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Genome-based approaches to develop vaccines against bacterial pathogens.

Abstract：

:Bacterial infectious diseases remain the single most important threat to health worldwide. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed to provide efficacious solutions against many others. The advent of whole-genome sequencing changed the way to think about vaccine development, enabling the targeting of possible vaccine candidates starting from the genomic information of a single bacterial isolate, with a process named reverse vaccinology. As the genomic era progressed, reverse vaccinology has evolved with a pan-genome approach and multi-strain genome analysis became fundamental for the design of universal vaccines. This review describes the applications of genome-based approaches in the development of new vaccines against bacterial pathogens.

journal_name

Vaccine

journal_title

Vaccine

authors

Serruto D,Serino L,Masignani V,Pizza M

doi

10.1016/j.vaccine.2009.01.072

subject

Has Abstract

pub_date

2009-05-26 00:00:00

pages

3245-50

issue

25-26

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)00084-X

journal_volume

27

pub_type

杂志文章,评审

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