Abstract：
:The immunopotentiating activities of colloidal iron hydroxide, a novel, experimental mineral adjuvant, and of aluminium hydroxide. the licensed adjuvant for human vaccines, were compared. Our studies revealed that colloidal iron hydroxide and aluminium hydroxide behaved comparably with respect to supporting induction of an antibody response to tetanus toxoid. Furthermore, mice immunized with both, the experimental vaccine (tick-borne encephalitis virus (TBEV) antigen adsorbed to colloidal iron hydroxide) or with a commercially available TBEV vaccine (adjuvanted with aluminium hydroxide), developed long-lasting antibody responses which protected the animals from TBEV infection even one year after vaccination. The use of colloidal iron hydroxide as adjuvant had the additional advantage to reproducibly support induction of HIV-1 envelope-specific cytotoxic T lymphocytes (CTL), when used as adjuvant for a HIV-1 env-carrying recombinant fowlpox virus and being applied via the subcutaneous route. Aluminium hydroxide was much less active in this respect. Non-adjuvanted recombinant fowlpox elicited CTLs only when given intravenously or intraperitoneally, vaccination routes considered not to be suitable for routine use in humans. Further studies to evaluate the use of colloidal iron as possible alternative and/or supplement for routinely used mineral adjuvants may therefore be warranted.
journal_name
Vaccinejournal_title
Vaccineauthors
Leibl H,Tomasits R,Brühl P,Kerschbaum A,Eibl MM,Mannhalter JWdoi
10.1016/s0264-410x(98)00201-1subject
Has Abstractpub_date
1999-03-05 00:00:00pages
1017-23issue
9-10eissn
0264-410Xissn
1873-2518pii
S0264-410X(98)00201-1journal_volume
17pub_type
杂志文章相关文献
VACCINE文献大全abstract：:The replication of simian immunodeficiency virus (SIV) in acutely infected CD4+ cells can be inhibited in vitro by CD8-suppressor factors (SF) and beta-chemokines induced by immunization of macaques with SIV gp120 and p27 in Alum. A comparison between intradermal, naso-rectal-i.m. and targeted iliac lymph node (TILN) ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)00482-4
更新日期：1999-04-09 00:00:00
abstract：:We have previously shown that vaccination of BALB/c mice with a combination of BCG plus killed Leishmania promastigotes, applied by the i.p. route 10 and 3 days before Trypanosoma cruzi inoculation, prolonged their survival and decreased their parasitaemia. In the present study we show that the BCG-Leishmania vaccine ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00426-0
更新日期：2000-03-06 00:00:00
abstract：BACKGROUND:The study was designed to determine the feasibility of implementing routine dTpa vaccination in the maternity ward to new mothers and to assess midwives' attitudes toward pertussis booster vaccination, their perceived susceptibility and severity of pertussis in their patients' communities, the perceived barr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.05.049
更新日期：2011-08-05 00:00:00
abstract：:Universal infant vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) has nearly eliminated PCV7-serotype invasive pneumococcal disease (IPD) in young U.S. children, but has been accompanied by increases in the incidence of serotype 19A IPD. Because antibiotic-non-susceptible 19A has increased more than...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.03.030
更新日期：2010-05-07 00:00:00
abstract：:The development of potent adjuvants, conditioning innate and adaptative immunity, particularly CTL responses, has become currently a hot point in the rational design of vaccines for cancer immunotherapy. We have described a new approach, in which gangliosides are incorporated into vesicles from Neisseria meningitidis ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.08.111
更新日期：2006-03-24 00:00:00
abstract：:Panton-Valentine leukocidin (PVL) is a Staphylococcus aureus toxin associated with skin and soft-tissue infections (SSTIs) and life-threatening necrotizing pneumonia in humans. Recent reports have demonstrated that neutralizing antibody to PVL is not protective against SSTI recurrence, thus raising a controversy about...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.04.033
更新日期：2011-06-06 00:00:00
abstract：:The rectum as an effective site for induction of systemic and local immunity has received little attention. Rectal immunization with microspheres-containing ovalbumin (MS-OVA) was tested for its ability to elicit systemic and mucosal immune responses. Rectal immunization with MS-OVA enhanced both Th2 dominant OVA-spec...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00360-7
更新日期：2001-11-12 00:00:00
