Durability of antibody responses after receipt of the monovalent 2009 pandemic influenza A (H1N1) vaccine among HIV-infected and HIV-uninfected adults.


BACKGROUND:Human immunodeficiency virus (HIV)-infected persons are at risk for severe influenza infections. Although vaccination against the H1N1 pandemic influenza strain is recommended, currently there are no data on the durability of post-vaccination antibody responses in this population. METHODS:HIV-infected and HIV-uninfected adults (18-50 years old) received a single dose of monovalent 2009 influenza A (H1N1) vaccine (strain A/California/7/2009H1N1). Antibody levels to the 2009 H1N1 pandemic strain were determined at day 0, day 28, and 6 months by hemagglutination-inhibition assay. A seroprotective response was a post-vaccination titer of ≥1:40 among those with a pre-vaccination level of ≤1:10. Geometric mean titers (GMT) and factors associated with higher levels were also evaluated. RESULTS:We studied 127 participants with a median age of 35 (interquartile range (IQR) 28, 42) years. Among the HIV-infected arm (n=63), the median CD4 count was 595 (IQR 476, 819)cells/mm(3) and 83% were receiving HAART. Thirty-five percent of all participants had a pre-vaccination level of >1:10. HIV-infected compared to HIV-uninfected adults were less likely to generate a seroprotective response at day 28 (54% vs. 75%, adjusted OR 0.23, p=0.021) or have a durable response at 6 months post-vaccination (28% vs. 56%, adjusted OR 0.19, p=0.005). Additionally, although pre-vaccination GMT were similar in both arms (median 7 vs. 8, p=0.11), the GMT at 6 months was significantly lower among HIV-infected versus HIV-uninfected adults (median 20 vs. 113, p=0.003). Among HIV-infected persons, younger age (p=0.035) and receipt of HAART (p=0.028) were associated with higher GMTs at 6 months. CONCLUSIONS:Despite vaccination, most HIV-infected adults do not generate durable seroprotective antibody responses to the 2009 influenza A (H1N1) virus, and hence may remain vulnerable to infection. In addition to HAART use, more immunogenic vaccines are likely needed for improving protection against influenza in this population.






Crum-Cianflone NF,Iverson E,Defang G,Blair PJ,Eberly LE,Maguire J,Ganesan A,Faix D,Duplessis C,Lalani T,Whitman T,Brandt C,Macalino G,Millar EV,Burgess T




Has Abstract


2011-04-12 00:00:00
















  • Prophylaxis of experimental HTLV-I infection in cynomolgus monkeys by passive immunization.

    abstract::The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV...


    pub_type: 杂志文章


    authors: Akari H,Suzuki T,Ikeda K,Hoshino H,Tomono T,Murotsuka T,Terao K,Ito H,Yoshikawa Y

    更新日期:1997-08-01 00:00:00

  • The V3 loop based multi-epitope polypeptide TAB9 adjuvated with montanide ISA720 is highly immunogenic in nonhuman primates and induces neutralizing antibodies against five HIV-1 isolates.

    abstract::In a previous work we selected montanide ISA720 (M-ISA720) among different adjuvants for the vaccination with a V3 loop based multi-epitope polypeptide TAB9. In this paper we present the evaluation of the toxicity and immunogenicity of this formulation in non-human primates. TAB9 in M-ISA720 was highly immunogenic in ...


    pub_type: 杂志文章


    authors: Gómez CE,Navea L,Lobaina L,Dubed M,Expósito N,Soto A,Duarte CA

    更新日期:1999-05-04 00:00:00

  • Immunity to mumps before and after MMR vaccination at 12 years of age in the first generation offered the two-dose immunization programme.

    abstract::Sweden was the first country in the world to introduce a two-dose programme of vaccination against measles, mumps and rubella with a combined vaccine (MMR). It was commenced in 1982 and the vaccination was carried out at the ages of 18 months and 12 years. In 1992-93 the first age-group vaccinated at 18 months reached...


    pub_type: 杂志文章


    authors: Broliden K,Abreu ER,Arneborn M,Böttiger M

    更新日期:1998-01-01 00:00:00

  • Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines - A phase II, randomised, observer-blind study in Gambian infants.

