The potential cost-effectiveness of acellular pertussis booster vaccination in England and Wales.

Abstract:

:A cost-effectiveness analysis of the introduction of acellular pertussis booster doses at either 4 or 15 years of age was performed. A transmission dynamic model was used to predict the level of indirect protection in those too young to be vaccinated. Multivariate sensitivity analyses were performed. In England and Wales there are an estimated 35,000 general practitioner (GP) consultations, 5500 inpatient days, and nine deaths annually attributable to pertussis, despite high levels of coverage for the primary course (approximately 95%). Around 80% of the bed-days and 90% of the deaths occur in those too young to be immunised (< 3 months of age). The introduction of acellular booster doses at 4 years is expected to reduce morbidity and mortality in the younger age groups by 40-100%, and at 15 years by 0-100%. From the perspective of the health care provider, roughly 50% of the simulations result in a cost per life-year gained of less than 10,000 pounds for vaccination at 4 years, the corresponding proportion for vaccination at 15 years being only 35%. Apart from the degree of indirect protection the model was most sensitive to the discount rate, the price of the vaccine, and the mortality rate. Significant uncertainty remains regarding the epidemiology of pertussis and the impact of booster doses. Nevertheless, the introduction of acellular boosters, particularly at 4 years, has the potential to be cost-effective in the UK.

journal_name

Vaccine

journal_title

Vaccine

authors

Edmunds WJ,Brisson M,Melegaro A,Gay NJ

doi

10.1016/s0264-410x(01)00473-x

subject

Has Abstract

pub_date

2002-01-31 00:00:00

pages

1316-30

issue

9-10

eissn

0264-410X

issn

1873-2518

pii

S0264410X0100473X

journal_volume

20

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication.

    abstract::Cellular proteins that support influenza virus infection represent potential therapeutic targets. Cytoplasmic egress intermediates of influenza A/WSN/33 were isolated and shown to be associated with the cellular enzymes peroxiredoxins-1 (Prdx-1) during glycerol gradient fractionation. Prdx-1 also co-localizes with inf...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2018.05.125

    authors: Dai X,Li N,Roller RJ

    更新日期:2018-07-16 00:00:00

  • Prospects for oral replicating adenovirus-vectored vaccines.

    abstract::Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immuniza...

    journal_title:Vaccine

    pub_type: 杂志文章,评审

    doi:10.1016/j.vaccine.2013.05.016

    authors: Deal C,Pekosz A,Ketner G

    更新日期:2013-07-11 00:00:00

  • Immunogenicity and safety of a booster vaccination against tick-borne encephalitis more than 3 years following the last immunisation.

    abstract::This study investigated the immune response and safety in 430 adults, when boosted more than 3 years after primary or booster TBE immunisation as measured by neutralization test (NT) and ELISA. Tested by NT, the post-booster day 21 geometric mean titer (GMT) was 331 and 142 for the 18-49 and > or =50 years old, respec...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.vaccine.2004.07.002

    authors: Rendi-Wagner P,Kundi M,Zent O,Banzhoff A,Jaehnig P,Stemberger R,Dvorak G,Grumbeck E,Laaber B,Kollaritsch H

    更新日期:2004-12-09 00:00:00

  • Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice.

    abstract::Antibodies specific for Vibrio cholerae lipopolysaccaride (LPS) are common in humans recovering from cholera, and constitute a primary component of the vibriocidal response, a serum complement-mediated bacteriocidal response correlated with protection against cholera. In order to determine whether transcutaneous immun...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.06.040

    authors: Rollenhagen JE,Kalsy A,Saksena R,Sheikh A,Alam MM,Qadri F,Calderwood SB,Kovác P,Ryan ET

    更新日期:2009-08-06 00:00:00

  • Psychological factors associated with uptake of the childhood influenza vaccine and perception of post-vaccination side-effects: A cross-sectional survey in England.

