Priority allocation of pandemic influenza vaccines in Australia - Recommendations of 3 community juries.


BACKGROUND:Pandemic planning has historically been oriented to respond to an influenza virus, with vaccination strategy being a key focus. As the current COVID-19 pandemic plays out, the Australian government is closely monitoring progress towards development of SARS-CoV2 vaccines as a definitive intervention. However, as in any pandemic, initial supply will likely be exceeded by demand due to limited manufacturing output. METHODS:We convened community juries in three Australian locations in 2019 to assess public acceptability and perceived legitimacy of influenza pandemic vaccination distribution strategies. Preparatory work included literature reviews on pandemic vaccine allocation strategies and on vaccine allocation ethics, and simulation modelling studies. We assumed vaccine would be provided to predefined priority groups. Jurors were then asked to recommend one of two strategies for distributing remaining early doses of vaccine: directly vaccinate people at higher risk of adverse outcomes from influenza; or indirectly protect the general population by vaccinating primary school students, who are most likely to spread infection. RESULTS:Thirty-four participants of diverse backgrounds and ages were recruited through random digit dialling and topic-blinded social media advertising. Juries heard evidence and arguments supporting different vaccine distribution strategies, and questioned expert presenters. All three community juries supported prioritising school children for influenza vaccination (aiming for indirect protection), one by 10-2 majority and two by consensus. Justifications included that indirect protection benefits more people and is likely to be more publicly acceptable. CONCLUSIONS:In the context of an influenza pandemic, informed citizens were not opposed to prioritising groups at higher risks of adverse outcomes, but if resources and epidemiological conditions allow, achieving population benefits should be a strategic priority. These insights may inform future SARS-CoV-2 vaccination strategies.






Degeling C,Williams J,Carter SM,Moss R,Massey P,Gilbert GL,Shih P,Braunack-Mayer A,Crooks K,Brown D,McVernon J




Has Abstract


2021-01-08 00:00:00
















  • Global Vaccine Action Plan Lessons Learned II: Stakeholder Perspectives.

    abstract:INTRODUCTION:The Global Vaccine Action Plan (GVAP), unanimously endorsed by the World Health Assembly in 2012, defined an ambitious strategy to improve immunization. At the end of the decade, significant progress has been made but four of the five GVAP goals are likely to be missed. This report describes a set of surve...


    pub_type: 杂志文章


    authors: Hwang A,Veira C,Malvolti S,Cherian T,MacDonald N,Steffen C,Jones I,Hinman A,Mantel C

    更新日期:2020-07-14 00:00:00

  • A quality improvement initiative to increase Tdap (tetanus, diphtheria, acellular pertussis) vaccination coverage among direct health care providers at a children's hospital.

    abstract:OBJECTIVES:Health care providers (HCP) are at high risk of acquiring and transmitting pertussis to susceptible family members, co-workers, and patients. Public health authorities recommend administering a single dose of Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis) vaccine to all adults, inc...


    pub_type: 杂志文章


    authors: Jiang C,Whitmore-Sisco L,Gaur AH,Adderson EE,Tdap Working Group.

    更新日期:2018-01-04 00:00:00

  • Zika virus knowledge, attitudes, and vaccine interest among university students.

    abstract:BACKGROUND:Zika virus vaccine development is underway. We examined interest in receiving a Zika virus vaccine (after one becomes commercially available) among students at a large public university in Northern Virginia. METHODS:An online survey of Zika virus-related knowledge, attitudes, and interest in receiving a Zik...


    pub_type: 杂志文章


    authors: Painter JE,Plaster AN,Tjersland DH,Jacobsen KH

    更新日期:2017-02-07 00:00:00

  • Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns.

    abstract::Carbopol is a polyanionic carbomer used in man for topical application and drug delivery purposes. However parenteral administration of Carbopol in animal models results in systemic adjuvant activity including strong pro-inflammatory type-1 T-cell (Th1) polarization. Here we investigated potential pathways of immune a...


    pub_type: 杂志文章


    authors: Gartlan KH,Krashias G,Wegmann F,Hillson WR,Scherer EM,Greenberg PD,Eisenbarth SC,Moghaddam AE,Sattentau QJ

