当前位置： SCI文献检索 > VACCINE期刊下所有文献 > A novel peptide isolated from phage library to substitute a complex system for a vaccine against staphylococci infection.

A novel peptide isolated from phage library to substitute a complex system for a vaccine against staphylococci infection.

Abstract：

:Staphylococcus aureus is a major human pathogen and many of the strains are resistant to conventional antibacterial treatment. The bacteria cause disease largely due to the production of multiple toxins, whose synthesis is controlled by an RNA molecule termed RNAIII. The production of RNAIII is induced by quorum sensing systems, one of them containing the protein RNAIII activating protein (RAP). Here we show that we partially purified supernatant of S. aureus, used this fraction to vaccinate mice, and selected antibody-binding peptides by phage display. Mice were vaccinated with the various peptides and challenged with S. aureus. One of the binding peptide termed R13 induced a protective immune response. Western blot analysis showed that the anti-R13 antibodies specifically bind to native or recombinant RAP. Mice vaccinated with R13 were protected and protection was sustained for the duration of the 6-month study period. Our results show that R13 could be used as a long-term effective protective-peptide-vaccine to prevent S. aureus infections and once again show that targeting the RAP quorum sensing system is an effective approach to preventing staphylococcal infections. In addition our studies show that selection of specific protective peptides by phage display using sera induced by complex antigens is a rapid and effective way to identify the protective antigen and select for a peptide vaccine.

journal_name

Vaccine

journal_title

Vaccine

authors

Yang G,Gao Y,Dong J,Xue Y,Fan M,Shen B,Liu C,Shao N

doi

10.1016/j.vaccine.2005.09.004

subject

Has Abstract

pub_date

2006-02-20 00:00:00

pages

1117-23

issue

8

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)00938-2

journal_volume

24

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Complement and antibodies: a dangerous liaison in HIV infection?

    abstract：:Due to ongoing recombination and mutations, HIV permanently escapes from neutralizing antibody (nAb) responses of the host. By the masking of epitopes or shedding of gp120, HIV-1 further impedes an efficient neutralization by Abs. Therefore, nAbs responses of the host are chasing behind a rapidly evolving virus and ma...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.11.050

    authors： Stoiber H,Soederholm A,Wilflingseder D,Gusenbauer S,Hildgartner A,Dierich MP

    更新日期：2008-12-30 00:00:00

  • Economic assessment of a high-dose versus a standard-dose influenza vaccine in the US Veteran population: Estimating the impact on hospitalization cost for cardio-respiratory disease.

    abstract：OBJECTIVE:To compare the economic impact of high-dose trivalent (HD) versus standard-dose trivalent (SD) influenza vaccination on direct medical costs for cardio-respiratory hospitalizations in adults aged 65 years or older enrolled in the United States (US) Veteran's Health Administration (VHA). METHODS:Leveraging a ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.06.066

    authors： van Aalst R,Russo EM,Neupane N,Mahmud SM,Mor V,Wilschut J,Chit A,Postma M,Young-Xu Y

    更新日期：2019-07-26 00:00:00

  • A unique algorithm for the determination of peptide-carrier protein conjugation ratio by amino acid analysis using intrinsic internal standard.

    abstract：:An N-terminal peptide of the HIV-1 fusion peptide (FP) with eight amino acid residues (FP8) was conjugated to a recombinant Tetanus Toxoid Heavy Chain Fragment C (rTTHc) as a carrier protein to help boosting immunogenicity against HIV-1. In this rapid communication, a unique algorithm to determine FP-rTTHc conjugation...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.04.080

    authors： Yang GJ,Yang Y,Shaddeau A,Cai CX,Li Y,Gulla K,Zhang Y,Ou L,Cooper JW,Lei QP

    更新日期：2020-06-15 00:00:00

  • Cost-effectiveness of the introduction of two-dose bi-valent (Cervarix) and quadrivalent (Gardasil) HPV vaccination for adolescent girls in Bangladesh.

