Intradermal immunization improves protective efficacy of a novel TB vaccine candidate.

Abstract:

:We have developed the Mycobacterium tuberculosis (Mtb) fusion protein (ID83), which contains the three Mtb proteins Rv1813, Rv3620 and Rv2608. We evaluated the immunogenicity and protective efficacy of ID83 in combination with several emulsion-formulated toll-like receptor agonists. The ID83 subunit vaccines containing synthetic TLR4 or TLR9 agonists generated a T helper-1 immune response and protected mice against challenge with Mtb regardless of route. The ID83 vaccine formulated with gardiquimod (a TLR7 agonist) also resulted in a protective response when administered intradermally, whereas the same vaccine given subcutaneously failed to provide protection. This highlights the need to explore different routes of immunization based on the adjuvant formulations used.

journal_name

Vaccine

journal_title

Vaccine

authors

Baldwin SL,Bertholet S,Kahn M,Zharkikh I,Ireton GC,Vedvick TS,Reed SG,Coler RN

doi

10.1016/j.vaccine.2009.03.018

subject

Has Abstract

pub_date

2009-05-18 00:00:00

pages

3063-71

issue

23

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)00409-5

journal_volume

27

pub_type

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