    更新日期:2016-04-27 00:00:00

  • Use of o-phthalaldehyde assay to determine protein contents of Alhydrogel-based vaccines.

    abstract::Aluminum based adjuvants (alum), including aluminum hydroxide (Alhydrogel) and aluminum phosphate are the most commonly used adjuvant in the US. In order to ensure quality of vaccines, regulatory authorities require evaluation of antigen content in final vaccine products. Currently, there are no generic methods availa...


    pub_type: 杂志文章


    authors: Zhu D,Saul A,Huang S,Martin LB,Miller LH,Rausch KM

    更新日期:2009-10-09 00:00:00

  • The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B--a prerequisite for clinical development.

    abstract::We have recently shown that immunization against the extra domain-B (ED-B) of fibronectin, using Freund's adjuvant, reduces tumor growth in mice by 70%. In the present study we compare the immune response generated against ED-B using the non-toxic and biodegradable adjuvant Montanide ISA 720/CpG with the response elic...


    pub_type: 杂志文章


    authors: Huijbers EJ,Femel J,Andersson K,Björkelund H,Hellman L,Olsson AK

    更新日期:2012-01-05 00:00:00

  • Evaluation of Japanese encephalitis virus E and NS1 proteins immunogenicity using a recombinant Newcastle disease virus in mice.

    abstract::Japanese encephalitis (JE) is the most important cause of acute encephalitis syndrome (AES). Japanese encephalitis virus (JEV), the prototype member of the JE serocomplex, belongs to the genus Flavivirus. The immunogenic proteins envelope (E) and non-structural protein 1 (NS1) of JEV are widely explored for the develo...


    pub_type: 杂志文章


    authors: Nath B,Vandna,Saini HM,Prasad M,Kumar S

    更新日期:2020-02-11 00:00:00

  • The feasibility of HIV vaccine efficacy trials among Russian injection drug users.

    abstract::IDU exposure remains a primary driver of the Russian HIV epidemic, and recent incidence data provide little evidence that this epidemic is slowing. While there are multiple important challenges that need to be further explored before starting vaccine trials, most importantly access to evidence-based drug treatment ser...


    pub_type: 杂志文章


    authors: Beyrer C,Baral S,Shaboltas A,Dukhovlinova E,Masharsky A,Verevochkin S,Latkin C,Heimer R,Hoffman I,Kozlov A

    更新日期:2007-10-10 00:00:00

  • Safety and immunogenicity of a quadrivalent human papillomavirus vaccine in HIV-infected and HIV-negative adolescents and young adults.

    abstract::Human papillomavirus (HPV) infection is highly prevalent and can lead to cancer; the development of safe and efficacious vaccines for HPV is a major public health concern. The two licensed HPV vaccines contain recombinant virus-like particles of HPV 16 and 18; one of such vaccines also protects against HPV types 6 and...


    pub_type: 杂志文章


    authors: Giacomet V,Penagini F,Trabattoni D,Viganò A,Rainone V,Bernazzani G,Bonardi CM,Clerici M,Bedogni G,Zuccotti GV

    更新日期:2014-09-29 00:00:00

  • Midwives' knowledge, attitudes and confidence in discussing maternal and childhood immunisation with parents: A national study.

    abstract:INTRODUCTION:Despite the enormous benefits of childhood and maternal immunisation to individual and population health, the uptake of maternal vaccines during pregnancy remains suboptimal. Midwives are a trusted information source for parents and play an important role in the provision of immunisation information. Under...


    pub_type: 杂志文章


    authors: Frawley JE,McKenzie K,Sinclair L,Cummins A,Wardle J,Hall H

    更新日期:2020-01-10 00:00:00

  • Impact of vaccination against Haemophilus influenzae type b with and without a booster dose on meningitis in four South American countries.

    abstract::To inform World Health Organization recommendations regarding use of Haemophilus influenzae type b (Hib) vaccines in national immunization programs, a multi-country evaluation of trends in Hib meningitis incidence and prevalence of nasopharyngeal Hib carriage was conducted in four South American countries using either...


