Real world TB vaccines: clinical trials in TB-endemic regions.

abstract：:The immunogenicity of two meningococcal outer membrane vesicle (OMV) vaccines, namely the Norwegian wild-type OMV vaccine and the Dutch hexavalent PorA OMV vaccine, were examined in infant cynomolgus monkeys. For the first time, a wild-type- and a recombinant OMV vaccine were compared. Furthermore, the induction of me...

journal_title：Vaccine

authors： Rouppe van der Voort E,Schuller M,Holst J,de Vries P,van der Ley P,van den Dobbelsteen G,Poolman J

更新日期：2000-01-31 00:00:00

abstract：:The safety and immunogenicity of a single dose of virosome-formulated hepatitis A vaccine was evaluated in healthy seronegative Thai volunteers. Immunization elicited primarily mild transient reactions which did not interfere with normal activities. All subjects possessed > 20 mIU of anti-hepatitis A virus antibody pe...

journal_title：Vaccine

authors： Poovorawan Y,Theamboonlers A,Chumdermpadetsuk S,Glück R,Cryz SJ Jr

更新日期：1995-07-01 00:00:00

abstract：:Although largely considered benign, Plasmodium vivax causes disease in nearly 75 million people each year and the available strategies are not sufficient to reduce the burden of disease, therefore pointing to vaccine development as a cost-effective control measure. In this study, the P. vivax merozoite surface protein...

journal_title：Vaccine

authors： Giraldo MA,Arevalo-Pinzon G,Rojas-Caraballo J,Mongui A,Rodriguez R,Patarroyo MA

更新日期：2009-12-10 00:00:00

abstract：:We previously demonstrated that mucosal immunization with SHIV virus-like particles (VLPs) was able to induce strong humoral and cellular immune responses against HIV envelope protein (Env). To understand the mechanism for such enhanced immune responses, we studied the interaction between VLPs and dendritic cells (DCs...

journal_title：Vaccine

authors： Zhang R,Li M,Chen C,Yao Q

更新日期：2004-11-25 00:00:00

abstract：PURPOSE:We conducted a cancer vaccine clinical trial with MAGE-A4 protein. Safety, clinical response, and antigen-specific immune responses were analyzed and the prognostic factors by vaccination were investigated. EXPERIMENTAL DESIGN:Twenty patients with advanced esophageal, stomach or lung cancer were administered M...

journal_title：Vaccine

authors： Saito T,Wada H,Yamasaki M,Miyata H,Nishikawa H,Sato E,Kageyama S,Shiku H,Mori M,Doki Y

更新日期：2014-10-14 00:00:00

abstract：BACKGROUND:Vaccine hesitancy is a complex behaviour which involves various degrees of indecision about specific vaccines or vaccination uptake. Access to antenatal care had been associated with positive vaccine behavior. OBJECTIVE:To determine the prevalence of vaccine hesitancy towards childhood immunisation amongst ...

journal_title：Vaccine

authors： Kalok A,Loh SYE,Chew KT,Abdul Aziz NH,Shah SA,Ahmad S,Mohamed Ismail NA,Abdullah Mahdy Z

更新日期：2020-02-24 00:00:00

abstract：:The feasibility of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine was assessed and a comparison made of immunogenicity and reactogenicity to DTPa and HBV vaccines mixed in one syringe and to concomitant but separate injections as a primary vaccination course in three groups of infants...

journal_title：Vaccine

authors： Usonis V,Bakasenas V,Willems P,Clemens R

更新日期：1997-10-01 00:00:00

abstract：:In this review we aim to provide the reader with an understanding of the capsular-based complexity of Streptococcus pneumoniae, one of the main limitations to current vaccine development. We then discuss the need for a new vaccine strategy based on proteic antigen candidates discovered in silico. Describing specifical...

journal_title：Vaccine

authors： Barocchi MA,Censini S,Rappuoli R

更新日期：2007-04-20 00:00:00

abstract：BACKGROUND:The Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program is the immunization safety monitoring component of FDA's Mini-Sentinel project, a program to actively monitor the safety of medical products using electronic health information. FDA sought to assess the surveillance capabilities of this ...

journal_title：Vaccine

authors： Baker MA,Nguyen M,Cole DV,Lee GM,Lieu TA

更新日期：2013-12-30 00:00:00

abstract：BACKGROUND:In early 2011, following an increased number of reports of severe vaccine-related injection site reactions, Australian authorities recommended against administering repeat doses of the 23-valent pneumococcal polysaccharide vaccine (23vPPV) in otherwise healthy adults. The aim of this study was to assess a so...

journal_title：Vaccine

authors： Trinh L,Macartney K,McIntyre P,Chiu C,Dey A,Menzies R

更新日期：2017-03-13 00:00:00

abstract：:Salmonella strains have great potential as live carriers of heterologous antigens to induce immunity against a variety of infectious diseases. However, the amount of heterologous antigen required to induce an adequate immune response may be toxic for the bacterium and result in cell death, overattenuation or loss of e...

