Breastfeeding linked to the reduction of both rotavirus shedding and IgA levels after Rotarix® immunization in Mexican infants.


:We examined potential risk factors on vaccine virus shedding and antibody seroresponse to human rotavirus vaccine (Rotarix) in Mexican infants. Two doses of Rotarix were administered to infants during the first two visits for their routine childhood immunization (∼8 and 15weeks of age) in Mexico City. Infant's characteristics and socioeconomic indicators were obtained, including history of long-term feeding practices (exclusively/predominantly breastfed and exclusively/predominantly non-breastfed). Two serum specimens were collected, one during the second rotavirus vaccine visit and one 7weeks later. Stool specimens were collected between days 4-7 after each of the two rotavirus vaccine doses. Rotavirus IgA and IgG titers in serum were determined by enzyme immunoassays (EIA) and rotavirus shedding in stool was assessed by EIA and confirmed by RT-PCR. The overall rotavirus IgA geometric mean titers (GMT) increased significantly post dose 2 from post dose 1 [176 (95%CI: 113-273) to 335 (238-471); p=0.020). Infants who were exclusively/predominantly breastfed were less likely to shed vaccine virus in stool than those who were formula-fed (22% vs. 43%, p=0.016). Infants who were breastfed had lower rotavirus IgA titers than those who were formula-fed after dose 1 [GMT: 145 (84-250) vs. 267 (126-566) p=0.188] and dose 2 [236 (147-378) vs.578 (367-910), p=0.007]. Infants who shed vaccine virus post dose 1 had significantly higher serum IgA GMT than those who did not shed [425 (188-965) vs. 150 (84-266), p=0.038]. Breastfeeding was linked with the reduction of both stool vaccine shedding, and IgA seroresponse. The reduced rotavirus replication in the gut and shedding after dose 1 may explain in part the lower IgA response in serum.






Bautista-Marquez A,Velasquez DE,Esparza-Aguilar M,Luna-Cruz M,Ruiz-Moran T,Sugata K,Jiang B,Parashar U,Patel M,Richardson V




Has Abstract


2016-10-17 00:00:00
















  • Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HPIV3cp45) among susceptible infants and toddlers.

    abstract:BACKGROUND:This study examined the transmissibility between young children of an intranasally administered live attenuated human parainfluenza virus type 3 (HPIV3)-cp45 vaccine candidate. METHODS:Eighty subjects were enrolled in playgroups among whom there was at least one infected vaccinee in close contact with a ser...


    pub_type: 杂志文章,随机对照试验


    authors: Madhi SA,Cutland C,Zhu Y,Hackell JG,Newman F,Blackburn N,Murphy BR,Belshe RB,Karron RA,Deatly AM,Gruber WC,Bernstein DI,Wright PF

    更新日期:2006-03-20 00:00:00

  • Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease.

    abstract::Lyme disease is a major human health problem which continues to increase in incidence and geographic distribution. As a vector-borne zoonotic disease, Lyme disease may be amenable to reservoir targeted strategies for control. We have previously reported that a vaccinia virus (VV) based vaccine expressing outer surface...


    pub_type: 杂志文章


    authors: Bhattacharya D,Bensaci M,Luker KE,Luker G,Wisdom S,Telford SR,Hu LT

    更新日期:2011-10-13 00:00:00

  • Induction of a secretory IgA response in the murine female urogenital tract by immunization of the lungs with liposome-supplemented viral subunit antigen.

    abstract::This study demonstrates that liposomes administered to the lower respiratory tract of mice have the capacity to stimulate secretory IgA (s-IgA) antibody production in the female urogenital system. Total respiratory tract immunization of mice with influenza virus subunit antigen simply mixed with negatively charged lip...


    pub_type: 杂志文章


    authors: de Haan A,Renegar KB,Small PA Jr,Wilschut J

    更新日期:1995-05-01 00:00:00

  • Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor.

