Abstract:
:Measles is one of the most important diseases of mankind, which is so highly contagious and evokes such persistent immunity that the virus cannot be sustained in a population of less than about 500,000 persons. The first of the licensed live virus vaccines against measles was developed empirically and was approved in 1963. It provides high level and lasting immunity and is a paradigm for solving major medical problems without really understanding them. In spite of means for control by prophylactic immunization, research on measles infection continues to be part of the effort to understand the pathogenesis of many different viruses, which may have important similarities and differences and provide important insights. Measles, usually, is spontaneously reversible and is a prime model for understanding virus-induced immunodeficiency disease (AIDS) which is rarely reversible. Much has been learned of basic immunology and vaccinology in measles through observation of the inappropriate use of vaccines of appropriate composition, and through inappropriate host response to measles vaccines of inappropriate composition. This review provides a current overview of selected highlights of measles, the virus, its immunopathogenesis, and its control by use of live virus vaccine which may lead to elimination of the disease and eventually to eradication of the virus.
journal_name
Vaccinejournal_title
Vaccineauthors
Hilleman MRdoi
10.1016/s0264-410x(01)00384-xsubject
Has Abstractpub_date
2001-12-12 00:00:00pages
651-65issue
5-6eissn
0264-410Xissn
1873-2518pii
S0264-410X(01)00384-Xjournal_volume
20pub_type
杂志文章,评审相关文献
VACCINE文献大全abstract::Neisseria meningitidis is a leading cause of severe bacterial infections in infants and young children. As a major virulence factor, meningococcal capsular polysaccharide (PS) is poorly immunogenic and generally does not induce immunological memory. Conjugation of PS with a carrier protein can significantly increase t...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.09.021
更新日期:2015-10-26 00:00:00
abstract::A reassortant virus possessing RNA segment 7, which codes for the M1 and M2 proteins, of the avian influenza A/Mallard/New York/6750/78 (H2N2) virus and the other seven RNA segments of the human influenza A/Udorn/307/72 (H3N2) virus had been shown previously to be markedly restricted in replication in the respiratory ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(89)90283-1
更新日期:1989-12-01 00:00:00
abstract::Mycoplasma hyopneumoniae, the primary pathogen of enzootic pneumonia, occurs worldwide and causes major economic losses to the pig industry. M. hyopneumoniae infects pigs at mucosal surfaces of respiratory tract. The aim of the present study was to investigate if the protection rate against M. hyopneumoniae infection ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.01.028
更新日期:2012-03-09 00:00:00
abstract::We evaluated the prevalence and concentration of serum antibodies 18-24 months after primary inoculation with anthrax and botulinum vaccines, and assessed the reactogenicity and immunogenicity of a significantly delayed booster dose of these vaccines. Five hundred and eight male active-duty military personnel received...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(02)00058-0
更新日期:2002-05-15 00:00:00
abstract::The glutamate-rich protein (GLURP) of P. falciparum is the target of cytophilic antibodies which are significantly associated with protection against clinical malaria. A phase 1 clinical trial was conducted in healthy adult volunteers with the long synthetic peptide (LSP) GLURP(85-213) combined with either Aluminum Hy...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2006.06.081
更新日期:2007-04-12 00:00:00
abstract::Only viruses of the Influenzavirus A genus have been isolated from birds and termed avian influenza [AI] viruses, but viruses with all 16 haemagglutinin [H1-H16] and all 9 neuraminidase [N1-N9] influenza A subtypes in the majority of possible combinations have been isolated from avian species. Influenza A viruses infe...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2006.10.051
更新日期:2007-07-26 00:00:00
abstract::Ethnicity may be associated with the incidence of pneumococcal infections and the frequency of protective vaccine responses. Earlier studies have suggested that HIV-infected persons of black ethnicity develop less robust immune responses to pneumococcal vaccination that may relate to their higher incidence of invasive...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.09.056
更新日期:2010-11-10 00:00:00
abstract::Viral hepatitis remains a major contributor to the global disease burden. Mass immunisation strategies against hepatitis B have been adopted by more than 90 developing and industrialised countries. Countries with low hepatitis A endemicity are experiencing cyclical outbreaks and an epidemiological shift, with larger n...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(00)00193-6
更新日期:2000-10-15 00:00:00
abstract::Bovine herpesvirus-1 (BHV-1) glycoprotein D (gD), an envelope glycoprotein, engenders mucosal and systemic immunity protecting cattle from viral infection. Production of gD with authentic immunogenicity is required for a subunit vaccine. We placed the truncated BHV-1 gD gene, lacking its putative transmembrane and cyt...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(96)00234-4
