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Development of an attenuated strain of chikungunya virus for use in vaccine production.

Abstract：

:An attenuated chikungunya (CHIK) virus clone was developed for production of a live vaccine for human use. CHIK strain 15561 was subjected to 18 plaque-to-plaque passages in MRC-5 cultures before CHIK 181/clone 25 was selected as vaccine seed based on homogeneous small plaque size, suckling mouse avirulence, reduced monkey viraemia and genetic stability. Oligonucleotide mapping demonstrated differences between parent and clone. Vaccine (pilot-lot production) elicited neutralizing antibody and protected mice and rhesus monkeys against challenge. After challenge, viraemias were absent in vaccinated monkeys. Vaccine was then produced and tested in accordance with governmental regulatory requirements of human use.

journal_name

Vaccine

journal_title

Vaccine

authors

Levitt NH,Ramsburg HH,Hasty SE,Repik PM,Cole FE Jr,Lupton HW

doi

10.1016/0264-410x(86)90003-4

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

157-62

issue

3

eissn

0264-410X

issn

1873-2518

pii

0264-410X(86)90003-4

journal_volume

4

pub_type

杂志文章

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