Inclusion of the value of herd immunity in economic evaluations of vaccines. A systematic review of methods used.


OBJECTIVE:The objectives of this review were to identify vaccine economic evaluations that include herd immunity and describe the methodological approaches used. METHODS:We used Kim and Goldie's search strategy from a systematic review (1976-2007) of modelling approaches used in vaccine economic evaluations and additionally searched PubMed/MEDLINE and Embase for 2007-2015. Studies were classified according to modelling approach used. Methods for estimating herd immunity effects were described, in particular for the static models. RESULTS:We identified 625 economic evaluations of vaccines against human-transmissible diseases from 1976 to 2015. Of these, 172 (28%) included herd immunity. While 4% of studies included herd immunity in 2001, 53% of those published in 2015 did this. Pneumococcal, human papilloma and rotavirus vaccines represented the majority of studies (63%) considering herd immunity. Ninety-five of the 172 studies utilised a static model, 59 applied a dynamic model, eight a hybrid model and ten did not clearly state which method was used. Relatively crude methods and assumptions were used in the majority of the static model studies. CONCLUSION:The proportion of economic evaluations using a dynamic model has increased in recent years. However, 55% of the included studies used a static model for estimating herd immunity. Values from a static model can only be considered reliable if high quality surveillance data are incorporated into the analysis. Without this, the results are questionable and they should only be included in sensitivity analysis.






Nymark LS,Sharma T,Miller A,Enemark U,Griffiths UK




Has Abstract


2017-12-14 00:00:00




49 Pt B












  • Salmonella Typhimurium lacking the Znuabc transporter is attenuated and immunogenic in pigs.

    abstract::Meat contamination by Salmonella spp. is emerging as a major cause of human enteric infections in industrialized countries. The attempts to reduce human cases of salmonellosis encompass pre- and post-harvest interventions. In this context, vaccination of pigs may represent an effective instrument in eliminating/reduci...


    pub_type: 杂志文章


    authors: Pesciaroli M,Gradassi M,Martinelli N,Ruggeri J,Pistoia C,Raffatellu M,Magistrali CF,Battistoni A,Pasquali P,Alborali GL

    更新日期:2013-06-12 00:00:00

  • United States of America Department of Health and Human Services support for advancing influenza vaccine manufacturing in the developing world.

    abstract::Since 2005, the Government of the United States of America has provided more than US$ 50 million to advance influenza vaccine development in low-resourced countries. This programme has provided a unique opportunity for the US Government to develop a comprehensive view of, and to understand better the challenges and fu...


    pub_type: 杂志文章,评审


    authors: Perdue ML,Bright RA

    更新日期:2011-07-01 00:00:00

  • Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor.

    abstract::It is of great interest to develop a pneumonic plague vaccine that would induce combined humoral and cellular immunity in the lung. Here we investigate a novel approach based on targeting of dendritic cells using the DEC-205/CD205 receptor (DEC) via the intranasal route as way to improve mucosal cellular immunity to t...


    pub_type: 杂志文章


    authors: Do Y,Didierlaurent AM,Ryu S,Koh H,Park CG,Park S,Perlin DS,Powell BS,Steinman RM

    更新日期:2012-10-05 00:00:00

  • Convening on the influenza human viral challenge model for universal influenza vaccines, Part 2: Methodologic considerations.

    abstract::In response to global interest in the development of a universal influenza vaccine, the Bill & Melinda Gates Foundation, PATH, and the Global Funders Consortium for Universal Influenza Vaccine Development convened a meeting of experts (London, UK, May 2018) to assess the role of a standardized controlled human influen...


    pub_type: 杂志文章


    authors: Innis BL,Scorza FB,Blum JS,Jain VK,Aguilar AO,Post DJ,Roberts PC,Wairagkar N,White J,Bresee J

    更新日期:2019-08-14 00:00:00

  • Estimates of the effectiveness of a whole-cell pertussis vaccine from an outbreak in an immunized population.

