Abstract:
:The study evaluated the immunogenicity and efficacy of a trivalent subunit MF59-adjuvanted influenza vaccine (A/Wisconsin/67/05 (H3N2), A/Solomon Islands/3/06 (H1N1) and B/Malaysia/2506/04) in preventing serologically diagnosed infections in a group of 67 institutionalized elderly volunteers during 2007/2008 winter, characterized by co-circulation of drifted A/H3N2, A/H1N1 and B influenza viruses. Influenza vaccination induced a significant increase in the amounts of hemagglutination inhibiting antibodies, both against the vaccine and the epidemic drifted strains. However, vaccination did not prevent the circulation of the new drifted influenza B virus (B/Florida/4/06-like), belonging to the B/Yamagata/16/88-lineage, antigenically and genetically distinct from B/Victoria/2/87-lineage viruses from which the vaccine B strain was derived.
journal_name
Vaccinejournal_title
Vaccineauthors
Camilloni B,Neri M,Lepri E,Basileo M,Sigismondi N,Puzelli S,Donatelli I,Iorio AMdoi
10.1016/j.vaccine.2010.08.064subject
Has Abstractpub_date
2010-11-03 00:00:00pages
7536-41issue
47eissn
0264-410Xissn
1873-2518pii
S0264-410X(10)01221-1journal_volume
28pub_type
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