Abstract：
:The objective of this investigation was to analyze conditions leading to antibody responses against innocuous dietary protein antigens in the chick. The physical form of antigen was found to be important for immunization of mature chicks: bovine serum albumin (BSA) in solution was a powerful immunogen, while BSA powder was ignored. When BSA was fed to newly hatched chicks, either in solution or as powder, specific oral tolerance was induced. Tolerance increased with the dose of antigen fed, and was most effective in suppressing BSA-specific oral immunization. Hence, immune responses of mature chicks to innocuous dietary proteins are not likely to constitute a health hazard due to (a) prevalence of oral tolerance induced at hatch, and (b) availability of dietary proteins in solid form.
journal_name
Vaccinejournal_title
Vaccineauthors
Klipper E,Sklan D,Friedman Adoi
10.1016/s0264-410x(00)00557-0subject
Has Abstractpub_date
2001-04-06 00:00:00pages
2890-7issue
20-22eissn
0264-410Xissn
1873-2518pii
S0264-410X(00)00557-0journal_volume
19pub_type
杂志文章相关文献
VACCINE文献大全abstract：:DNA vaccines are promising tools to fight parasitic diseases, including amoebiasis caused by the protozoan Entamoeba histolytica. Here we studied the immunogenicity and protective efficacy of a DNA vaccine against this parasite composed by the EhCPADH surface complex encoding genes (Ehcp112 and Ehadh112). EhCPADH is f...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.04.051
更新日期：2009-06-24 00:00:00
abstract：BACKGROUND:Vaccination coverage with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine in pregnancy or immediately postpartum has been low. Limited data exist on rigorously evaluated interventions to increase maternal vaccination, including Tdap. Tailored messaging based on the Elaborati...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2017.01.037
更新日期：2017-03-13 00:00:00
abstract：:Current recommendations have not resulted in routine vaccination of correctional facility inmates for hepatitis B. We investigated two hepatitis B outbreaks. Outbreak 1 involved 4 cases epidemiologically linked to persons who had been in jail. Outbreak 2 involved 48 community cases; 69% had a history of incarceration....
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.09.023
更新日期：2006-02-27 00:00:00
abstract：BACKGROUND:Influenza A/H7N9 viruses are undergoing antigenic drift since their emergence in 2013, and vaccination strategies are needed for pandemic preparedness. Two doses of adjuvanted monovalent inactivated influenza A/H7N9 vaccine (IIV1 A/H7N9) are needed for optimal serological responses. However, administering 2 ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.03.071
更新日期：2019-05-01 00:00:00
abstract：:Vaccines are everywhere hugely successful but are also under attack. The reason for the latter is the perception by some people that vaccines are unsafe. However that may be, vaccine safety, life any other scientific subject, must be constantly studied. It was from this point of view that a meeting was organized at th...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.01.024
更新日期：2020-02-18 00:00:00
abstract：:T-lymphocyte responses to influenza vaccination were measured in healthy young and older adult volunteers. All participants were vaccinated with the 1995-96 trivalent influenza vaccine. Cytokine and granzyme B levels were measured in peripheral blood mononuclear cells (PBMC) cultures after virus stimulation, prior to ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)00133-9
更新日期：1998-11-01 00:00:00
abstract：:A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the precursor to the heat-stable enterotoxin of Escherichia coli, has been created by recombinant genetic techniques. It is exported successfully to the bacterial periplasm and assembles into pentamers which retain the ability t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(93)90022-p
更新日期：1993-01-01 00:00:00
abstract：:Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to implement, here we ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.09.031
更新日期：2010-11-03 00:00:00
abstract：INTRODUCTION:Two types of Japanese encephalitis (JE) vaccines, inactivated JE vaccine (JE-I) and live-attenuated JE vaccine (JE-L), are available and used in China. In particular, one JE-L, produced by a domestic manufacturer in China, was prequalified by WHO in 2013. We assessed the safety of JE vaccines in China duri...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.05.021
更新日期：2017-06-22 00:00:00
abstract：:Salmonella Enteritidis mutants with deletions in phoP, fliC or phoPfliC were tested for their virulence and their ability to induce parameters of the innate and adaptive immunity in addition to their potential for serological differentiation between vaccinated, non-vaccinated and infected chickens. The double phoPfliC...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.02.030
更新日期：2011-04-12 00:00:00
abstract：:Leishmania donovani promastigote soluble antigens (sLAg) were encapsulated in non-phosphatidylcholine (non-PC) liposomes (escheriosomes) prepared from E. coli lipids. The escheriosome-based vaccine was investigated for its potential to elicit a protective immune response against experimental visceral leishmaniasis. Th...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.10.025
更新日期：2006-03-10 00:00:00
abstract：:The next-generation human anthrax vaccine developed by the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) is based upon purified Bacillus anthracis recombinant protective antigen (rPA) adsorbed to aluminum hydroxide adjuvant (Alhydrogel). In addition to being safe, and effective, it is...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.02.013
更新日期：2006-04-24 00:00:00
abstract：:The varied rates of protection induced by Mycobacterium bovis BCG vaccine against tuberculosis has been attributed to many factors such as genetic variability among BCG strains, rapid clearance of BCG in some populations, and different levels of previous exposure of vaccinated populations to environmental mycobacteria...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.12.044
更新日期：2012-02-01 00:00:00
abstract：:To assess human papillomavirus (HPV) prevalence and genotype distribution by age and cervical cytology/histology status among women undergoing routine gynecological examinations, and to discuss the possible impact on preventive strategies. Liquid-based cytology (LBC) samples were tested for HPV DNA, mRNA, and HPV geno...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.06.013
更新日期：2012-07-27 00:00:00
abstract：:A systematic review was performed to assess the safety and immunogenicity of the prepandemic H5N1 influenza vaccines licensed so far. A bibliographic search according to the COSI protocol was carried out and 8 of 235 potentially relevant publications were selected. Quality assessment was defined with both CASP and Jad...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2010.03.068
更新日期：2010-06-11 00:00:00
abstract：:The safety, reactogenicity and immunogenicity of three candidate Lyme vaccines based on recombinant outer surface protein (OspA) presented in either lipidated or unlipidated forms, were assessed in 300 seronegative volunteers. Subjects received three doses of one of the three formulations at monthly intervals and were...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0264-410x(96)00146-6
更新日期：1996-12-01 00:00:00
abstract：:Successful launches of recently licensed vaccines contrast with pharmaceutical industry concerns about unfavorable market conditions, making the status and future of vaccine development uncertain. We assessed trends in private-sector vaccine research and development for the period 1995-2008, using a global pharmaceuti...
