Abstract：
:Sera were taken over a 5 year period from Gambian children vaccinated in 1983, when aged 1-4 years, with A + C meningococcal capsular polysaccharide, ELISA tests were devised to determine the concentrations of immunoglobulin A, G and M reacting with A polysaccharide and of IgG reacting with Opc protein, IgA1 protease and an internal 104 mer peptide derived from IgA1 protease. Vaccination resulted in a brief rise of antibodies to A polysaccharide followed by decline to pre-immunization levels. IgM levels were very high even before vaccination. Antibodies to Opc protein stimulated by natural exposure also declined over the 5 year period. In contrast, antibodies stimulated by natural exposure to IgA1 protease or to the internal peptide remained constant or increased (final geometric mean level of 47 micrograms IgG ml-1). We speculate that healthy carriage of Neisseria meningitidis or Haemophilus influenzae is responsible for this increase in IgG concentration.
journal_name
Vaccinejournal_title
Vaccineauthors
Thiesen B,Greenwood B,Brieske N,Achtman Mdoi
10.1016/s0264-410x(96)00138-7subject
Has Abstractpub_date
1997-02-01 00:00:00pages
209-19issue
2eissn
0264-410Xissn
1873-2518pii
S0264-410X(96)00138-7journal_volume
15pub_type
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