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVES:Adoption of human papillomavirus (HPV) vaccination in the US has been slow. In 2011, HPV vaccination of boys was recommended by CDC for routine use at ages 11-12. We conducted and evaluated a social marketing intervention with parents and providers to stimulate HPV vaccination among preteen boys. METHODS:We...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.05.044
更新日期:2014-07-16 00:00:00
abstract::Respiratory mucosa immunization is capable of eliciting both local and distal mucosal immune responses; it is a potentially powerful yet largely unused modality for vaccination against respiratory diseases. Targeting the lower versus upper airways by aerosol delivery alters the immunogenicity profile of a vaccine, alt...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2016.12.008
更新日期:2017-01-23 00:00:00
abstract::Neonatal infection with hepatitis B virus carries a very high risk of resulting in a persistent infection. Babies born to hepatitis B carrier mothers are at risk of infection through exposure to blood and body fluids during birth. These 'at risk' babies can only be identified through screening of all mothers during pr...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/s0264-410x(98)00289-8
更新日期:1998-11-01 00:00:00
abstract::Current recommendations have not resulted in routine vaccination of correctional facility inmates for hepatitis B. We investigated two hepatitis B outbreaks. Outbreak 1 involved 4 cases epidemiologically linked to persons who had been in jail. Outbreak 2 involved 48 community cases; 69% had a history of incarceration....
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.09.023
更新日期:2006-02-27 00:00:00
abstract:BACKGROUND:Pandemic planning has historically been oriented to respond to an influenza virus, with vaccination strategy being a key focus. As the current COVID-19 pandemic plays out, the Australian government is closely monitoring progress towards development of SARS-CoV2 vaccines as a definitive intervention. However,...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.12.010
更新日期:2021-01-08 00:00:00
abstract::Cytotoxic T cells are the main antigen-specific effector cells of the cellular immune system and MHC class I restricted cytotoxic T-lymphocyte (CTL) responses in mice, acting against the HIV-1 envelope protein, are known to be predominantly directed against an amino acid sequence in the third hypervariable domain. We ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(93)90251-r
更新日期:1993-01-01 00:00:00
abstract::Metered-dose propellant-driven small particle aerosols of a killed whole bacterium, Streptococcus suis, were produced and characterized for their aerodynamic particle sizes and antigenicity as potential respiratory mucosal vaccines against S. suis infections in swine. To facilitate the efficient delivery of such vacci...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(97)00297-1
更新日期:1997-08-01 00:00:00
abstract::Vaccines utilizing poorly immunogenic subunit antigens are dependent upon adjuvants to drive the appropriate T cell responses. In an effort to determine the ability of several adjuvants to promote cell-mediated immunity (CMI), we assessed delayed-type hypersensitivity (DTH) in mice inoculated with heat-killed Listeria...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(96)00199-5
更新日期:1997-03-01 00:00:00
abstract::Respiratory syncytial virus is one of the major respiratory pathogens for infants and immunocompromized children. With the exception of young children, all the population has encountered RSV and is seropositive. Recent reports have demonstrated however that the virus also affects the elderly and represents a major cau...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(00)00064-5
更新日期:2000-06-01 00:00:00
abstract::The availability of an inactivated hepatitis A virus (HAV) vaccine, and the development of live attenuated virus vaccines against hepatitis represent great advances in the effort to control an important cause of viral hepatitis. There are a number of ways hepatitis A vaccines could be used, depending on the epidemiolo...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/0264-410x(92)90555-x
更新日期:1992-01-01 00:00:00
abstract::The development of a stable live attenuated Salmonella Enteritidis (SE) vaccine, resisting heat stress during transportation and storage in unequipped tropical and subtropical zones of the world, is highly recommended. Twelve stabilizers were individually supplemented into a 9 ml volume of sterile distilled water resu...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(02)00107-x
更新日期:2002-05-22 00:00:00
abstract::Immunogenicity and safety of a newly developed liquid DTwP-Hib/HepB-IPV hexavalent vaccine (EasySix™) was evaluated and compared with administration of commercially licensed Pentavac SD® (DTwP-HepB/Hib) and Imovax Polio® vaccine in an open-label, randomized multi-centric trial. 284 participants, aged 6-10weeks, random...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2017.09.029
更新日期:2018-04-19 00:00:00
abstract::The development of a safe and effective vaccine against enterotoxigenic Escherichia coli (ETEC) would be useful for travellers and for young children in endemic areas. A feasibility study of an enteral ETEC vaccine prototype consisting of colonization factor antigen II (CFA/II), containing two component antigens CS1 a...