    pub_type: 杂志文章


    authors: Garcia S,Lagos R,Muñoz A,Picón T,Rosa R,Alfonso A,Abriata G,Gentile A,Romanin V,Regueira M,Chiavetta L,Agudelo CI,Castañeda E,De la Hoz F,Higuera AB,Arce P,Cohen AL,Verani J,Zuber P,Gabastou JM,Pastor D,Flannery

    更新日期:2012-01-05 00:00:00

  • Immunogenic properties of chimeric protein from espA, eae and tir genes of Escherichia coli O157:H7.

    abstract::Enterohemorrhagic Escherichia coli (EHEC) comprise an important group of enteric pathogens causing hemorrhagic colitis and hemolytic uremic syndrome. These bacteria need EspA (E) as a conduct for Tir (T) delivery to the host cell and surface arrayed intimin (I) which docks the bacterium to the translocated Tir. This p...


    pub_type: 杂志文章


    authors: Amani J,Salmanian AH,Rafati S,Mousavi SL

    更新日期:2010-10-04 00:00:00

  • What maintains parental support for vaccination when challenged by anti-vaccination messages? A qualitative study.

    abstract::This study sought to explore how parents respond to competing media messages about vaccine safety. Six focus groups with mothers of infants were shown television vignettes of typical pro- and anti-vaccination claims. Thematic analysis of transcripts was undertaken. Mothers expressed surprise and concern about alleged ...


    pub_type: 杂志文章


    authors: Leask J,Chapman S,Hawe P,Burgess M

    更新日期:2006-11-30 00:00:00

  • Crossreactive neutralizing antibodies induced by immunization with caprine arthritis-encephalitis virus surface glycoprotein.

    abstract::Four Saanen goats were immunized with affinity purified gp135 surface glycoprotein (SU) of caprine arthritis-encephalitis virus isolate 79-63 (CAEV-63) and evaluated for homologous and crossreactive serum neutralizing antibodies. CAEV-63 neutralizing antibodies were detected in all goats after seven immunizations with...


    pub_type: 杂志文章


    authors: Kemp RK,Knowles DP,Perry LL,McGuire TC,Besser TE,Cheevers WP

    更新日期:2000-01-18 00:00:00

  • Glutamate-rich protein (GLURP) induces antibodies that inhibit in vitro growth of Plasmodium falciparum in a phase 1 malaria vaccine trial.

    abstract::The glutamate-rich protein (GLURP) of P. falciparum is the target of cytophilic antibodies which are significantly associated with protection against clinical malaria. A phase 1 clinical trial was conducted in healthy adult volunteers with the long synthetic peptide (LSP) GLURP(85-213) combined with either Aluminum Hy...


    pub_type: 杂志文章


    authors: Hermsen CC,Verhage DF,Telgt DS,Teelen K,Bousema JT,Roestenberg M,Bolad A,Berzins K,Corradin G,Leroy O,Theisen M,Sauerwein RW

    更新日期:2007-04-12 00:00:00

  • Safety and immunogenicity of influenza A(H5N1) vaccine stored up to twelve years in the National Pre-Pandemic Influenza Vaccine Stockpile (NPIVS).

    abstract:BACKGROUND:As part of the U.S. Department of Health and Human Services (HHS) Pandemic Influenza Plan preparedness and response strategy, the National Pre-Pandemic Influenza Vaccine Stockpile (NPIVS) program was established by the Biomedical Advanced Research and Development Authority (BARDA) in 2005 with the goal of bu...


    pub_type: 杂志文章,随机对照试验


    authors: Oshansky CM,Zhou J,Gao Y,Schweinle JE,Biscardi K,DeBeauchamp J,Pavetto C,Wollish A,BRITE Study Coordination Team.,Webby RJ,Cioce V,Donis RO,Bright RA

    更新日期:2019-01-14 00:00:00

  • Evaluation of hepatitis B vaccine immunogenicity among older adults during an outbreak response in assisted living facilities.

