当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Myxomavirus as a vector for the immunisation of sheep: protection study against challenge with bluetongue virus.

Myxomavirus as a vector for the immunisation of sheep: protection study against challenge with bluetongue virus.

Abstract：

:Recombinant poxviruses are well suited for the development of new vaccine vectors. Our previous data supported the idea that Myxomavirus (MYXV) is efficient at priming antibody responses in sheep. To provide definitive evidence on the potential of MYXV for vaccination against infectious diseases in ruminants, we investigated the immune protection provided by recombinant MYXV against bluetongue, a devastating disease in sheep. To test this concept, sheep were injected twice with an MYXV expressing the immunodominant VP2 protein (SG33-VP2). The SG33-VP2 vector promoted the production of neutralising antibodies and partially protected sheep against disease after challenge with a highly virulent strain of serotype-8 bluetongue virus (BTV-8). In contrast, an MYXV expressing both VP2 and VP5 proteins (SG33-VP2/5) elicited very little protection. The expression levels of the VP2 and VP5 proteins suggested that, greater than the co-expression of the VP5 protein which was previously thought to favour anti-VP2 antibody response, the high expression of VP2 may be critical in the MYXV context to stimulate a protective response in sheep. This highlights the requirement for a careful examination of antigen expression before any conclusion can be drawn on the respective role of the protective antigens. As a proof of principle, our study shows that an MYXV vaccine vector is possible in ruminants.

journal_name

Vaccine

journal_title

Vaccine

authors

Top S,Foucras G,Deplanche M,Rives G,Calvalido J,Comtet L,Bertagnoli S,Meyer G

doi

10.1016/j.vaccine.2011.12.108

subject

Has Abstract

pub_date

2012-02-21 00:00:00

pages

1609-16

issue

9

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)02069-X

journal_volume

30

pub_type

杂志文章

相关文献

VACCINE文献大全
  • A novel peptide isolated from phage library to substitute a complex system for a vaccine against staphylococci infection.

    abstract：:Staphylococcus aureus is a major human pathogen and many of the strains are resistant to conventional antibacterial treatment. The bacteria cause disease largely due to the production of multiple toxins, whose synthesis is controlled by an RNA molecule termed RNAIII. The production of RNAIII is induced by quorum sensi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.09.004

    authors： Yang G,Gao Y,Dong J,Xue Y,Fan M,Shen B,Liu C,Shao N

    更新日期：2006-02-20 00:00:00

  • The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus.

    abstract：:Seven volunteers involved in flavivirus studies have been immunized with commercial Japanese encephalitis and yellow fever vaccines JE-VAX and YF-VAX. Strong homologous and cross-reactive with West Nile virus (WNV) antibody responses with titers 1:1600 to 1:51200 were found in all donors. All donors developed high lev...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.04.036

    authors： Yamshchikov G,Borisevich V,Kwok CW,Nistler R,Kohlmeier J,Seregin A,Chaporgina E,Benedict S,Yamshchikov V

    更新日期：2005-09-15 00:00:00

  • Human immune response to a Pseudomonas aeruginosa outer membrane protein vaccine.

    abstract：:In order to evaluate in humans the safety and immunogenicity of a Pseudomonas aeruginosa vaccine composed of outer membrane proteins (OMPs), CFC-101, we carried out a phase I/IIa clinical trial in healthy male volunteers. Groups of six volunteers were immunized either subcutaneously (s.c.) or intramuscularly (i.m.) wi...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0264-410x(98)00159-5

    authors： Jang IJ,Kim IS,Park WJ,Yoo KS,Yim DS,Kim HK,Shin SG,Chang WH,Lee NG,Jung SB,Ahn DH,Cho YJ,Ahn BY,Lee Y,Kim YG,Nam SW,Kim HS

    更新日期：1999-01-01 00:00:00

  • Development of an ex vivo human skin model for intradermal vaccination: tissue viability and Langerhans cell behaviour.

