Streptococcus pneumoniae serotypes in Utah adults at the end of the PCV7 era.


:While heptavalent pneumococcal conjugate vaccine (PCV) has decreased vaccine type invasive pneumococcal disease (IPD) nationwide, rapid serotype replacement and increasing parapneumonic empyema, has been reported in Utah children. The effect of pediatric vaccination on adults in this population is unknown. We identified 117 adults with IPD from the Intermountain Healthcare Central Laboratory between November 2009 and October 2010. We serotyped 61 (52%) stored isolates. We compared the serotype distribution of adult IPD isolates with that of pediatric isolates collected in 2009-2010. PCV7 serotypes were rare in adults (3%) and children (3%). Emerging 13-valent PCV serotypes 3, 7F, and 19A caused the majority of IPD in adults (63%) and children (56%). Fifty-one (84%) adult isolates were serotypes included in 23-valent polysaccharide vaccine and 66% in PCV13. Adult and pediatric IPD serotypes are closely associated in Utah. PCV13 vaccination in Utah children is likely to significantly impact IPD in Utah adults.






Kendall BA,Dascomb KK,Mehta RR,Mason EO,Ampofo K,Pombo DJ,Pavia AT,Byington CL




Has Abstract


2011-11-15 00:00:00
















  • Role of interferon-gamma during CpG oligodeoxynucleotide-adjuvanted immunization with recombinant proteins.

    abstract::Synthetic oligonucleotides (ODNs) containing immunostimulatory CpG motifs (CpG) are a new class of adjuvants suitable for the development of recombinant vaccines. Here we describe that endogenous interferon (IFN) was critical for the adjuvant activity of CpG ODN as genetically deficient mice developed significantly lo...


    pub_type: 杂志文章


    authors: Rosa DS,Bastos KR,Bargieri DY,Tzelepis F,Nomizo A,Russo M,Soares IS,Rodrigues MM

    更新日期:2007-08-10 00:00:00

  • Acceptability of intranasal live attenuated influenza vaccine, influenza knowledge and vaccine intent in The Gambia.

    abstract:BACKGROUND:The burden of influenza is increasingly recognised in Africa. The WHO recommends introducing influenza vaccination to high-risk groups: pregnant women, children <5 years, and the elderly. The Gambia currently has no influenza vaccination policy, but the NASIMMUNE study, a clinical trial of intranasal live at...


    pub_type: 杂志文章


    authors: Armitage EP,Camara J,Bah S,Forster AS,Clarke E,Kampmann B,de Silva TI

    更新日期:2018-03-20 00:00:00

  • Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae.

    abstract::Actinobacillus pleuropneumoniae is an important respiratory pathogen of swine, for which there is no highly effective vaccine. A phage expression library of the A. pleuropneumoniae genome was constructed and screened to identify potential vaccine components. Open reading frames within immuno-reactive phage were analyz...


    pub_type: 杂志文章


    authors: Oldfield NJ,Donovan EA,Worrall KE,Wooldridge KG,Langford PR,Rycroft AN,Ala'Aldeen DA

    更新日期:2008-04-07 00:00:00

  • Arguments and sources on Italian online forums on childhood vaccinations: Results of a content analysis.

    abstract:BACKGROUND:Despite being committed to the immunization agenda set by the WHO, Italy is currently experiencing decreasing vaccination rates and increasing incidence of vaccine-preventable diseases. Our aim is to analyze Italian online debates on pediatric immunizations through a content analytic approach in order to qua...


    pub_type: 杂志文章


    authors: Fadda M,Allam A,Schulz PJ

    更新日期:2015-12-16 00:00:00

  • Responses to influenza vaccination in different T-cell subsets: a comparison of healthy young and older adults.

    abstract::T-lymphocyte responses to influenza vaccination were measured in healthy young and older adult volunteers. All participants were vaccinated with the 1995-96 trivalent influenza vaccine. Cytokine and granzyme B levels were measured in peripheral blood mononuclear cells (PBMC) cultures after virus stimulation, prior to ...


    pub_type: 杂志文章


    authors: McElhaney JE,Upshaw CM,Hooton JW,Lechelt KE,Meneilly GS

    更新日期:1998-11-01 00:00:00

  • DNA vaccine against the non-structural 1 protein (NS1) of dengue 2 virus.

    abstract::Dengue is one of the most important mosquito-borne viral disease causing dengue fever and/or dengue shock syndrome/haemorrhagic fever. In some reports, the non-structural protein 1 (NS1) has been identified as a promising antigen for the development of vaccines against dengue virus (DENV). Apparently, it can elicit a ...