    abstract::Pertussis has re-emerged as a public health problem in Canada in recent years, emphasizing concerns about the effectiveness of the currently licensed whole-cell vaccine. Following a 1994 outbreak in Nova Scotia, we conducted a case-control study of 483 children aged < 10 years to assess vaccine effectiveness. Ninety-t...


    pub_type: 杂志文章


    authors: Bentsi-Enchill AD,Halperin SA,Scott J,MacIsaac K,Duclos P

    更新日期:1997-02-01 00:00:00

  • Comparative incidence dynamics and serotypes of meningitis, bacteremic pneumonia and other-IPD in young children in the PCV era: Insights from Israeli surveillance studies.

    abstract:INTRODUCTION:Widespread introduction of pneumococcal conjugated vaccines (PCVs) impacted on invasive pneumococcal disease (IPD). However, IPD reduction may not be similar in all outcomes within IPD. We assessed PCV7/PCV13 impact on pneumococcal meningitis, bacteremic pneumonia (BP) and other (non-meningitis, non-pneumo...


    pub_type: 杂志文章


    authors: Ben-Shimol S,Givon-Lavi N,Grisaru-Soen G,Megged O,Greenberg D,Dagan R,Israel Bacteremia and Meningitis Active Surveillance Group.

    更新日期:2018-08-28 00:00:00

  • Accelerated and long term stability study of Pfs25-EPA conjugates adjuvanted with Alhydrogel®.

    abstract::Pfs25, a Plasmodium falciparum surface protein expressed during zygote and ookinete stages in infected mosquitoes, is a lead transmission-blocking vaccine candidate against falciparum malaria. To enhance immunogenicity, recombinant Pfs25 was chemically conjugated to recombinant nontoxic Pseudomonas aeruginosa ExoProte...


    pub_type: 杂志文章


    authors: Zhu D,Wu Y,McClellan H,Dai W,Rausch K,Jones D,Aebig J,Barnafo E,Butler B,Lambert L,Narum DL,Duffy PE

    更新日期:2017-05-31 00:00:00

  • Comparing pneumococcal conjugate vaccine schedules based on 3 and 2 primary doses: systematic review and meta-analysis.

    abstract:BACKGROUND:Pneumococcal conjugate vaccines (PCV) were first licensed for use with 3 primary doses in infancy and a booster dose. The evidence for the effects of different schedules was examined in this systematic review and meta-analysis. METHODS:We searched 12 databases and trial registers up to March 2010. We select...


    pub_type: 杂志文章,meta分析,评审


    authors: Scott P,Rutjes AW,Bermetz L,Robert N,Scott S,Lourenço T,Egger M,Low N

    更新日期:2011-12-06 00:00:00

  • The virulence-related rhoptry protein 5 (ROP5) of Toxoplasma Gondii is a novel vaccine candidate against toxoplasmosis in mice.

    abstract::Infections with the intracellular protozoan parasite Toxoplasma gondii pose a serious public health problem and are of great economic importance worldwide. The parasite rhoptry protein 5 (ROP5) has been implicated as a major virulence factor that reduces the accumulation of immunity-related GTPases (IRG) in parasitoph...


    pub_type: 杂志文章


    authors: Zheng B,Lu S,Tong Q,Kong Q,Lou D

    更新日期:2013-09-23 00:00:00

  • Review of vaccine hesitancy: Rationale, remit and methods.

    abstract::Despite a wide array of safe and effective vaccines in use globally, with major impacts on health worldwide, the WHO Strategic Advisory Group of Experts (SAGE) on Immunization has been repeatedly confronted with reports of hesitancy towards accepting specific vaccines or vaccination programmes. This paper summarizes t...


    pub_type: 杂志文章,评审


    authors: Schuster M,Eskola J,Duclos P,SAGE Working Group on Vaccine Hesitancy.

