Abstract：
:The safety and immunogenicity of two PorA-based meningococcal outer membrane vesicle (OMV) vaccines against the P1.4 serosubtype adsorbed with AlPO(4) or Al(OH)(3) were studied in 134 toddlers. Vaccinations were given three times with an interval of 3-6 weeks or twice with an interval of 6-10 weeks. A vaccination was repeated after 20-40 weeks. Pre- and post-immunization sera were tested for bactericidal activity against an isogenic strain expressing P1.7(h), 4 PorA. Both meningococcal OMV vaccines were well tolerated. The percentage of children with a fourfold increase in bactericidal activity was 96% (AlPO(4)-adjuvated vaccine/2+1 schedule), 100% (AlPO(4)-adjuvated vaccine/3+1 schedule), 93% (Al(OH)(3)-adjuvated vaccine/2+1 schedule) and 97% (Al(OH)(3)-adjuvated vaccine/3+1 schedule). Adsorption with AlPO(4) makes the OMV vaccine more immunogenic than adsorption with Al(OH)(3). Bactericidal activity was highest after the 3+1 schedule, although the response shortly after the primary series was higher in the two-dose priming group.
journal_name
Vaccinejournal_title
Vaccineauthors
de Kleijn ED,de Groot R,Lafeber AB,Labadie J,van Limpt KC,Visser J,Berbers GA,van Alphen L,Rümke HCdoi
10.1016/s0264-410x(00)00320-0subject
Has Abstractpub_date
2000-12-08 00:00:00pages
1141-8issue
9-10eissn
0264-410Xissn
1873-2518pii
S0264-410X(00)00320-0journal_volume
19pub_type
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