    pub_type: 杂志文章


    authors: Costa SM,Freire MS,Alves AM

    更新日期:2006-05-22 00:00:00

  • Improved vaccination against Newcastle disease by an in ovo recombinant HVT-ND combined with an adjuvanted live vaccine at day-old.

    abstract::The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. In this context, maternally immune conventional layer chickens were vaccinated in ovo with a turkey herpe...


    pub_type: 杂志文章


    authors: Rauw F,Gardin Y,Palya V,Anbari S,Lemaire S,Boschmans M,van den Berg T,Lambrecht B

    更新日期:2010-01-08 00:00:00

  • Impact of unfounded vaccine safety concerns on the nationwide measles-rubella immunization campaign, Georgia, 2008.

    abstract::Vaccine safety fears following media reports of adverse events led to low (50.3%) coverage in a supplementary measles-rubella immunization campaign in Georgia in 2008. Review of adverse events associated with the campaign identified 432 reports (<0.1% of ∼ 493,000 vaccinees) including 338 (78.2%) cases of syncope. The...


    pub_type: 杂志文章


    authors: Khetsuriani N,Imnadze P,Baidoshvili L,Jabidze L,Tatishili N,Kurtsikashvili G,Lezhava T,Laurent E,Martin R

    更新日期:2010-09-07 00:00:00

  • Immune response to a booster dose of enhanced potency inactivated polio vaccine administered in association with HBV vaccine in adolescents.

    abstract::The immunogenicity and reactogenicity of a booster dose of enhanced potency inactivated polio vaccine (EIPV) were evaluated in 492 healthy 12 year old adolescents. The booster was administered at the same time as the HBV vaccine compulsory in Italy at this age. Blood samples and questionnaires on reactogenicity were c...


    pub_type: 临床试验,杂志文章


    authors: Pregliasco F,Grilli G,Andreassi A,D'Addezio E,Vacca F,Squarcione S,Biasio LR,Profeta M

    更新日期:1996-03-01 00:00:00

  • Compliance with immunization against hepatitis B. A pragmatic study in sexually transmitted disease clinics.

    abstract::The efficacy of a vaccine is based primarily on the adherence of the subject to the immunization schedule. This paper compares the compliance rates (CR) for the third dose of hepatitis B virus (HBV) vaccine given according to one of two vaccination schedules among subjects attending two sexually transmitted disease (S...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Dal-Ré R,González A,Ramirez V,Ballesteros J,del Romero J,Bru F

    更新日期:1995-02-01 00:00:00

  • Antibodies to measles, mumps and rubella in UK children 4 years after vaccination with different MMR vaccines.

    abstract::Persistence of antibodies 4 years after vaccination with measles, mumps and rubella (MMR) vaccine from three different manufacturers was compared in 475 children who received a single injection of vaccine when aged 12-18 months. Antibodies to measles and mumps were measured using a plaque reduction neutralisation assa...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miller E,Hill A,Morgan-Capner P,Forsey T,Rush M

    更新日期:1995-06-01 00:00:00

  • Impact of the National Perinatal Hepatitis B Prevention Programme in the Republic of Korea: A retrospective registry-based cohort study.

    abstract:INTRODUCTION:Hepatitis B is a major preventable cause of morbidity and mortality from chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. We aimed to evaluate the performance and outcomes of the Korean Perinatal Hepatitis B Prevention Programme (PHBPP) and to investigate the impact of the current post-exp...


    pub_type: 杂志文章


    authors: Yang TU,Jung CW,Kim D,Park HA,Jee Y

    更新日期:2020-07-22 00:00:00

  • Biologic properties and vaccine potential of the staphylococcal poly-N-acetyl glucosamine surface polysaccharide.

    abstract::Staphylococci have become the most common causes of nosocomial bacterial infections, and this fact, along with increasing problems associated with antimicrobial resistance, spurs the need for finding immunotherapeutic alternatives to prevent and possibly treat these infections. Most virulent, clinical isolates of both...


    pub_type: 杂志文章,评审


    authors: Maira-Litran T,Kropec A,Goldmann D,Pier GB

    更新日期:2004-02-17 00:00:00

  • The bovine viral diarrhea virus E2 protein formulated with a novel adjuvant induces strong, balanced immune responses and provides protection from viral challenge in cattle.

    abstract::Bovine viral diarrhea virus (BVDV) is still one of the most serious pathogens in cattle, meriting the development of improved vaccines. Recently, we developed a new adjuvant consisting of poly[di(sodium carboxylatoethylphenoxy)]-phosphazene (PCEP), either CpG ODN or poly(I:C), and an immune defense regulator (IDR) pep...


    pub_type: 杂志文章


    authors: Snider M,Garg R,Brownlie R,van den Hurk JV,van Drunen Littel-van den Hurk S

