Paraflagellar rod proteins administered with alum and IL-12 or recombinant adenovirus expressing IL-12 generates antigen-specific responses and protective immunity in mice against Trypanosoma cruzi.

abstract：:A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73...

journal_title：Vaccine

authors： Cainelli Gebara VC,Risoléo L,Lopes AP,Ferreira VR,Quintilio W,Lépine F,Silva WD,Raw I

更新日期：2007-01-08 00:00:00

abstract：:Several studies have emphasized the importance of an early, highly neutralizing antibody response in the clearance of Hepatitis C virus (HCV) infection. The envelope glycoprotein E2 is a major target for HCV neutralizing antibodies. Here, we compared antibody responses in mice immunized with native soluble E2 (sE2) fr...

journal_title：Vaccine

authors： Naarding MA,Falkowska E,Xiao H,Dragic T

更新日期：2011-04-05 00:00:00

abstract：:Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the coreceptor-ligand interactions. We identified a direct interaction between HIV-1 envelope and a cellular rece...

journal_title：Vaccine

authors： Wahren B,Ljungberg K,Rollman E,Levi M,Zuber B,Kjerrström Zuber A,Hinkula J,Leandersson AC,Calarota S,Hejdeman B,Bratt G,Sandström E

更新日期：2002-05-06 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) remains a threat to cause epidemics as evidenced by recent sporadic cases in China. In this communication, we evaluated the efficacy and safety of two SARS vaccine candidates based on the recombinant modified vaccinia Ankara (...

journal_title：Vaccine

authors： Czub M,Weingartl H,Czub S,He R,Cao J

更新日期：2005-03-18 00:00:00

abstract：BACKGROUND:To evaluate the immunological impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPS) at 12 months, for children who have received zero to three infant doses of seven-valent pneumococcal conjugate vaccine (PCV), on responses to a subsequent exposure to a small dose of 23vPPS (mPPS). METHODS:Fiv...

journal_title：Vaccine

authors： Russell FM,Carapetis JR,Balloch A,Licciardi PV,Jenney AW,Tikoduadua L,Waqatakirewa L,Pryor J,Nelson J,Byrnes GB,Cheung YB,Tang ML,Mulholland EK

更新日期：2010-04-26 00:00:00

abstract：:The development of strategies to augment the immunogenicity of plasmid DNA vaccines is critical for improving their clinical utility. One such strategy involves the coadministration of plasmid cytokine adjuvants with DNA vaccines. Although a large number of plasmid cytokines have shown promise as adjuvants in preclini...

journal_title：Vaccine

authors： Barouch DH,Truitt DM,Letvin NL

更新日期：2004-08-13 00:00:00

abstract：:As a step in the development of an oral vaccine against ETEC, we evaluated the safety and immunogenicity of CS6, a polymeric protein commonly found on the surface of ETEC. Formulations included 1 and 5mg doses of CS6, either encapsulated in biodegradable polymer poly(D, L)-lactide-co-glycolide (PLG), or as free protei...

journal_title：Vaccine

authors： Katz DE,DeLorimier AJ,Wolf MK,Hall ER,Cassels FJ,van Hamont JE,Newcomer RL,Davachi MA,Taylor DN,McQueen CE

更新日期：2003-01-17 00:00:00

abstract：:Influenza virus hemagglutinin (HA) and neuraminidase (NA) proteins elicit protective antibody responses and therefore, are used as targets for vaccination, especially the HA protein. However, these proteins are subject to antigenic drift, decreasing vaccine efficacy, and few to no studies have analyzed antigenic varia...

journal_title：Vaccine

authors： DeDiego ML,Chiem K,Topham DJ

更新日期：2018-10-15 00:00:00

abstract：:Purified Vero cell culture rabies vaccine "Abhayrab" manufactured by Human Biologicals Institute, Ooty, India was subjected for immunogenicity studies. Pre-exposure study was undertaken on 60 healthy volunteers (Group I) with vaccination on days 0, 7 and 21. A group of 75 patients of category II (Group II), 67 of cate...

journal_title：Vaccine

authors： Sampath G,Reddy SV,Rao ML,Rao YU,Palaniappan C

更新日期：2005-01-04 00:00:00

abstract：:Salmonellae are commonly isolated from dogs. The number of dogs infected with Salmonella spp. is surprisingly high and greater than the incidence of clinical disease would suggest. Salmonellosis is common in greyhound kennels. Morbidity can approach 100% in puppies and the mortality ranges to nearly 40%. To date, ther...

journal_title：Vaccine

authors： McVey DS,Chengappa MM,Mosier DE,Stone GG,Oberst RD,Sylte MJ,Gabbert NM,Kelly-Aehle SM,Curtiss R

更新日期：2002-02-22 00:00:00

abstract：:Immunization of hairless mice with a TK-, ACVr, non-pathogenic herpes simplex virus (HSV) type 1 mutant protected the mice against reinfection with lethal doses of the parental pathogenic HSV strain. The protection conferred by the mutant against the establishment of latency after reinfection with the parental strain ...