    abstract::It is of great interest to develop a pneumonic plague vaccine that would induce combined humoral and cellular immunity in the lung. Here we investigate a novel approach based on targeting of dendritic cells using the DEC-205/CD205 receptor (DEC) via the intranasal route as way to improve mucosal cellular immunity to t...


    pub_type: 杂志文章


    authors: Do Y,Didierlaurent AM,Ryu S,Koh H,Park CG,Park S,Perlin DS,Powell BS,Steinman RM

    更新日期:2012-10-05 00:00:00

  • Protection of trivalent inactivated influenza vaccine against hospitalizations among pandemic influenza A (H1N1) cases in Argentina.

    abstract::The aim of this study was to estimate the effectiveness of 2009 seasonal trivalent inactivated vaccine in reducing hospitalizations due to the novel influenza A H1N1 virus among positive cases. Data collected from Argentina's national epidemiological surveillance system were analyzed. All patients had a clinical diagn...


    pub_type: 杂志文章


    authors: Orellano PW,Reynoso JI,Carlino O,Uez O

    更新日期:2010-07-19 00:00:00

  • Effective adjuvants for the induction of antigen-specific delayed-type hypersensitivity.

    abstract::Vaccines utilizing poorly immunogenic subunit antigens are dependent upon adjuvants to drive the appropriate T cell responses. In an effort to determine the ability of several adjuvants to promote cell-mediated immunity (CMI), we assessed delayed-type hypersensitivity (DTH) in mice inoculated with heat-killed Listeria...


    pub_type: 杂志文章


    authors: Baldridge JR,Ward JR

    更新日期:1997-03-01 00:00:00

  • Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI).

    abstract:BACKGROUND:Previous studies have demonstrated a correlation between Clostridium difficile anti-toxin A serum antibodies and protection against symptomatic disease and recurrence. METHODS:A neutralizing monoclonal antibody to C. difficile toxin A (CDA1) developed by MBL and Medarex, Inc. was studied in a phase II, rand...


    pub_type: 杂志文章,随机对照试验


    authors: Leav BA,Blair B,Leney M,Knauber M,Reilly C,Lowy I,Gerding DN,Kelly CP,Katchar K,Baxter R,Ambrosino D,Molrine D

    更新日期:2010-01-22 00:00:00

  • Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets.

    abstract::Codon-pair bias de-optimization (CPBD) of viruses involves re-writing viral genes using statistically underrepresented codon pairs, without any changes to the amino acid sequence or codon usage. Previously, this technology has been used to attenuate the influenza A/Puerto Rico/8/34 (H1N1) virus. The de-optimized virus...


    pub_type: 杂志文章


    authors: Broadbent AJ,Santos CP,Anafu A,Wimmer E,Mueller S,Subbarao K

    更新日期:2016-01-20 00:00:00

  • Vaccination coverage against hepatitis A and B viruses, Streptococcus pneumoniae, seasonal flu, and A(H1N1)2009 pandemic influenza in HIV-infected patients.

    abstract:BACKGROUND:Several vaccines are recommended in HIV-infected patients due to an increased risk of vaccine-preventable infections, severe forms of the disease, or shared transmission routes. Few data are available regarding vaccination coverage and its determinants in this population. METHODS:A cross-sectional study was...


    pub_type: 杂志文章


    authors: Valour F,Cotte L,Voirin N,Godinot M,Ader F,Ferry T,Vanhems P,Chidiac C

    更新日期:2014-07-31 00:00:00

  • Co-administration of IL-12 DNA with rORFF antigen confers long-term protective immunity against experimental visceral leishmaniaisis.

    abstract::Visceral leishmaniasis, caused by the intracellular parasite Leishmania donovani is a significant public health problem in many regions of the world. Anti-leishmanial immune defences are primarily dependent on the ability of the host to mount an interleukin-12 (IL-12) driven Th1 type of responses. Thus, IL-12 plays a ...