journal_title:Vaccine
pub_type: 临床试验,杂志文章
doi:10.1016/s0264-410x(94)80038-2
更新日期:1994-11-01 00:00:00
abstract::The current total of AIDS cases in Mexico is 37,000 of which 86% have occurred in men. The major route of transmission is sexual. The campaign to prevent AIDS has fallen into four phases, and has now been extended to other sexually transmitted diseases, including hepatitis B. The first phase (1985-1989) was based arou...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(99)00475-2
更新日期:2000-02-18 00:00:00
abstract::Dendritic cells (DCs) have been identified as the most effective antigen-presenting cell (APC), much attention has been directed toward the use of DCs in vaccine strategies for the treatment of cancer or chronic virus infection. B7-H1 (PD-L1) is a ligand for programmed cell death-1 (PD-1) and does not bind to other CD...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.11.076
更新日期:2012-01-17 00:00:00
abstract::Integration of health services brings together common functions within and between organizations to solve common problems, developing a commitment to a shared vision and goals, and using common technologies and resources to achieve these goals. Integration has been the frustrated rally call of Primary Health Care for ...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2008.02.032
更新日期:2008-04-07 00:00:00
abstract:BACKGROUND:Inactivated quadrivalent influenza vaccine (IIV4) containing two influenza A strains and one strain from each B lineage (Yamagata and Victoria) may offer broader protection against seasonal influenza than inactivated trivalent influenza vaccine (IIV3), containing a single B strain. This study examined the sa...
journal_title:Vaccine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.vaccine.2015.03.065
更新日期:2015-05-15 00:00:00
abstract::The recent spread of Zika virus (ZIKV) in the Americas and the Pacific has reached alarming levels in more than 60 countries. However, relatively little is known about the disease on a virological and epidemiological level and its consequences for humans. Accordingly, a large demand for in vitro derived Brazilian ZIKV...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.03.018
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Vaccinating pregnant women may prevent invasive Group B Streptococcus (GBS) disease in their young infants. In a low-middle income setting, we sought to determine an association between natural maternal antibody responses and the development of invasive GBS disease. METHODS:We undertook a matched case-contr...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.10.019
更新日期:2015-11-27 00:00:00
abstract::Bovine mastitis is responsible of major economic losses on dairy farms worldwide. In Argentine dairy herds, Staphylococcus aureus is the main causative agent of the disease. The ineffectiveness of some current practices to control S. aureus infections, often leads to a chronic and recurrent infection with persistent b...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.04.056
更新日期:2010-06-17 00:00:00
abstract::Viral vectors are promising vaccine candidates for eliciting suitable Ag-specific immune response. Since Mycobacterium tuberculosis (Mtb) normally enters hosts via the mucosal surface of the lung, the best defense against Mtb is mucosal vaccines that are capable of inducing both systemic and mucosal immunity. Although...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.11.108
更新日期:2014-03-26 00:00:00