    abstract:OBJECTIVES:To identify predictors of: uptake of the childhood influenza vaccine in the 2015-2016 influenza season, parental perceptions of side-effects from the influenza vaccine and intention to vaccinate one's child for influenza in the 2016-2017 influenza season. DESIGN:Cross-sectional online survey. SETTING:Data ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2017.02.031

    authors: Smith LE,Webster RK,Weinman J,Amlôt R,Yiend J,Rubin GJ

    更新日期:2017-04-04 00:00:00

  • Oral immunization with a Streptococcal pneumoniae polysaccharide conjugate vaccine in enterocoated microparticles induces serum antibodies against type specific polysaccharides.

    abstract::The authors examined the antibody responses of mice orally immunized with pneumococcal polysaccharide (type 23F) or a pneumococcal polysaccharide conjugated to the outer membrane protein complex of Neisseria meningitides (23F-OMPC). These antigens were administered either in solution or entrapped within microcapsules....

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(98)00118-2

    authors: Flanagan MP,Michael JG

    更新日期:1999-01-01 00:00:00

  • Humoral and cellular immunity induced by antigens adjuvanted with colloidal iron hydroxide.

    abstract::The immunopotentiating activities of colloidal iron hydroxide, a novel, experimental mineral adjuvant, and of aluminium hydroxide. the licensed adjuvant for human vaccines, were compared. Our studies revealed that colloidal iron hydroxide and aluminium hydroxide behaved comparably with respect to supporting induction ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(98)00201-1

    authors: Leibl H,Tomasits R,Brühl P,Kerschbaum A,Eibl MM,Mannhalter JW

    更新日期:1999-03-05 00:00:00

  • Influenza vaccination rates in Ontario children: implications for universal childhood vaccination policy.

    abstract::The aims of this study were to estimate influenza vaccination coverage for children during the 2006-2007 influenza season in Ontario, Canada, where universal vaccination is available, and to compare the rate among children aged 6-23 months with corresponding rates from other Canadian provinces that specifically target...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.02.017

    authors: Moran K,Maaten S,Guttmann A,Northrup D,Kwong JC

    更新日期:2009-04-14 00:00:00

  • More vaccines for children? Parents' views.

    abstract:AIM:To investigate parents' views regarding potential new vaccines. We examined attitudes towards severity of specific infections, acceptability of potential vaccines and preferences for the number of injections they would want their child to receive on any one occasion. DESIGN:Cross sectional survey. METHODS:Parents...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2007.08.057

    authors: Bedford H,Lansley M

    更新日期:2007-11-07 00:00:00

  • Measles vaccination in Africa: by how much could routine coverage be improved?

    abstract::Assuming that the level of Bacille Calmette Guerin (BCG) coverage gives a measure of access to immunisation services, it is possible to derive what fraction of infants are not immunised against measles due to under-utilisation of existing services (rather than unavailability of services). According to the most recent ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(01)00264-x

    authors: Edmunds WJ,Gay NJ,Henao Restrepo AM,Olivé JM,Bele O

    更新日期:2001-10-12 00:00:00

  • Vaccine effectiveness against severe laboratory-confirmed influenza in children: results of two consecutive seasons in Italy.

    abstract:OBJECTIVE:To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. METHODS:We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospita...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.06.048

    authors: Menniti-Ippolito F,Da Cas R,Traversa G,Santuccio C,Felicetti P,Tartaglia L,Trotta F,Di Pietro P,Barabino P,Renna S,Riceputi L,Tovo PA,Gabiano C,Urbino A,Baroero L,Le Serre D,Virano S,Perilongo G,Daverio M,Gnoato E,

    更新日期:2014-07-31 00:00:00

  • Towards developing standardized protocols for evaluation of cellular mucosal immune responses - Recommendations from a DAIDS/NIH workshop, June 15-16, 2009.

    abstract::Although 80% of HIV infections occur through mucosal routes and vaccine strategies need to be designed for inducing protective immune responses at the site of the viral entry, it has proven to be very challenging to measure these responses. A 2-day workshop was convened by Division of AIDS, National Institutes of Heal...