    pub_type: 杂志文章


    authors: Tewary P,Saxena S,Madhubala R

    更新日期:2006-03-20 00:00:00

  • The effect of pneumococcal conjugate vaccines on the incidence of invasive pneumococcal disease caused by ten non-vaccine serotypes in Denmark.

    abstract:BACKGROUND:Surveillance data on invasive pneumococcal disease (IPD) in Denmark (1999-2014) was analysed regarding the incidence and age-distribution due to ten selected non-PCV serotypes (10-Non-PCV). The effect of PCV-7 and PCV-13 vaccines on the 10-Non-PCV IPD incidence was examined. METHODS:IPD cases caused by sero...


    pub_type: 杂志文章


    authors: Slotved HC,Dalby T,Hoffmann S

    更新日期:2016-02-03 00:00:00

  • RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol.

    abstract::Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose. RiVax without adjuvant given intramuscularly (i.m.) protected mice against intraperitonea...


    pub_type: 杂志文章


    authors: Smallshaw JE,Richardson JA,Vitetta ES

    更新日期:2007-10-16 00:00:00

  • Vaxvec: The first web-based recombinant vaccine vector database and its data analysis.

    abstract::A recombinant vector vaccine uses an attenuated virus, bacterium, or parasite as the carrier to express a heterologous antigen(s). Many recombinant vaccine vectors and related vaccines have been developed and extensively investigated. To compare and better understand recombinant vectors and vaccines, we have generated...


    pub_type: 杂志文章


    authors: Deng S,Martin C,Patil R,Zhu F,Zhao B,Xiang Z,He Y

    更新日期:2015-11-27 00:00:00

  • Lack of immune interference between inactivated polio vaccine and inactivated rotavirus vaccine co-administered by intramuscular injection in two animal species.

    abstract::A parenteral inactivated rotavirus vaccine (IRV) in development could address three problems with current live oral rotavirus vaccines (ORV): their lower efficacy in low and middle-income countries (LMICs), lingering concerns about their association with intussusception, and their requirement for a separate supply cha...


    pub_type: 杂志文章


    authors: Wang Y,Zade J,Moon SS,Weldon W,Pisal SS,Glass RI,Dhere RM,Jiang B

    更新日期:2019-01-29 00:00:00

  • Immunological and physical evaluation of the multistage tuberculosis subunit vaccine candidate H56/CAF01 formulated as a spray-dried powder.

    abstract::Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain facilities. This is advantageous for mass...


    pub_type: 杂志文章


    authors: Thakur A,Ingvarsson PT,Schmidt ST,Rose F,Andersen P,Christensen D,Foged C

    更新日期:2018-05-31 00:00:00

  • Phase I/II studies to evaluate safety and immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy adults.

    abstract::Two double-blind randomised controlled studies (phase I and I/II) were performed to assess for the first time the safety and immunogenicity of a recombinant subunit gp350 Epstein-Barr virus (EBV) vaccine in 148 healthy adult volunteers. All candidate vaccine formulations had a good safety profile and were well tolerat...


    pub_type: 杂志文章,随机对照试验


    authors: Moutschen M,Léonard P,Sokal EM,Smets F,Haumont M,Mazzu P,Bollen A,Denamur F,Peeters P,Dubin G,Denis M

    更新日期:2007-06-11 00:00:00

  • In vitro evaluation of human hybrid cell lines generated by fusion of B-lymphoblastoid cells and ex vivo tumour cells as candidate vaccines for haematological malignancies.

    abstract::Fusions of dendritic cells (DCs) and tumour cells have been shown to induce protective immunity to tumour challenge in animal models, and to represent a promising approach to cancer immunotherapy. The broader clinical application of this approach, however, is potentially constrained by the lack of replicative capacity...


    pub_type: 杂志文章


    authors: Mohamed YS,Dunnion D,Teobald I,Walewska R,Browning MJ

    更新日期:2012-10-12 00:00:00

  • Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model.

    abstract::Preclinical vaccine efficacy studies are generally limited to certain read out parameters such as assessment of virus titers in swabs and organs, clinical signs, serum antibody titers, and pathological changes. These parameters are not always routinely applied and not always scheduled in a logical standardized way. We...


