Streptococcus pneumoniae serotypes in Utah adults at the end of the PCV7 era.

Abstract:

:While heptavalent pneumococcal conjugate vaccine (PCV) has decreased vaccine type invasive pneumococcal disease (IPD) nationwide, rapid serotype replacement and increasing parapneumonic empyema, has been reported in Utah children. The effect of pediatric vaccination on adults in this population is unknown. We identified 117 adults with IPD from the Intermountain Healthcare Central Laboratory between November 2009 and October 2010. We serotyped 61 (52%) stored isolates. We compared the serotype distribution of adult IPD isolates with that of pediatric isolates collected in 2009-2010. PCV7 serotypes were rare in adults (3%) and children (3%). Emerging 13-valent PCV serotypes 3, 7F, and 19A caused the majority of IPD in adults (63%) and children (56%). Fifty-one (84%) adult isolates were serotypes included in 23-valent polysaccharide vaccine and 66% in PCV13. Adult and pediatric IPD serotypes are closely associated in Utah. PCV13 vaccination in Utah children is likely to significantly impact IPD in Utah adults.

journal_name

Vaccine

journal_title

Vaccine

authors

Kendall BA,Dascomb KK,Mehta RR,Mason EO,Ampofo K,Pombo DJ,Pavia AT,Byington CL

doi

10.1016/j.vaccine.2011.10.009

subject

Has Abstract

pub_date

2011-11-15 00:00:00

pages

9123-6

issue

49

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)01603-3

journal_volume

29

pub_type

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