    abstract:BACKGROUND:During the past decade, in the United States, an increasing number of hepatitis B outbreaks have been reported in assisted living facilities (ALFs) as a result of breaches in infection control practices. We evaluated the seroprotection rates conferred by hepatitis B vaccine among older adults during a respon...


    pub_type: 杂志文章


    authors: Tohme RA,Awosika-Olumo D,Nielsen C,Khuwaja S,Scott J,Xing J,Drobeniuc J,Hu DJ,Turner C,Wafeeg T,Sharapov U,Spradling PR

    更新日期:2011-11-21 00:00:00

  • Process development for the mass production of Ehrlichia ruminantium.

    abstract::This work describes the optimization of a cost-effective process for the production of an inactivated bacterial vaccine against heartwater and the first attempt to produce the causative agent of this disease, the rickettsia Ehrlichia ruminantium (ER), using stirred tanks. In vitro, it is possible to produce ER using c...


    pub_type: 杂志文章


    authors: Marcelino I,Sousa MF,Veríssimo C,Cunha AE,Carrondo MJ,Alves PM

    更新日期:2006-03-06 00:00:00

  • Specificity of anti-Nef antibodies produced in mice immunized with DNA encoding the HIV-1 nef gene product.

    abstract::Mice immunized with plasmid DNA encoding Nef regulatory protein of human immunodeficiency virus type 1 developed high levels of anti-Nef antibodies. After 4 intramuscular injections of 100 microg plasmid DNA, anti-Nef antibodies reached titers up to 2 x 10(4). A significant specific antibody response was maintained fo...


    pub_type: 杂志文章


    authors: Moureau C,Moynier M,Kavsan V,Montagnier L,Bahraoui E

    更新日期:1999-09-01 00:00:00

  • Observational study of vaccine effectiveness 20 years after the introduction of universal hepatitis B vaccination in Tunisia.

    abstract:OBJECTIVES:The objectives of this study were to estimate the national prevalence of hepatitis B infection in Tunisia using data from a nationwide survey, to compare results with those obtained in 1996 survey and to evaluate the impact of vaccination twenty years after its introduction. METHODS:A National household-bas...


    pub_type: 杂志文章


    authors: Ben Hadj M,Bouguerra H,Saffar F,Chelly S,Hechaichi A,Talmoudi K,Bahrini A,Chouki T,Hazgui O,Hannachi N,Letaief H,Bellali H,Bahri O,Ben-Alaya-Bouafif N

    更新日期:2018-09-18 00:00:00

  • An influenza B outbreak during the 2007/2008 winter among appropriately immunized elderly people living in a nursing home.

    abstract::The study evaluated the immunogenicity and efficacy of a trivalent subunit MF59-adjuvanted influenza vaccine (A/Wisconsin/67/05 (H3N2), A/Solomon Islands/3/06 (H1N1) and B/Malaysia/2506/04) in preventing serologically diagnosed infections in a group of 67 institutionalized elderly volunteers during 2007/2008 winter, c...


    pub_type: 杂志文章


    authors: Camilloni B,Neri M,Lepri E,Basileo M,Sigismondi N,Puzelli S,Donatelli I,Iorio AM

    更新日期:2010-11-03 00:00:00

  • Immunogenicity and efficacy of codon optimized DNA vaccines encoding the F-protein of respiratory syncytial virus.

    abstract::Respiratory syncytial virus F-protein (RSV-F) is poorly expressed from DNA expression plasmids containing the wild type RSV-F open reading frame. By codon optimization, premature polyadenylation signals were deleted and a striking enhancement of RSV-F expression levels was achieved. Therefore, the immunogenicity and e...


    pub_type: 杂志文章


    authors: Ternette N,Tippler B,Uberla K,Grunwald T

    更新日期:2007-10-10 00:00:00

  • Intradermal immunization improves protective efficacy of a novel TB vaccine candidate.

    abstract::We have developed the Mycobacterium tuberculosis (Mtb) fusion protein (ID83), which contains the three Mtb proteins Rv1813, Rv3620 and Rv2608. We evaluated the immunogenicity and protective efficacy of ID83 in combination with several emulsion-formulated toll-like receptor agonists. The ID83 subunit vaccines containin...