    pub_type: 杂志文章


    authors: Veldhuis Kroeze EJ,Stittelaar KJ,Teeuwsen VJ,Dijkshoorn ML,van Amerongen G,de Waal L,Kuiken T,Krestin GP,Hinkula J,Osterhaus AD

    更新日期:2012-12-07 00:00:00

  • Two decades of hepatitis B vaccination in mentally retarded patients: effectiveness, antibody persistence and duration of immune memory.

    abstract:INTRODUCTION:Institutionalized mentally retarded subjects are well-known to be at-risk for HBV infection. We studied the persistence of vaccine-induced anti-HBs antibodies and the robustness of the HBsAg-specific immune memory in this population, 18-20 years after the first vaccine dose. MATERIALS AND METHODS:Non-immu...


    pub_type: 杂志文章


    authors: Braeckman T,Van Herck K,Jilg W,Bauer T,Van Damme P

    更新日期:2012-07-06 00:00:00

  • Rubella susceptibility in pregnant women and results of a postpartum immunization strategy in Catalonia, Spain.

    abstract:BACKGROUND:Elimination of congenital rubella syndrome depends not only on effective childhood immunization but also on the identification and immunization of rubella susceptible women. We assessed rubella susceptibility among pregnant women and evaluated the adherence and response to postpartum immunization with measle...


    pub_type: 杂志文章


    authors: Vilajeliu A,García-Basteiro AL,Valencia S,Barreales S,Oliveras L,Calvente V,Goncé A,Bayas JM

    更新日期:2015-04-08 00:00:00

  • Biodistribution and lymph node retention of polysaccharide-based immunostimulating nanocapsules.

    abstract::The adjuvant properties of polyglucosamine/squalene-based nanocapsules (PG-nanocapsules) associated with different subunit antigens has been previously reported. Thus, the aim of the present study was to monitor the biodistribution of PG-nanocapsules and their affinity for the draining lymph nodes after subcutaneous (...


    pub_type: 杂志文章


    authors: Vicente S,Goins BA,Sanchez A,Alonso MJ,Phillips WT

    更新日期:2014-03-26 00:00:00

  • Characterization of West Nile virus live vaccine candidates attenuated by capsid deletion mutations.

    abstract::Protein C deletion mutants of West Nile virus (WNV) were evaluated for their potential use as live virus vaccine candidates in vivo. Double and triple mutants carrying small deletions and second-site point mutations, as well as mutants with large deletions of 36 and 37 amino acid residues were tested in a stringent mo...


    pub_type: 杂志文章


    authors: Schlick P,Kofler RM,Schittl B,Taucher C,Nagy E,Meinke A,Mandl CW

    更新日期:2010-08-16 00:00:00

  • Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV.

    abstract::Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prev...


    pub_type: 杂志文章,评审


    authors: Ferrantelli F,Rasmussen RA,Hofmann-Lehmann R,Xu W,McClure HM,Ruprecht RM

    更新日期:2002-12-19 00:00:00

  • Salmonella Enteritidis ghost vaccine carrying the hemagglutinin globular head (HA1) domain from H1N1 virus protects against salmonellosis and influenza in chickens.

    abstract::This study evaluated the attenuated Salmonella Enteritidis (SE) ghost strain JOL2114 (Δlon ΔcpxR Δasd), which displays on the bacterial surface the H1N1 hemagglutinin globular head portion (HA1; amino acid residues 63-286) on the bacterial surface for protective efficacy against Salmonella and H1N1 challenge in the ch...


    pub_type: 杂志文章


    authors: Won G,Senevirathne A,Lee JH

    更新日期:2020-06-09 00:00:00

  • Effects of Taishan Pinus massoniana pollen polysaccharide on immune response of rabbit haemorrhagic disease tissue inactivated vaccine and on production performance of Rex rabbits.

