Immune responses in mice induced by prime-boost schemes of the Plasmodium falciparum apical membrane antigen 1 (PfAMA1)-based DNA, protein and recombinant modified vaccinia Ankara vaccines.

abstract：:One hundred and eight primary school students who had been vaccinated with three doses of a plasma-derived hepatitis B vaccine were randomly divided into two groups, to receive a booster dose of either the same vaccine or of a recombinant yeast-derived vaccine. The pre-booster anti-hepatitis B surface antigen (HBs) ge...

journal_title：Vaccine

authors： Chan CY,Lee SD,Tsai YT,Lo KJ

更新日期：1991-10-01 00:00:00

abstract：:In future, a policy of "vaccinate-to-live" may be included in the repertoire of foot-and-mouth disease (FMD) control measures and in support of this approach, we have investigated the hypothesis that vaccine-induced reduction in virus replication and excretion from pigs can be correlated to the severity of clinical si...

journal_title：Vaccine

authors： Parida S,Fleming L,Oh Y,Mahapatra M,Hamblin P,Gloster J,Doel C,Gubbins S,Paton DJ

更新日期：2007-11-07 00:00:00

abstract：:The gene encoding for a major surface glycoprotein, gp63, of Leishmania major was cloned into the eukaryotic expression plasmid pCDNAI with CMV or RSV promoters. The highly susceptible Balb/c mice were injected intramuscularly with 100 micrograms/mouse of the purified plasmid. The plasmids were found to be stable in v...

journal_title：Vaccine

authors： Xu D,Liew FY

更新日期：1994-12-01 00:00:00

abstract：:We report on 30 in-depth mental models interviews with parents discussing vaccination for their children, both in general terms and in response to communications drawn from sources supporting and opposing vaccines. We found that even parents favourable to vaccination can be confused by the ongoing debate, leading them...

journal_title：Vaccine

authors： Downs JS,de Bruin WB,Fischhoff B

更新日期：2008-03-17 00:00:00

abstract：:Former investigations demonstrated that the envelope glycoprotein E2 could protect pigs from classical swine fever virus (CSFV). Based on these findings, we prepared synthetic peptide vaccine using E2 N-terminal antigenic units B/C and hoped to induce protective activity against lethal challenge of virulent CSFV strai...

journal_title：Vaccine

authors： Dong XN,Wei K,Liu ZQ,Chen YH

更新日期：2002-12-13 00:00:00

abstract：:Mathematical models provide valuable insights into the public health and economic impact of cervical cancer vaccination programmes. An in-depth economic analysis should explore the effects of different vaccine-related factors and vaccination scenarios (independent of screening practices) on health benefits and costs. ...

journal_title：Vaccine

authors： Suárez E,Smith JS,Bosch FX,Nieminen P,Chen CJ,Torvinen S,Demarteau N,Standaert B

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:To better understand how to prevent and respond to pneumococcal meningitis outbreaks in the meningitis belt, we retrospectively examined Burkina Faso's case-based meningitis surveillance data for pneumococcal meningitis clusters and assessed potential usefulness of response strategies. METHODS:Demographic a...

journal_title：Vaccine

authors： Soeters HM,Kambiré D,Sawadogo G,Ouédraogo-Traoré R,Bicaba B,Medah I,Sangaré L,Ouédraogo AS,Ouangraoua S,Yaméogo I,Congo-Ouédraogo M,Ky Ba A,Aké F,Velusamy S,McGee L,Van Beneden C,Whitney CG

更新日期：2020-07-31 00:00:00

abstract：:Currently, commercial porcine rotavirus vaccines remain varied limitations. The objective of this study is to develop an alternative porcine rotavirus subunit vaccine candidate by parenteral administration, which enables to elicit robust immune responses against most prevalence porcine rotavirus strains. The bacterial...

journal_title：Vaccine

authors： Wen X,Wei X,Ran X,Ni H,Cao S,Zhang Y

更新日期：2015-08-26 00:00:00

abstract：:T-lymphocyte responses to influenza vaccination were measured in healthy young and older adult volunteers. All participants were vaccinated with the 1995-96 trivalent influenza vaccine. Cytokine and granzyme B levels were measured in peripheral blood mononuclear cells (PBMC) cultures after virus stimulation, prior to ...

journal_title：Vaccine

authors： McElhaney JE,Upshaw CM,Hooton JW,Lechelt KE,Meneilly GS

更新日期：1998-11-01 00:00:00

abstract：:The worldwide HIV-1 vaccine research endeavor is focused increasingly on subtype C, which is now the predominant strain of the present HIV/AIDS epidemic. Expression cassettes of HIV-1 subtype C gag, pol and versions of gagpol fusion cassettes were constructed and evaluated for their relative abilities to induce cellul...

journal_title：Vaccine

authors： Megede JZ,Otten GR,Doe B,Liu H,Srivastava R,Greer C,Legg H,Tang T,Polo JM,Donnelly JJ,Ulmer JB,Barnett SW