    abstract：BACKGROUND:Cervical cancer is one of the most prevalent cancers in women caused by the human papillomavirus (HPV) that leads to a substantial disease burden for health systems. Prevention through vaccination can significantly reduce the prevalence of cervical cancer. The objective of this study is to evaluate the poten...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.10.037

    authors： Mahumud RA,Gow J,Alam K,Keramat SA,Hossain MG,Sultana M,Sarker AR,Islam SMS

    更新日期：2020-01-10 00:00:00

  • Pharmacies versus doctors' offices for adolescent vaccination.

    abstract：PURPOSE:We sought to understand the relative advantage of pharmacies compared to doctors' offices for delivering HPV vaccination to adolescents. METHODS:Participants were a national sample of 1500 U.S. parents of adolescents ages 11-17 recruited in 2014-15. In an online survey, items informed by Diffusion of Innovatio...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.04.088

    authors： Shah PD,Marciniak MW,Golden SD,Trogdon JG,Golin CE,Brewer NT

    更新日期：2018-06-07 00:00:00

  • A dynamic model of pneumococcal infection in the United States: implications for prevention through vaccination.

    abstract：:Universal infant vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) has nearly eliminated PCV7-serotype invasive pneumococcal disease (IPD) in young U.S. children, but has been accompanied by increases in the incidence of serotype 19A IPD. Because antibiotic-non-susceptible 19A has increased more than...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.03.030

    authors： Van Effelterre T,Moore MR,Fierens F,Whitney CG,White L,Pelton SI,Hausdorff WP

    更新日期：2010-05-07 00:00:00

  • Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.

    abstract：:Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.11.015

    authors： Nagai K,Domon H,Maekawa T,Hiyoshi T,Tamura H,Yonezawa D,Habuka R,Saitoh A,Terao Y

    更新日期：2019-01-03 00:00:00

  • The age-dependent risk of postvaccination complications in vaccinees with smallpox vaccine.

    abstract：:The use of vaccinia virus in recombinant systems may result in the occurrence of complications observed following smallpox vaccination. The results are presented of a large survey carried out in the USSR between 1968 and 1979. High complication rates are reported, particularly in older primary vaccinees; for example, ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(92)90023-d

    authors： Gurvich EB

    更新日期：1992-01-01 00:00:00

  • Cultivating fertile ground for the introduction of plant-derived vaccines in developing countries.

    abstract：:Like any biotechnology innovation, the production of human vaccines in plants will succeed partly on its technical merits, and partly on the social acceptance of the new technology. The latter is harder to predict than the former, and may pose the most significant challenges to plant-derived vaccines' (PDVs) success. ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2004.11.022

    authors： Castle D,Dalgleish J

    更新日期：2005-03-07 00:00:00

  • Long-term follow-up: no effect of therapeutic vaccination with HIV-1 p17/p24:Ty virus-like particles on HIV-1 disease progression.

    abstract：:Long-term effects of therapeutic vaccination of human immunodeficiency virus (HIV)-1-infected subjects with HIV-1 p17/p24:Ty virus-like particles (p24-VLP) on progression to AIDS, death, a CD4 cell count

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0264-410x(02)00102-0

    authors： Lindenburg CE,Stolte I,Langendam MW,Miedema F,Williams IG,Colebunders R,Weber JN,Fisher M,Coutinho RA

    更新日期：2002-05-22 00:00:00

  • Characterization of size, structure and purity of serogroup X Neisseria meningitidis polysaccharide, and development of an assay for quantification of human antibodies.

    abstract：:Serogroup X Neisseria meningitidis (MenX) has recently emerged as a cause of localized disease outbreaks in sub-Saharan Africa. In order to prepare for vaccine development, MenX polysaccharide (MenX PS) was purified by standard methods and analyzed for identity and structure by NMR spectroscopy. This study presents th...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.07.032

    authors： Xie O,Bolgiano B,Gao F,Lockyer K,Swann C,Jones C,Delrieu I,Njanpop-Lafourcade BM,Tamekloe TA,Pollard AJ,Norheim G

