Abstract：
:Preventive immunization against HIV-1 infection requires a rapid immune response that does not rely exclusively on B or T cell memory. Innate immunity may fulfill this function as it may be activated directly at the time of HIV-1 transmission, inhibit early HIV-1 replication, stimulate adaptive immunity and enable specific antibodies followed by CD8(+) T cells to deal with the virus effectively. The three components of innate immunity - cellular, extracellular and intracellular - are presented, with an example given for each of these components; gammadelta T cells, CC chemokines and APOBEC3G. This brief account is presented to highlight the immuno-virological concept of coordinating activated innate immunity with adaptive antibody and T cell responses in preventive vaccination against HIV-1 infection.
journal_name
Vaccinejournal_title
Vaccineauthors
Lehner T,Wang Y,Pido-Lopez J,Whittall T,Bergmeier LA,Babaahmady Kdoi
10.1016/j.vaccine.2007.11.060subject
Has Abstractpub_date
2008-06-06 00:00:00pages
2997-3001issue
24eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)01378-3journal_volume
26pub_type
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