更新日期：2006-04-05 00:00:00

abstract：:The aim of this study was to characterize the adverse events of attenuated measles vaccine in mainland China. We carried out prospective follow-up of adverse events after mass measles immunization practices, categorizing them into two groups: allergic reactions and serious adverse events. The incidence of anaphylaxis ...

journal_title：Vaccine

authors： Shu M,Liu Q,Wang J,Ao R,Yang C,Fang G,Wan C,Guo W

更新日期：2011-04-18 00:00:00

abstract：:A recombinant ricin vaccine from E. coli (RVEc™), was developed at the US Army Medical Research Institute of Infectious Diseases (USAMRIID) and assessed in an FDA sponsored Phase 1a clinical trial. At the maximum dosage, two of the study participants developed physiological responses that were elevated to the level of...

journal_title：Vaccine

authors： Montgomery VA,Lindsey CY,Smith LA,Webb RP

更新日期：2021-01-15 00:00:00

abstract：:Bacterial infectious diseases remain the single most important threat to health worldwide. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed to provide efficacious solutions against many others. The advent of whole-genome sequencing changed the ...

journal_title：Vaccine

authors： Serruto D,Serino L,Masignani V,Pizza M

更新日期：2009-05-26 00:00:00

abstract：:The global health community is beginning to gain an understanding of the global burden of norovirus-associated disease, which appears to have significant burden in both developed- and developing-country populations. Of particular importance is the growing recognition of norovirus as a leading cause of gastroenteritis ...

journal_title：Vaccine

authors： Riddle MS,Walker RI

更新日期：2016-06-03 00:00:00

abstract：:We investigated whether pre-existing adenovirus-specific immunity influenced the development of immunity to a foreign antigen expressed by recombinant adenovirus. Active adenovirus-specific immunity was induced in cotton rats by i.n. administration of wild type human adenovirus type 5 (HAd5) two weeks before immunisat...

journal_title：Vaccine

authors： Papp Z,Babiuk LA,Baca-Estrada ME

更新日期：1999-02-26 00:00:00

abstract：:The use of viral vectors in heterologous prime-boost regimens to induce potent T cell responses in addition to humoral immunity is a promising vaccination strategy in the fight against malaria. We conducted an open-label, first-in-human, controlled Phase I study evaluating the safety and immunogenicity of Matrix-M adj...

journal_title：Vaccine

authors： Venkatraman N,Anagnostou N,Bliss C,Bowyer G,Wright D,Lövgren-Bengtsson K,Roberts R,Poulton I,Lawrie A,Ewer K,V S Hill A

更新日期：2017-10-27 00:00:00

abstract：:The annual contact for influenza vaccination provides an opportunity to ensure that adults have received other recommended vaccines such as Tdap. Healthy 19-64 year-olds were randomized to receive concomitant administration of Tdap and influenza vaccines or influenza vaccine followed (in 4-6 weeks by) Tdap. 720 partic...

journal_title：Vaccine

authors： McNeil SA,Noya F,Dionne M,Predy G,Meekison W,Ojah C,Ferro S,Mills EL,Langley JM,Halperin SA

更新日期：2007-04-30 00:00:00

abstract：:In this study, the potential of N-Trimethyl chitosan (TMC, degree of quaternization 50%) and dextran microparticles for pulmonary delivery of diphtheria toxoid (DT) was investigated. The antigen-containing microparticles were prepared by drying of an aqueous solution of polymer and DT through a supercritical fluid (SC...

journal_title：Vaccine

authors： Amidi M,Pellikaan HC,Hirschberg H,de Boer AH,Crommelin DJ,Hennink WE,Kersten G,Jiskoot W

更新日期：2007-09-17 00:00:00

abstract：:As companies, countries, and governments consider investments in vaccine production for routine immunization and outbreak response, understanding the complexity and cost drivers associated with vaccine production will help to inform business decisions. Leading multinational corporations have good understanding of the ...

journal_title：Vaccine

authors： Plotkin S,Robinson JM,Cunningham G,Iqbal R,Larsen S

更新日期：2017-07-24 00:00:00

abstract：OBJECTIVES:The aims of this study were to (a) assess knowledge of official vaccination recommendations and attitudes towards vaccinations among adults and (b) examine their association with vaccination uptake among adults. METHODS:This study was part of the HaBIDS study (Hygiene and Behaviour Infectious Diseases Surve...

journal_title：Vaccine

authors： Akmatov MK,Rübsamen N,Deyneko IV,Karch A,Mikolajczyk RT

更新日期：2018-04-25 00:00:00

abstract：BACKGROUND:Vietnam has high endemic hepatitis B virus infection with >8% of adults estimated to have chronic infection. Hepatitis B vaccine was first introduced in the national childhood immunization program in 1997 in high-risk areas, expanded nationwide in 2002, and included birth dose vaccination in 2003. This surve...

