Abstract：
:Recombinant antigens from the oncosphere stage of the parasite Taenia solium were expressed in Escherichia coli. The TSOL16, TSOL45-1A and TSOL45-1B recombinant antigens, each consisting of fibronectin type III (FnIII) domain S, were produced as fusion proteins with glutathione S-transferase (GST) and maltose binding protein (MBP). Groups of pigs were immunized twice with the GST fusions of the antigens and boosted a third time with the MBP fusions prior to receiving a challenge infection with T. solium eggs. The TSOL16 antigen was found to be capable of inducing high levels of immunity in pigs against a challenge infection with T. solium. Immunological investigations identified differences in immune responses in the pigs vaccinated with the various antigens. The results demonstrate that the TSOL16 antigen could be a valuable adjunct to current porcine vaccination approaches and may allow the further development of new vaccination strategies against T. solium cysticercosis.
journal_name
Vaccinejournal_title
Vaccineauthors
Gauci CG,Jayashi CM,Gonzalez AE,Lackenby J,Lightowlers MWdoi
10.1016/j.vaccine.2012.04.019subject
Has Abstractpub_date
2012-06-06 00:00:00pages
3824-8issue
26eissn
0264-410Xissn
1873-2518pii
S0264-410X(12)00541-5journal_volume
30pub_type
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