    abstract:BACKGROUND:Two conserved pneumococcal proteins, pneumolysin toxoid (dPly) and pneumococcal histidine triad protein D (PhtD), combined with 10 polysaccharide conjugates from the pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) in two investigational pneumococcal vaccine (PHiD-CV/dPl...


    pub_type: 杂志文章,随机对照试验


    authors: Odutola A,Ota MOC,Antonio M,Ogundare EO,Saidu Y,Owiafe PK,Worwui A,Idoko OT,Owolabi O,Kampmann B,Greenwood BM,Alderson M,Traskine M,Swinnen K,Verlant V,Dobbelaere K,Borys D

    更新日期:2019-05-01 00:00:00

  • Evaluation of pneumococcal meningitis clusters in Burkina Faso and implications for potential reactive vaccination.

    abstract:BACKGROUND:To better understand how to prevent and respond to pneumococcal meningitis outbreaks in the meningitis belt, we retrospectively examined Burkina Faso's case-based meningitis surveillance data for pneumococcal meningitis clusters and assessed potential usefulness of response strategies. METHODS:Demographic a...


    pub_type: 杂志文章


    authors: Soeters HM,Kambiré D,Sawadogo G,Ouédraogo-Traoré R,Bicaba B,Medah I,Sangaré L,Ouédraogo AS,Ouangraoua S,Yaméogo I,Congo-Ouédraogo M,Ky Ba A,Aké F,Velusamy S,McGee L,Van Beneden C,Whitney CG

    更新日期:2020-07-31 00:00:00

  • Improving adolescent HPV vaccination in a randomized controlled cluster trial using the 4 Pillars™ practice Transformation Program.

    abstract:OBJECTIVE:Uptake of meningococcal vaccine (MCV) and tetanus, diphtheria and pertussis (Tdap) vaccine among adolescents has approached Healthy People 2020 goals, but human papillomavirus (HPV) vaccination has not. This study evaluated an intervention using the 4 Pillars™ Practice Transformation Program to increase HPV, ...


    pub_type: 杂志文章,随机对照试验


    authors: Zimmerman RK,Moehling KK,Lin CJ,Zhang S,Raviotta JM,Reis EC,Humiston SG,Nowalk MP

    更新日期:2017-01-03 00:00:00

  • The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is a highly protective antigen against serotype 2.

    abstract::Streptococcus suis (S. suis) is a major porcine pathogen causing meningitis, arthritis and several other pathologies. Recently, we identified a highly specific immunoglobulin M degrading enzyme of S. suis, designated IdeSsuis, which is expressed by various serotypes. The objective of this work was to access the immuno...


    pub_type: 杂志文章


    authors: Seele J,Hillermann LM,Beineke A,Seitz M,von Pawel-Rammingen U,Valentin-Weigand P,Baums CG

    更新日期:2015-05-05 00:00:00

  • Efficacy of a divalent and a multivalent water-in-oil formulated vaccine against a highly virulent strain of Flavobacterium psychrophilum after intramuscular challenge of rainbow trout (Oncorhynchus mykiss).

    abstract::Flavobacterium psychrophilum is a well-known pathogen causing significant problems in aquaculture worldwide. In recent years an increasing number of disease outbreaks caused by F. psychrophilum has been reported on juvenile and post smolts of rainbow trout (Oncorhynchus mykiss) in Norway. The current study was perform...


    pub_type: 杂志文章


    authors: Fredriksen BN,Olsen RH,Furevik A,Souhoka RA,Gauthier D,Brudeseth B

    更新日期:2013-04-08 00:00:00

  • Isotype profiles induced in Balb/c mice during foot and mouth disease (FMD) virus infection or immunization with different FMD vaccine formulations.

    abstract::The IgG isotype response in Balb/c mice infected with FMDV or immunized with different vaccine formulations using inactivated virus particles as antigen was analyzed at various times post-inoculation. For this purpose an ELISA based on polyclonal antibodies for detection and quantification of mouse IgG isotypes with F...


    pub_type: 杂志文章


    authors: Pérez Filgueira DM,Berinstein A,Smitsaart E,Borca MV,Sadir AM

    更新日期:1995-07-01 00:00:00

  • Development of recombinant VP2 vaccine for the prevention of infectious bursal disease of chickens.