    更新日期：2012-08-31 00:00:00

  • Non PC liposome entrapped promastigote antigens elicit parasite specific CD8+ and CD4+ T-cell immune response and protect hamsters against visceral leishmaniasis.

    abstract：:Leishmania donovani promastigote soluble antigens (sLAg) were encapsulated in non-phosphatidylcholine (non-PC) liposomes (escheriosomes) prepared from E. coli lipids. The escheriosome-based vaccine was investigated for its potential to elicit a protective immune response against experimental visceral leishmaniasis. Th...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.10.025

    authors： Sharma SK,Dube A,Nadeem A,Khan S,Saleem I,Garg R,Mohammad O

    更新日期：2006-03-10 00:00:00

  • Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates.

    abstract：:The critical first step in the clinical development of a malaria vaccine, based on live-attenuated Plasmodium falciparum sporozoites, is the guarantee of complete arrest in the liver. We report on an approach for assessing adequacy of attenuation of genetically attenuated sporozoites in vivo using the Plasmodium bergh...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.02.010

    authors： Annoura T,Ploemen IH,van Schaijk BC,Sajid M,Vos MW,van Gemert GJ,Chevalley-Maurel S,Franke-Fayard BM,Hermsen CC,Gego A,Franetich JF,Mazier D,Hoffman SL,Janse CJ,Sauerwein RW,Khan SM

    更新日期：2012-03-30 00:00:00

  • Intussusception and Kawasaki disease after rotavirus vaccination in Taiwanese infants.

    abstract：BACKGROUND:Since 2006, two rotavirus vaccines have been licensed in Taiwan, either as a 2- (RV1) or 3-dose (RV5) schedule administered at ages 2, 4, and 6 months. This study assessed the risk of intussusception and Kawasaki disease (KD) associated with rotavirus vaccines among infants. METHODS:Cases of intussusception...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.07.038

    authors： Huang WT,Juan YC,Liu CH,Yang YY,Chan KA

    更新日期：2020-09-11 00:00:00

  • The defect in the metabolism of erythritol of the Brucella abortus B19 vaccine strain is unrelated with its attenuated virulence in mice.

    abstract：:The role of the defect in erythritol catabolism in the attenuated virulence of Brucella abortus B19 vaccine strain in mice was investigated by means of five different strains: (i) the erythritol sensitive B19 vaccine strain; (ii) a natural erythritol tolerant (NET) mutant obtained spontaneously from B19; (iii) an eryt...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(98)00063-2

    authors： Sangari FJ,Grilló MJ,Jiménez De Bagüés MP,González-Carreró MI,García-Lobo JM,Blasco JM,Agüero J

    更新日期：1998-10-01 00:00:00

  • Safety and immunogenicity of heterologous prime-boost immunization with viral-vectored malaria vaccines adjuvanted with Matrix-M™.

    abstract：:The use of viral vectors in heterologous prime-boost regimens to induce potent T cell responses in addition to humoral immunity is a promising vaccination strategy in the fight against malaria. We conducted an open-label, first-in-human, controlled Phase I study evaluating the safety and immunogenicity of Matrix-M adj...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.09.028

    authors： Venkatraman N,Anagnostou N,Bliss C,Bowyer G,Wright D,Lövgren-Bengtsson K,Roberts R,Poulton I,Lawrie A,Ewer K,V S Hill A

    更新日期：2017-10-27 00:00:00

  • Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia.

    abstract：INTRODUCTION:Implementation of the 7-valent pneumococcal conjugate vaccine (PCV7) in infant vaccination programs has substantially reduced the burden of PCV7 serotypes also in adult community-acquired pneumonia (CAP). Currently, it is unclear, if this extensive herd protection effect can be extrapolated to the addition...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.11.026

    authors： Forstner C,Kolditz M,Kesselmeier M,Ewig S,Rohde G,Barten-Neiner G,Rupp J,Witzenrath M,Welte T,Pletz MW,CAPNETZ study group.

