Complement and antibodies: a dangerous liaison in HIV infection?

abstract：BACKGROUND:Postherpetic neuralgia (PHN) occurs in 5-30% of individuals with herpes zoster (HZ) and is characterized by long-lasting pain. Zoster vaccine live (ZVL) is licensed for people 50 years and older to prevent HZ and PHN. This study evaluated vaccine effectiveness (VE) of ZVL against PHN. METHODS:We conducted a...

journal_title：Vaccine

authors： Klein NP,Bartlett J,Fireman B,Marks MA,Hansen J,Lewis E,Aukes L,Saddier P

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:There is a demand of affordable IPV in the World. Statens Serum Institut (SSI) has developed three reduced dose IPV formulations adsorbed to aluminium hydroxide; 1/3 IPV-Al, 1/5 IPV-Al and 1/10 IPV-Al SSI, and now report the results of the first investigations in humans. METHODS:240 Danish adolescents, aged...

journal_title：Vaccine

authors： Lindgren LM,Tingskov PN,Justesen AH,Nedergaard BS,Olsen KJ,Andreasen LV,Kromann I,Sørensen C,Dietrich J,Thierry-Carstensen B

更新日期：2017-01-23 00:00:00

abstract：:EBA-175 protein is used as ligand in Plasmodium falciparum binding to erythrocytes. Evidence shows that conserved peptide 1815 from this protein having high red blood cell binding ability plays an important role in the invasion process. This peptide is neither immunogenic nor protective. Residues were substituted by a...

journal_title：Vaccine

authors： Cifuentes G,Salazar LM,Vargas LE,Parra CA,Vanegas M,Cortes J,Patarroyo ME

更新日期：2005-02-18 00:00:00

abstract：:Because recombinant empty viral capsids are potentially attractive vectors for gene therapy, here we examined the ability of human papillomavirus (HPV) virus-like particles (VLPs) to mediate delivery and expression of DNA plasmids in vitro and in vivo. VLP-mediated delivery and expression of a GFP reporter construct i...

journal_title：Vaccine

authors： Malboeuf CM,Simon DA,Lee YE,Lankes HA,Dewhurst S,Frelinger JG,Rose RC

更新日期：2007-04-30 00:00:00

abstract：BACKGROUND:Launched in 1974, the Expanded Program on Immunization (EPI) is estimated to prevent two-three million deaths annually from polio, diphtheria, tuberculosis, pertussis, measles, and tetanus. Additional lives could be saved through better understanding what influences adherence to the EPI schedule in specific ...

journal_title：Vaccine

authors： Hoest C,Seidman JC,Lee G,Platts-Mills JA,Ali A,Olortegui MP,Bessong P,Chandyo R,Babji S,Mohan VR,Mondal D,Mahfuz M,Mduma ER,Nyathi E,Abreu C,Miller MA,Pan W,Mason CJ,Knobler SL,MAL-ED Network Investigators.

更新日期：2017-01-11 00:00:00

abstract：:Age related deterioration in the function of the immune system has been recognised in many species. The clinical presentations of such immune dysfunction are an age-related increased susceptibility to certain infections, and an increased incidence of autoimmune disease and certain cancers. Laboratory investigations re...

journal_title：Vaccine

authors： Aspinall R,Andrew D

更新日期：2000-02-25 00:00:00

abstract：BACKGROUND:In 2018/19, English NHS trusts (NHSTs) implemented an 'opt-out' policy for seasonal flu vaccination in frontline healthcare workers (HCWs). HCWs declining the vaccination were asked to sign an opt-out form and provide a reason for their decision. In addition, HCWs working in higher risk hospital environments...

journal_title：Vaccine

authors： Bell S,Chantler T,Paterson P,Mounier-Jack S

更新日期：2020-05-27 00:00:00

abstract：:Neospora caninum is a causative and transmissible agent of dog and bovine neosporosis. The resulting reproductive failures in infected cattle lead to significant economic losses worldwide. However, there is no satisfactory treatment or vaccine currently available to combat this pathogen. Thus, the development of appro...

journal_title：Vaccine

authors： Xu J,Hiramatsu R,Suhaimi H,Kato T,Fujimoto A,Tokiwa T,Ike K,Park EY

更新日期：2019-10-08 00:00:00

abstract：:Young children are very susceptible to typhoid fever, emphasizing the need for vaccination in under five age groups. The parenteral Vi polysaccharide vaccine is not immunogenic in children under 2 years and the oral Ty21a vaccine (Vivotif) available in capsular formulation is only recommended for those over 5 years. W...

journal_title：Vaccine

authors： Bhuiyan TR,Choudhury FK,Khanam F,Saha A,Sayeed MA,Salma U,Lundgren A,Sack DA,Svennerholm AM,Qadri F

更新日期：2014-02-19 00:00:00

abstract：:Safety of and humoral immune response to the anti-influenza vaccine in coronary artery disease (CAD) patients were evaluated. The trivalent vaccine was administered to 137 eligible CAD patients and 67 age- and sex-matched healthy individuals. Antibody (Ab) titers were measured before and 1 month after vaccination. CAD...

