Abstract:
:We have developed the Mycobacterium tuberculosis (Mtb) fusion protein (ID83), which contains the three Mtb proteins Rv1813, Rv3620 and Rv2608. We evaluated the immunogenicity and protective efficacy of ID83 in combination with several emulsion-formulated toll-like receptor agonists. The ID83 subunit vaccines containing synthetic TLR4 or TLR9 agonists generated a T helper-1 immune response and protected mice against challenge with Mtb regardless of route. The ID83 vaccine formulated with gardiquimod (a TLR7 agonist) also resulted in a protective response when administered intradermally, whereas the same vaccine given subcutaneously failed to provide protection. This highlights the need to explore different routes of immunization based on the adjuvant formulations used.
journal_name
Vaccinejournal_title
Vaccineauthors
Baldwin SL,Bertholet S,Kahn M,Zharkikh I,Ireton GC,Vedvick TS,Reed SG,Coler RNdoi
10.1016/j.vaccine.2009.03.018subject
Has Abstractpub_date
2009-05-18 00:00:00pages
3063-71issue
23eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)00409-5journal_volume
27pub_type
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