    abstract：:The presence of resident Langerhans cells (LCs) in the epidermis makes the skin an attractive target for DNA vaccination. However, reliable animal models for cutaneous vaccination studies are limited. We demonstrate an ex vivo human skin model for cutaneous DNA vaccination which can potentially bridge the gap between ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.07.088

    authors： Ng KW,Pearton M,Coulman S,Anstey A,Gateley C,Morrissey A,Allender C,Birchall J

    更新日期：2009-10-09 00:00:00

  • Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial.

    abstract：BACKGROUND:The Bacille Calmette-Guérin (BCG) vaccine against tuberculosis (TB) may have beneficial non-specific effects (NSEs) beyond the protection against TB. This may be related to modifications of the innate immune system. We investigated the effect of BCG at birth on differential white blood cell (WBC) count in he...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.02.006

    authors： Jensen SK,Jensen TM,Birk NM,Stensballe LG,Benn CS,Jensen KJ,Pryds O,Jeppesen DL,Nissen TN

    更新日期：2020-03-04 00:00:00

  • Opportunities and challenges of Web 2.0 for vaccination decisions.

    abstract：:A growing number of people use the Internet to obtain health information, including information about vaccines. Websites that allow and promote interaction among users are an increasingly popular source of health information. Users of such so-called Web 2.0 applications (e.g. social media), while still in the minority...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.02.025

    authors： Betsch C,Brewer NT,Brocard P,Davies P,Gaissmaier W,Haase N,Leask J,Renkewitz F,Renner B,Reyna VF,Rossmann C,Sachse K,Schachinger A,Siegrist M,Stryk M

    更新日期：2012-05-28 00:00:00

  • Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children.

    abstract：:Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations w...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00180-8

    authors： Nurkka A,MacLennan J,Jäntti V,Obaro S,Greenwood B,Käyhty H

    更新日期：2000-10-15 00:00:00

  • Enhancing immune responses to inactivated porcine parvovirus oil emulsion vaccine by co-inoculating porcine transfer factor in mice.

    abstract：:Inactivated porcine parvovirus (PPV) vaccines are available commercially and widely used in the breeding herds. However, inactivated PPV vaccines have deficiencies in induction of specific cellular immune response. Transfer factor (TF) is a material that obtained from the leukocytes, and is a novel immune-stimulatory ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.05.077

    authors： Wang RN,Wang YB,Geng JW,Guo DH,Liu F,Chen HY,Zhang HY,Cui BA,Wei ZY

    更新日期：2012-07-27 00:00:00

  • An ESAT-6:CFP10 DNA vaccine administered in conjunction with Mycobacterium bovis BCG confers protection to cattle challenged with virulent M. bovis.

    abstract：:The potency of genetic immunization observed in the mouse has demonstrated the utility of DNA vaccines to induce cell-mediated and humoral immune responses. However, it has been relatively difficult to generate comparable responses in non-rodent species. The use of molecular adjuvants may increase the magnitude of the...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2007.03.052

    authors： Maue AC,Waters WR,Palmer MV,Nonnecke BJ,Minion FC,Brown WC,Norimine J,Foote MR,Scherer CF,Estes DM

    更新日期：2007-06-11 00:00:00

  • The virulence-related rhoptry protein 5 (ROP5) of Toxoplasma Gondii is a novel vaccine candidate against toxoplasmosis in mice.

    abstract：:Infections with the intracellular protozoan parasite Toxoplasma gondii pose a serious public health problem and are of great economic importance worldwide. The parasite rhoptry protein 5 (ROP5) has been implicated as a major virulence factor that reduces the accumulation of immunity-related GTPases (IRG) in parasitoph...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.07.058

    authors： Zheng B,Lu S,Tong Q,Kong Q,Lou D

    更新日期：2013-09-23 00:00:00

  • A DNA vaccine encoding VP22 of herpes simplex virus type I (HSV-1) and OprF confers enhanced protection from Pseudomonas aeruginosa in mice.