    更新日期：2020-01-29 00:00:00

  • Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens.

    abstract：:In this study, we compare four different adjuvants, LT(R192G), CpG ODN, MPL((R))TDM, and alum, for their ability to affect the magnitude, distribution, and duration of antibody responses against F1-V, the lead-candidate antigen for the next generation vaccine against plague, in a murine model. In addition, three diffe...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.09.030

    authors： Uddowla S,Freytag LC,Clements JD

    更新日期：2007-11-19 00:00:00

  • Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U] (Ampligen R).

    abstract：:Human papilloma virus (HPV) found in 99.7% of cervical cancers represents an attractive immunotherapeutic target for novel adjuvant dendritic cell (DC) immunotherapy. DC primed with HPV antigens have been shown to be capable of inducing CTL responses powerful enough to eradicate established murine tumours expressing H...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(02)00599-6

    authors： Adams M,Navabi H,Jasani B,Man S,Fiander A,Evans AS,Donninger C,Mason M

    更新日期：2003-01-30 00:00:00

  • A recombinant fowl adenovirus expressing the S1 gene of infectious bronchitis virus protects against challenge with infectious bronchitis virus.

    abstract：:The spike peplomer S1 subunit sequence from avian infectious bronchitis virus (IBV) Vic S strain was expressed in a plasmid under the control of the fowl adenovirus (FAV) major late promoter (MLP). Two recombinants were constructed in FAV serotype 8 (FAV 8) by inserting the expression cassette between the SnaBI and Xb...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00227-5

    authors： Johnson MA,Pooley C,Ignjatovic J,Tyack SG

    更新日期：2003-06-20 00:00:00

  • A novel, broad spectrum therapeutic HPV vaccine targeting the E7 proteins of HPV16, 18, 31, 45 and 52 that elicits potent E7-specific CD8T cell immunity and regression of large, established, E7-expressing TC-1 tumors.

    abstract：:Persistent infection by high risk genotypes of human papillomavirus (HPV) is the cause of cervical cancer, which remains one of the most common cancers among women worldwide. In addition, there is a growing appreciation that high risk HPVs are associated with a number of other cancers including anogenital cancers as w...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.07.090

    authors： Wick DA,Webb JR

    更新日期：2011-10-13 00:00:00

  • Factors affecting compliance with measles vaccination in Lao PDR.

    abstract：:In line with WHO objectives, the Lao Government is committed to eliminate measles by 2012. Yet from 1992 to 2007, the annual incidence of measles remained high while the vaccination coverage showed a wide diversity across provinces. A descriptive study was performed to determine factors affecting compliance with vacci...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.07.077

    authors： Phimmasane M,Douangmala S,Koffi P,Reinharz D,Buisson Y

    更新日期：2010-09-24 00:00:00

  • Seroprevalence of anti-polio antibodies in a population 7 months to 39 years of age in Uruguay: Implications for future polio vaccination strategies.

    abstract：:This study evaluated the seroprevalence of poliovirus types 1, 2 and 3 antibodies and vaccination coverage in 780 subjects aged between 7 months and 39 years in Montevideo, Uruguay, where oral polio vaccine (OPV) is used. Antibody titers were measured and seroprotection rates and geometric mean titers (GMTs) were comp...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.02.042

    authors： Pírez MC,Olivera I,Diabarboure H,Montano A,Barañano R,Badía F,Bonnet MC

    更新日期：2009-05-05 00:00:00

  • Intranasal vaccination with ebola virus GP amino acids 258-601 protects mice against lethal challenge.