journal_title：Vaccine

authors： Keshtkar-Jahromi M,Vakili H,Rahnavardi M,Gholamin S,Razavi SM,Eskandari A,Sadeghi R,Vatan-Pour H,Keshtkar-Jahromi M,Haghighat B,Ghaffaripour M,Mokhtari-Azad T

更新日期：2009-12-10 00:00:00

abstract：:A devastating disease spread by mosquitoes with high-efficiency, malaria imposes an enormous burden for which no licensed vaccine currently exists. Although the genome complexity of the parasite has made vaccine development tenuous, an effective malaria vaccine would be a valuable tool for control, elimination and eve...

journal_title：Vaccine

authors： Palacpac NM,Arisue N,Tougan T,Ishii KJ,Horii T

更新日期：2011-08-11 00:00:00

abstract：:Streptococcus pneumoniae is the leading cause of bacterial pneumonia, meningitis and sepsis in children worldwide. Despite available evidence on pneumococcal conjugate vaccine (PCV) impact on pneumonia hospitalizations in children, studies demonstrating PCV impact in morbidity and mortality in middle-income countries ...

journal_title：Vaccine

authors： Suarez V,Michel F,Toscano CM,Bierrenbach AL,Gonzales M,Alencar AP,Ruiz Matus C,Andrus JK,de Oliveira LH

更新日期：2016-09-07 00:00:00

abstract：BACKGROUND:The study was designed to determine the feasibility of implementing routine dTpa vaccination in the maternity ward to new mothers and to assess midwives' attitudes toward pertussis booster vaccination, their perceived susceptibility and severity of pertussis in their patients' communities, the perceived barr...

journal_title：Vaccine

authors： Robbins SC,Leask J,Hayles EH,Sinn JK

更新日期：2011-08-05 00:00:00

abstract：:Integration of health services brings together common functions within and between organizations to solve common problems, developing a commitment to a shared vision and goals, and using common technologies and resources to achieve these goals. Integration has been the frustrated rally call of Primary Health Care for ...

journal_title：Vaccine

authors： Clements CJ,Nshimirimanda D,Gasasira A

更新日期：2008-04-07 00:00:00

abstract：:The efficacy of a 10 or 20 micrograms antigen load of HB recombinant vaccines is still being debated. A comparison of anti-HBs titres in two groups of healthy subjects vaccinated by the same schedule (0, 1 and 6 months) employing recombinant HB vaccines with different antigen loads, 20 micrograms (group A, 251 subject...

journal_title：Vaccine

authors： Chiaramonte M,Majori S,Ngatchu T,Moschen ME,Baldo V,Renzulli G,Simoncello I,Rocco S,Bertin T,Naccarato R,Trivello R

更新日期：1996-02-01 00:00:00

abstract：:Oligoclonal combinations of several monoclonal antibodies (MAbs) are being considered for the treatment of various infectious pathologies. These combinations are less sensitive to antigen structural changes than individual MAbs; at the same time, their characteristics can be more efficiently controlled than those of p...

journal_title：Vaccine

authors： Lukic I,Filipovic A,Inic-Kanada A,Marinkovic E,Miljkovic R,Stojanovic M

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:RTS,S/AS01 is a safe and moderately efficacious vaccine considered for implementation in endemic Africa. Model predictions of impact and cost-effectiveness of this new intervention could aid in country adoption decisions. METHODS:The impact of RTS,S was assessed in 43 countries using an ensemble of models o...

journal_title：Vaccine

authors： Galactionova K,Tediosi F,Camponovo F,Smith TA,Gething PW,Penny MA

更新日期：2017-01-03 00:00:00

abstract：:Three recombinant strains of Mycobacterium bovis Bacille Calmette Guerin (rBCG) were prepared in which the immunogenic B subunit of human Escherichia coli heat labile enterotoxin (LT-Bh) was expressed either as a cytoplasm protein, a cell wall associated lipoprotein or a secreted protein. Intraperitoneal immunisation ...

journal_title：Vaccine

authors： Hayward CM,O'Gaora P,Young DB,Griffin GE,Thole J,Hirst TR,Castello-Branco LR,Lewis DJ

更新日期：1999-03-05 00:00:00

abstract：:Neonatal infection with hepatitis B virus carries a very high risk of resulting in a persistent infection. Babies born to hepatitis B carrier mothers are at risk of infection through exposure to blood and body fluids during birth. These 'at risk' babies can only be identified through screening of all mothers during pr...

journal_title：Vaccine

authors： Boxall E

更新日期：1998-11-01 00:00:00

abstract：:Development of recombinant protective antigen (rPA)-based anthrax vaccines has been hindered by a lack of stability of the vaccines associated with spontaneous deamidation of asparagine (Asn) residues of the rPA antigen during storage. In this study, we explored the role that two deamidation-prone Asn residues located...