    journal_title:Vaccine

    pub_type:

    doi:10.1016/j.vaccine.2010.04.092

    authors: Mehra V,Musib R,Schito ML

    更新日期:2010-07-05 00:00:00

  • Synthetic luteinizing hormone releasing hormone (LHRH) vaccine for effective androgen deprivation and its application to prostate cancer immunotherapy.

    abstract::We have designed a peptide-based immunotherapeutic vaccine for treatment of androgen-responsive prostate cancer. The vaccine targets the luteinizing hormone-releasing hormone (LHRH) decapeptide that results in an androgen-deprivation immunotherapy. The design elements of the peptide immunogens are the LHRH peptide or ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2003.08.044

    authors: Finstad CL,Wang CY,Kowalski J,Zhang M,Li ML,Li XM,Xia WG,Bosland MC,Murthy KK,Walfield AM,Koff WC,Zamb TJ

    更新日期:2004-03-12 00:00:00

  • Vaccination of sheep against M. paratuberculosis: immune parameters and protective efficacy.

    abstract::Johne's disease in ruminants is caused by the pathogenic bacterium Mycobacterium avium subspecies paratuberculosis (Map). Currently available Map commercial vaccines protect against clinical disease but not infection. In this study, the proprietary Johne's vaccine Neoparasec and an aqueous formulation of Map 316F (Aqu...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.vaccine.2005.05.031

    authors: Begg DJ,Griffin JF

    更新日期:2005-10-10 00:00:00

  • Assessment of potential miRNA biomarkers of VERO-cell tumorigenicity in a new line (AGMK1-9T7) of African green monkey kidney cells.

    abstract::Patterns of microRNA expression appear to delineate the process of spontaneous neoplastic development-transformation (SPNDT) occurring in the African green monkey kidney (AGMK) VERO cell line (Teferedegne et al., 2010). Analysis of microarray data identified 6 microRNAs whose high-level of expression peaked when the W...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2017.04.004

    authors: Teferedegne B,Rotroff DM,Macauley J,Foseh G,Lewis G,Motsinger-Rief A,Lewis AM Jr

    更新日期:2017-10-04 00:00:00

  • Immunogenicity of virus-like particles containing modified human immunodeficiency virus envelope proteins.

    abstract::Extensive glycosylation and variable loops of the HIV envelope protein (Env) are reported to shield some neutralizing epitopes. Here, we investigated the immunogenicity of mutated HIV Envs presented in virus-like particles (VLPs). We immunized mice with simian human immunodeficiency virus (SHIV) VLPs containing mutant...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2007.01.107

    authors: Quan FS,Sailaja G,Skountzou I,Huang C,Vzorov A,Compans RW,Kang SM

    更新日期:2007-05-10 00:00:00

  • A novel lamprey antibody sequence to multimerize and increase the immunogenicity of recombinant viral and bacterial vaccine antigens.

    abstract::Hemagglutinin, the major surface protein of influenza viruses, was recombinantly expressed in eukaryotic cells as a monomer instead of its native trimer, and was only immunogenic when administered with an adjuvant [Pion et al. 2014]. In order to multimerize this antigen to increase its immunogenicity, a cysteine-rich ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2020.10.073

    authors: Peubez I,Margot S,Buffin S,Pion C,Bernard MC,Dinadayala P,Poncet D,Deloire S,Marco S,Legastelois I

    更新日期:2020-11-25 00:00:00

  • Efficacy of the oral pentavalent rotavirus vaccine in Mali.

    abstract::The oral, pentavalent rotavirus vaccine (PRV), RotaTeq was assessed for prevention of severe rotavirus gastroenteritis (RVGE) in young children in two multi-site, randomized, placebo-controlled field trials; one in Asia (Vietnam and Bangladesh) and the other in sub-Saharan Africa (Ghana, Kenya and Mali). The efficacy ...

