Abstract：
:Studies conducted at neonatal intensive care units in Pune, western India, suggested early exposure to rotaviruses and predominance of unusual human-bovine-like G12P[11] strains. The whole genome sequencing and phylogenetic analyses of a naturally attenuated, culture adapted neonatal strain, (NIV-1740121) revealed multiple-gene reassortment events, containing ROTAVAC® vaccine strain, 116E-like VP4, VP6, NSP3, NSP5 genes, VP7 gene of G12 origin and VP3 gene of porcine ancestry in a human Wa-like backbone. Analysis of 3D structure modeling of the VP7 and VP4 proteins with respect to 116E suggested amino acid variations in the major neutralizing epitopes of VP7, contributed to a modified charge density. Visualization of receptor-glycan interaction structures of NIV-1740121 and 116E VP8* showed type I glycan binds with a similar conformation at the same active site as represented in the available crystal structure of G10P[11] VP8*. The study adds to the knowledge of age restricted tropism of P[11] strains in neonates.
journal_name
Vaccinejournal_title
Vaccineauthors
Ranshing SS,Cherian SS,Agarwal MS,Jagtap AS,Patil CM,Gopalkrishna Vdoi
10.1016/j.vaccine.2020.01.081subject
Has Abstractpub_date
2020-02-28 00:00:00pages
2275-2291issue
10eissn
0264-410Xissn
1873-2518pii
S0264-410X(20)30123-7journal_volume
38pub_type
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