    更新日期:2014-11-28 00:00:00

  • Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?

    abstract::B. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and animals. The closely related bacterium B. mallei, which cases glanders, is considered to be a clonal derivative of B. pseudomallei. Both B. pseudomallei and B. mallei were evaluated by the United States and the former USSR as p...


    pub_type: 杂志文章,评审


    authors: Titball RW,Burtnick MN,Bancroft GJ,Brett P

    更新日期:2017-10-20 00:00:00

  • Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18.

    abstract::Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenici...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Villa LL,Ault KA,Giuliano AR,Costa RL,Petta CA,Andrade RP,Brown DR,Ferenczy A,Harper DM,Koutsky LA,Kurman RJ,Lehtinen M,Malm C,Olsson SE,Ronnett BM,Skjeldestad FE,Steinwall M,Stoler MH,Wheeler CM,Taddeo FJ,Yu J,

    更新日期:2006-07-07 00:00:00

  • A cross sectional survey to evaluate knowledge, attitudes and practices regarding seasonal influenza and influenza vaccination among diabetics in Pretoria, South Africa.

    abstract:BACKGROUND:In South Africa, influenza vaccination is recommended to all diabetics. However, vaccination coverage among diabetics remains low. Therefore, this study aimed to explore the knowledge, attitudes, and practices among people with diabetes in Pretoria regarding seasonal influenza and influenza vaccination. MET...


    pub_type: 杂志文章


    authors: Olatunbosun OD,Esterhuizen TM,Wiysonge CS

    更新日期:2017-11-07 00:00:00

  • Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells.

    abstract::We compared the effects of yeast-treated human dendritic cells (DCs) with CD40L-matured human DCs for the induction of effector cells and the number and functionality of CD4(+)CD25(+)CD127(-)FoxP3(+) regulatory T cells (Tregs). DCs were treated with yeast or CD40L and cocultured with isolated autologous CD4(+) T cells...


    pub_type: 杂志文章


    authors: Cereda V,Vergati M,Huen NY,di Bari MG,Jochems C,Intrivici C,Gulley JL,Apelian D,Schlom J,Tsang KY

    更新日期:2011-07-12 00:00:00

  • Evaluation of the cellular immune responses induced by a non-adjuvanted inactivated whole virus A/H5N1/VN/1203 pandemic influenza vaccine in humans.

    abstract::In the present study the homologous and heterologous type and subtype specific cellular immune response induced by a wild type inactivated whole virus H5N1 Influenza (A/Vietnam/1203/2004) vaccine was evaluated. Two immunizations with the Vero cell derived H5N1 influenza vaccine on Day 0 and Day 21 induced significant ...


    pub_type: 杂志文章


    authors: Crowe BA,Brühl P,Gerencer M,Schwendinger MG,Pilz A,Kistner O,Koelling-Schlebusch K,Aichinger G,Singer J,Zeitlinger M,Müller M,Ehrlich H,Barrett PN

    更新日期:2010-12-16 00:00:00

  • Antibodies against Haemophilus influenzae type b in The Gambia: investigating the extent of protection across age groups.

    abstract::Following a landmark clinical trial, the vaccine against Haemophilus influenzae type b (Hib) was introduced in The Gambia in 1997. Whilst the immunogenicity of this vaccine is well established subsequent to the doses administered under the EPI schedule, little data exists assessing longevity of protection, using serol...


    pub_type: 杂志文章


    authors: Idoko OT,Roberts E,Cox M,Jafali J,Njie-Jobe J,Mackenzie G,Ota MO,Kampmann B

    更新日期:2014-08-06 00:00:00

  • Haemophilus influenzae meningitis 5 years after introduction of the Haemophilus influenzae type b conjugate vaccine in Brazil.

    abstract::The long-term impact of Haemophilus influenzae type b (Hib) conjugate vaccine, introduced throughout Latin America in the late 1990s, has not been evaluated. Active surveillance for H. influenzae meningitis was performed from August 9, 1996 to August 8, 2004 in Metropolitan Salvador, Brazil. Five years after the intro...


    pub_type: 杂志文章


    authors: Ribeiro GS,Lima JB,Reis JN,Gouveia EL,Cordeiro SM,Lobo TS,Pinheiro RM,Ribeiro CT,Neves AB,Salgado K,Silva HR,Reis MG,Ko AI

    更新日期:2007-05-30 00:00:00

  • Envelope protein and p18(IIIB) peptide recognized by cytotoxic T lymphocytes from humans immunized with human immunodeficiency virus envelope.

    abstract::Cytotoxic T cells are the main antigen-specific effector cells of the cellular immune system and MHC class I restricted cytotoxic T-lymphocyte (CTL) responses in mice, acting against the HIV-1 envelope protein, are known to be predominantly directed against an amino acid sequence in the third hypervariable domain. We ...