    journal_title:Vaccine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.vaccine.2011.11.094

    authors: Sow SO,Tapia M,Haidara FC,Ciarlet M,Diallo F,Kodio M,Doumbia M,Dembélé RD,Traoré O,Onwuchekwa UU,Lewis KD,Victor JC,Steele AD,Neuzil KM,Kotloff KL,Levine MM

    更新日期:2012-04-27 00:00:00

  • Specificity of anti-Nef antibodies produced in mice immunized with DNA encoding the HIV-1 nef gene product.

    abstract::Mice immunized with plasmid DNA encoding Nef regulatory protein of human immunodeficiency virus type 1 developed high levels of anti-Nef antibodies. After 4 intramuscular injections of 100 microg plasmid DNA, anti-Nef antibodies reached titers up to 2 x 10(4). A significant specific antibody response was maintained fo...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(99)00203-0

    authors: Moureau C,Moynier M,Kavsan V,Montagnier L,Bahraoui E

    更新日期:1999-09-01 00:00:00

  • Mucosal immunization with experimental feline immunodeficiency virus (FIV) vaccines induces both antibody and T cell responses but does not protect against rectal FIV challenge.

    abstract::Feline immunodeficiency virus (FIV) is a natural lentiviral pathogen of cats which can be experimentally transmitted via rectal and vaginal routes--the major routes of human immunodeficiency virus type 1 transmission in man. An important objective for lentiviral research is the development of vaccine strategies which ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(00)00131-6

    authors: Finerty S,Stokes CR,Gruffydd-Jones TJ,Hillman TJ,Reeves NA,Whiting CV,Schaaper WM,Dalsgaard K,Harbour DA

    更新日期:2000-08-01 00:00:00

  • Varicella vaccination as useful strategy for reducing the risk of varicella-related hospitalizations in both vaccinated and unvaccinated cohorts (Italy, 2003-2018).

    abstract:INTRODUCTION:The present study summarizes evidences of the impact that varicella vaccination (VV) introduction and coverage can have on varicella attributable hospitalization rates. METHODS:A retrospective observational study was carried out by considering hospital discharge records and VV coverage at 24 months collec...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2020.06.076

    authors: Amodio E,Casuccio A,Tramuto F,Costantino C,Marrella A,Maida CM,Vitale F,Restivo V

    更新日期:2020-07-31 00:00:00

  • Development of a vaccine-challenge model for avian metapneumovirus subtype C in turkeys.

    abstract::The objective of this study was to evaluate different preparations of avian metapneumovirus (aMPV) subtype C as vaccine challenge in turkeys. Two aMPV isolates and their respective nasal turbinate homogenates after propagation in turkeys were used in the study. Significantly higher clinical sign scores were recorded i...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2006.10.037

    authors: Velayudhan BT,Noll SL,Thachil AJ,Shaw DP,Goyal SM,Halvorson DA,Nagaraja KV

    更新日期:2007-02-26 00:00:00

  • Brucella abortusΔcydCΔcydD and ΔcydCΔpurD double-mutants are highly attenuated and confer long-term protective immunity against virulent Brucella abortus.

    abstract::We constructed double deletion (ΔcydCΔcydD and ΔcydCΔpurD) mutants from virulent Brucella abortus biovar 1 field isolate (BA15) by deleting the genes encoding an ATP-binding cassette-type transporter (cydC and cydD genes) and a phosphoribosylamine-glycine ligase (purD). Both BA15ΔcydCΔcydD and BA15ΔcydCΔpurD double-mu...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.11.030

    authors: Truong QL,Cho Y,Park S,Kim K,Hahn TW

    更新日期:2016-01-04 00:00:00

  • The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model.

    abstract::Clostridium difficile infection (CDI) causes nosocomial antibiotic-associated diarrhea and colitis in the developed world. Two potent cytotoxins, toxin A (TcdA) and toxin B (TcdB) are the virulence factors of this disease and can be a good vaccine candidate against CDI. In the present study, we genetically engineered ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.02.006

    authors: Guo S,Yan W,McDonough SP,Lin N,Wu KJ,He H,Xiang H,Yang M,Moreira MA,Chang YF