journal_title：Vaccine

authors： Klein RJ,Kaley LA,Friedman-Kien AE

更新日期：1984-09-01 00:00:00

abstract：:The development of live attenuated vaccines, allowing for the safe and effective immunisation at mucosal surfaces, is a strategy of great interest for vaccinologists. The main advantage of this approach over conventional parenteral vaccines is the induction of strong mucosal immune responses, allowing targeting of the...

journal_title：Vaccine

authors： Viret JF,Dietrich G,Favre D

更新日期：2004-06-23 00:00:00

abstract：INTRODUCTION:Online media may influence women's decision to undergo vaccination during pregnancy. The aims of this mixed-methods study were to: (1) examine the portrayal of maternal vaccination in online media and (2) establish the perceived target of vaccine protection as viewed by pregnant women and maternity healthc...

journal_title：Vaccine

authors： Wilcox CR,Bottrell K,Paterson P,Schulz WS,Vandrevala T,Larson HJ,Jones CE

更新日期：2018-11-29 00:00:00

abstract：:Polysaccharide-protein conjugate vaccines against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae have proven efficacy against radiologically confirmed pneumonia. Measurement of pneumonia incidence provides a platform to estimate of the vaccine-preventable burden. Over 24 months, we conducted surveill...

journal_title：Vaccine

authors： Roca A,Sigaúque B,Quintó L,Morais L,Berenguera A,Corachan M,Ribó JL,Naniche D,Bassat Q,Sacoor Ch,Nhalungo D,Macete E,Schuchat A,Soriano-Gabarró M,Flannery B,Alonso PL

更新日期：2010-07-05 00:00:00

abstract：:A parenteral inactivated rotavirus vaccine (IRV) in development could address three problems with current live oral rotavirus vaccines (ORV): their lower efficacy in low and middle-income countries (LMICs), lingering concerns about their association with intussusception, and their requirement for a separate supply cha...

journal_title：Vaccine

authors： Wang Y,Zade J,Moon SS,Weldon W,Pisal SS,Glass RI,Dhere RM,Jiang B

更新日期：2019-01-29 00:00:00

abstract：:Rift Valley fever virus (RVFV), a member of the family Bunyaviridae, causes severe to fatal disease in newborn ruminants, as well as abortions in pregnant animals; both preventable by vaccination. Availability of a challenge model is a pre-requisite for vaccine efficacy trials. Several modes of inoculation with RVFV Z...

journal_title：Vaccine

authors： Weingartl HM,Miller M,Nfon C,Wilson WC

更新日期：2014-04-25 00:00:00

abstract：:In case of a bite by a rabies infected animal, the World Health Organisation recommends a prophylactic treatment including the administration of Human Rabies Immunoglobulins (HRIGs) or highly purified F(ab')2 fragments produced from Equine Rabies Immunoglobulin (F(ab')2 - ERIGs). According to international regulation,...

journal_title：Vaccine

authors： Korimbocus J,Dehay N,Tordo N,Cano F,Morgeaux S

更新日期：2016-06-14 00:00:00

abstract：:We compared the effects of yeast-treated human dendritic cells (DCs) with CD40L-matured human DCs for the induction of effector cells and the number and functionality of CD4(+)CD25(+)CD127(-)FoxP3(+) regulatory T cells (Tregs). DCs were treated with yeast or CD40L and cocultured with isolated autologous CD4(+) T cells...

journal_title：Vaccine

authors： Cereda V,Vergati M,Huen NY,di Bari MG,Jochems C,Intrivici C,Gulley JL,Apelian D,Schlom J,Tsang KY

更新日期：2011-07-12 00:00:00

abstract：:Efficacy studies of investigational HIV vaccines require enrollment of individuals at 'high risk' for HIV. This paper examines participation in HIV vaccine trials among women at 'high risk' for HIV acquisition. In-depth interviews were conducted with 17 African-American women who use crack cocaine and/or exchange sex ...

journal_title：Vaccine

authors： Voytek CD,Jones KT,Metzger DS

更新日期：2011-08-18 00:00:00

abstract：OBJECTIVE:Uptake of meningococcal vaccine (MCV) and tetanus, diphtheria and pertussis (Tdap) vaccine among adolescents has approached Healthy People 2020 goals, but human papillomavirus (HPV) vaccination has not. This study evaluated an intervention using the 4 Pillars™ Practice Transformation Program to increase HPV, ...

journal_title：Vaccine

authors： Zimmerman RK,Moehling KK,Lin CJ,Zhang S,Raviotta JM,Reis EC,Humiston SG,Nowalk MP