    abstract::Varied doses of Taishan Pinus massoniana pollen polysaccharide (TPPPS) and Astragalus polysaccharide (APS) extracted by hot water extraction and ethanol precipitation method were added to the vaccine in order to prepare polysaccharide-rabbit haemorrhagic disease (RHD) tissue inactivated vaccine. The purpose was to stu...


    pub_type: 杂志文章


    authors: Wei K,Sun Z,Yan Z,Tan Y,Wang H,Zhu X,Wang X,Sheng P,Zhu R

    更新日期:2011-03-21 00:00:00

  • Induction of mucosal immunity with a replication-defective adenoviral recombinant.

    abstract::A replication-defective adenoviral recombinant expressing the rabies virus glycoprotein was tested for induction of transgene specific central and mucosal antibodies upon systemic inoculation or upon application to the mucosa of the airways, the rectum or the female genital tract. Mice developed serum and mucosal anti...


    pub_type: 杂志文章


    authors: Xiang Z,Ertl HC

    更新日期:1999-04-09 00:00:00

  • The science of vaccine safety: Summary of meeting at Wellcome Trust.

    abstract::Vaccines are everywhere hugely successful but are also under attack. The reason for the latter is the perception by some people that vaccines are unsafe. However that may be, vaccine safety, life any other scientific subject, must be constantly studied. It was from this point of view that a meeting was organized at th...


    pub_type: 杂志文章


    authors: Plotkin SA,Offit PA,DeStefano F,Larson HJ,Arora NK,Zuber PLF,Fombonne E,Sejvar J,Lambert PH,Hviid A,Halsey N,Garçon N,Peden K,Pollard AJ,Markowitz LE,Glanz J

    更新日期:2020-02-18 00:00:00

  • Immunogenicity and safety of the inactivated Japanese encephalitis vaccine IXIARO® in elderly subjects: Open-label, uncontrolled, multi-center, phase 4 study.

    abstract:BACKGROUND:IXIARO® is a Vero cell-derived, inactivated Japanese encephalitis (JE) vaccine licensed mainly in western countries for children and adults traveling to JE endemic areas. Limited immunogenicity and safety data in elderly travelers have been available. OBJECTIVES:To evaluate safety and immunogenicity of IXIA...


    pub_type: 杂志文章,多中心研究


    authors: Cramer JP,Dubischar K,Eder S,Burchard GD,Jelinek T,Jilma B,Kollaritsch H,Reisinger E,Westritschnig K

    更新日期:2016-08-31 00:00:00

  • Repeated dose intramuscular injection of the CIMAvax-EGF vaccine in Sprague Dawley rats induces local and systemic toxicity.

    abstract::CIMAvax-EGF consists of a human recombinant epidermal growth factor (EGF), coupled to P64k, a recombinant carrier protein from N. meningitis, and Montanide ISA 51 as adjuvant. The vaccine immunization induces a specific antibody production, inhibiting the EGF/EGF-R interaction through EGF deprivation. The objective of...


    pub_type: 杂志文章


    authors: Mancebo A,Casacó A,González B,Ledón N,Sorlozabal J,León A,Gómez D,González Y,Bada AM,González C,Arteaga ME,Ramírez H,Fuentes D

    更新日期:2012-05-09 00:00:00

  • Acceptability of an inactivated influenza vaccine delivered by microneedle patch: Results from a phase I clinical trial of safety, reactogenicity, and immunogenicity.

    abstract:OBJECTIVE:This study sought to evaluate the acceptability of inactivated influenza vaccine delivered by microneedle patch (MNP) in comparison to inactivated influenza vaccine (IIV) delivered by hypodermic needle. DESIGN, SETTING, AND PARTICIPANTS:From the general population of Atlanta, Georgia, we screened 112 and enr...


    pub_type: 杂志文章


    authors: Frew PM,Paine MB,Rouphael N,Schamel J,Chung Y,Mulligan MJ,Prausnitz MR

    更新日期:2020-10-21 00:00:00