Envelope protein and p18(IIIB) peptide recognized by cytotoxic T lymphocytes from humans immunized with human immunodeficiency virus envelope.


:Cytotoxic T cells are the main antigen-specific effector cells of the cellular immune system and MHC class I restricted cytotoxic T-lymphocyte (CTL) responses in mice, acting against the HIV-1 envelope protein, are known to be predominantly directed against an amino acid sequence in the third hypervariable domain. We have investigated the epitope specificity of anti-HIV-1 CTL in healthy human volunteers inoculated with a recombinant vaccinia expressing the HIV-1 gp160 envelope gene. Their isolated lymphocytes were stimulated in vitro with autologous HIV-1 infected cells. Our results show that immunization with recombinant virus is able to generate virus-specific CTLs to the HIV-1 gp160 envelope protein and to a 15-residue synthetic peptide corresponding to a highly variable region of the envelope p18(IIIB). The CTL response was restricted by class I MHC molecules HLA-A2 and A3 that commonly occur in the human population.






Achour A,Picard O,Mbika JP,Willer A,Snart R,Bizzini B,Carelli C,Burny A,Zagury D




Has Abstract


1993-01-01 00:00:00
















  • Characterization of a multi-lipopeptides mixture used as an HIV-1 vaccine candidate.

    abstract::A multi-component vaccine has been defined, which contains six different synthetic 24- to 32-amino acid lipopeptides derived from the sequence of HIV-1 proteins. The physicochemical properties of the lipopeptide components were compatible with multi-dimensional analysis, using RP-HPLC, Edman sequencing, electrospray m...


    pub_type: 杂志文章


    authors: Klinguer C,David D,Kouach M,Wieruszeski JM,Tartar A,Marzin D,Levy JP,Gras-Masse H

    更新日期:1999-09-01 00:00:00

  • Experimental Rhodococcus equi and equine infectious anemia virus DNA vaccination in adult and neonatal horses: effect of IL-12, dose, and route.

    abstract::Improving the ability of DNA-based vaccines to induce potent Type1/Th1 responses against intracellular pathogens in large outbred species is essential. Rhodoccocus equi and equine infectious anemia virus (EIAV) are two naturally occurring equine pathogens that also serve as important large animal models of neonatal im...


    pub_type: 杂志文章


    authors: Mealey RH,Stone DM,Hines MT,Alperin DC,Littke MH,Leib SR,Leach SE,Hines SA

    更新日期:2007-10-23 00:00:00

  • Oral vaccination with Lactococcus lactis expressing the Vibrio cholerae Wzm protein to enhance mucosal and systemic immunity.

    abstract::A gene associated with lipopolysaccharide (LPS) transport was cloned from a local clinical Vibrio cholerae O1 strain of the Ogawa serotype by using the Lactococcus lactis nisin-controlled expression (NICE) system. The V. cholerae wzm gene, which codes for an integral membrane transporter protein, was expressed and tar...


    pub_type: 杂志文章


    authors: Zamri HF,Shamsudin MN,Rahim RA,Neela V

    更新日期:2012-05-02 00:00:00

  • A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix(®) in subjects aged 11-17 years: an open, randomised, controlled trial.

    abstract::The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix(®)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n=611) were randomised (3:1:1) to receive ...


    pub_type: 杂志文章,随机对照试验


    authors: Østergaard L,Silfverdal SA,Berglund J,Flodmark CE,West C,Bianco V,Baine Y,Miller JM

    更新日期:2012-01-17 00:00:00

  • Transepithelial immunomodulation by cholera toxin and non-toxic derivatives.

    abstract::Comparative analyses of murine dendritic cells (DC) isolated from the skin and from the intestinal mucosa after exposure to cholera toxin and its non-toxic B subunit disclose striking differences regarding the migratory and functional behaviour of these cells. The nature of the epithelial microenvironment, especially ...


    pub_type: 杂志文章


    authors: Anjuère F,Luci C,Hervouet C,Rousseau D,Czerkinsky C

    更新日期:2006-04-12 00:00:00

  • Monitoring of rotavirus vaccination in Morocco: establishing the baseline burden of rotavirus disease.

    abstract:BACKGROUND:Rotavirus is a leading cause of childhood morbidity and mortality worldwide. Clinical trials for two rotavirus vaccines recommended by the WHO for global use since 2009 have successfully demonstrated the safety and efficacy of these vaccines in a wide range of countries. To control the burden of severe and f...


    pub_type: 杂志文章


    authors: Benhafid M,Rguig A,Trivedi T,Elqazoui M,Teleb N,Mouane N,Maltouf AF,Parashar U,Patel M,Aouad RE