    更新日期:2015-03-24 00:00:00

  • Enhancement of human papillomavirus (HPV) type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine.

    abstract::TA-CIN is a vaccine that comprises the human papillomavirus (HPV) type 16 L2, E6 and E7 as a single fusion protein. In a mouse model, TA-CIN effectively prevented outgrowth of HPV16-positive tumour cells. To assess the safety and immunogenicity of TA-CIN, a dose escalating (26, 128, 533 micro g), double blind and plac...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0264-410x(02)00350-x

    authors: de Jong A,O'Neill T,Khan AY,Kwappenberg KM,Chisholm SE,Whittle NR,Dobson JA,Jack LC,St Clair Roberts JA,Offringa R,van der Burg SH,Hickling JK

    更新日期:2002-10-04 00:00:00

  • Reduced oligomeric and vascular amyloid-beta following immunization of TgCRND8 mice with an Alzheimer's DNA vaccine.

    abstract::Immunization with amyloid-beta (Abeta) peptide reduces amyloid load in animal studies and in humans; however clinical trials resulted in the development of a pro-inflammatory cellular response to Abeta. Apoptosis has been employed to stimulate humoral and Th2-biased cellular immune responses. Thus, we sought to invest...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2008.12.044

    authors: DaSilva KA,Brown ME,McLaurin J

    更新日期:2009-02-25 00:00:00

  • Factors affecting immunization rate in a cohort of elderly veterans: a retrospective pilot study of influenza vaccine compliance.

    abstract::A survey of aged veterans greater than or equal to 85 years old was undertaken to determine their vaccination behaviour prior to mounting a local education campaign on influenza vaccine. A questionnaire inquiring into circumstances which may have influenced their decision to be immunized against influenza was mailed t...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(89)90163-1

    authors: Ganguly R,Cameron D

    更新日期:1989-10-01 00:00:00

  • Routing dependent immune responses after experimental R848-adjuvated vaccination.

    abstract::Most traditional vaccines are administered via the intramuscular route. Other routes of administration however, can induce equal or improved protective memory responses and might provide practical advantages such as needle-free immunization, dose sparing and induction of tissue-specific (mucosal) immunity. Here we exp...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2018.01.077

    authors: van Aalst S,Jansen MAA,Ludwig IS,van der Zee R,van Eden W,Broere F

    更新日期:2018-03-07 00:00:00

  • Improving adolescent HPV vaccination in a randomized controlled cluster trial using the 4 Pillars™ practice Transformation Program.

    abstract:OBJECTIVE:Uptake of meningococcal vaccine (MCV) and tetanus, diphtheria and pertussis (Tdap) vaccine among adolescents has approached Healthy People 2020 goals, but human papillomavirus (HPV) vaccination has not. This study evaluated an intervention using the 4 Pillars™ Practice Transformation Program to increase HPV, ...

    journal_title:Vaccine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.vaccine.2016.11.018

    authors: Zimmerman RK,Moehling KK,Lin CJ,Zhang S,Raviotta JM,Reis EC,Humiston SG,Nowalk MP

    更新日期:2017-01-03 00:00:00

  • Cost-effectiveness analysis of the introduction of rotavirus vaccine in Iran.

    abstract:BACKGROUND:Although the mortality from diarrheal diseases has been decreasing dramatically in Iran, it still represents an important proportion of disease burden in children <5 years old. Rotavirus vaccines are among the most effective strategies against diarrheal diseases in specific epidemiological conditions. This s...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.12.035

    authors: Javanbakht M,Moradi-Lakeh M,Yaghoubi M,Esteghamati A,Mansour Ghanaie R,Mahmoudi S,Shamshiri AR,Zahraei SM,Baxter L,Shakerian S,Chaudhri I,Fleming JA,Munier A,Baradaran HR

    更新日期:2015-05-07 00:00:00