更新日期：2017-01-03 00:00:00

abstract：AIM:Design and immunogenicity assessment of the combined vaccine candidate against zoonotic hepatitis E virus (HEV) and foot-and-mouth disease virus (FMDV). METHODS:Using the molecular cloning technology, we produced and purified 9 HEV ORF2-truncated proteins (HEV genotype 4). Then, we compared their thermal stability...

journal_title：Vaccine

authors： Liu Z,Behloul N,Baha S,Wei W,Shi R,Meng J

更新日期：2019-10-31 00:00:00

abstract：:The level of protection conferred by foot-and-mouth disease (FMD) vaccines in primovaccinated animals primarily depends on the potency of the vaccine and the relatedness of the vaccine strain and circulating field isolate. The "Gold Standard" FMD vaccine potency test is the in vivo test performed in the target species...

journal_title：Vaccine

authors： Goris N,Maradei E,D'Aloia R,Fondevila N,Mattion N,Perez A,Smitsaart E,Nauwynck HJ,La Torre J,Palma E,De Clercq K

更新日期：2008-06-25 00:00:00

abstract：:The first 4 years of the 21st century have been an exciting time for tuberculosis (TB) research. After more than a half-century, the first new vaccines for TB are beginning to enter human clinical trials. Based on advances in proteomics and genomics, new vaccine candidates are filling the preclinical pipeline and our ...

journal_title：Vaccine

authors： Doherty TM

更新日期：2005-03-18 00:00:00

abstract：:The identification of MHC class II-restricted peptides has become a priority for the development of peptide-based prophylactic and therapeutic vaccines. The aim of this study was to assess the correlations between peptide-binding assays on purified HLA II molecules and immunization of human HLA II transgenic mice defi...

journal_title：Vaccine

authors： Depil S,Angyalosi G,Moralès O,Delacre M,Delhem N,François V,Georges B,Hammer J,Maillère B,Auriault C,Pancré V

更新日期：2006-03-20 00:00:00

abstract：:Human pythiosis is an emerging disease in the tropical, subtropical and temperate regions of the world. It is caused by the straminipilan, fungus-like, aquatic organism Pythium insidiosum. Pythiosis occurs in localized as well as systemic or vascular forms. Most patients with arterial pythiosis usually have underlying...

journal_title：Vaccine

authors： Wanachiwanawin W,Mendoza L,Visuthisakchai S,Mutsikapan P,Sathapatayavongs B,Chaiprasert A,Suwanagool P,Manuskiatti W,Ruangsetakit C,Ajello L

更新日期：2004-09-09 00:00:00

abstract：:Young Australian Aboriginal children in remote communities experience very high rates of pneumococcal carriage and otitis media. Prior to introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV, Prevenar), serotype 16F was an important type found in nasal and ear discharge swabs. Since commencement of pneum...

journal_title：Vaccine

authors： Marsh RL,Smith-Vaughan H,Beissbarth J,Hare K,Kennedy M,Wigger C,Mellon G,Stubbs E,Gadil JR,Pettit A,Mackenzie G,Tipakalippa P,Morris PS,Leach AJ

更新日期：2007-03-22 00:00:00

abstract：:Following a landmark clinical trial, the vaccine against Haemophilus influenzae type b (Hib) was introduced in The Gambia in 1997. Whilst the immunogenicity of this vaccine is well established subsequent to the doses administered under the EPI schedule, little data exists assessing longevity of protection, using serol...

journal_title：Vaccine

authors： Idoko OT,Roberts E,Cox M,Jafali J,Njie-Jobe J,Mackenzie G,Ota MO,Kampmann B

更新日期：2014-08-06 00:00:00

abstract：:Immunization protocols based on priming with plasmid DNA and boosting with recombinants of vaccinia virus (rVV) encoding the same antigen offer great promise for the prevention and treatment of many parasitic and viral infections for which conventional vaccination has little or no effect. To overcome some of the poten...

journal_title：Vaccine

authors： López-Fuertes L,Pérez-Jiménez E,Vila-Coro AJ,Sack F,Moreno S,Konig SA,Junghans C,Wittig B,Timón M,Esteban M

更新日期：2002-12-13 00:00:00

abstract：BACKGROUND:Liposome encapsulated neutralizing epitope protein of Hepatitis E virus (HEV), rNEp, our Hepatitis E vaccine candidate, was shown to be immunogenic and safe in pregnant and non-pregnant mice and yielded sterilizing immunity in rhesus monkeys. METHODS:The current study in Balb/c mice assessed the levels and ...

journal_title：Vaccine

authors： Kulkarni SP,Thanapati S,Arankalle VA,Tripathy AS

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:In England, coverage for childhood vaccines have decreased since 2012/13 in the context of an increasingly visible anti-vaccination discourse. We determined whether anti-vaccination sentiment is the likely cause of this decline in coverage. METHODS:Descriptive study triangulating a range of data sources (va...

journal_title：Vaccine

authors： Edelstein M,Müller M,Ladhani S,Yarwood J,Salathé M,Ramsay M

更新日期：2020-07-14 00:00:00