journal_title：Vaccine
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.vaccine.2009.11.007
更新日期：2010-02-03 00:00:00
abstract：:The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.06.080
更新日期：2013-09-13 00:00:00
abstract：BACKGROUND:The potential for development of autoimmune diseases after vaccination with new vaccines containing novel adjuvants is a theoretical concern. Randomised, placebo-controlled trials are the best method for assessing a potential causal relationship between an adverse event and vaccination, but usually have a sa...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.01.042
更新日期：2013-04-03 00:00:00
abstract：BACKGROUND:Several concepts are available to explain vaccine decision making by individual and inter-individual factors, including risk perception, social conformism and altruism. However, only a few studies have quantified the weight of these determinants in vaccine acceptance. Using a conjoint analysis tool, we aimed...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.03.086
更新日期：2017-05-09 00:00:00
abstract：:We previously demonstrated that intradermal and intramuscular vaccination with Leishmania amazonensis promastigote antigens (LaAg) increases the susceptibility of BALB/c mice to cutaneous leishmaniasis. In this study, we investigated the role played by serine and cysteine proteases as disease-promoting components of L...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.04.109
更新日期：2010-07-26 00:00:00
abstract：:TA-CIN is a vaccine that comprises the human papillomavirus (HPV) type 16 L2, E6 and E7 as a single fusion protein. In a mouse model, TA-CIN effectively prevented outgrowth of HPV16-positive tumour cells. To assess the safety and immunogenicity of TA-CIN, a dose escalating (26, 128, 533 micro g), double blind and plac...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0264-410x(02)00350-x
更新日期：2002-10-04 00:00:00
abstract：:In Italy systematic mandatory tetanus immunization of children started in 1968. In a national sample of 241 young males born after 1968 the prevalence of non-immune subjects was 11.2% (5.5% in the North-Centre, 15.9% in the South-Islands; p < 0.02). Comparing these data with the corresponding figure obtained in a prev...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(93)90381-7
更新日期：1993-01-01 00:00:00
abstract：:The most common preventative measure against mumps is vaccination with mumps vaccine. In most parts of the world, mumps vaccine is routinely delivered through live attenuated Measles-Mumps-Rubella (MMR) vaccine. In Japan, receiving mumps vaccine is voluntary and vaccine uptake rate is less than 30%. The introduction o...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.05.020
更新日期：2014-07-16 00:00:00
abstract：:Dengue disease is a global challenge for healthcare systems particularly during outbreaks, and millions of dollars are spent every year for vector control. An efficient and safe vaccine that is cost-effective could resolve the burden that dengue virus imposes on affected countries. We describe here the immunogenicity ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.01.074
更新日期：2015-03-17 00:00:00
abstract：:Optimized DNA vectors were constructed comprising the proteome of SIV including the structural, enzymatic, regulatory, and accessory proteins. In addition to native antigens as produced by the virus, fusion proteins and modified antigens with altered secretion, cellular localization and stability characteristics were ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.12.056
更新日期：2011-09-09 00:00:00
abstract：:Toxoplasma gondii is an intracellular parasite that causes severe neurologic and ocular disease in immune-compromised and congenitally infected individuals. There is no vaccine protective against human toxoplasmosis. Herein, immunization of L(d) mice with HF10 (HPGSVNEFDF) with palmitic acid moieties or a monophosphor...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.03.028
更新日期：2010-05-21 00:00:00
abstract：:Vaccination during pregnancy is increasingly being used as an effective approach for protecting both young infants and their mothers from serious infections. Drawing conclusions from published studies in this area can be difficult because of the inability to compare vaccine trial results across different studies and s...
journal_title：Vaccine
pub_type： 指南,杂志文章
doi：10.1016/j.vaccine.2016.07.032
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:By the time clinical symptoms of Alzheimer's disease (AD) manifest in patients there is already substantial tau pathology in the brain. Recent evidence also suggests that tau pathology can become self-propagating, further accelerating disease progression. Over the last decade several groups have tested the e...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.03.020
更新日期：2017-04-11 00:00:00
abstract：:Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere and there is no vaccine available for disease prevention. The majority of LB cases in Europe are caused by four different Borrelia species expressing six different OspA serotypes, whereas in the US only one of these serotypes is p...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.07.095
更新日期：2015-11-04 00:00:00