abstract：:Cytokines play an important role in the immune response to live measles virus immunization. To gain further insight into the cytokine production profile in response to measles vaccination, we studied interferon-gamma (IFN-gamma), tumor necrosis factor (TNF-alpha), soluble IL-2 receptor (sIL-2R), interleukin-2 (IL-2), ...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/s0264-410x(03)00272-x
更新日期：2003-09-08 00:00:00
abstract：BACKGROUND:Pandemic planning has historically been oriented to respond to an influenza virus, with vaccination strategy being a key focus. As the current COVID-19 pandemic plays out, the Australian government is closely monitoring progress towards development of SARS-CoV2 vaccines as a definitive intervention. However,...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.12.010
更新日期：2021-01-08 00:00:00
abstract：:To identify predictive factors of complete and age-appropriate vaccination status in Greece, we conducted a cross-sectional study, using stratified cluster sampling, among children attending the first year of the Greek Grammar school (about 6 years of age) and their parents/guardians. Almost 88% (N=3878) of pupils in ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.11.078
更新日期：2010-02-17 00:00:00
abstract：:Putative TB vaccine candidates were selected from lists of genes induced in response to in vivo-like stimuli, such as low oxygen and carbon starvation or growth in macrophages, and tested as plasmid DNA vaccines for their ability to protect against Mycobacterium tuberculosis challenge in a guinea pig aerosol infection...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.05.025
更新日期：2006-09-11 00:00:00
abstract：:Immunization protocols based on priming with plasmid DNA and boosting with recombinants of vaccinia virus (rVV) encoding the same antigen offer great promise for the prevention and treatment of many parasitic and viral infections for which conventional vaccination has little or no effect. To overcome some of the poten...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00450-4
更新日期：2002-12-13 00:00:00
abstract：:A nephropathogenic K2/01 strain of infectious bronchitis virus (IBV) was attenuated by 170 serial passages in embryonated chicken eggs for possible use as a future IBV vaccine strain. High-growth properties and narrow tissue tropisms (limited replication in respiratory tracts) were achieved by the adaptation process. ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.01.062
更新日期：2010-04-01 00:00:00
abstract：:Effective antigen delivery is one of the most important issues in vaccine development. It has been suggested that adjuvant action results from a depot effect by prolonging the duration of the interaction between antigen and cells, and thus is related to the antigen-releasing properties of emulsion adjuvants. The objec...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.09.007
更新日期：2005-04-08 00:00:00
abstract：BACKGROUD:Influenza viruses cause substantial morbidity, especially in older age groups. Thus, they are amongst high priority groups for routine vaccination. However, vaccine-induced immune responses and effectiveness were reported as relatively low. This study aims to systemically compare the immune responses elicited...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/j.vaccine.2017.10.106
更新日期：2017-12-19 00:00:00
abstract：:We have investigated immunological responses in BALB/c mice following transcutaneous (TC) delivery of fraction 1 (F1) and V subunits from Yersinia pestis in conjunction with an enterotoxin-derived adjuvant (cholera toxin, CT). It was found that two or more TC applications of F1 and V subunits (admixed with cholera tox...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.02.049
更新日期：2004-10-22 00:00:00
abstract：:In a single-center study, 66 healthy volunteers aged between 18 and 50years were randomized to be immunized against rabies with three different injection routes: intradermal with DebioJect™ (IDJ), standard intradermal with classical needle (IDS), also called Mantoux method, and intramuscular with classical needle (IM)...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.09.069
更新日期：2017-03-27 00:00:00
abstract：:A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protect...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.07.087
更新日期：2014-09-22 00:00:00
abstract：:This paper presents the results of a global survey that aimed to collect information on country's immunization policy development processes, particularly on the presence and function of national Immunization Technical Advisory Groups (ITAGs). Characteristics of national ITAGs are described as well as attributes of the...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.07.089