    更新日期:2015-08-14 00:00:00

  • Recombinant DNA hepatitis B vaccine containing Pre-S components of the HBV coat protein--a preliminary study on immunogenicity.

    abstract::A novel recombinant hepatitis B vaccine, trademarked Sci-B-Vac, was evaluated for safety, tolerability and immunogenicity in an open label trial performed in Singapore. The experimental vaccine, derived from Chinese hamster ovary (CHO) cells, consists of hepatitis B surface antigen (HBsAg) particles harbouring all thr...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yap I,Guan R,Chan SH

    更新日期:1992-01-01 00:00:00

  • Estimated protective effectiveness of intramuscular immune serum globulin post-exposure prophylaxis during a measles outbreak in British Columbia, Canada, 2014.

    abstract:INTRODUCTION:Intramuscular Immune Serum Globulin (IM ISG) is recommended as post-measles exposure prophylaxis (PEP) when administered within 6days of initial exposure, with variable effectiveness in preventing measles disease. Effectiveness of IM ISG PEP in preventing clinical measles was assessed during a 2014 measles...


    pub_type: 杂志文章


    authors: Bigham M,Murti M,Fung C,Hemming F,Loadman S,Stam R,Van Buynder P,Lem M

    更新日期:2017-05-09 00:00:00

  • Detecting AIDS restriction genes: from candidate genes to genome-wide association discovery.

    abstract::The screening of common genetic polymorphisms among candidate genes for AIDS pathology in HIV exposed cohort populations has led to the description of 20 AIDS restriction genes (ARGs), variants that affect susceptibility to HIV infection or to AIDS progression. The combination of high-throughput genotyping platforms a...


    pub_type: 杂志文章


    authors: Hutcheson HB,Lautenberger JA,Nelson GW,Pontius JU,Kessing BD,Winkler CA,Smith MW,Johnson R,Stephens R,Phair J,Goedert JJ,Donfield S,O'Brien SJ

    更新日期:2008-06-06 00:00:00

  • Assessment of neutralization of Micrurus venoms with a blend of anti-Micrurus tener and anti-ScNtx antibodies.

    abstract:BACKGROUND:Micrurus venoms contain two main groups of toxic protein components: short-chain α-neurotoxins (SNtx) and phospholipases type A2 (PLA2). In North America, generally, the Micrurus venoms have low abundance of SNtx compared to that of PLA2s; however, both are highly toxic to mammals, and consequently both can ...


    pub_type: 杂志文章


    authors: Archundia IG,de la Rosa G,Olvera F,Calderón A,Benard-Valle M,Alagón A,Corzo G

    更新日期:2021-02-05 00:00:00

  • Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant.

    abstract::Aluminium-containing adjuvants are often used to enhance the potency of vaccines. In the present work we studied whether adsorption of diphtheria toxoid to colloidal aluminium hydroxide induces conformational changes of the antigen. Diphtheria toxoid has a high affinity for the aluminium hydroxide particles based on a...


    pub_type: 杂志文章


    authors: Régnier M,Metz B,Tilstra W,Hendriksen C,Jiskoot W,Norde W,Kersten G

    更新日期:2012-11-06 00:00:00

  • Towards improved process efficiency in vaccine innovation: The Vaccine Innovation Cycle as a validated, conceptual stage-gate model.

    abstract::Continuing investments in vaccine innovation are insufficiently translated into market entries of novel vaccines. This innovation paradox is in part caused by stakeholders lacking complete understanding of the complex array of steps necessary for vaccine development and collaboration difficulties between the wide vari...


    pub_type: 杂志文章


    authors: Van de Burgwal LHM,Ribeiro CDS,Van der Waal MB,Claassen E

    更新日期:2018-11-26 00:00:00

  • Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells.

    abstract::We compared the effects of yeast-treated human dendritic cells (DCs) with CD40L-matured human DCs for the induction of effector cells and the number and functionality of CD4(+)CD25(+)CD127(-)FoxP3(+) regulatory T cells (Tregs). DCs were treated with yeast or CD40L and cocultured with isolated autologous CD4(+) T cells...


    pub_type: 杂志文章


    authors: Cereda V,Vergati M,Huen NY,di Bari MG,Jochems C,Intrivici C,Gulley JL,Apelian D,Schlom J,Tsang KY

    更新日期:2011-07-12 00:00:00

  • The science of vaccine safety: Summary of meeting at Wellcome Trust.

