Abstract：
:Three recombinant strains of Mycobacterium bovis Bacille Calmette Guerin (rBCG) were prepared in which the immunogenic B subunit of human Escherichia coli heat labile enterotoxin (LT-Bh) was expressed either as a cytoplasm protein, a cell wall associated lipoprotein or a secreted protein. Intraperitoneal immunisation of mice with these rBCG induced IgG and IgA antibodies to LT-Bh and shifted the serum IgG subclass response to subsequent challenge with purified LT-Bh from IgG1 to an IgG2a. Oral administration of recombinant BCG induced mucosal and serum IgA antibodies to LT-Bh which peaked four months after immunisation. Antibody responses were greater when LT-Bh was expressed as a secreted protein or lipoprotein rather than in the cytoplasm. Oral vaccination with recombinant BCG may be an effective approach, particularly to induce mucosal IgA and prime for a serum TH1 recall response.
journal_name
Vaccinejournal_title
Vaccineauthors
Hayward CM,O'Gaora P,Young DB,Griffin GE,Thole J,Hirst TR,Castello-Branco LR,Lewis DJdoi
10.1016/s0264-410x(98)00350-8subject
Has Abstractpub_date
1999-03-05 00:00:00pages
1272-81issue
9-10eissn
0264-410Xissn
1873-2518pii
S0264-410X(98)00350-8journal_volume
17pub_type
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