    abstract：:Ebola virus (EBOV) disease (EVD) leads to lethal hemorrhagic fever with a case fatality rate as high as 90%, thus posing a serious global public health concern. However, while several vaccines based on the EBOV glycoprotein have been confirmed to be effective in animal experiments, no licensed vaccines or effective tr...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.09.003

    authors： Su QD,He SH,Yi Y,Qiu F,Lu XX,Jia ZY,Meng QL,Fan XT,Tian RG,Audet J,Qiu XG,Bi SL

    更新日期：2018-10-01 00:00:00

  • Reducing pain at the time of vaccination: WHO position paper, September 2015-Recommendations.

    abstract：:This article presents the World Health Organization's (WHO) recommendations for pain mitigation at the time of vaccination from the WHO position paper on reducing pain at the time of vaccination: WHO position paper-September 2015, recently published in the Weekly Epidemiological Record [1]. This position paper summari...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.11.005

    authors： WHO.

    更新日期：2016-07-12 00:00:00

  • Immunisation status in the public care system: a comparative study.

    abstract：:Children in public care have poor health outcomes despite statutory health assessments. Incomplete immunisation of children entering the care system has been reported. Does this health disadvantage persist for those established in the care system? The immunisation status of 119 children in public care for at least 6 m...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.12.001

    authors： Barnes P,Price L,Maddocks A,Cheung WY,Williams J,Jackson S,Mason B

    更新日期：2005-04-15 00:00:00

  • Four year immunogenicity of the RTS,S/AS02(A) malaria vaccine in Mozambican children during a phase IIb trial.

    abstract：:Previous studies with the malaria vaccine RTS,S/AS02(A) in young children in a malaria endemic area of Mozambique have shown it to have a promising safety profile and to reduce the risk of Plasmodium falciparum infection and disease. In this study, we assessed the antibody responses to the P. falciparum and hepatitis ...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2011.03.041

    authors： Aide P,Dobaño C,Sacarlal J,Aponte JJ,Mandomando I,Guinovart C,Bassat Q,Renom M,Puyol L,Macete E,Herreros E,Leach A,Dubois MC,Demoitie MA,Lievens M,Vekemans J,Loucq C,Ballou WR,Cohen J,Alonso PL

    更新日期：2011-08-11 00:00:00

  • White Paper on studying the safety of the childhood immunization schedule in the Vaccine Safety Datalink.

    abstract：:While the large majority of parents in the U.S. vaccinate their children according to the recommended immunization schedule, some parents have refused or delayed vaccinating, often citing safety concerns. In response to public concern, the U.S. Institute of Medicine (IOM) evaluated existing research regarding the safe...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.10.082

    authors： Glanz JM,Newcomer SR,Jackson ML,Omer SB,Bednarczyk RA,Shoup JA,DeStefano F,Daley MF

    更新日期：2016-02-15 00:00:00

  • Oxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responses.

    abstract：:DNA immunization is an attractive form of vaccination, which has shown promising results only in small animal models. There is a need to develop efficient gene delivery systems. We previously demonstrated that oxidized (OM) and reduced mannan (RM) complexed to ovalbumin DNA via poly-l-lysine (PLL), were able to genera...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.05.008

    authors： Tang CK,Sheng KC,Pouniotis D,Esparon S,Son HY,Kim CW,Pietersz GA,Apostolopoulos V

    更新日期：2008-07-23 00:00:00

  • Current approaches to the development of vaccines against disease caused by respiratory syncytial virus (RSV) and parainfluenza virus (PIV). A meeting report of the WHO Programme for Vaccine Development.

    abstract：:The paramyxoviruses respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) are the two most common agents of severe lower respiratory tract disease in infants and children throughout the world. RSV causes yearly epidemics of bronchiolitis and pneumonia in infants and young children, while PIV3 is a co...

    journal_title：Vaccine

    pub_type：

    doi：10.1016/0264-410x(95)98266-d

    authors： Crowe JE Jr

    更新日期：1995-03-01 00:00:00