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Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children.

Abstract：

:Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response.

journal_name

Vaccine

journal_title

Vaccine

authors

Nurkka A,MacLennan J,Jäntti V,Obaro S,Greenwood B,Käyhty H

doi

10.1016/s0264-410x(00)00180-8

subject

Has Abstract

pub_date

2000-10-15 00:00:00

pages

547-56

issue

4-5

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(00)00180-8

journal_volume

19

pub_type

杂志文章

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