    abstract：:Pseudomonas aeruginosa antimicrobial resistance is a major therapeutic challenge. DNA vaccination is an attractive approach for antigen-specific immunotherapy against P. aeruginosa. We explored the feasibility of employing Herpes simplex virus type 1 tegument protein, VP22, as a molecular tool to enhance the immunogen...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.07.017

    authors： Yu X,Wang Y,Xia Y,Zhang L,Yang Q,Lei J

    更新日期：2016-08-17 00:00:00

  • Immunogenicity and safety of inactivated monovalent 2009 H1N1 influenza A vaccine in immunocompromised children and young adults.

    abstract：BACKGROUND:Influenza vaccination is recommended for immunocompromised patients. METHODS:Children (6 months to 21 years) with cancer, HIV infection, or sickle cell disease (SCD) received 1 or 2 doses of pandemic 2009 H1N1 monovalent influenza vaccine (H1N1 MIV). Safety and tolerability, hemagglutination inhibition (HI)...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.11.105

    authors： Hakim H,Allison KJ,Van De Velde LA,Li Y,Flynn PM,McCullers JA

    更新日期：2012-01-20 00:00:00

  • High rates of serological response to a modified hepatitis B vaccination schedule in HIV-infected adults subjects.

    abstract：:We evaluated a modified HBV regimen in a cohort of HIV-infected subjects in Rio de Janeiro, Brazil. HIV-infected subjects with no serologic evidences of previous hepatitis B infection were immunized with 4 doses (40 microg each) of recombinant hepatitis B vaccine given at 0, 1, 2 and 6 months. Blood samples were colle...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.11.066

    authors： Potsch DV,Oliveira ML,Ginuíno C,Miguel JC,Oliveira SA,Silva EF,Moreira RB,Cruz GV,Oliveira AL,Camacho LA,Barroso PF

    更新日期：2010-02-10 00:00:00

  • Killed Bacillus subtilis spores as a mucosal adjuvant for an H5N1 vaccine.

    abstract：:Heat killed spores of the Gram-positive bacterium Bacillus subtilis have been evaluated as a vaccine delivery system with mucosal adjuvant properties for influenza. Killed spores were able to bind H5N1 virions (NIBRG-14; clade 1) and, when intra-nasally administered to mice, resulting immune responses, both humoral an...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.03.016

    authors： Song M,Hong HA,Huang JM,Colenutt C,Khang DD,Nguyen TV,Park SM,Shim BS,Song HH,Cheon IS,Jang JE,Choi JA,Choi YK,Stadler K,Cutting SM

    更新日期：2012-05-09 00:00:00

  • Broad vaccine protection against Neisseria meningitidis using factor H binding protein.

    abstract：:Neisseria meningitidis, the causative agent of invasive meningococcal disease (IMD), is classified into different serogroups defined by their polysaccharide capsules. Meningococcal serogroups A, B, C, W, and Y are responsible for most IMD cases, with serogroup B (MenB) causing a substantial percentage of IMD cases in ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2020.08.031

    authors： Findlow J,Bayliss CD,Beernink PT,Borrow R,Liberator P,Balmer P

    更新日期：2020-11-17 00:00:00

  • Impact of measles national vaccination coverage on burden of measles across 29 Member States of the European Union and European Economic Area, 2006-2011.

    abstract：BACKGROUND:Challenges in reaching good vaccination coverage against measles emerged in several European Union/European Economic Area Member States (EU/EEA MS) leading to progressive accumulation of susceptible individuals and outbreaks. The Burden of Communicable Diseases in Europe (BCoDE) project developed a methodolo...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.01.094

    authors： Colzani E,McDonald SA,Carrillo-Santisteve P,Busana MC,Lopalco P,Cassini A

    更新日期：2014-04-01 00:00:00

  • The respiratory syncytial virus fusion protein formulated with a novel combination adjuvant induces balanced immune responses in lambs with maternal antibodies.

