 months of age. In 2006, routine vaccination was modified to two doses at 2 and 4-6 months and a booster dose during the second year of age. Additionally, successive catch-up campaigns were launched...

journal_title：Vaccine

authors： Garrido-Estepa M,León-Gómez I,Herruzo R,Cano R

更新日期：2014-05-07 00:00:00

abstract：:ErbB-2 is associated with several solid tumours of which breast cancer is the commonest cancer in women worldwide. Though anti-ErbB-2 antibody appears to play a significant role in prevention and therapy, naturally occurring anti-ErbB-2 antibody associated with the cleaved ectodomain of overexpressed ErbB-2 self antig...

journal_title：Vaccine

authors： Mukhopadhyay A,Dyring C,Stott DI

更新日期：2014-02-12 00:00:00

abstract：:The spike peplomer S1 subunit sequence from avian infectious bronchitis virus (IBV) Vic S strain was expressed in a plasmid under the control of the fowl adenovirus (FAV) major late promoter (MLP). Two recombinants were constructed in FAV serotype 8 (FAV 8) by inserting the expression cassette between the SnaBI and Xb...

journal_title：Vaccine

authors： Johnson MA,Pooley C,Ignjatovic J,Tyack SG

更新日期：2003-06-20 00:00:00

abstract：:In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven su...

journal_title：Vaccine

authors： Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA

更新日期：2010-04-09 00:00:00

abstract：:Live Shigella flexneri 2a and Shigella sonnei Phase I vaccine candidate strains with two virulence-reducing markers were constructed through stepwise incorporation of weakly attenuating purine auxotrophy with subsequent rifampicin-resistance (RNA polymerase) mutation to yield optimal attenuation. These vaccine candida...

journal_title：Vaccine

authors： Linde K,Dentchev V,Bondarenko V,Marinova S,Randhagen B,Bratoyeva M,Tsvetanov Y,Romanova Y

更新日期：1990-02-01 00:00:00

abstract：:Across the developing world peste des petits ruminants virus places a huge disease burden on agriculture, primarily affecting the production of small ruminant. The disease is most effectively controlled by vaccinating sheep and goats with live attenuated vaccines that provide lifelong immunity. However, the current va...

journal_title：Vaccine

authors： Muniraju M,Mahapatra M,Buczkowski H,Batten C,Banyard AC,Parida S

更新日期：2015-01-09 00:00:00

abstract：:Fusions of dendritic cells (DCs) and tumour cells have been shown to induce protective immunity to tumour challenge in animal models, and to represent a promising approach to cancer immunotherapy. The broader clinical application of this approach, however, is potentially constrained by the lack of replicative capacity...

journal_title：Vaccine

authors： Mohamed YS,Dunnion D,Teobald I,Walewska R,Browning MJ

更新日期：2012-10-12 00:00:00

abstract：BACKGROUND:Inactivated quadrivalent influenza vaccine (IIV4) containing two influenza A strains and one strain from each B lineage (Yamagata and Victoria) may offer broader protection against seasonal influenza than inactivated trivalent influenza vaccine (IIV3), containing a single B strain. This study examined the sa...

journal_title：Vaccine

authors： Cadorna-Carlos JB,Nolan T,Borja-Tabora CF,Santos J,Montalban MC,de Looze FJ,Eizenberg P,Hall S,Dupuy M,Hutagalung Y,Pépin S,Saville M

更新日期：2015-05-15 00:00:00

abstract：:Finding adjuvants in order to enhance immune responses against target immunogens has been a major and recurrent issue for the vaccine industry. It is yet to be solved, most particularly in the context of a growing interest in designing new types of vaccines capable of eliciting Th1 immune responses. A review of synthe...

journal_title：Vaccine

authors： Moingeon P,Haensler J,Lindberg A

更新日期：2001-08-14 00:00:00

abstract：:The safety and immunogenicity of a new formulation of the inactivated hepatitis A vaccine, Avaxim, was evaluated in 189 children, aged 18 months to 15 years in a monocentric, open trial. Two vaccinations were given six months apart. Enrollment was balanced within three age groups: 18 months to 3 years, 4-8 years and 9...

journal_title：Vaccine

authors： Dagan R,Greenberg D,Goldenbertg-Gehtman P,Vidor E,Briantais P,Pinsk V,Athias O,Dumas R