    abstract::Vaccines are everywhere hugely successful but are also under attack. The reason for the latter is the perception by some people that vaccines are unsafe. However that may be, vaccine safety, life any other scientific subject, must be constantly studied. It was from this point of view that a meeting was organized at th...


    pub_type: 杂志文章


    authors: Plotkin SA,Offit PA,DeStefano F,Larson HJ,Arora NK,Zuber PLF,Fombonne E,Sejvar J,Lambert PH,Hviid A,Halsey N,Garçon N,Peden K,Pollard AJ,Markowitz LE,Glanz J

    更新日期:2020-02-18 00:00:00

  • Chitosan alters inactivated respiratory syncytial virus vaccine elicited immune responses without affecting lung histopathology in mice.

    abstract::Chitosan is a polysaccharide capable of augmenting immune responses with a proven safety record in animals and humans. These properties make it a potentially attractive agent for the prevention and treatment of infectious disease. Infection by respiratory syncytial virus (RSV) is the leading cause of serious lower res...


    pub_type: 杂志文章


    authors: Muralidharan A,Russell MS,Larocque L,Gravel C,Sauvé S,Chen Z,Li C,Chen W,Cyr T,Rosu-Myles M,Wang L,Li X

    更新日期:2019-07-09 00:00:00

  • A systematic review of national immunization policy making processes.

    abstract::This systematic review aimed to collect and synthesize information available on immunization policy making processes in countries across the globe. Twenty-nine published articles and five websites in either English or French provided varied information on the immunization policy making processes in 33 countries. The i...


    pub_type: 杂志文章,评审


    authors: Bryson M,Duclos P,Jolly A,Bryson J

    更新日期:2010-04-19 00:00:00

  • Four year immunogenicity of the RTS,S/AS02(A) malaria vaccine in Mozambican children during a phase IIb trial.

    abstract::Previous studies with the malaria vaccine RTS,S/AS02(A) in young children in a malaria endemic area of Mozambique have shown it to have a promising safety profile and to reduce the risk of Plasmodium falciparum infection and disease. In this study, we assessed the antibody responses to the P. falciparum and hepatitis ...


    pub_type: 杂志文章,随机对照试验


    authors: Aide P,Dobaño C,Sacarlal J,Aponte JJ,Mandomando I,Guinovart C,Bassat Q,Renom M,Puyol L,Macete E,Herreros E,Leach A,Dubois MC,Demoitie MA,Lievens M,Vekemans J,Loucq C,Ballou WR,Cohen J,Alonso PL

    更新日期:2011-08-11 00:00:00

  • Immunogenicity, safety and reactogenicity of the pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in 2-17-year-old children with asplenia or splenic dysfunction: A phase 3 study.

    abstract:BACKGROUND:Immunization with pneumococcal vaccines is an important prophylactic strategy for children with asplenia or splenic dysfunction, who are at high risk of bacterial infections (including S. pneumoniae). This study aimed to assess immunogenicity and safety of pneumococcal non-typeable Haemophilus influenzae pro...


    pub_type: 杂志文章,多中心研究


    authors: Szenborn L,Osipova IV,Czajka H,Kharit SM,Jackowska T,François N,Habib MA,Borys D

    更新日期:2017-09-25 00:00:00

  • Immunisation status in the public care system: a comparative study.

    abstract::Children in public care have poor health outcomes despite statutory health assessments. Incomplete immunisation of children entering the care system has been reported. Does this health disadvantage persist for those established in the care system? The immunisation status of 119 children in public care for at least 6 m...


    pub_type: 杂志文章


    authors: Barnes P,Price L,Maddocks A,Cheung WY,Williams J,Jackson S,Mason B

    更新日期:2005-04-15 00:00:00

  • Comparison of measles virus-specific antibody titres as measured by enzyme-linked immunosorbent assay and virus neutralisation assay.

    abstract::We assessed whether measles virus-specific antibody levels in the Dutch population as estimated by an enzyme-linked immunosorbent assay (ELISA) were comparable with estimates by virus neutralisation assay (NT), prompted by a relatively low ELISA seroprevalence in the 10-21-year-old group. We tested 791 sera from indiv...