journal_title：Vaccine

authors： Tijhaar EJ,Zheng-Xin Y,Karlas JA,Meyer TF,Stukart MJ,Osterhaus AD,Mooi FR

更新日期：1994-08-01 00:00:00

abstract：:Pediatric patients with severe chronic kidney disease (CKD) on conservative treatment, on dialysis, and those with renal transplantation are at a higher risk for infectious diseases as the result of impaired immune responses against infectious agents. Infections in these patients can have drastic consequences for dise...

journal_title：Vaccine

authors： Esposito S,Mastrolia MV,Prada E,Pietrasanta C,Principi N

更新日期：2014-11-20 00:00:00

abstract：:Clostridium difficile is a pathogen with increasing severity for which host antibody responses provide protection from disease. DNA vaccination has several advantages compared to traditional vaccine methods, however no study has examined this platform against C. difficile toxins. A synthetic gene was created encoding ...

journal_title：Vaccine

authors： Gardiner DF,Rosenberg T,Zaharatos J,Franco D,Ho DD

更新日期：2009-06-02 00:00:00

abstract：:Dengue is one of the most important arboviral diseases in humans, and although efforts over the last decades have dealt with the development of a vaccine, this vaccine is not available yet. In order to evaluate the potential of a DNA vaccine based on the non-structural 1 (NS1) protein against dengue virus (DENV), we c...

journal_title：Vaccine

authors： Costa SM,Paes MV,Barreto DF,Pinhão AT,Barth OM,Queiroz JL,Armôa GR,Freire MS,Alves AM

更新日期：2006-01-12 00:00:00

abstract：:The full-length ecdysone receptor cDNA of Choristoneura fumiferana (CfEcR-B) was cloned into bacterial expression systems and the recombinant protein was expressed either with a His-tag (His-EcR-B) or glutathione-S-transferase (GST) fusion (GST-EcR-B). The His-EcR-B was expressed mostly as insoluble aggregates, while ...

journal_title：Vaccine

authors： Yang DH,Makhmoudova A,Arif BM,Feng Q,Retnakaran A,Palli SR,Krell PJ

更新日期：2006-04-12 00:00:00

abstract：:Sporozoite vaccination of both humans and rodents elicits potent anti-malarial immunity, but the dose of sporozoites and the number of immunizations required varies with vaccination approach. Here we examine the immunological basis for superior protection afforded from single-dose vaccination with virulent sporozoites...

journal_title：Vaccine

authors： Doll KL,Butler NS,Harty JT

更新日期：2014-01-16 00:00:00

abstract：:We evaluated a modified HBV regimen in a cohort of HIV-infected subjects in Rio de Janeiro, Brazil. HIV-infected subjects with no serologic evidences of previous hepatitis B infection were immunized with 4 doses (40 microg each) of recombinant hepatitis B vaccine given at 0, 1, 2 and 6 months. Blood samples were colle...

journal_title：Vaccine

authors： Potsch DV,Oliveira ML,Ginuíno C,Miguel JC,Oliveira SA,Silva EF,Moreira RB,Cruz GV,Oliveira AL,Camacho LA,Barroso PF

更新日期：2010-02-10 00:00:00

abstract：:Recombinant antigens from the oncosphere stage of the parasite Taenia solium were expressed in Escherichia coli. The TSOL16, TSOL45-1A and TSOL45-1B recombinant antigens, each consisting of fibronectin type III (FnIII) domain S, were produced as fusion proteins with glutathione S-transferase (GST) and maltose binding ...

journal_title：Vaccine

authors： Gauci CG,Jayashi CM,Gonzalez AE,Lackenby J,Lightowlers MW

更新日期：2012-06-06 00:00:00

abstract：:Purified tetanus toxoid, a high-molecular-weight protein, was entrapped within poly(L-lactic acid) (PLA) and poly(D,L-lactic/glycolic acid) (PLGA) microspheres prepared by either a solvent extraction or a solvent evaporation method carried out in a multiple emulsion system (water-in-oil-in-water). The physical integri...

journal_title：Vaccine

authors： Alonso MJ,Gupta RK,Min C,Siber GR,Langer R

更新日期：1994-03-01 00:00:00

abstract：:Peptidoglycan monomer (PGM) originating from Brevibacterium divaricatum is a non-toxic, non-pyrogenic, water-soluble immunostimulator. It potentiates humoral immune response to ovalbumin (OVA) in mice upregulating both immunoglobulin (IgG) 1 and IgG2a antibody subclasses. This study concerns the influence of PGM on T ...

journal_title：Vaccine

authors： Halassy Spoljar B,Cimbora T,Hanzl-Dujmović I,Dojnović B,Sabioncello A,Krstanović M,Tomasić J