更新日期：1999-04-09 00:00:00

abstract：:To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 microg of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15 microg of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only lo...

journal_title：Vaccine

authors： Couch RB,Winokur P,Brady R,Belshe R,Chen WH,Cate TR,Sigurdardottir B,Hoeper A,Graham IL,Edelman R,He F,Nino D,Capellan J,Ruben FL

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Vaccination coverage is the usual metrics to evaluate the immunization programs performance. For the 10-valent pneumococcal conjugate (PCV10) vaccine, measuring the delay of vaccination is also important, particularly as younger children are at increased risk of disease. Routinely collected administrative da...

journal_title：Vaccine

authors： Sartori AL,Minamisava R,Afonso ET,Policena GM,Pessoni GC,Bierrenbach AL,Andrade AL

更新日期：2017-02-15 00:00:00

abstract：INTRODUCTION:This multi-center, hospital-based observational study determined the seroprevalence of pertussis antibodies amongst healthcare professionals from three different hospitals in Spain to ascertain the health status of professionals attending to susceptible groups who are at risk of contracting and transmittin...

journal_title：Vaccine

authors： Rodríguez de la Pinta ML,Castro Lareo MI,Ramon Torrell JM,García de Lomas J,Devadiga R,Reyes J,McCoig C,Tafalla M,García-Corbeira P

更新日期：2016-02-17 00:00:00

abstract：:The effects of beta-propiolactone (BPL), an alkylating and virus inactivating agent, on the structural and in vitro biological properties of different DNA preparations from BHK-21 cells were investigated. Both uninfected and rabies virus-infected cells were used. Purified cellular DNA (celDNA) was used as the referenc...

journal_title：Vaccine

authors： Morgeaux S,Tordo N,Gontier C,Perrin P

更新日期：1993-01-01 00:00:00

abstract：:The immunopotentiating activities of colloidal iron hydroxide, a novel, experimental mineral adjuvant, and of aluminium hydroxide. the licensed adjuvant for human vaccines, were compared. Our studies revealed that colloidal iron hydroxide and aluminium hydroxide behaved comparably with respect to supporting induction ...

journal_title：Vaccine

authors： Leibl H,Tomasits R,Brühl P,Kerschbaum A,Eibl MM,Mannhalter JW

更新日期：1999-03-05 00:00:00

abstract：:We assessed the tetanus immunity of the general Dutch population and of religious groups refusing vaccination by means of population-based study to evaluate the effect of tetanus vaccination. More than 95% of those born after the introduction of routine vaccination had tetanus antitoxin levels above the minimum protec...

journal_title：Vaccine

authors： de Melker HE,van den Hof S,Berbers GA,Nagelkerke NJ,Rümke HC,Conyn-van Spaendonck MA

更新日期：1999-08-20 00:00:00

abstract：:The ability of ALVAC- or fowlpox-based simian immunodeficiency virus (SIV) vaccines to boost SIV-specific CD4+ and CD8+ T-cell responses was tested in 10 vaccinia-experienced macaques infected with SIVmac251. The CD8+ T-cell response to the dominant Gag(181-189) CM9 was quantitated in seven Mamu-A*01-positive macaques...

journal_title：Vaccine

authors： Nacsa J,Radaelli A,Edghill-Smith Y,Venzon D,Tsai WP,Morghen Cde G,Panicali D,Tartaglia J,Franchini G

更新日期：2004-01-26 00:00:00

abstract：:Since 2000, there has been a legal requirement in the UK that dogs and cats should have an effective rabies vaccination with demonstrable sero-conversion if their owners wish to avoid quarantine on re-entry to the UK. In 2002, 10,483 rabies titres were determined on dogs at the VLA. Statistical analyses assessed the e...

journal_title：Vaccine

authors： Kennedy LJ,Lunt M,Barnes A,McElhinney L,Fooks AR,Baxter DN,Ollier WE

更新日期：2007-12-12 00:00:00

abstract：:Although vaccination has had a dramatic impact on reducing economic losses due to infectious diseases, vaccination technology has not changed dramatically over the last 200 years. However, with the advent of biotechnology and our understanding of virulence factors of infectious agents combined with our knowledge of th...

journal_title：Vaccine

authors： Babiuk LA

更新日期：1999-03-26 00:00:00