Abstract：
:Heat shock proteins (hsps) are known to be immunodominant antigens of bacteria. Hsps are evolutionarily strongly conserved proteins present in all eukaryotic and prokaryotic cellular organisms and upregulated by several forms of stress. Despite (the paradigm of) self-tolerance, hsp-epitopes homologous to endogenous host hsp sequences have been implicated as T cell epitopes to endow crossreactive, hsp-specific T cells with the capacity to regulate inflammation, such as in experimentally induced autoimmune diseases. Such T cells were found to produce regulatory cytokines like IL10, in contrast to T cells induced with other conserved microbial proteins that are not upregulated by stress. Hsps have been implicated in immune regulation not only as upregulated targets of adaptive immunity during inflammatory stress, but recently also as triggering factors for innate immunity through activation via Toll-like receptors (TLRs).
journal_name
Vaccinejournal_title
Vaccineauthors
van Eden W,Koets A,van Kooten P,Prakken B,van der Zee Rdoi
10.1016/s0264-410x(02)00538-8subject
Has Abstractpub_date
2003-02-14 00:00:00pages
897-901issue
9-10eissn
0264-410Xissn
1873-2518pii
S0264410X02005388journal_volume
21pub_type
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