    abstract::The objective of the present study was to investigate the feasibility of a subunit vaccine and a live bacteria vaccine to protect chickens against infectious bursal disease virus (IBDV) infection. The gene for VP2 of a new wild-type very virulent IBDV (vvIBDV) strain was cloned into an Escherichia coli expression syst...


    pub_type: 杂志文章


    authors: Rong J,Cheng T,Liu X,Jiang T,Gu H,Zou G

    更新日期:2005-09-23 00:00:00

  • pH-sensitive carbonate apatite nanoparticles as DNA vaccine carriers enhance humoral and cellular immunity.

    abstract::To demonstrate the potential of pH-sensitive carbonate apatite (CO₃Ap) nanoparticles as DNA vaccine carriers to enhance vaccination efficacy, we examined the humoral and cellular immune responses of C57BL/6 mice immunized with the plasmid expression vector pCI-neo encoding the full-length soluble ovalbumin (OVA) (pCI-...


    pub_type: 杂志文章


    authors: He P,Takeshima SN,Tada S,Akaike T,Ito Y,Aida Y

    更新日期:2014-10-29 00:00:00

  • The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014.

    abstract:BACKGROUND:Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis and septicaemia although infection by some serogroups may be prevented through vaccination. We aimed to describe the epidemiology of IMD in EU/EEA countries during 2004-2014 to monitor serogroup- and age-specific trends, and compar...


    pub_type: 杂志文章


    authors: Whittaker R,Dias JG,Ramliden M,Ködmön C,Economopoulou A,Beer N,Pastore Celentano L,ECDC network members for invasive meningococcal disease.

    更新日期:2017-04-11 00:00:00

  • Attitudes towards influenza vaccination of multi-nationality health-care workers in Saudi Arabia.

    abstract:BACKGROUND:The compliance with influenza vaccination among health-care workers (HCWs) is known to be low. A multi-nationality survey to explore the reasons for such poor compliance has not been studied in depth. MATERIALS AND METHODS:An epidemiologic survey to evaluate the compliance rates with influenza vaccination a...


    pub_type: 杂志文章


    authors: Al-Tawfiq JA,Antony A,Abed MS

    更新日期:2009-09-04 00:00:00

  • Global Vaccine and Immunization Research Forum: Opportunities and challenges in vaccine discovery, development, and delivery.

    abstract::The World Health Organization, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, and the Bill & Melinda Gates Foundation convened the first Global Vaccine and Immunization Research Forum (GVIRF) in March 2014. This first GVIRF aimed to track recent progress of the Gl...


    pub_type: 杂志文章


    authors: Ford AQ,Touchette N,Hall BF,Hwang A,Hombach J

    更新日期:2016-03-18 00:00:00

  • Estimating the herd immunity effect of rotavirus vaccine.

    abstract:INTRODUCTION:Diarrhea is one of the leading causes of death in children under 5, and an estimated 39% of these deaths are attributable to rotavirus. Currently two live, oral rotavirus vaccines have been introduced on the market; however, the herd immunity effect associated with rotavirus vaccine has not yet been quanti...


    pub_type: 杂志文章,meta分析,评审


    authors: Pollard SL,Malpica-Llanos T,Friberg IK,Fischer-Walker C,Ashraf S,Walker N

    更新日期:2015-07-31 00:00:00

  • Can the rolling cross-sectional survey design be used to estimate the effectiveness of influenza vaccines?

    abstract:INTRODUCTION:Observational studies of influenza vaccine effectiveness often study persons seeking medical care for acute respiratory infection (ARI). We conducted a pilot study to determine if vaccine effectiveness could be estimated in the general population with a novel rolling cross-sectional survey sampling design ...


    pub_type: 杂志文章


    authors: Donahue JG,Kieke BA,Szilagy PG,Blumkin AK,Hilgemann D,Flanders WD,Shay DK,Meece J,Gallivan S,Treanor J,Belongia EA

    更新日期:2014-11-12 00:00:00

  • Uptake of varicella vaccine--a cross sectional survey of parental attitudes to nationally recommended but unfunded varicella immunisation.

