Envelope protein and p18(IIIB) peptide recognized by cytotoxic T lymphocytes from humans immunized with human immunodeficiency virus envelope.

Abstract:

:Cytotoxic T cells are the main antigen-specific effector cells of the cellular immune system and MHC class I restricted cytotoxic T-lymphocyte (CTL) responses in mice, acting against the HIV-1 envelope protein, are known to be predominantly directed against an amino acid sequence in the third hypervariable domain. We have investigated the epitope specificity of anti-HIV-1 CTL in healthy human volunteers inoculated with a recombinant vaccinia expressing the HIV-1 gp160 envelope gene. Their isolated lymphocytes were stimulated in vitro with autologous HIV-1 infected cells. Our results show that immunization with recombinant virus is able to generate virus-specific CTLs to the HIV-1 gp160 envelope protein and to a 15-residue synthetic peptide corresponding to a highly variable region of the envelope p18(IIIB). The CTL response was restricted by class I MHC molecules HLA-A2 and A3 that commonly occur in the human population.

journal_name

Vaccine

journal_title

Vaccine

authors

Achour A,Picard O,Mbika JP,Willer A,Snart R,Bizzini B,Carelli C,Burny A,Zagury D

doi

10.1016/0264-410x(93)90251-r

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

609-701

issue

7

eissn

0264-410X

issn

1873-2518

pii

0264-410X(93)90251-R

journal_volume

11

pub_type

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