    更新日期:2012-10-12 00:00:00

  • Use of o-phthalaldehyde assay to determine protein contents of Alhydrogel-based vaccines.

    abstract::Aluminum based adjuvants (alum), including aluminum hydroxide (Alhydrogel) and aluminum phosphate are the most commonly used adjuvant in the US. In order to ensure quality of vaccines, regulatory authorities require evaluation of antigen content in final vaccine products. Currently, there are no generic methods availa...


    pub_type: 杂志文章


    authors: Zhu D,Saul A,Huang S,Martin LB,Miller LH,Rausch KM

    更新日期:2009-10-09 00:00:00

  • A systems approach to vaccine decision making.

    abstract::Vaccines reside in a complex multiscale system that includes biological, clinical, behavioral, social, operational, environmental, and economical relationships. Not accounting for these systems when making decisions about vaccines can result in changes that have little effect rather than solutions, lead to unsustainab...


    pub_type: 杂志文章


    authors: Lee BY,Mueller LE,Tilchin CG

    更新日期:2017-01-20 00:00:00

  • The bovine viral diarrhea virus E2 protein formulated with a novel adjuvant induces strong, balanced immune responses and provides protection from viral challenge in cattle.

    abstract::Bovine viral diarrhea virus (BVDV) is still one of the most serious pathogens in cattle, meriting the development of improved vaccines. Recently, we developed a new adjuvant consisting of poly[di(sodium carboxylatoethylphenoxy)]-phosphazene (PCEP), either CpG ODN or poly(I:C), and an immune defense regulator (IDR) pep...


    pub_type: 杂志文章


    authors: Snider M,Garg R,Brownlie R,van den Hurk JV,van Drunen Littel-van den Hurk S

    更新日期:2014-11-28 00:00:00

  • Immunisation of a cohort Pacific children living in New Zealand over the first 2 years of life.

    abstract::Pacific children have had consistently evidenced low rates for routine childhood immunisations. Using the Pacific Islands Families: First 2 Years of Life cohort study, we investigated the immunisation rate of Pacific infants residing in New Zealand at 24-months postpartum. Full immunisation was reported for 89% of inf...


    pub_type: 杂志文章


    authors: Paterson J,Schluter P,Percival T,Carter S

    更新日期:2006-05-29 00:00:00

  • Efficacy of inactivated trivalent influenza vaccine in alleviating the febrile illness of culture-confirmed influenza in children in the 2000-2001 influenza season.

    abstract::During the 2000/2001 influenza season in Japan, children ranging in age from 6 months to 13 years with fever exceeding 37.5 degrees C were recruited. Vaccine efficacy was evaluated by comparing the rates of pre-seasonal vaccination between groups stratified by fever severity. Seven hundred and sixty one patients (33.1...


    pub_type: 杂志文章,多中心研究


    authors: Kamada M,Nagai T,Kumagai T,Igarashi M,Ihara T,Okafuji T,Ochiai H,Sakiyama H,Shimomura K,Suzuki E,Torigoe S,Miyazaki C,Miyata A,Yuri K,Ito Y,Nakayama T,Kase T,Okuno Y

    更新日期:2006-04-24 00:00:00

  • Epitope-based sieve analysis of Plasmodium falciparum sequences from a FMP2.1/AS02A vaccine trial is consistent with differential vaccine efficacy against immunologically relevant AMA1 variants.

    abstract::To prevent premature dismissal of promising vaccine programs, it is critical to determine if lack of efficacy in the field is due to allele specific-efficacy, rather than to the lack of immunogenicity of the candidate antigen. Here we use samples collected during a field trial of the AMA1-based FMP2.1/AS02A malaria va...


    pub_type: 杂志文章


    authors: Ouattara A,Niangaly A,Adams M,Coulibaly D,Kone AK,Traore K,Laurens MB,Tolo Y,Kouriba B,Diallo DA,Doumbo OK,Plowe CV,Djimdé A,Thera MA,Laufer MK,Takala-Harrison S,Silva JC

    更新日期:2020-07-31 00:00:00

  • Development and validation of a quantitative competitive ELISA for potency testing of equine anti rabies sera with other potential use.

    abstract::In case of a bite by a rabies infected animal, the World Health Organisation recommends a prophylactic treatment including the administration of Human Rabies Immunoglobulins (HRIGs) or highly purified F(ab')2 fragments produced from Equine Rabies Immunoglobulin (F(ab')2 - ERIGs). According to international regulation,...


    pub_type: 杂志文章


    authors: Korimbocus J,Dehay N,Tordo N,Cano F,Morgeaux S

    更新日期:2016-06-14 00:00:00

  • Adverse events following immunization in patients with primary immunodeficiencies.