    abstract：:Respiratory syncytial virus (RSV) causes severe respiratory illness in infants. There are no licensed vaccines to prevent RSV infection. The neonate receives short-term protection from maternally derived antibodies, which, however, can also interfere with the active response to vaccination. A RSV vaccine consisting of...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.01.041

    authors： Garg R,Latimer L,Gerdts V,Potter A,van Drunen Littel-van den Hurk S

    更新日期：2015-03-10 00:00:00

  • Epidemiology of varicella in Haidian district, Beijing, China-2007-2015.

    abstract：BACKGROUND:1-Dose varicella vaccination was recommended for children in Beijing before November 2012. To further control school-based outbreaks and decrease incidence, a 2-dose vaccination was implemented in 2013. We described the varicella epidemiology and assessed impact of the 2-dose vaccination in Haidian district,...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.03.044

    authors： Fu J,Jiang C,Wang J,Zhao F,Ma T,Shi R,Zhao Y,Zhang X

    更新日期：2017-04-25 00:00:00

  • Evaluation of immune responses to an oral typhoid vaccine, Ty21a, in children from 2 to 5 years of age in Bangladesh.

    abstract：:Young children are very susceptible to typhoid fever, emphasizing the need for vaccination in under five age groups. The parenteral Vi polysaccharide vaccine is not immunogenic in children under 2 years and the oral Ty21a vaccine (Vivotif) available in capsular formulation is only recommended for those over 5 years. W...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2014.01.001

    authors： Bhuiyan TR,Choudhury FK,Khanam F,Saha A,Sayeed MA,Salma U,Lundgren A,Sack DA,Svennerholm AM,Qadri F

    更新日期：2014-02-19 00:00:00

  • Classification of measles cases from 2014 to 2018: Implications for progress towards measles elimination in China.

    abstract：:Measles incidence has decreased dramatically in China due to the implement of measles-containing vaccine (MCV). However, a measles epidemic caused resurgence recently, even among vaccinated individuals. To evaluate the effectiveness of current immunization programs and discuss initiatives for the next step in measles ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.03.049

    authors： Cui A,Zhang Y,Zhu Z,Wang H,Mao N,Song J,Xu W

    更新日期：2020-05-08 00:00:00

  • Control of tick infestations in wild roe deer (Capreolus capreolus) vaccinated with the Q38 Subolesin/Akirin chimera.

    abstract：:Ticks (Acari: Ixodidae) are considered to be the most important vectors of disease-causing pathogens in domestic and wild animals, and emerging and re-emerging tick-borne diseases (TBD) exert an enormous impact on them. Wild ungulates are hosts for a wide variety of tick species and tick-borne pathogens that affect hu...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.07.062

    authors： Contreras M,San José C,Estrada-Peña A,Talavera V,Rayas E,Isabel León C,Luis Núñez J,García Fernández de Mera I,de la Fuente J

    更新日期：2020-09-22 00:00:00

  • Estimating the effect of measles vaccination on child growth using 191 DHS from 65 low- and middle-income countries.

    abstract：BACKGROUND:Childhood vaccinations reduce morbidity and mortality and are highly cost-effective. They may also protect children from malnutrition and lead to improved child growth. Stunting, wasting and underweight are targets used to monitor progress towards the achievement of the sustainable development goals (SDGs). ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.06.054

    authors： Bogler L,Jantos N,Bärnighausen T,Vollmer S

    更新日期：2019-08-14 00:00:00

  • Comparison of immunization systems in Japan and the United States - What can be learned?

    abstract：:Recently, efforts have been made to fill a so-called "vaccine gap" between Japan and other countries; however, more work remains. Concerns about adverse events following immunization (AEFI) resulted in an historically passive approach to policy making in the National Immunization Program (NIP). For example, reports of...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2020.09.028

    authors： Katsuta T,Moser CA,Feemster KA,Saitoh A,Offit PA

    更新日期：2020-10-27 00:00:00

  • Strategies to prevent and control hepatitis B and C virus infections: a global perspective.