更新日期：2010-04-19 00:00:00
abstract：:Randomized controlled clinical trials represent the best way to establish the therapeutic or preventive value of medicines. This decade has seen a strong shift in the location of clinical trials from industrialized countries to developing countries, including many in Africa. However, without independent strong regulat...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.08.113
更新日期：2009-12-09 00:00:00
abstract：:These studies were performed to determine the effects of GPI-0100, a semi synthetic Quillaja Saponin analog, formulated with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) on immunity to HSV. SKH-1 hairless mice, used as a model of herpes labialis, inoculated with HSV-1 results in facial lesions, virus replic...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.10.017
更新日期：2006-03-06 00:00:00
abstract：:After introduction of a mono-component vaccine, containing only pertussis toxoid (PT), the incidence of pertussis was significantly higher in the Gothenburg area among children during the period October 1, 1997 until end of 2006 compared to the Rest of Sweden where a vaccine containing PT and two other pertussis antig...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.02.070
更新日期：2011-04-18 00:00:00
abstract：BACKGROUND:Challenges in reaching good vaccination coverage against measles emerged in several European Union/European Economic Area Member States (EU/EEA MS) leading to progressive accumulation of susceptible individuals and outbreaks. The Burden of Communicable Diseases in Europe (BCoDE) project developed a methodolo...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.01.094
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Patients with inflammatory rheumatic diseases are at higher risk for influenza and current guidelines recommend vaccination for this group of patients. The aim of this study was to evaluate the vaccination coverage and predictors for influenza vaccination among patients with inflammatory rheumatic diseases. ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.06.065
更新日期：2018-08-06 00:00:00
abstract：:Human papillomavirus (HPV)-related morbidity and mortality from cervical cancer primarily occurs in the developing world, where, unfortunately, access to vaccines in general, and expensive newer vaccines in particular, is often more limited than in the industrialized world. In addition, secondary prevention methods su...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2006.05.128
更新日期：2006-08-31 00:00:00
abstract：:The development of a safe and effective vaccine against enterotoxigenic Escherichia coli (ETEC) would be useful for travellers and for young children in endemic areas. A feasibility study of an enteral ETEC vaccine prototype consisting of colonization factor antigen II (CFA/II), containing two component antigens CS1 a...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/s0264-410x(94)80038-2
更新日期：1994-11-01 00:00:00
abstract：:We cloned six mycobacterial antigens into a mammalian expression vector as fusion proteins with the enhanced green fluorescent protein (EGFP). Plasmid DNA was injected intramuscularly, and the injection sites were examined 1 week later. Expression of each antigen-EGFP fusion protein was visualized as green fluorescenc...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00253-0
更新日期：2002-08-19 00:00:00
abstract：:The development of systemic autoimmunity may result as an undesired side-effect following vaccination, and this condition was recently shown to occur in farmed salmon (Salmo salar). Several of previously reported side-effects following vaccination of fish should therefore be reviewed in the light of this condition. He...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.05.032
更新日期：2010-07-12 00:00:00
abstract：:We previously demonstrated that recombinant raccoonpox (RCN) virus could serve as a vector for an influenza vaccine. RCN constructs expressing the hemagglutinin (HA) from H5N1 viruses were immunogenic in chickens. In the current study, we generated several recombinant RCN constructs expressing influenza (H5N1) antigen...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.08.018
更新日期：2012-10-05 00:00:00
abstract：:With the emergence of raccoons (Procyon lotor) as the primary rabies reservoir in the United States of America, a recombinant vaccinia-rabies glycoprotein (V-RG) virus vaccine was developed that protected raccoons by the oral route from rabies infection. Despite extensive laboratory evaluation, vaccine safety concerns...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(96)00163-6
更新日期：1997-02-01 00:00:00