    abstract::The aim of this study was to assess the uptake of varicella vaccine in South Australian children under circumstances where varicella immunisation is recommended, but is not funded by Government. The study examined the main reasons that determined a parent's decision whether or not to have their child immunised with va...


    pub_type: 杂志文章


    authors: Marshall H,Ryan P,Roberton D

    更新日期:2005-11-16 00:00:00

  • Evaluation of human immunodeficiency virus type 1 subtype C gag, pol, and gagpol DNA and alphavirus replicon vaccines.

    abstract::The worldwide HIV-1 vaccine research endeavor is focused increasingly on subtype C, which is now the predominant strain of the present HIV/AIDS epidemic. Expression cassettes of HIV-1 subtype C gag, pol and versions of gagpol fusion cassettes were constructed and evaluated for their relative abilities to induce cellul...


    pub_type: 杂志文章


    authors: Megede JZ,Otten GR,Doe B,Liu H,Srivastava R,Greer C,Legg H,Tang T,Polo JM,Donnelly JJ,Ulmer JB,Barnett SW

    更新日期:2006-04-05 00:00:00

  • Immunization of eyed channel catfish, Ictalurus punctatus, eggs with monovalent Flavobacterium columnare vaccine and bivalent F. columnare and Edwardsiella ictaluri vaccine.

    abstract::The efficacy of a modified live monovalent Flavobacterium columnare vaccine and bivalent F. columnare and Edwardsiella ictaluri vaccines were evaluated following immersion vaccination of eyed channel catfish (Ictalurus punctatus) eggs. The modified live F. columnare vaccine was grown in modified Shieh broth and admini...


    pub_type: 杂志文章


    authors: Shoemaker CA,Klesius PH,Evans JJ

    更新日期:2007-01-22 00:00:00

  • Pandemic unadjuvanted influenza A (H1N1) vaccine in dermatomyositis and polymyositis: immunogenicity independent of therapy and no harmful effect in disease.

    abstract::The goal of the present study was to evaluate the influence of the influenza A H1N1/2009 vaccine on dermatomyositis/polymyositis (DM/PM) disease parameters and the potential deleterious effect of therapy on immune response. Thirty-seven DM and 21 PM patients (Bohan and Peter's criteria) were gender- and age-matched to...


    pub_type: 杂志文章


    authors: Shinjo SK,de Moraes JC,Levy-Neto M,Aikawa NE,de Medeiros Ribeiro AC,Schahin Saad CG,Precioso A,Silva CA,Bonfá E

    更新日期:2012-12-17 00:00:00

  • Group M consensus Gag and Nef peptides are as efficient at detecting clade A1 and D cross-subtype T-cell functions as subtype-specific consensus peptides.

    abstract:OBJECTIVE:Evaluating HIV-1 specific T-cell response in African populations is sometimes compromised by extensive virus diversity and paucity of non-clade B reagents. We evaluated whether consensus group M (ConM) peptides could serve as comparable substitutes for detecting immune responses in clade A and clade D HIV-1 i...


    pub_type: 杂志文章


    authors: Mugaba S,Nakiboneka R,Nanyonjo M,Bugembe-Lule D,Kaddu I,Nanteza B,Tweyongyere R,Kaleebu P,Serwanga J

    更新日期:2014-06-24 00:00:00

  • Development of an ex vivo human skin model for intradermal vaccination: tissue viability and Langerhans cell behaviour.

    abstract::The presence of resident Langerhans cells (LCs) in the epidermis makes the skin an attractive target for DNA vaccination. However, reliable animal models for cutaneous vaccination studies are limited. We demonstrate an ex vivo human skin model for cutaneous DNA vaccination which can potentially bridge the gap between ...


    pub_type: 杂志文章


    authors: Ng KW,Pearton M,Coulman S,Anstey A,Gateley C,Morrissey A,Allender C,Birchall J

    更新日期:2009-10-09 00:00:00

  • Antibody and T-cell responses to a virosomal adjuvanted H9N2 avian influenza vaccine: impact of distinct additional adjuvants.