    abstract：:Hepatitis B virus (HBV) and hepatitis C virus (HCV) are major causes of acute and chronic liver disease worldwide. Chronic infection with these viruses often leads to chronic liver disease, including cirrhosis or primary hepatocellular carcinoma. Both HBV and HCV are bloodborne viruses; however, HBV is transmitted eff...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(98)00415-0

    authors： Mast EE,Alter MJ,Margolis HS

    更新日期：1999-03-26 00:00:00

  • The impact of parental postpartum pertussis vaccination on infection in infants: A population-based study of cocooning in Western Australia.

    abstract：:During a pertussis epidemic in 2011-2012 the Western Australian (WA) Department of Health implemented a 'cocooning' programme, offering free pertussis-containing vaccine (dTpa) to new parents. We assessed the impact of vaccinating parents with dTpa on the incidence of pertussis infection in newborns. Births in WA duri...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.08.066

    authors： Carcione D,Regan AK,Tracey L,Mak DB,Gibbs R,Dowse GK,Bulsara M,Effler PV

    更新日期：2015-10-13 00:00:00

  • Humoral immunity against tick-borne encephalitis virus following manifest disease and active immunization.

    abstract：:Humoral immunity against tick-borne encephalitis virus (TBEV) in patients with a well-documented history of naturally acquired tick-borne encephalitis (TBE) was compared with immunity resulting from vaccination in a carefully controlled immunization programme. The vaccination study was performed with a highly purified...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0264-410x(91)90315-w

    authors： Klockmann U,Bock HL,Kwasny H,Praus M,Cihlová V,Tomková E,Krivanec K

    更新日期：1991-01-01 00:00:00

  • Risk factors for human papillomavirus exposure and co-factors for cervical cancer in Latin America and the Caribbean.

    abstract：:The incidence of cervical cancer in Latin America and the Caribbean (LAC) is among the highest in the world. Because there are major demographic shifts happening in LAC countries (population growth, urbanization and ageing) cervical cancer incidence and mortality will likely continue to be a significant public health ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.06.008

    authors： Almonte M,Albero G,Molano M,Carcamo C,García PJ,Pérez G

    更新日期：2008-08-19 00:00:00

  • The use of sequence analysis of a feline calicivirus (FCV) hypervariable region in the epidemiological investigation of FCV related disease and vaccine failures.

    abstract：:A reverse transcriptase polymerase chain reaction (PCR) was used to amplify a 235 bp hypervariable region of the feline calicivirus (FCV) genome which encodes part of the capsid protein. Sequence from this region was used to compare viruses used in three attenuated vaccines to viruses isolated from vaccinated cats wit...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00059-5

    authors： Radford AD,Bennett M,McArdle F,Dawson S,Turner PC,Glenn MA,Gaskell RM

    更新日期：1997-08-01 00:00:00

  • The defect in the metabolism of erythritol of the Brucella abortus B19 vaccine strain is unrelated with its attenuated virulence in mice.

    abstract：:The role of the defect in erythritol catabolism in the attenuated virulence of Brucella abortus B19 vaccine strain in mice was investigated by means of five different strains: (i) the erythritol sensitive B19 vaccine strain; (ii) a natural erythritol tolerant (NET) mutant obtained spontaneously from B19; (iii) an eryt...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(98)00063-2

    authors： Sangari FJ,Grilló MJ,Jiménez De Bagüés MP,González-Carreró MI,García-Lobo JM,Blasco JM,Agüero J

    更新日期：1998-10-01 00:00:00

  • Effects of Taishan Pinus massoniana pollen polysaccharide on immune response of rabbit haemorrhagic disease tissue inactivated vaccine and on production performance of Rex rabbits.

    abstract：:Varied doses of Taishan Pinus massoniana pollen polysaccharide (TPPPS) and Astragalus polysaccharide (APS) extracted by hot water extraction and ethanol precipitation method were added to the vaccine in order to prepare polysaccharide-rabbit haemorrhagic disease (RHD) tissue inactivated vaccine. The purpose was to stu...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.01.068

    authors： Wei K,Sun Z,Yan Z,Tan Y,Wang H,Zhu X,Wang X,Sheng P,Zhu R

    更新日期：2011-03-21 00:00:00