    pub_type: 杂志文章


    authors: Baldwin SL,Bertholet S,Kahn M,Zharkikh I,Ireton GC,Vedvick TS,Reed SG,Coler RN

    更新日期:2009-05-18 00:00:00

  • Challenges to health workers and their opinions about parents' refusal of oral polio vaccination in the Khyber Pakhtoon Khawa (KPK) province, Pakistan.

    abstract::A qualitative study design was adapted to explore the challenges faced by health workers (HWs) during the polio health campaign. In addition, HWs' opinions about the factors causing parents to refuse oral polio vaccination (OPV) were also explored. Four focus group discussions (FGDs) were held (from 1st January 2015-3...


    pub_type: 杂志文章


    authors: Khan TM,Sahibzada MU

    更新日期:2016-04-19 00:00:00

  • Midwife attitudes: an important determinant of maternal postpartum pertussis booster vaccination.

    abstract:BACKGROUND:The study was designed to determine the feasibility of implementing routine dTpa vaccination in the maternity ward to new mothers and to assess midwives' attitudes toward pertussis booster vaccination, their perceived susceptibility and severity of pertussis in their patients' communities, the perceived barr...


    pub_type: 杂志文章


    authors: Robbins SC,Leask J,Hayles EH,Sinn JK

    更新日期:2011-08-05 00:00:00

  • Using solar-powered refrigeration for vaccine storage where other sources of reliable electricity are inadequate or costly.

    abstract::Large areas of many developing countries have no grid electricity. This is a serious challenge that threatens the continuity of the vaccine cold chain. The main alternatives to electrically powered refrigerators available for many years--kerosene- and gas-driven refrigerators--are plagued by problems with gas supply i...


    pub_type: 杂志文章,评审


    authors: McCarney S,Robertson J,Arnaud J,Lorenson K,Lloyd J

    更新日期:2013-12-09 00:00:00

  • Development of an o-pthalaldehyde (OPA) assay to measure protein content in Ricin Vaccine E. coli (RVEc™).

    abstract::A recombinant ricin vaccine from E. coli (RVEc™), was developed at the US Army Medical Research Institute of Infectious Diseases (USAMRIID) and assessed in an FDA sponsored Phase 1a clinical trial. At the maximum dosage, two of the study participants developed physiological responses that were elevated to the level of...


    pub_type: 杂志文章


    authors: Montgomery VA,Lindsey CY,Smith LA,Webb RP

    更新日期:2021-01-15 00:00:00

  • Co-administration of IL-12 DNA with rORFF antigen confers long-term protective immunity against experimental visceral leishmaniaisis.

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    pub_type: 杂志文章


    authors: Tewary P,Saxena S,Madhubala R

    更新日期:2006-03-20 00:00:00

  • Modelling the epidemiological impact of rotavirus vaccination in Germany--a Bayesian approach.

    abstract:BACKGROUND:Rotavirus (RV) infection is the primary cause of severe gastroenteritis in children aged <5 years in Germany and worldwide. In 2013 the German Standing Committee on Vaccination (STIKO) developed a national recommendation for routine RV-immunization of infants. To support informed decision-making we predicted...


    pub_type: 杂志文章


    authors: Weidemann F,Dehnert M,Koch J,Wichmann O,Höhle M

    更新日期:2014-09-08 00:00:00

  • The mucosal adjuvanticity of the oligodeoxynucleotides containing a non-methylated CpG motif on BCG and diphtheria toxoid.

    abstract::CpG-DNA is currently attracting attention as an effective and safe vaccine adjuvant to prevent from microbial infections. In this report, we examined the effects of oligo B, which is a synthetic CpG-DNA, in mucosal administration of Bacillus Calmette-Guérin (BCG) and diphtheria toxoid (DT). Co-administration with olig...


    pub_type: 杂志文章


    authors: Maeyama J,Komiya T,Takahashi M,Isaka M,Goto N,Yamamoto S

    更新日期:2009-02-18 00:00:00