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Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.

Abstract：

:The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p=0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.

journal_name

Vaccine

journal_title

Vaccine

authors

Delbos V,Lemée L,Bénichou J,Berthelot G,Deghmane AE,Leroy JP,Houivet E,Hong E,Taha MK,Caron F,B14 STOP study group.

doi

10.1016/j.vaccine.2013.06.080

subject

Has Abstract

pub_date

2013-09-13 00:00:00

pages

4416-20

issue

40

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(13)00890-6

journal_volume

31

pub_type

杂志文章

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