    pub_type: 杂志文章


    authors: van den Hof S,van Gageldonk-Lafeber AB,van Binnendijk RS,van Gageldonk PG,Berbers GA

    更新日期:2003-10-01 00:00:00

  • Attitudes and perceptions of private pediatricians regarding polio immunization in India.

    abstract:BACKGROUND:India has faced considerable challenges in eradicating polio. Uttar Pradesh (UP) and Bihar are the two states in India where transmission of polio has never been interrupted. Private pediatricians are important stakeholders for vaccine delivery and maintaining public confidence in vaccines. The purpose of th...


    pub_type: 杂志文章


    authors: Choudhury P,Thacker N,Gargano LM,Weiss PS,Vashishtha VM,Amladi T,Pazol K,Orenstein WA,Omer SB,Hughes JM

    更新日期:2011-10-26 00:00:00

  • No evidence for priming response in Galleria mellonella larvae exposed to toxin protein PirA2B2 from Photorhabdus luminescens TT01: An association with the inhibition of the host cellular immunity.

    abstract::There is accumulating evidence that many invertebrates including insects can acquire enhanced immune protection against subsequently pathogens infection through immune priming. However, whether the toxin protein from pathogenic bacteria can induce such priming response remains unclear. Here we cloned, expressed and pu...


    pub_type: 杂志文章


    authors: Wu G,Yi Y,Sun J,Li M,Qiu L

    更新日期:2015-11-17 00:00:00

  • The epidemiology of hepatitis B virus infection in HIV-infected and HIV-uninfected pregnant women in the Western Cape, South Africa.

    abstract:OBJECTIVES:Persistent hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in sub-Saharan Africa. The HIV epidemic has the potential to affect its biology. Immunisation protocols established in the pre-HIV era are based upon data showing predominantly horizontal infant transmission. This study ...


    pub_type: 杂志文章


    authors: Andersson MI,Maponga TG,Ijaz S,Barnes J,Theron GB,Meredith SA,Preiser W,Tedder RS

    更新日期:2013-11-12 00:00:00

  • Formalin-inactivated bovine RSV vaccine enhances a Th2 mediated immune response in infected cattle.

    abstract::Safe RSV vaccine development has challenged the medical community since a formalin-killed RSV vaccine caused disease exacerbation in the 1960s. Disease was replicated using the bovine RSV system in one of two studies. The studies differed in viral protein dose and length of time between vaccination and infection. Dise...


    pub_type: 杂志文章


    authors: Kalina WV,Woolums AR,Berghaus RD,Gershwin LJ

    更新日期:2004-03-29 00:00:00

  • Influenza vaccine effectiveness in preventing influenza-associated intensive care admissions and attenuating severe disease among adults in New Zealand 2012-2015.

    abstract:BACKGROUND:Little is known about inactivated influenza vaccine effectiveness (IVE) in preventing very severe disease, including influenza-associated intensive care unit (ICU) admissions. METHODS:The Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) project enrolled adults (age...


    pub_type: 杂志文章


    authors: Thompson MG,Pierse N,Sue Huang Q,Prasad N,Duque J,Claire Newbern E,Baker MG,Turner N,McArthur C,SHIVERS investigation team.

    更新日期:2018-09-18 00:00:00

  • Size determination of bacterial capsular oligosaccharides used to prepare conjugate vaccines.

    abstract::We recently described the use of ion exchange chromatography for analysis and the industrial scale preparation of pools of oligosaccharides of intermediate chain length from polysaccharides of Haemophilus influenzae type b (Hib) and Neisseria meningitidis groups A and C. These negatively charged "sized" oligosaccharid...


    pub_type: 杂志文章


    authors: Ravenscroft N,Averani G,Bartoloni A,Berti S,Bigio M,Carinci V,Costantino P,D'Ascenzi S,Giannozzi A,Norelli F,Pennatini C,Proietti D,Ceccarini C,Cescutti P

    更新日期:1999-07-16 00:00:00