    abstract:BACKGROUND:Adverse events following immunization (AEFI) requires special consideration in patients with primary immunodeficiency diseases (PID) because they may represent a "red flag" for the initial diagnosis and may cause disease complications. Therefore, the definition of appropriate vaccination schemes is a major i...


    pub_type: 杂志文章


    authors: Sarmiento JD,Villada F,Orrego JC,Franco JL,Trujillo-Vargas CM

    更新日期:2016-03-18 00:00:00

  • Development and evaluation of live attenuated Salmonella vaccines in newly hatched duckings.

    abstract::Domestic ducks remain a major source of zoonotic Salmonella enterica infections for man worldwide and approaches to protection should include vaccine-mediated immunity. With this in mind we developed several genetically defined mutants in a virulent duck Salmonella typhimurium isolate TT-1. From initial tests for viru...


    pub_type: 杂志文章


    authors: Tang T,Gao Q,Barrow P,Wang M,Cheng A,Jia R,Zhu D,Chen S,Liu M,Sun K,Yang Q,Chen X

    更新日期:2015-10-13 00:00:00

  • Brucella abortusΔcydCΔcydD and ΔcydCΔpurD double-mutants are highly attenuated and confer long-term protective immunity against virulent Brucella abortus.

    abstract::We constructed double deletion (ΔcydCΔcydD and ΔcydCΔpurD) mutants from virulent Brucella abortus biovar 1 field isolate (BA15) by deleting the genes encoding an ATP-binding cassette-type transporter (cydC and cydD genes) and a phosphoribosylamine-glycine ligase (purD). Both BA15ΔcydCΔcydD and BA15ΔcydCΔpurD double-mu...


    pub_type: 杂志文章


    authors: Truong QL,Cho Y,Park S,Kim K,Hahn TW

    更新日期:2016-01-04 00:00:00

  • Prevalence of type-specific human papillomavirus infection among women in France: Implications for screening, vaccination, and a future generation of multivalent HPV vaccines.

    abstract::To assess human papillomavirus (HPV) prevalence and genotype distribution by age and cervical cytology/histology status among women undergoing routine gynecological examinations, and to discuss the possible impact on preventive strategies. Liquid-based cytology (LBC) samples were tested for HPV DNA, mRNA, and HPV geno...


    pub_type: 杂志文章


    authors: Monsonego J,Zerat L,Syrjänen K,Zerat JC,Smith JS,Halfon P

    更新日期:2012-07-27 00:00:00

  • Persistence of anti-HBs in children vaccinated against viral hepatitis B in the first year of life: follow-up at 5 and 10 years.

    abstract::The persistence of anti-HBs protective levels in groups of children who had been immunized against Hepatitis B 5 and 10 years earlier, in their first year of life, has been studied. The results were analyzed according to the type of vaccine (both plasma-derived and DNA recombinant) and the number of doses administered...


    pub_type: 杂志文章


    authors: Da Villa G,Peluso F,Picciotto L,Bencivenga M,Elia S,Pelliccia MG

    更新日期:1996-11-01 00:00:00

  • Seasonal influenza vaccine efficacy and its determinants in children and non-elderly adults: a systematic review with meta-analyses of controlled trials.

    abstract:CONTEXT:The true level of influenza vaccine efficacy is controversial and many factors may influence its estimation. OBJECTIVES:To estimate the efficacy of vaccination of children and non-elderly adults for the prevention of influenza and to explore the impact of type of vaccine, age, degree of strain matching, influe...


    pub_type: 杂志文章,meta分析,评审


    authors: DiazGranados CA,Denis M,Plotkin S

    更新日期:2012-12-17 00:00:00

  • DNA vaccination with the serine rich Entamoeba histolytica protein (SREHP) prevents amebic liver abscess in rodent models of disease.

    abstract::Amebiasis remains one of the leading parasitic causes of death worldwide. A vaccine that prevented amebic liver abscess would significantly reduce mortality from this disease. To test the feasibility of a DNA vaccine to prevent amebic liver abscess, we immunized both mice and gerbils with plasmid DNA encoding the seri...


    pub_type: 杂志文章


    authors: Zhang T,Stanley SL Jr

    更新日期:1999-12-10 00:00:00

  • Comparative proteome and transcriptome analyses of wild-type and live vaccine strains of Salmonella enterica serovar Gallinarum.

    abstract::Salmonella enterica serovar Gallinarum causes fowl typhoid in chickens and is of economic importance to the chicken industry. A serovar Gallinarum live vaccine strain 9R (SG 9R) has been used to control fowl typhoid in many areas where the disease is endemic. Because the attenuation mechanism of SG 9R was not defined,...


