Abstract：
:Dengue disease is a global challenge for healthcare systems particularly during outbreaks, and millions of dollars are spent every year for vector control. An efficient and safe vaccine that is cost-effective could resolve the burden that dengue virus imposes on affected countries. We describe here the immunogenicity of a tetravalent formulation of a recombinant fusion protein consisting of E domain III and the capsid protein of dengue serotypes 1-4 (Tetra DIIIC). E domain III is an epitope for efficient neutralizing antibodies while the capsid protein contains T cell epitopes. Besides combining B and T cell epitopes, Tetra DIIIC is highly immunogenic due to its aggregate form and a two-component adjuvant. Following previous studies assessing the monovalent DIIIC formulations, we addressed here the quality and breadth of the T cell- and antibody response of Tetra DIIIC in mice. Tetra DIIIC induced a Th1-type response against all four DENV serotypes and dengue-specific antibodies were predominantly IgG1 and IgG2a and neutralizing, while the induction of neutralizing antibodies was dependent on IFN signaling. Importantly, the Th1 and IgG1/IgG2a profile of the DIIIC vaccine approach is similar to an efficient natural anti-dengue response.
journal_name
Vaccinejournal_title
Vaccineauthors
Zuest R,Valdes I,Skibinski D,Lin Y,Toh YX,Chan K,Hermida L,Connolly J,Guillen G,Fink Kdoi
10.1016/j.vaccine.2015.01.074subject
Has Abstractpub_date
2015-03-17 00:00:00pages
1474-82issue
12eissn
0264-410Xissn
1873-2518pii
S0264-410X(15)00131-0journal_volume
33pub_type
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