journal_title：Vaccine

authors： Nguyen TH,Vu MH,Nguyen VC,Nguyen LH,Toda K,Nguyen TN,Dao S,Wannemuehler KA,Hennessey KA

更新日期：2014-01-03 00:00:00

abstract：BACKGROUND:This randomised, open label, phase I, immunotherapeutic study investigated the effects of interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), recombinant human growth hormone (rhGH), and therapeutic immunisation (a Clade B DNA vaccine) on combination antiretroviral therapy (cART)-t...

journal_title：Vaccine

authors： Herasimtschuk A,Downey J,Nelson M,Moyle G,Mandalia S,Sikut R,Adojaan M,Stanescu I,Gotch F,Imami N

更新日期：2014-12-05 00:00:00

abstract：:Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity a...

journal_title：Vaccine

authors： Carrion R Jr,Patterson JL,Johnson C,Gonzales M,Moreira CR,Ticer A,Brasky K,Hubbard GB,Moshkoff D,Zapata J,Salvato MS,Lukashevich IS

更新日期：2007-05-16 00:00:00

abstract：:Recombinant replication-defective human adenovirus type 5 (Ad5) vaccines containing capsid-coding regions from foot-and-mouth disease virus (FMDV) have been demonstrated to induce effective immune responses and provide homologous protective immunity against FMDV in cattle. However, basic mechanisms of Ad5-FMDV vaccine...

journal_title：Vaccine

authors： Montiel N,Smoliga G,Arzt J

更新日期：2012-02-21 00:00:00

abstract：:Recent outbreaks of a novel H7N9 avian influenza virus in humans in China raise pandemic concerns and underscore an urgent need to develop effective vaccines. Theoretically, live influenza vaccines are of multiple advantages over traditional inactivated influenza vaccines to be used in a pandemic, because they can be ...

journal_title：Vaccine

authors： Jiang WM,Wang SC,Liu HL,Yu JM,Du X,Hou GY,Li JP,Liu S,Wang KC,Zhuang QY,Liu XM,Chen JM

更新日期：2014-11-12 00:00:00

abstract：:A gene encoding the mature Escherichia coli heat-labile enterotoxin B subunit (LTB) was introduced in a vector pNU212 and expressed at high levels in Bacillus brevis HPD31. The maximum amount of recombinant LTB (rLTB) secreted into the modified 5PY medium containing erythromycin was about 350 mg l(-1) when cultivated ...

journal_title：Vaccine

authors： Kozuka S,Yasuda Y,Isaka M,Masaki N,Taniguchi T,Matano K,Moriyama A,Ohkuma K,Goto N,Udaka S,Tochikubo K

更新日期：2000-03-06 00:00:00

abstract：:HPV vaccines are highly immunogenic. A two-dose schedule for 9-14 year-old is recommended. However, no data exist regarding the impact of age, menarche status and body mass index (BMI) on the immune response to a two-dose schedule. In this post-hoc analysis, we present antibody titers to HPV6/11/16/18 in 9-13 year-old...

journal_title：Vaccine

authors： Sauvageau C,Gilca V,Donken R,Fan SY,Ogilvie G,Dobson S

更新日期：2019-11-20 00:00:00

abstract：BACKGROUND:The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public-private collaboration aiming to develop and test a system for rapid benefit-risk (B/R) monitoring of vaccines using European healthcare databases. Event misclassification can result in biased estimates. Using di...

journal_title：Vaccine

authors： Gini R,Dodd CN,Bollaerts K,Bartolini C,Roberto G,Huerta-Alvarez C,Martín-Merino E,Duarte-Salles T,Picelli G,Tramontan L,Danieli G,Correa A,McGee C,Becker BFH,Switzer C,Gandhi-Banga S,Bauwens J,van der Maas NAT,Spiteri

更新日期：2020-12-22 00:00:00

abstract：:Vaccine safety fears following media reports of adverse events led to low (50.3%) coverage in a supplementary measles-rubella immunization campaign in Georgia in 2008. Review of adverse events associated with the campaign identified 432 reports (<0.1% of ∼ 493,000 vaccinees) including 338 (78.2%) cases of syncope. The...

journal_title：Vaccine

authors： Khetsuriani N,Imnadze P,Baidoshvili L,Jabidze L,Tatishili N,Kurtsikashvili G,Lezhava T,Laurent E,Martin R

更新日期：2010-09-07 00:00:00

abstract：:Using immunopotentiating, reconstituted influenza virosomes (IRIV) as a delivery vehicle, a number of vaccines have been developed. In humans, IRIV-based vaccines containing hepatitis A and influenza antigens have been found to possess enhanced immunogenicity compared to alum-adsorbed vaccine for hepatitis A or commer...

journal_title：Vaccine

authors： Glück R

更新日期：1999-03-26 00:00:00