    pub_type: 杂志文章


    authors: Kang MS,Kwon YK,Kim HR,Oh JY,Kim MJ,An BK,Shin EG,Kwon JH,Park CK

    更新日期:2012-10-05 00:00:00

  • Generation of tumor-specific cytotoxic T lymphocyte and prolongation of the survival of tumor-bearing mice using interleukin-18-secreting fibroblasts loaded with an epitope peptide.

    abstract::There is currently much interest in generating cytotoxic T lymphocyte (CTL) responses against tumor antigens as a therapy for cancer. In this study mouse fibroblasts (H-2(b)) were genetically modified to express a costimulatory B7.1 and a mature interleukin (IL)-18, and then loaded with an ovalbumin (OVA) epitope (SII...


    pub_type: 杂志文章


    authors: Chung SW,Cohen EP,Kim TS

    更新日期:2004-06-30 00:00:00

  • Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates.

    abstract::The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than f...


    pub_type: 杂志文章


    authors: Ohara N,Matsuoka M,Nomaguchi H,Naito M,Yamada T

    更新日期:2001-02-28 00:00:00

  • Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study.

    abstract:INTRODUCTION:We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season. METHODS:We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were co...


    pub_type: 杂志文章,多中心研究


    authors: Puig-Barberà J,Díez-Domingo J,Arnedo-Pena A,Ruiz-García M,Pérez-Vilar S,Micó-Esparza JL,Belenguer-Varea A,Carratalá-Munuera C,Gil-Guillén V,Schwarz-Chavarri H

    更新日期:2012-08-24 00:00:00

  • Methods for systematic reviews of administrative database studies capturing health outcomes of interest.

    abstract::This report provides an overview of methods used to conduct systematic reviews for the US Food and Drug Administration (FDA) Mini-Sentinel project, which is designed to inform the development of safety monitoring tools for FDA-regulated products including vaccines. The objective of these reviews was to summarize the l...


    pub_type: 杂志文章,评审


    authors: McPheeters ML,Sathe NA,Jerome RN,Carnahan RM

    更新日期:2013-12-30 00:00:00

  • Characterization and optimization of a novel vaccine for protection against Lyme borreliosis.

    abstract::Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere and there is no vaccine available for disease prevention. The majority of LB cases in Europe are caused by four different Borrelia species expressing six different OspA serotypes, whereas in the US only one of these serotypes is p...


    pub_type: 杂志文章


    authors: Comstedt P,Hanner M,Schüler W,Meinke A,Schlegl R,Lundberg U

    更新日期:2015-11-04 00:00:00

  • Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals.

    abstract::We evaluated immunologic predictors of response to HBV vaccine administered in the presence or absence of GM-CSF in HIV infected individuals. We measured peripheral blood hematopoietic progenitor, monocyte and myeloid-derived suppressor cell (MDSC) frequencies, and expression of GMCSF receptor on monocytes and MDSCs, ...


    pub_type: 杂志文章,随机对照试验


    authors: Anthony DD,Umbleja T,Aberg JA,Kang M,Medvik K,Lederman MM,Peters MG,Koziel MJ,Overton ET

    更新日期:2011-04-27 00:00:00

  • Achieving a "Grand Convergence" in global health by 2035.

    abstract::Historical evidence demonstrates the validity of the concept "Grand Convergence". The Lancet commission identified the major challenges facing low and lower middle income countries including the unfinished agenda, non-communicable diseases and injuries and an approach to funding and achieving these objectives along wi...


    pub_type: 杂志文章


    authors: Mahmoud A

    更新日期:2017-01-20 00:00:00

  • Considerations for controlling invasive meningococcal disease in high income countries.

    abstract::The development of conjugate vaccines has enabled the prevention and control of Neisseria meningitidis caused by serogroups A, C, W-135 and Y. Vaccines that provide protection against a broad number of serogroup B strains likely will be available soon to enable greater control of meningococcal disease in high income c...


    pub_type: 杂志文章,评审


    authors: Holst J,Nøkleby H,Bettinger JA

    更新日期:2012-05-30 00:00:00

  • U.K. parents' decision-making about measles-mumps-rubella (MMR) vaccine 10 years after the MMR-autism controversy: a qualitative analysis.

    abstract:BACKGROUND AND OBJECTIVES:Public concern about an unsubstantiated link between MMR vaccine and autism stemmed from a 1998 paper by Dr Andrew Wakefield and colleagues, and the substantial media coverage which that work attracted. Though the Wakefield paper is now discredited and an MMR-autism link has never been demonst...


    pub_type: 杂志文章


    authors: Brown KF,Long SJ,Ramsay M,Hudson MJ,Green J,Vincent CA,Kroll JS,Fraser G,Sevdalis N

    更新日期:2012-02-27 00:00:00