更新日期：2002-10-04 00:00:00

abstract：:Hepatitis B infections are responsible for more than 300 thousand deaths per year in the Western Pacific Region. Because of this high burden, the countries and areas of the Region established a goal of reducing hepatitis B chronic infection prevalence among children to less than 1% by 2017. This study was conducted to...

journal_title：Vaccine

authors： Wiesen E,Diorditsa S,Li X

更新日期：2016-05-27 00:00:00

abstract：:Annual vaccination rates among French health care workers (HCWs) are in decline even in Emergency Services to which patients at highest risk of influenza complications are admitted, and in which HCWs have the greatest risk of exposure to influenza from patients. We aimed here to identify knowledge and attitudes toward...

journal_title：Vaccine

authors： Hulo S,Nuvoli A,Sobaszek A,Salembier-Trichard A

更新日期：2017-01-05 00:00:00

abstract：:We recently reported that administration of low doses of myotoxins at vaccination sites potentiated antigen-specific T-cell immunity induced by genetic cancer vaccines in mice, an effect which was superior to TLR agonists. In the current study, we found unexpectedly that the mechanism of this potent adjuvant effect wa...

journal_title：Vaccine

authors： Qin H,Cha SC,Neelapu SS,Liu C,Wang YH,Wei J,Qin XF,Liu YJ,Kwak LW

更新日期：2010-11-23 00:00:00

abstract：:Putative TB vaccine candidates were selected from lists of genes induced in response to in vivo-like stimuli, such as low oxygen and carbon starvation or growth in macrophages, and tested as plasmid DNA vaccines for their ability to protect against Mycobacterium tuberculosis challenge in a guinea pig aerosol infection...

journal_title：Vaccine

authors： Vipond J,Vipond R,Allen-Vercoe E,Clark SO,Hatch GJ,Gooch KE,Bacon J,Hampshire T,Shuttleworth H,Minton NP,Blake K,Williams A,Marsh PD

更新日期：2006-09-11 00:00:00

abstract：:Yellow Fever (YF) is an acute febrile illness caused by yellow fever virus (YFV), a mosquito-borne flavivirus transmitted to humans and non-human primates. In Brazil, YF is a public health threat and may cause recurrent epidemics, even with the availability of a vaccine. We evaluated the sero-status for YFV in 581 ind...

journal_title：Vaccine

authors： Stoffella-Dutra AG,Silva de Oliveira J,Barbosa Costa G,Geessien Kroon E,Santos Abrahão J,Desiree LaBeaud A,Paiva Drumond B,Bretas de Oliveira D,de Souza Trindade G

更新日期：2020-09-29 00:00:00

abstract：:The ability to readily elicit broadly neutralizing antibodies to HIV-1 remains elusive. We and others have hypothesized that interaction of the viral envelope glycoprotein (Env, gp120-gp41) with its receptor molecules could enhance the exposure of conserved epitopes that may facilitate the elicitation of broadly neutr...

journal_title：Vaccine

authors： Xiao X,Phogat S,Shu Y,Phogat A,Chow YH,Wei OL,Goldstein H,Broder CC,Dimitrov DS

更新日期：2003-10-01 00:00:00

abstract：:We hypothesized that the ability of BCG vaccination to protect against Mycobacterium tuberculosis is less in hosts exposed to chronic helminthes infection compared to unexposed individuals. To test this hypothesis we evaluated the efficacy of BCG vaccination in protecting against M. tuberculosis challenge in Schistoso...

journal_title：Vaccine

authors： Elias D,Akuffo H,Pawlowski A,Haile M,Schön T,Britton S

更新日期：2005-02-03 00:00:00

abstract：:Measles is one of the most important diseases of mankind, which is so highly contagious and evokes such persistent immunity that the virus cannot be sustained in a population of less than about 500,000 persons. The first of the licensed live virus vaccines against measles was developed empirically and was approved in ...

journal_title：Vaccine

authors： Hilleman MR

更新日期：2001-12-12 00:00:00

abstract：OBJECTIVES:To assess the effectiveness and cost-effectiveness of routine childhood vaccination by new vaccines against rotavirus in France. METHODS:We constructed a Markov decision tree to compare two alternatives: "no vaccination" and "vaccination". A hypothetical birth cohort of 750,000 children was followed until 3...

journal_title：Vaccine

authors： Melliez H,Levybruhl D,Boelle PY,Dervaux B,Baron S,Yazdanpanah Y

更新日期：2008-01-30 00:00:00

abstract：BACKGROUND:FP-01.1 is a novel synthetic influenza A vaccine consisting of six fluorocarbon-modified 35-mer peptides that encapsulate multiple CD4+ and CD8+ T-cell epitopes and is designed to induce an immune response across a broad population. METHODS:FP-01.1 was evaluated for safety and immunogenicity in a randomised...

journal_title：Vaccine

authors： Francis JN,Bunce CJ,Horlock C,Watson JM,Warrington SJ,Georges B,Brown CB

更新日期：2015-01-03 00:00:00