    pub_type: 杂志文章


    authors: Achour A,Picard O,Mbika JP,Willer A,Snart R,Bizzini B,Carelli C,Burny A,Zagury D

    更新日期:1993-01-01 00:00:00

  • Evaluation of adverse effects of vaccines: the case-control approach.

    abstract::When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpr...


    pub_type: 杂志文章


    authors: Smeeth L,Rodrigues LC,Hall AJ,Fombonne E,Smith PG

    更新日期:2002-06-07 00:00:00

  • Immunogenicity and reactogenicity of co-administered tetanus-diphtheria-acellular pertussis (Tdap) and tetravalent meningococcal conjugate (MCV4) vaccines compared to their separate administration.

    abstract::In the United States, co-administration of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine and tetravalent meningococcal conjugate vaccine (MCV4) is recommended in adolescents. In this clinical study, 1341 adolescents received Tdap (Boostrix® GlaxoSmithKline) and MCV4 (Menactra®, Sanof...


    pub_type: 杂志文章,随机对照试验


    authors: Weston WM,Friedland LR,Wu X,Howe B

    更新日期:2011-01-29 00:00:00

  • A phase I trial evaluating the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime - MVA85A boost in healthy UK adults.

    abstract:BACKGROUND:This phase I trial evaluated the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime-MVA85A boost, previously demonstrated to be protective in animal studies, in healthy UK adults. METHODS:We enrolled 42 healthy, BCG-vaccinated adults into 4 groups: low dose Starter ...


    pub_type: 杂志文章


    authors: Wilkie M,Satti I,Minhinnick A,Harris S,Riste M,Ramon RL,Sheehan S,Thomas ZM,Wright D,Stockdale L,Hamidi A,O'Shea MK,Dwivedi K,Behrens HM,Davenne T,Morton J,Vermaak S,Lawrie A,Moss P,McShane H

    更新日期:2020-01-22 00:00:00

  • The biology of influenza viruses.

    abstract::The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure ofthe influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in vir...


    pub_type: 杂志文章,评审


    authors: Bouvier NM,Palese P

    更新日期:2008-09-12 00:00:00

  • Comparative analysis of immunization schedules using a novel adenovirus-based immunotherapeutic targeting hepatitis B in naïve and tolerant mouse models.

    abstract::Development of active targeted immunotherapeutics is a rapid developing field in the arena of chronic infectious diseases. The question of repeated, closely spaced administration of immunotherapeutics to achieve a rapid impact on the replicating agent is an important one. We analyzed here, using a prototype adenovirus...


    pub_type: 杂志文章


    authors: Boukhebza H,Dubois C,Koerper V,Evlachev A,Schlesinger Y,Menguy T,Silvestre N,Riedl P,Inchauspé G,Martin P

    更新日期:2014-05-30 00:00:00

  • Like mother, like daughter? Mother's history of cervical cancer screening and daughter's Human Papillomavirus vaccine uptake in Flanders (Belgium).

    abstract:OBJECTIVE:We investigated whether and to what extent the uptake of the Human Papillomavirus (HPV) vaccine by girls aged 12-18 was related to the cervical cancer screening history of age-appropriate older female household members (assumed to be their mothers) in Flanders (Belgium). METHODS:We studied administrative rec...


    pub_type: 杂志文章


    authors: Lefevere E,Hens N,Theeten H,Van den Bosch K,Beutels P,De Smet F,Van Damme P

    更新日期:2011-10-26 00:00:00

  • Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2.

    abstract::An ideal prophylactic human papillomavirus (HPV) vaccine would provide broadly protective and long-lasting immune responses against all high-risk HPV types, would be effective after a single dose, and would be formulated in such a manner to allow for long-term storage without the necessity for refrigeration. We have d...


    pub_type: 杂志文章


    authors: Tumban E,Muttil P,Escobar CA,Peabody J,Wafula D,Peabody DS,Chackerian B

    更新日期:2015-06-26 00:00:00

  • A history of Panton-Valentine leukocidin (PVL)-associated infection protects against death in PVL-associated pneumonia.

    abstract::Panton-Valentine leukocidin (PVL) is a Staphylococcus aureus toxin associated with skin and soft-tissue infections (SSTIs) and life-threatening necrotizing pneumonia in humans. Recent reports have demonstrated that neutralizing antibody to PVL is not protective against SSTI recurrence, thus raising a controversy about...


    pub_type: 杂志文章


    authors: Rasigade JP,Sicot N,Laurent F,Lina G,Vandenesch F,Etienne J

    更新日期:2011-06-06 00:00:00