journal_title：Vaccine

authors： Verma A,Burns DL

更新日期：2018-10-15 00:00:00

abstract：:The most common preventative measure against mumps is vaccination with mumps vaccine. In most parts of the world, mumps vaccine is routinely delivered through live attenuated Measles-Mumps-Rubella (MMR) vaccine. In Japan, receiving mumps vaccine is voluntary and vaccine uptake rate is less than 30%. The introduction o...

journal_title：Vaccine

authors： Hoshi SL,Kondo M,Okubo I

更新日期：2014-07-16 00:00:00

abstract：:Selection bias is of critical concern in the study of influenza vaccine effectiveness when using an observational study design. This bias is attributable to the inherently different characteristics between vaccinees and non-vaccinees. The differences, which are related both to vaccination and signs of clinical disease...

journal_title：Vaccine

authors： Fukushima W,Hayashi Y,Mizuno Y,Suzuki K,Kase T,Ohfuji S,Fujieda M,Maeda A,Hirota Y

更新日期：2008-11-25 00:00:00

abstract：:Cattle produce specific serum antibody mainly of the IgG1 isotype in response to infection with the liver fluke, Fasciola hepatica. In these animals a positive correlation between fluke-specific serum IgG1 levels and fluke-burden in non-immunized infected animals was observed. In contrast, immunization of cattle with ...

journal_title：Vaccine

authors： Mulcahy G,O'Connor F,McGonigle S,Dowd A,Clery DG,Andrews SJ,Dalton JP

更新日期：1998-05-01 00:00:00

abstract：:We exploited the powerful adjuvant properties of cholera holotoxin (CT) to create a mucosally administered subunit vaccine against respiratory syncytial virus (RSV). A genetically detoxified mutant CT with an E to H substitution at amino acid 29 of the CT-A1 subunit (CT-E29H) was compared to wild type CT for toxicity ...

journal_title：Vaccine

authors： Tebbey PW,Scheuer CA,Peek JA,Zhu D,LaPierre NA,Green BA,Phillips ED,Ibraghimov AR,Eldridge JH,Hancock GE

更新日期：2000-06-01 00:00:00

abstract：:The use of viral vectors in heterologous prime-boost regimens to induce potent T cell responses in addition to humoral immunity is a promising vaccination strategy in the fight against malaria. We conducted an open-label, first-in-human, controlled Phase I study evaluating the safety and immunogenicity of Matrix-M adj...

journal_title：Vaccine

authors： Venkatraman N,Anagnostou N,Bliss C,Bowyer G,Wright D,Lövgren-Bengtsson K,Roberts R,Poulton I,Lawrie A,Ewer K,V S Hill A

更新日期：2017-10-27 00:00:00

abstract：:To provide a safer live challenge strain for use in clinical vaccine trials, a double drug sensitive strain of Leishmania major was derived using advances in gene targeting technology by stably introducing into the chromosome a modified HSV-1 thymidine kinase gene (tk), conferring increased sensitivity to ganciclovir ...

journal_title：Vaccine

authors： Davoudi N,Tate CA,Warburton C,Murray A,Mahboudi F,McMaster WR

更新日期：2005-01-19 00:00:00

abstract：:The 2-1-1 rabies postexposure treatment schedule is an abbreviated regimen in which a tissue culture rabies vaccine is administered intramuscularly at two sites on day 0, and at one site on days 7 and 21. Compared to the standard five-dose intramuscular regimen, the 2-1-1 schedule reduces the number of clinic visits f...

journal_title：Vaccine

authors： Chutivongse S,Wilde H,Fishbein DB,Baer GM,Hemachudha T

更新日期：1991-08-01 00:00:00

abstract：:The shelf life and thermal stability of an antifertility vaccine, in which gonadotropin subunits are linked to carriers such as tetanus toxoid and cholera toxin chain B and has successfully completed phase-I clinical trials at five centres in India, was studied. The vaccine adsorbed on alum was stored at three tempera...

journal_title：Vaccine

authors： Alam A,Singh O,Talwar GP

更新日期：1989-04-01 00:00:00

abstract：:The calculation of p(epitope) values, a sequence-based measure of antigenic distance between strains, was developed for human influenza. The potential to apply the p(epitope) value to equine influenza vaccine strain selection was assessed. There was a negative correlation between p(epitope) value and vaccine efficacy ...

journal_title：Vaccine

authors： Daly JM,Elton D

更新日期：2013-12-09 00:00:00

abstract：:Tick-borne encephalitis virus isolates from widely separated geographic regions of the USSR, six isolates from Hungary and one from France were compared with the European and Far Eastern prototype viruses. Peptide mapping by limited proteolysis yielded similar patterns for five selected isolates from the USSR. All iso...

journal_title：Vaccine

authors： Holzmann H,Vorobyova MS,Ladyzhenskaya IP,Ferenczi E,Kundi M,Kunz C,Heinz FX

更新日期：1992-01-01 00:00:00