    abstract::A highly efficacious vaccine is required to counteract a threat of an avian influenza pandemic. Increasing the potency of vaccines by adjuvation is essential not only to overcome generally low immunogenicity of pandemic strains, but also to allow dose sparing and as such to make it feasible to satisfy huge global prod...


    pub_type: 杂志文章


    authors: Radosević K,Rodriguez A,Mintardjo R,Tax D,Bengtsson KL,Thompson C,Zambon M,Weverling GJ,Uytdehaag F,Goudsmit J

    更新日期:2008-07-04 00:00:00

  • Midwives' perceptions of vaccines and their role as vaccinators: The emergence of a new immunization corps.

    abstract:BACKGROUND:In France, midwives have recently been authorized to administer various vaccines to women (including pregnant women), newborns, and their family members. This is expected to enhance vaccine coverage. However, the French high level of vaccine hesitancy is also observed in some healthcare workers. We thus aime...


    pub_type: 杂志文章


    authors: Massot E,Epaulard O

    更新日期:2018-08-16 00:00:00

  • Disparities in varicella vaccine coverage in the absence of public funding.

    abstract::Varicella vaccine has been licensed in Canada since December 1998 but not provided free in all provinces. Through a cross-sectional telephone survey to a random sample of parents, we assessed factors associated with varicella vaccine uptake in the absence of public funding. Parents of children aged 2-3 years (Group I)...


    pub_type: 杂志文章


    authors: Gustafson R,Skowronski DM

    更新日期:2005-05-20 00:00:00

  • Impact of introduction of the 9-valent human papillomavirus vaccine on vaccination coverage of youth in North Carolina.

    abstract:OBJECTIVES:The objective of this study was to evaluate the impact of introduction of 9vHPV vaccine on HPV vaccination uptake (doses per capita) and initiation (≥1 doses), completion (≥3 doses) and compliance (≥3 doses within 12 months) by adolescents. METHODS:We used a retrospective cohort analysis using North Carolin...


    pub_type: 杂志文章


    authors: Trogdon JG,Shafer P,Lindsay B,Coyne-Beasley T

    更新日期:2018-02-28 00:00:00

  • Antigen-specific IgA titres after 23-valent pneumococcal vaccine indicate transient antibody deficiency disease in children.

    abstract::Paediatric patients with antibody deficiency may either be delayed in development of humoral immunity or may be persistently deficient in antibody production. To differentiate between these entities, we examined the 23-valent pneumococcal polysaccharide (PnPS) vaccine-induced IgM-, IgG- and IgA antibody responses in a...


    pub_type: 杂志文章


    authors: Janssen WJ,Nierkens S,Sanders EA,Boes M,van Montfrans JM

    更新日期:2015-11-17 00:00:00

  • Regulation of CD4 T cell memory by OX40 (CD134).

    abstract::CD4 memory T cells play a critical role in protection against repeated exposure to infectious agents such as viruses, bacteria, and helminth parasites, yet can also contribute to the aberrant immune responses associated with autoimmune and allergic reactions. Understanding the mechanisms that control effective memory ...


    pub_type: 杂志文章,评审


    authors: Salek-Ardakani S,Croft M

    更新日期:2006-02-13 00:00:00

  • In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment.

    abstract::Targeting immune checkpoint receptors has emerged as an effective strategy to induce immune-mediated cancer regression in the subset of patients who have significant pre-existing anti-tumor immunity. For the remainder, effective anti tumor responses may require vaccination. Radiotherapy, traditionally used to achieve ...


    pub_type: 杂志文章,评审


    authors: Vanpouille-Box C,Pilones KA,Wennerberg E,Formenti SC,Demaria S

    更新日期:2015-12-16 00:00:00

  • Contrasting substitution patterns between HA proteins of avian and human influenza viruses: Implication for monitoring human influenza epidemics.

    abstract::The HA1 domain of influenza A viruses is critical for immune escape and host receptor recognition. However, the association between HA1 evolution and host species-specific adaptations remains unclear. We have identified the amino acid sites that are related to the host species-specific adaptations by systematically co...


    pub_type: 杂志文章


    authors: Liao YC,Chen FC,Hsiung CA

    更新日期:2010-11-23 00:00:00